Hdc (histidine decarboxylase) - Rat Genome Database
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Gene: Hdc (histidine decarboxylase) Ictidomys tridecemlineatus
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Symbol: Hdc
Name: histidine decarboxylase
RGD ID: 12532910
Description: ENCODES a protein that exhibits amino acid binding (ortholog); histidine decarboxylase activity (ortholog); identical protein binding (ortholog); INVOLVED IN histamine biosynthetic process (ortholog); histamine metabolic process (ortholog); histidine catabolic process (ortholog); PARTICIPATES IN histidine metabolic pathway; histidinemia pathway; ASSOCIATED WITH asthma (ortholog); Chlamydophila Infections (ortholog); Gilles de la Tourette syndrome (ortholog); FOUND IN cytosol (ortholog); dendrite (ortholog); neuronal cell body (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Orthologs:
Homo sapiens (human) : HDC (histidine decarboxylase)  HGNC  Alliance
Mus musculus (house mouse) : Hdc (histidine decarboxylase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Hdc (histidine decarboxylase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hdc (histidine decarboxylase)
Pan paniscus (bonobo/pygmy chimpanzee) : HDC (histidine decarboxylase)
Canis lupus familiaris (dog) : HDC (histidine decarboxylase)
Sus scrofa (pig) : HDC (histidine decarboxylase)
Chlorocebus sabaeus (African green monkey) : HDC (histidine decarboxylase)
Heterocephalus glaber (naked mole-rat) : Hdc (histidine decarboxylase)
more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493647112,303,802 - 12,324,613 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
Hdc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493647112,303,802 - 12,324,613 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HDC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1550,241,947 - 50,265,965 (-)EnsemblGRCh38hg38GRCh38
GRCh381550,241,945 - 50,266,049 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371550,534,144 - 50,558,162 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361548,321,436 - 48,345,218 (-)NCBINCBI36hg18NCBI36
Build 341548,321,442 - 48,345,214NCBI
Celera1527,426,734 - 27,450,752 (-)NCBI
Cytogenetic Map15q21.2NCBI
HuRef1527,365,086 - 27,389,097 (-)NCBIHuRef
CHM1_11550,652,084 - 50,676,103 (-)NCBICHM1_1
Hdc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392126,435,579 - 126,465,942 (-)NCBI
GRCm382126,593,659 - 126,624,025 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2126,593,667 - 126,619,299 (-)EnsemblGRCm38mm10GRCm38
MGSCv372126,419,404 - 126,444,401 (-)NCBIGRCm37mm9NCBIm37
MGSCv362126,285,109 - 126,310,106 (-)NCBImm8
Celera2127,832,271 - 127,857,347 (-)NCBICelera
Cytogenetic Map2F1NCBI
cM Map261.76NCBI
Hdc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.03119,057,524 - 119,075,599 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3119,057,517 - 119,075,619 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03125,585,190 - 125,603,276 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43114,119,316 - 114,138,107 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13114,024,891 - 114,043,687 (-)NCBI
Celera3112,689,823 - 112,707,916 (-)NCBICelera
Cytogenetic Map3q36NCBI
Hdc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554094,051,271 - 4,072,642 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554094,051,574 - 4,072,641 (+)NCBIChiLan1.0ChiLan1.0
HDC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11547,510,629 - 47,534,577 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1547,510,629 - 47,534,577 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01529,188,296 - 29,212,327 (-)NCBIMhudiblu_PPA_v0panPan3
HDC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl3016,201,589 - 16,223,662 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.13016,201,222 - 16,223,452 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
HDC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1121,505,742 - 121,525,255 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11121,505,677 - 121,525,416 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21135,147,966 - 135,167,683 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HDC
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl2633,051,966 - 33,074,563 (+)Ensembl
ChlSab1.12633,051,048 - 33,074,872 (+)NCBI
Hdc
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247319,835,585 - 9,856,743 (+)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_005316555   ⟹   XP_005316612
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0NW_00493647112,303,802 - 12,324,613 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005316556   ⟹   XP_005316613
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0NW_00493647112,303,835 - 12,324,607 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013358591   ⟹   XP_013214045
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0NW_00493647112,303,835 - 12,324,570 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005316612 (Get FASTA)   NCBI Sequence Viewer  
  XP_005316613 (Get FASTA)   NCBI Sequence Viewer  
  XP_013214045 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005316612   ⟸   XM_005316555
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_005316613   ⟸   XM_005316556
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_013214045   ⟸   XM_013358591
- Peptide Label: isoform X2
- Sequence:


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000002266 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSTOP00000002024 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000002266 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 3.40.640.10 UniProtKB/TrEMBL
  3.90.1150.10 UniProtKB/TrEMBL
InterPro Aromatic_deC UniProtKB/TrEMBL
  PyrdxlP-dep_de-COase UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase_dom1 UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase_major UniProtKB/TrEMBL
  Pyridoxal-P_BS UniProtKB/TrEMBL
NCBI Gene Hdc ENTREZGENE
Pfam Pyridoxal_deC UniProtKB/TrEMBL
PRINTS YHDCRBOXLASE UniProtKB/TrEMBL
PROSITE DDC_GAD_HDC_YDC UniProtKB/TrEMBL
Superfamily-SCOP SSF53383 UniProtKB/TrEMBL
UniProt I3M033_ICTTR UniProtKB/TrEMBL