HDAC2 (histone deacetylase 2) - Rat Genome Database

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Gene: HDAC2 (histone deacetylase 2) Sus scrofa
Analyze
Symbol: HDAC2
Name: histone deacetylase 2
RGD ID: 14055959
Description: ENCODES a protein that exhibits chromatin binding (ortholog); chromatin DNA binding (ortholog); deacetylase activity (ortholog); INVOLVED IN behavioral response to ethanol (ortholog); cardiac muscle cell development (ortholog); cardiac muscle hypertrophy (ortholog); PARTICIPATES IN CHD family mediated chromatin remodeling pathway; Hedgehog signaling pathway; histone modification pathway; ASSOCIATED WITH acute kidney failure (ortholog); acute lymphoblastic leukemia (ortholog); alcohol use disorder (ortholog); FOUND IN chromatin (ortholog); heterochromatin (ortholog); replication fork (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl179,863,094 - 79,901,585 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1179,867,713 - 79,901,597 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2189,929,206 - 89,962,996 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
behavioral response to ethanol  (ISO)
cardiac muscle cell development  (ISO)
cardiac muscle hypertrophy  (ISO)
cellular response to dopamine  (ISO)
cellular response to heat  (ISO)
cellular response to hydrogen peroxide  (ISO)
cellular response to retinoic acid  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
cellular response to trichostatin A  (ISO)
chromatin organization  (IEA)
chromatin remodeling  (IEA)
circadian regulation of gene expression  (ISO)
dendrite development  (ISO)
DNA-templated transcription  (IEA)
embryonic digit morphogenesis  (ISO)
epidermal cell differentiation  (ISO)
eyelid development in camera-type eye  (ISO)
fungiform papilla formation  (ISO)
hair follicle placode formation  (ISO)
heterochromatin formation  (IBA,IEA)
hippocampus development  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of canonical Wnt signaling pathway  (ISO)
negative regulation of cardiac muscle cell proliferation  (ISO)
negative regulation of dendritic spine development  (ISO)
negative regulation of DNA binding  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of gene expression, epigenetic  (ISO)
negative regulation of intrinsic apoptotic signaling pathway  (ISO)
negative regulation of miRNA transcription  (ISO)
negative regulation of neuron projection development  (ISO)
negative regulation of peptidyl-lysine acetylation  (ISO)
negative regulation of transcription by competitive promoter binding  (IEA)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
neuron differentiation  (ISO)
obsolete positive regulation of DNA-binding transcription factor activity  (ISO)
odontogenesis of dentin-containing tooth  (ISO)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of epithelial to mesenchymal transition  (ISO)
positive regulation of interleukin-1 production  (ISO)
positive regulation of intracellular estrogen receptor signaling pathway  (ISO)
positive regulation of male mating behavior  (ISO)
positive regulation of oligodendrocyte differentiation  (ISO)
positive regulation of protein modification process  (ISO)
positive regulation of proteolysis  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA)
positive regulation of tumor necrosis factor production  (ISO)
progesterone receptor signaling pathway  (ISO)
protein modification process  (ISO)
regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
regulation of protein deacetylation  (ISO)
regulation of sarcomere organization  (ISO)
response to alcohol  (ISO)
response to amphetamine  (ISO)
response to amyloid-beta  (ISO)
response to caffeine  (ISO)
response to cocaine  (ISO)
response to hyperoxia  (ISO)
response to lipopolysaccharide  (ISO)
response to nicotine  (ISO)
response to xenobiotic stimulus  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
HDAC2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl179,863,094 - 79,901,585 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1179,867,713 - 79,901,597 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2189,929,206 - 89,962,996 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HDAC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386113,933,028 - 113,971,148 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6113,933,028 - 114,011,308 (-)Ensemblhg38GRCh38
GRCh376114,254,192 - 114,292,312 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366114,364,019 - 114,399,047 (-)NCBIBuild 36Build 36hg18NCBI36
Build 346114,368,619 - 114,398,967NCBI
Celera6114,998,693 - 115,033,733 (-)NCBICelera
Cytogenetic Map6q21NCBI
HuRef6111,834,121 - 111,869,161 (-)NCBIHuRef
CHM1_16114,520,179 - 114,555,225 (-)NCBICHM1_1
T2T-CHM13v2.06115,116,117 - 115,154,233 (-)NCBIT2T-CHM13v2.0
Hdac2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391036,850,293 - 36,877,885 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1036,850,540 - 36,877,885 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381036,974,297 - 37,001,889 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1036,974,544 - 37,001,889 (+)Ensemblmm10GRCm38
MGSCv371036,694,350 - 36,721,694 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361036,663,960 - 36,691,304 (+)NCBIMGSCv36mm8
Celera1037,867,952 - 37,895,247 (+)NCBICelera
Cytogenetic Map10B1NCBI
cM Map1019.44NCBI
Hdac2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82042,101,815 - 42,126,486 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2042,102,861 - 42,126,311 (+)EnsemblGRCr8
mRatBN7.22040,548,244 - 40,571,609 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2040,548,250 - 40,571,609 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2042,287,370 - 42,310,647 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02041,946,582 - 41,969,860 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02042,695,816 - 42,719,094 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd2042,124,585 - 42,147,573 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive2043,191,000 - 43,213,990 (+)NCBILyon_Normotensive
Lyon_Hypertensive2043,254,225 - 43,277,217 (+)NCBILyon_Hypertensive
F344_StmMcwi2042,075,522 - 42,098,492 (+)NCBIF344_StmMcwi
Rnor_6.02043,084,870 - 43,108,198 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2043,084,870 - 43,108,198 (-)Ensemblrn6Rnor6.0
Rnor_5.02044,811,967 - 44,835,337 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42041,162,093 - 41,186,492 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2041,298,790 - 41,322,159 (+)NCBICelera
RGSC_v3.12041,204,917 - 41,209,275 (+)NCBI
Cytogenetic Map20q12NCBI
Hdac2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555262,728,377 - 2,759,707 (+)Ensembl
ChiLan1.0NW_0049555262,739,099 - 2,759,640 (+)NCBIChiLan1.0ChiLan1.0
HDAC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25133,936,717 - 133,967,655 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16131,832,186 - 131,863,124 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06111,731,139 - 111,761,826 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16115,802,367 - 115,833,004 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6115,802,367 - 115,833,004 (-)EnsemblpanPan2panpan1.1
HDAC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11270,053,822 - 70,083,491 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1270,053,297 - 70,103,578 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1269,799,259 - 69,828,714 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01270,933,049 - 70,962,557 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1270,932,535 - 70,961,523 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11270,285,352 - 70,314,769 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01270,123,758 - 70,153,135 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01270,454,633 - 70,484,021 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Hdac2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946105,216,548 - 105,242,461 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366792,448,390 - 2,474,641 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366792,448,676 - 2,474,641 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HDAC2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11359,873,248 - 59,904,542 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1359,873,767 - 59,905,742 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604032,233,290 - 32,264,328 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hdac2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248564,834,217 - 4,861,592 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248564,834,197 - 4,861,546 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in HDAC2
707 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 23 3 2 5 14 12 23 3 6 3

Sequence


Ensembl Acc Id: ENSSSCT00000004897   ⟹   ENSSSCP00000004781
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl179,863,094 - 79,901,572 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000068032   ⟹   ENSSSCP00000063028
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl179,871,418 - 79,901,585 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000095301   ⟹   ENSSSCP00000076306
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl179,870,896 - 79,901,572 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000102052   ⟹   ENSSSCP00000078450
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl179,870,681 - 79,901,572 (-)Ensembl
RefSeq Acc Id: XM_001925318   ⟹   XP_001925353
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1179,867,713 - 79,901,597 (-)NCBI
Sequence:
RefSeq Acc Id: XP_001925353   ⟸   XM_001925318
- UniProtKB: F1RZK8 (UniProtKB/TrEMBL),   A0A4X1V7Y5 (UniProtKB/TrEMBL),   A0A8D1F4E7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000063028   ⟸   ENSSSCT00000068032
Ensembl Acc Id: ENSSSCP00000004781   ⟸   ENSSSCT00000004897
Ensembl Acc Id: ENSSSCP00000078450   ⟸   ENSSSCT00000102052
Ensembl Acc Id: ENSSSCP00000076306   ⟸   ENSSSCT00000095301
Protein Domains
Histone deacetylase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000004432 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015027475 UniProtKB/TrEMBL
  ENSSSCG00025022583 UniProtKB/TrEMBL
  ENSSSCG00030053522 UniProtKB/TrEMBL
  ENSSSCG00035016641 UniProtKB/TrEMBL
  ENSSSCG00040051672 UniProtKB/TrEMBL
  ENSSSCG00045030458 UniProtKB/TrEMBL
  ENSSSCG00050053005 UniProtKB/TrEMBL
  ENSSSCG00055027185 UniProtKB/TrEMBL
  ENSSSCG00060028706 UniProtKB/TrEMBL
  ENSSSCG00065060879 UniProtKB/TrEMBL
  ENSSSCG00070022255 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000004897 ENTREZGENE
  ENSSSCT00000004897.4 UniProtKB/TrEMBL
  ENSSSCT00000068032.1 UniProtKB/TrEMBL
  ENSSSCT00000095301.1 UniProtKB/TrEMBL
  ENSSSCT00000102052.1 UniProtKB/TrEMBL
  ENSSSCT00015036536.1 UniProtKB/TrEMBL
  ENSSSCT00015036628.1 UniProtKB/TrEMBL
  ENSSSCT00025030696.1 UniProtKB/TrEMBL
  ENSSSCT00025030734.1 UniProtKB/TrEMBL
  ENSSSCT00030074641.1 UniProtKB/TrEMBL
  ENSSSCT00030074675.1 UniProtKB/TrEMBL
  ENSSSCT00030074696.1 UniProtKB/TrEMBL
  ENSSSCT00035021284.1 UniProtKB/TrEMBL
  ENSSSCT00035021287.1 UniProtKB/TrEMBL
  ENSSSCT00035021292.1 UniProtKB/TrEMBL
  ENSSSCT00040069989.1 UniProtKB/TrEMBL
  ENSSSCT00040070118.1 UniProtKB/TrEMBL
  ENSSSCT00040070294.1 UniProtKB/TrEMBL
  ENSSSCT00040070379.1 UniProtKB/TrEMBL
  ENSSSCT00045052427.1 UniProtKB/TrEMBL
  ENSSSCT00045052558.1 UniProtKB/TrEMBL
  ENSSSCT00045052689.1 UniProtKB/TrEMBL
  ENSSSCT00050072184.1 UniProtKB/TrEMBL
  ENSSSCT00050072185.1 UniProtKB/TrEMBL
  ENSSSCT00055053744.1 UniProtKB/TrEMBL
  ENSSSCT00055053849.1 UniProtKB/TrEMBL
  ENSSSCT00060038815.1 UniProtKB/TrEMBL
  ENSSSCT00060038818.1 UniProtKB/TrEMBL
  ENSSSCT00060038831.1 UniProtKB/TrEMBL
  ENSSSCT00060038835.1 UniProtKB/TrEMBL
  ENSSSCT00065083420.1 UniProtKB/TrEMBL
  ENSSSCT00065083424.1 UniProtKB/TrEMBL
  ENSSSCT00070044288.1 UniProtKB/TrEMBL
  ENSSSCT00070044292.1 UniProtKB/TrEMBL
  ENSSSCT00070044295.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.800.20 UniProtKB/TrEMBL
InterPro His_deacetylse UniProtKB/TrEMBL
  His_deacetylse_1 UniProtKB/TrEMBL
  His_deacetylse_dom UniProtKB/TrEMBL
  His_deacetylse_dom_sf UniProtKB/TrEMBL
  Ureohydrolase_dom_sf UniProtKB/TrEMBL
KEGG Report ssc:100156170 UniProtKB/TrEMBL
NCBI Gene HDAC2 ENTREZGENE
PANTHER HISTONE DEACETYLASE 2 UniProtKB/TrEMBL
  HISTONE DEACETYLASE HDAC1-RELATED UniProtKB/TrEMBL
Pfam Hist_deacetyl UniProtKB/TrEMBL
PIRSF His_deacetylse_1 UniProtKB/TrEMBL
PRINTS HDASUPER UniProtKB/TrEMBL
  HISDACETLASE UniProtKB/TrEMBL
Superfamily-SCOP SSF52768 UniProtKB/TrEMBL
UniProt A0A4X1V3N6_PIG UniProtKB/TrEMBL
  A0A4X1V6P2_PIG UniProtKB/TrEMBL
  A0A4X1V7Y5 ENTREZGENE, UniProtKB/TrEMBL
  A0A5G2QGU2_PIG UniProtKB/TrEMBL
  A0A8D0LID2_PIG UniProtKB/TrEMBL
  A0A8D0XFX6_PIG UniProtKB/TrEMBL
  A0A8D1F4E7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1N1G1_PIG UniProtKB/TrEMBL
  A0A8W4FA90_PIG UniProtKB/TrEMBL
  A0A8W4FGU0_PIG UniProtKB/TrEMBL
  F1RZK8 ENTREZGENE, UniProtKB/TrEMBL
  Q6Q6E9_PIG UniProtKB/TrEMBL
VGNC ID VGNC:88813 ENTREZGENE