Nsd2 (nuclear receptor binding SET domain protein 2) - Rat Genome Database

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Gene: Nsd2 (nuclear receptor binding SET domain protein 2) Rattus norvegicus
Analyze
Symbol: Nsd2
Name: nuclear receptor binding SET domain protein 2
RGD ID: 1307955
Description: Predicted to enable chromatin binding activity; histone H3K36 trimethyltransferase activity; and sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to act upstream of or within several processes, including bone development; cardiac septum morphogenesis; and regulation of nucleobase-containing compound metabolic process. Predicted to be located in chromatin and nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human NSD2 (nuclear receptor binding SET domain protein 2); PARTICIPATES IN lysine degradation pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: histone-lysine N-methyltransferase NSD2; LOC305456; LOC680537; probable histone-lysine N-methyltransferase NSD2; RGD1565590; similar to Wolf-Hirschhorn syndrome candidate 1 protein isoform 1; Whsc1; Whsc1_predicted; Wolf-Hirschhorn syndrome candidate 1; Wolf-Hirschhorn syndrome candidate 1 (human); Wolf-Hirschhorn syndrome candidate 1 (predicted)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81481,057,727 - 81,135,866 (-)NCBIGRCr8
mRatBN7.21476,833,179 - 76,911,304 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1476,835,637 - 76,913,641 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1481,285,034 - 81,363,681 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01482,525,677 - 82,604,318 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01478,970,930 - 79,049,584 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01482,119,210 - 82,196,501 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1482,119,210 - 82,171,480 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01482,803,450 - 82,885,540 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41482,528,213 - 82,580,192NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1475,757,842 - 75,809,420 (-)NCBICelera
Cytogenetic Map14q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrolein  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
berberine  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
ciguatoxin CTX1B  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibenzo[a,l]pyrene  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
entinostat  (ISO)
ethanol  (ISO)
fenthion  (ISO)
fipronil  (EXP)
FR900359  (ISO)
geraniol  (ISO)
glycerol 2-phosphate  (ISO)
L-ascorbic acid  (ISO)
lead(0)  (ISO)
lithium chloride  (ISO)
methidathion  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
nickel atom  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
PCB138  (ISO)
perfluorohexanesulfonic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
topotecan  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
xylitol  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromatin  (IBA)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Circular RNA WHSC1 exerts oncogenic properties by regulating miR-7/TAB2 in lung cancer. Guan S, etal., J Cell Mol Med. 2021 Oct;25(20):9784-9795. doi: 10.1111/jcmm.16925. Epub 2021 Sep 22.
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:15632090   PMID:19483677   PMID:23241889   PMID:31040165  


Genomics

Comparative Map Data
Nsd2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81481,057,727 - 81,135,866 (-)NCBIGRCr8
mRatBN7.21476,833,179 - 76,911,304 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1476,835,637 - 76,913,641 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1481,285,034 - 81,363,681 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01482,525,677 - 82,604,318 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01478,970,930 - 79,049,584 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01482,119,210 - 82,196,501 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1482,119,210 - 82,171,480 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01482,803,450 - 82,885,540 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41482,528,213 - 82,580,192NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1475,757,842 - 75,809,420 (-)NCBICelera
Cytogenetic Map14q21NCBI
NSD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3841,871,393 - 1,982,192 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl41,871,393 - 1,982,207 (+)EnsemblGRCh38hg38GRCh38
GRCh3741,873,120 - 1,983,919 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3641,842,921 - 1,953,728 (+)NCBINCBI36Build 36hg18NCBI36
Build 3441,908,238 - 1,948,753NCBI
Celera41,806,735 - 1,896,162 (+)NCBICelera
Cytogenetic Map4p16.3NCBI
HuRef41,835,879 - 1,925,293 (+)NCBIHuRef
CHM1_141,838,966 - 1,982,597 (+)NCBICHM1_1
T2T-CHM13v2.041,869,868 - 1,980,701 (+)NCBIT2T-CHM13v2.0
Nsd2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39533,974,286 - 34,055,310 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl533,978,069 - 34,055,319 (+)EnsemblGRCm39 Ensembl
GRCm38533,820,676 - 33,897,966 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl533,820,725 - 33,897,975 (+)EnsemblGRCm38mm10GRCm38
MGSCv37534,185,761 - 34,240,615 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36534,137,582 - 34,212,733 (+)NCBIMGSCv36mm8
Celera531,320,283 - 31,375,217 (+)NCBICelera
Cytogenetic Map5B2NCBI
cM Map517.83NCBI
Nsd2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555141,069,085 - 1,162,624 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555141,084,522 - 1,162,624 (+)NCBIChiLan1.0ChiLan1.0
NSD2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v232,199,534 - 2,309,496 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan142,136,630 - 2,244,129 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v042,009,276 - 2,119,182 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.141,938,777 - 2,027,425 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl41,945,307 - 2,027,425 (+)Ensemblpanpan1.1panPan2
NSD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1362,164,888 - 62,228,006 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl362,167,939 - 62,228,035 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha364,685,041 - 64,745,834 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0362,642,652 - 62,703,479 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl362,640,335 - 62,728,323 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1362,136,547 - 62,197,103 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0362,339,914 - 62,400,643 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0362,698,946 - 62,759,731 (-)NCBIUU_Cfam_GSD_1.0
Nsd2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528567,758,741 - 67,832,919 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647721,460,478 - 21,534,909 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647721,460,442 - 21,531,563 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NSD2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8964,893 - 1,018,028 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18938,832 - 1,018,032 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28412,141 - 514,862 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NSD2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12746,787,325 - 46,896,898 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2746,787,154 - 46,867,792 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660513,159,458 - 3,273,021 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nsd2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475525,509,301 - 25,588,204 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475525,510,329 - 25,588,540 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nsd2
172 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:593
Count of miRNA genes:268
Interacting mature miRNAs:355
Transcripts:ENSRNOT00000021952
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313089Bss81Bone structure and strength QTL 813.40.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)143766971982669719Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1455624247100624247Rat
1582236Gluco22Glucose level QTL 223.30.0164blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1455147478100147478Rat
70153Bp59Blood pressure QTL 593.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)146875779683368335Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143032009280829842Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)144079346098037301Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1470053989104886043Rat
1582197Gluco27Glucose level QTL 273.40.0006blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)147341532392554092Rat
2313100Bss82Bone structure and strength QTL 8230.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143766971982669719Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1458184885103184885Rat
1582250Gluco26Glucose level QTL 263.30.0009blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532395876975Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1456631369101631369Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1470053989104886043Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
1582255Gluco29Glucose level QTL 293.10.0025blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)147341532392554092Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1455624247100624247Rat
1582209Gluco20Glucose level QTL 203.80.0005blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
2313048Bss84Bone structure and strength QTL 843.10.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143766971982669719Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144226252995023211Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)145002321195023211Rat
738037Hcas6Hepatocarcinoma susceptibility QTL 62.93liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)143905723783368335Rat
2313084Bss83Bone structure and strength QTL 832.90.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143766971982669719Rat

Markers in Region
RH127704  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21476,835,714 - 76,835,917 (+)MAPPERmRatBN7.2
Rnor_6.01482,120,630 - 82,120,832NCBIRnor6.0
Rnor_5.01482,804,870 - 82,805,072UniSTSRnor5.0
RGSC_v3.41482,529,633 - 82,529,835UniSTSRGSC3.4
Celera1475,759,262 - 75,759,464UniSTS
Cytogenetic Map14q21UniSTS
BI290800  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21476,834,649 - 76,834,827 (+)MAPPERmRatBN7.2
Rnor_6.01482,119,565 - 82,119,742NCBIRnor6.0
Rnor_5.01482,803,805 - 82,803,982UniSTSRnor5.0
RGSC_v3.41482,528,568 - 82,528,745UniSTSRGSC3.4
Celera1475,758,197 - 75,758,374UniSTS
RH 3.4 Map14489.99UniSTS
Cytogenetic Map14q21UniSTS
RH140649  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21476,833,835 - 76,834,046 (+)MAPPERmRatBN7.2
Rnor_6.01482,118,751 - 82,118,961NCBIRnor6.0
Rnor_5.01482,802,991 - 82,803,201UniSTSRnor5.0
RGSC_v3.41482,527,754 - 82,527,964UniSTSRGSC3.4
Celera1475,757,383 - 75,757,593UniSTS
Cytogenetic Map14q21UniSTS
RH141045  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21476,859,206 - 76,859,410 (+)MAPPERmRatBN7.2
Rnor_6.01482,144,844 - 82,145,047NCBIRnor6.0
Rnor_5.01482,829,084 - 82,829,287UniSTSRnor5.0
RGSC_v3.41482,553,123 - 82,553,326UniSTSRGSC3.4
Celera1475,782,752 - 75,782,955UniSTS
Cytogenetic Map14q21UniSTS
BF390060  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21476,841,864 - 76,842,022 (+)MAPPERmRatBN7.2
Rnor_6.01482,126,780 - 82,126,937NCBIRnor6.0
Rnor_5.01482,811,020 - 82,811,177UniSTSRnor5.0
RGSC_v3.41482,535,783 - 82,535,940UniSTSRGSC3.4
Celera1475,765,412 - 75,765,569UniSTS
Cytogenetic Map14q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001191552 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006251372 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006251373 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006251374 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006251375 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006251376 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006251377 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006251378 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006251379 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770363 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770364 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599377 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599379 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092429 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092430 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092431 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092432 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092433 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092434 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092435 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092436 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092437 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092438 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092439 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273616 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273619 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC133613 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000021952   ⟹   ENSRNOP00000021952
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1476,835,637 - 76,913,641 (-)Ensembl
Rnor_6.0 Ensembl1482,119,210 - 82,171,480 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000106566   ⟹   ENSRNOP00000082542
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1476,858,331 - 76,913,641 (-)Ensembl
RefSeq Acc Id: NM_001191552   ⟹   NP_001178481
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81481,057,727 - 81,135,864 (-)NCBI
mRatBN7.21476,833,179 - 76,911,304 (-)NCBI
Rnor_6.01482,119,210 - 82,171,480 (-)NCBI
Rnor_5.01482,803,450 - 82,885,540 (-)NCBI
Celera1475,757,842 - 75,809,420 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006251372   ⟹   XP_006251434
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81481,060,185 - 81,135,267 (-)NCBI
mRatBN7.21476,833,194 - 76,910,699 (-)NCBI
Rnor_6.01482,120,552 - 82,196,501 (-)NCBI
Rnor_5.01482,803,450 - 82,885,540 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006251373   ⟹   XP_006251435
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81481,060,185 - 81,135,267 (-)NCBI
mRatBN7.21476,833,194 - 76,910,699 (-)NCBI
Rnor_6.01482,120,552 - 82,196,501 (-)NCBI
Rnor_5.01482,803,450 - 82,885,540 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006251376   ⟹   XP_006251438
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81481,060,185 - 81,135,267 (-)NCBI
mRatBN7.21476,833,194 - 76,910,699 (-)NCBI
Rnor_6.01482,120,552 - 82,196,501 (-)NCBI
Rnor_5.01482,803,450 - 82,885,540 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006251378   ⟹   XP_006251440
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81481,060,185 - 81,135,267 (-)NCBI
mRatBN7.21476,833,194 - 76,910,699 (-)NCBI
Rnor_6.01482,120,552 - 82,196,501 (-)NCBI
Rnor_5.01482,803,450 - 82,885,540 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008770364   ⟹   XP_008768586
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81481,060,185 - 81,135,267 (-)NCBI
mRatBN7.21476,833,194 - 76,910,699 (-)NCBI
Rnor_6.01482,120,552 - 82,196,501 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017599379   ⟹   XP_017454868
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81481,060,185 - 81,135,267 (-)NCBI
mRatBN7.21476,833,194 - 76,910,699 (-)NCBI
Rnor_6.01482,120,552 - 82,196,501 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039092429   ⟹   XP_038948357
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81481,060,185 - 81,135,866 (-)NCBI
mRatBN7.21476,833,194 - 76,911,304 (-)NCBI
RefSeq Acc Id: XM_039092430   ⟹   XP_038948358
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81481,060,185 - 81,135,866 (-)NCBI
mRatBN7.21476,833,194 - 76,911,304 (-)NCBI
RefSeq Acc Id: XM_039092431   ⟹   XP_038948359
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81481,060,185 - 81,135,866 (-)NCBI
mRatBN7.21476,833,194 - 76,911,304 (-)NCBI
RefSeq Acc Id: XM_039092432   ⟹   XP_038948360
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81481,060,185 - 81,135,866 (-)NCBI
mRatBN7.21476,833,194 - 76,911,304 (-)NCBI
RefSeq Acc Id: XM_039092433   ⟹   XP_038948361
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81481,060,185 - 81,135,866 (-)NCBI
mRatBN7.21476,833,194 - 76,911,304 (-)NCBI
RefSeq Acc Id: XM_039092434   ⟹   XP_038948362
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81481,060,185 - 81,135,866 (-)NCBI
mRatBN7.21476,833,194 - 76,911,304 (-)NCBI
RefSeq Acc Id: XM_039092435   ⟹   XP_038948363
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81481,060,185 - 81,135,866 (-)NCBI
mRatBN7.21476,833,194 - 76,911,304 (-)NCBI
RefSeq Acc Id: XM_039092436   ⟹   XP_038948364
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81481,060,185 - 81,135,866 (-)NCBI
mRatBN7.21476,833,194 - 76,911,304 (-)NCBI
RefSeq Acc Id: XM_039092437   ⟹   XP_038948365
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81481,060,185 - 81,135,866 (-)NCBI
mRatBN7.21476,833,194 - 76,911,304 (-)NCBI
RefSeq Acc Id: XM_039092438   ⟹   XP_038948366
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81481,060,185 - 81,135,864 (-)NCBI
mRatBN7.21476,833,194 - 76,911,299 (-)NCBI
RefSeq Acc Id: XM_039092439   ⟹   XP_038948367
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81481,077,281 - 81,135,866 (-)NCBI
mRatBN7.21476,852,735 - 76,911,304 (-)NCBI
RefSeq Acc Id: XM_063273616   ⟹   XP_063129686
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81481,060,185 - 81,135,267 (-)NCBI
RefSeq Acc Id: XM_063273619   ⟹   XP_063129689
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81481,060,185 - 81,135,267 (-)NCBI
RefSeq Acc Id: NP_001178481   ⟸   NM_001191552
- UniProtKB: D4A9J4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251440   ⟸   XM_006251378
- Peptide Label: isoform X1
- UniProtKB: D4A9J4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251435   ⟸   XM_006251373
- Peptide Label: isoform X1
- UniProtKB: D4A9J4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251438   ⟸   XM_006251376
- Peptide Label: isoform X1
- UniProtKB: D4A9J4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251434   ⟸   XM_006251372
- Peptide Label: isoform X1
- UniProtKB: D4A9J4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008768586   ⟸   XM_008770364
- Peptide Label: isoform X1
- UniProtKB: D4A9J4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017454868   ⟸   XM_017599379
- Peptide Label: isoform X1
- UniProtKB: D4A9J4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000021952   ⟸   ENSRNOT00000021952
RefSeq Acc Id: XP_038948361   ⟸   XM_039092433
- Peptide Label: isoform X1
- UniProtKB: D4A9J4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038948358   ⟸   XM_039092430
- Peptide Label: isoform X1
- UniProtKB: D4A9J4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038948364   ⟸   XM_039092436
- Peptide Label: isoform X1
- UniProtKB: D4A9J4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038948357   ⟸   XM_039092429
- Peptide Label: isoform X1
- UniProtKB: D4A9J4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038948362   ⟸   XM_039092434
- Peptide Label: isoform X1
- UniProtKB: D4A9J4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038948365   ⟸   XM_039092437
- Peptide Label: isoform X1
- UniProtKB: D4A9J4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038948359   ⟸   XM_039092431
- Peptide Label: isoform X1
- UniProtKB: D4A9J4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038948363   ⟸   XM_039092435
- Peptide Label: isoform X1
- UniProtKB: D4A9J4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038948360   ⟸   XM_039092432
- Peptide Label: isoform X1
- UniProtKB: D4A9J4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038948366   ⟸   XM_039092438
- Peptide Label: isoform X1
- UniProtKB: D4A9J4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038948367   ⟸   XM_039092439
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZU53 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000082542   ⟸   ENSRNOT00000106566
RefSeq Acc Id: XP_063129689   ⟸   XM_063273619
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063129686   ⟸   XM_063273616
- Peptide Label: isoform X1
Protein Domains
AWS   HMG box   PHD-type   Post-SET   PWWP   RING-type   SET

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A9J4-F1-model_v2 AlphaFold D4A9J4 1-1346 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307955 AgrOrtholog
BioCyc Gene G2FUF-15270 BioCyc
Ensembl Genes ENSRNOG00000038140 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000021952.7 UniProtKB/TrEMBL
  ENSRNOT00000106566.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.30.10 UniProtKB/TrEMBL
  2.170.270.10 UniProtKB/TrEMBL
  2.30.30.140 UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/TrEMBL
InterPro AWS UniProtKB/TrEMBL
  C5HCH UniProtKB/TrEMBL
  HMG-box_NSD2 UniProtKB/TrEMBL
  HMG_box_dom_sf UniProtKB/TrEMBL
  HMG_superfamily UniProtKB/TrEMBL
  NSD_PHD UniProtKB/TrEMBL
  PHD1_NSD1_2 UniProtKB/TrEMBL
  PHD3_NSD2 UniProtKB/TrEMBL
  PHD5_NSD2 UniProtKB/TrEMBL
  PHDvar_NSD UniProtKB/TrEMBL
  Post-SET_dom UniProtKB/TrEMBL
  PWWP UniProtKB/TrEMBL
  PWWP_NSD2_rpt1 UniProtKB/TrEMBL
  PWWP_NSD2_rpt2 UniProtKB/TrEMBL
  SET2_Histone-Lys_MeTrsfase UniProtKB/TrEMBL
  SET_dom UniProtKB/TrEMBL
  SET_dom_sf UniProtKB/TrEMBL
  SET_NSD2 UniProtKB/TrEMBL
  ZCWPW1/ZCWPW2 UniProtKB/TrEMBL
  Zinc_finger_PHD-type_CS UniProtKB/TrEMBL
  Znf_FYVE_PHD UniProtKB/TrEMBL
  Znf_PHD UniProtKB/TrEMBL
  Znf_PHD-finger UniProtKB/TrEMBL
  Znf_RING UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
NCBI Gene Nsd2 ENTREZGENE
PANTHER HISTONE-LYSINE N-METHYLTRANSFERASE NSD2 UniProtKB/TrEMBL
  SET DOMAIN PROTEINS UniProtKB/TrEMBL
  UNCHARACTERIZED UniProtKB/TrEMBL
  ZINC FINGER CW-TYPE PWWP DOMAIN PROTEIN 1 UniProtKB/TrEMBL
Pfam AWS UniProtKB/TrEMBL
  C5HCH UniProtKB/TrEMBL
  HMG_box UniProtKB/TrEMBL
  NSD_PHD UniProtKB/TrEMBL
  PHD UniProtKB/TrEMBL
  PHD-1st_NSD UniProtKB/TrEMBL
  PHDvar_NSD UniProtKB/TrEMBL
  PWWP UniProtKB/TrEMBL
  SET UniProtKB/TrEMBL
PhenoGen Nsd2 PhenoGen
PROSITE AWS UniProtKB/TrEMBL
  HMG_BOX_2 UniProtKB/TrEMBL
  POST_SET UniProtKB/TrEMBL
  PWWP UniProtKB/TrEMBL
  SET UniProtKB/TrEMBL
  ZF_PHD_1 UniProtKB/TrEMBL
  ZF_PHD_2 UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000038140 RatGTEx
SMART AWS UniProtKB/TrEMBL
  HMG UniProtKB/TrEMBL
  PHD UniProtKB/TrEMBL
  PostSET UniProtKB/TrEMBL
  PWWP UniProtKB/TrEMBL
  SET UniProtKB/TrEMBL
Superfamily-SCOP FYVE_PHD_ZnF UniProtKB/TrEMBL
  HMG-box UniProtKB/TrEMBL
  SSF82199 UniProtKB/TrEMBL
  Tudor/PWWP/MBT UniProtKB/TrEMBL
UniProt A0A8I5ZU53 ENTREZGENE, UniProtKB/TrEMBL
  D4A9J4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-11-29 Nsd2  nuclear receptor binding SET domain protein 2  Whsc1  Wolf-Hirschhorn syndrome candidate 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-02-04 Whsc1  Wolf-Hirschhorn syndrome candidate 1  Whsc1  Wolf-Hirschhorn syndrome candidate 1 (human)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-04 Whsc1  Wolf-Hirschhorn syndrome candidate 1 (human)  Whsc1_predicted  Wolf-Hirschhorn syndrome candidate 1 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 Whsc1_predicted  Wolf-Hirschhorn syndrome candidate 1 (predicted)  LOC682525  similar to Wolf-Hirschhorn syndrome candidate 1 protein isoform 1  Data merged from RGD:1597949 1643240 APPROVED
2007-02-16 Whsc1_predicted  Wolf-Hirschhorn syndrome candidate 1 (predicted)  LOC680537  similar to Wolf-Hirschhorn syndrome candidate 1 protein isoform 1  Data merged from RGD:1590623 737654 APPROVED
2006-11-20 LOC680537  similar to Wolf-Hirschhorn syndrome candidate 1 protein isoform 1      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-20 LOC682525  similar to Wolf-Hirschhorn syndrome candidate 1 protein isoform 1      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-12 Whsc1_predicted  Wolf-Hirschhorn syndrome candidate 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED