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Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Kank4 | Rat | 1-naphthyl isothiocyanate | increases expression | EXP | | 6480464 | 1-Naphthylisothiocyanate results in increased expression of KANK4 mRNA | CTD | PMID:30723492 | Kank4 | Rat | 17beta-estradiol | multiple interactions | ISO | KANK4 (Homo sapiens) | 6480464 | [Estradiol co-treated with TGFB1 protein] results in increased expression of KANK4 mRNA | CTD | PMID:30165855 | Kank4 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | KANK4 (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of KANK4 mRNA | CTD | PMID:20106945 | Kank4 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of KANK4 mRNA | CTD | PMID:34747641 | Kank4 | Rat | 4,4'-sulfonyldiphenol | increases expression | ISO | Kank4 (Mus musculus) | 6480464 | bisphenol S results in increased expression of KANK4 mRNA | CTD | PMID:30951980 | Kank4 | Rat | 4,4'-sulfonyldiphenol | affects methylation | ISO | Kank4 (Mus musculus) | 6480464 | bisphenol S affects the methylation of KANK4 gene | CTD | PMID:31683443 | Kank4 | Rat | 5-aza-2'-deoxycytidine | affects expression | ISO | KANK4 (Homo sapiens) | 6480464 | Decitabine affects the expression of KANK4 mRNA | CTD | PMID:23300844 | Kank4 | Rat | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of KANK4 mRNA | CTD | PMID:24780913 | Kank4 | Rat | acetamide | increases expression | EXP | | 6480464 | acetamide results in increased expression of KANK4 mRNA | CTD | PMID:31881176 | Kank4 | Rat | aflatoxin B1 | decreases expression | ISO | KANK4 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased expression of KANK4 mRNA | CTD | PMID:21632981 more ... | Kank4 | Rat | aflatoxin B1 | increases methylation | ISO | KANK4 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of KANK4 intron | CTD | PMID:30157460 | Kank4 | Rat | all-trans-retinoic acid | increases expression | ISO | KANK4 (Homo sapiens) | 6480464 | Tretinoin results in increased expression of KANK4 mRNA | CTD | PMID:21934132 | Kank4 | Rat | antirheumatic drug | increases expression | ISO | KANK4 (Homo sapiens) | 6480464 | Antirheumatic Agents results in increased expression of KANK4 mRNA | CTD | PMID:24449571 | Kank4 | Rat | arsenite(3-) | increases methylation | ISO | KANK4 (Homo sapiens) | 6480464 | arsenite results in increased methylation of KANK4 promoter | CTD | PMID:23974009 | Kank4 | Rat | arsenous acid | decreases expression | ISO | KANK4 (Homo sapiens) | 6480464 | Arsenic Trioxide results in decreased expression of KANK4 mRNA | CTD | PMID:26705709 | Kank4 | Rat | atrazine | increases expression | ISO | KANK4 (Homo sapiens) | 6480464 | Atrazine results in increased expression of KANK4 mRNA | CTD | PMID:22378314 | Kank4 | Rat | atrazine | decreases expression | EXP | | 6480464 | Atrazine results in decreased expression of KANK4 mRNA | CTD | PMID:36841081 | Kank4 | Rat | azathioprine | decreases expression | ISO | KANK4 (Homo sapiens) | 6480464 | Azathioprine results in decreased expression of KANK4 mRNA | CTD | PMID:22623647 | Kank4 | Rat | benzo[a]pyrene | increases expression | ISO | Kank4 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of KANK4 mRNA | CTD | PMID:22610609 | Kank4 | Rat | benzo[a]pyrene | affects methylation | ISO | KANK4 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of KANK4 5' UTR and Benzo(a)pyrene affects the methylation of KANK4 exon | CTD | PMID:27901495 and PMID:30157460 | Kank4 | Rat | benzo[a]pyrene | decreases methylation | ISO | KANK4 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of KANK4 3' UTR | CTD | PMID:27901495 | Kank4 | Rat | benzo[a]pyrene | multiple interactions | ISO | Kank4 (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of KANK4 mRNA | CTD | PMID:27858113 | Kank4 | Rat | benzo[a]pyrene | decreases expression | ISO | KANK4 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of KANK4 mRNA | CTD | PMID:20106945 more ... | Kank4 | Rat | benzo[b]fluoranthene | increases expression | ISO | Kank4 (Mus musculus) | 6480464 | benzo(b)fluoranthene results in increased expression of KANK4 mRNA | CTD | PMID:26377693 | Kank4 | Rat | benzo[b]fluoranthene | multiple interactions | ISO | Kank4 (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of KANK4 mRNA | CTD | PMID:27858113 | Kank4 | Rat | benzo[e]pyrene | decreases methylation | ISO | KANK4 (Homo sapiens) | 6480464 | benzo(e)pyrene results in decreased methylation of KANK4 intron | CTD | PMID:30157460 | Kank4 | Rat | bisphenol A | decreases expression | ISO | Kank4 (Mus musculus) | 6480464 | bisphenol A results in decreased expression of KANK4 mRNA | CTD | PMID:26063408 | Kank4 | Rat | bisphenol A | decreases methylation | ISO | KANK4 (Homo sapiens) | 6480464 | bisphenol A results in decreased methylation of KANK4 gene | CTD | PMID:31601247 | Kank4 | Rat | bisphenol A | affects expression | ISO | KANK4 (Homo sapiens) | 6480464 | bisphenol A affects the expression of KANK4 mRNA | CTD | PMID:30903817 | Kank4 | Rat | bisphenol A | increases expression | ISO | Kank4 (Mus musculus) | 6480464 | bisphenol A results in increased expression of KANK4 mRNA | CTD | PMID:30951980 and PMID:32156529 | Kank4 | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of KANK4 mRNA | CTD | PMID:25181051 | Kank4 | Rat | bisphenol F | increases expression | ISO | Kank4 (Mus musculus) | 6480464 | bisphenol F results in increased expression of KANK4 mRNA | CTD | PMID:30951980 | Kank4 | Rat | butanal | decreases expression | ISO | KANK4 (Homo sapiens) | 6480464 | butyraldehyde results in decreased expression of KANK4 mRNA | CTD | PMID:26079696 | Kank4 | Rat | calcium silicate | decreases expression | ISO | Kank4 (Mus musculus) | 6480464 | calcium silicate results in decreased expression of KANK4 mRNA | CTD | PMID:29279043 | Kank4 | Rat | carbamazepine | affects expression | ISO | KANK4 (Homo sapiens) | 6480464 | Carbamazepine affects the expression of KANK4 mRNA | CTD | PMID:25979313 | Kank4 | Rat | carbon nanotube | affects expression | ISO | Kank4 (Mus musculus) | 6480464 | Nanotubes and Carbon affects the expression of KANK4 mRNA | CTD | PMID:25554681 | Kank4 | Rat | carbon nanotube | decreases expression | ISO | Kank4 (Mus musculus) | 6480464 | Nanotubes and Carbon analog results in decreased expression of KANK4 mRNA | CTD | PMID:25554681 | Kank4 | Rat | chloroprene | decreases expression | EXP | | 6480464 | Chloroprene results in decreased expression of KANK4 mRNA | CTD | PMID:23125180 | Kank4 | Rat | choline | multiple interactions | ISO | Kank4 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of KANK4 gene | CTD | PMID:20938992 | Kank4 | Rat | chrysene | multiple interactions | ISO | Kank4 (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of KANK4 mRNA | CTD | PMID:27858113 | Kank4 | Rat | cisplatin | affects expression | ISO | KANK4 (Homo sapiens) | 6480464 | Cisplatin affects the expression of KANK4 mRNA | CTD | PMID:23300844 | Kank4 | Rat | clobetasol | decreases expression | ISO | Kank4 (Mus musculus) | 6480464 | Clobetasol results in decreased expression of KANK4 mRNA | CTD | PMID:27462272 | Kank4 | Rat | cobalt dichloride | decreases expression | EXP | | 6480464 | cobaltous chloride results in decreased expression of KANK4 mRNA | CTD | PMID:24386269 | Kank4 | Rat | crocidolite asbestos | decreases expression | ISO | Kank4 (Mus musculus) | 6480464 | Asbestos and Crocidolite results in decreased expression of KANK4 mRNA | CTD | PMID:29279043 | Kank4 | Rat | cyclosporin A | decreases expression | ISO | KANK4 (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of KANK4 mRNA | CTD | PMID:20106945 more ... | Kank4 | Rat | cytarabine | decreases expression | ISO | KANK4 (Homo sapiens) | 6480464 | Cytarabine results in decreased expression of KANK4 mRNA | CTD | PMID:21198554 | Kank4 | Rat | diarsenic trioxide | decreases expression | ISO | KANK4 (Homo sapiens) | 6480464 | Arsenic Trioxide results in decreased expression of KANK4 mRNA | CTD | PMID:26705709 | Kank4 | Rat | dibenz[a,h]anthracene | increases expression | ISO | Kank4 (Mus musculus) | 6480464 | 1 more ... | CTD | PMID:26377693 | Kank4 | Rat | dioxygen | multiple interactions | ISO | Kank4 (Mus musculus) | 6480464 | [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of KANK4 mRNA | CTD | PMID:30529165 | Kank4 | Rat | dorsomorphin | multiple interactions | ISO | KANK4 (Homo sapiens) | 6480464 | [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | Kank4 | Rat | endosulfan | decreases expression | EXP | | 6480464 | Endosulfan results in decreased expression of KANK4 mRNA | CTD | PMID:29391264 | Kank4 | Rat | fenamidone | increases expression | ISO | Kank4 (Mus musculus) | 6480464 | fenamidone results in increased expression of KANK4 mRNA | CTD | PMID:27029645 | Kank4 | Rat | folic acid | multiple interactions | ISO | Kank4 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of KANK4 gene | CTD | PMID:20938992 | Kank4 | Rat | genistein | decreases expression | ISO | Kank4 (Mus musculus) | 6480464 | Genistein results in decreased expression of KANK4 mRNA | CTD | PMID:32186404 | Kank4 | Rat | gentamycin | decreases expression | EXP | | 6480464 | Gentamicins results in decreased expression of KANK4 mRNA | CTD | PMID:33387578 | Kank4 | Rat | glyphosate | increases expression | ISO | Kank4 (Mus musculus) | 6480464 | Glyphosate results in increased expression of KANK4 mRNA | CTD | PMID:35897073 | Kank4 | Rat | hydralazine | multiple interactions | ISO | KANK4 (Homo sapiens) | 6480464 | [Hydralazine co-treated with Valproic Acid] results in increased expression of KANK4 mRNA | CTD | PMID:17183730 | Kank4 | Rat | L-methionine | multiple interactions | ISO | Kank4 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of KANK4 gene | CTD | PMID:20938992 | Kank4 | Rat | methapyrilene | decreases methylation | ISO | KANK4 (Homo sapiens) | 6480464 | Methapyrilene results in decreased methylation of KANK4 intron | CTD | PMID:30157460 | Kank4 | Rat | N-nitrosodiethylamine | decreases expression | ISO | KANK4 (Homo sapiens) | 6480464 | Diethylnitrosamine results in decreased expression of KANK4 mRNA | CTD | PMID:21527772 | Kank4 | Rat | nickel atom | decreases expression | ISO | KANK4 (Homo sapiens) | 6480464 | Nickel results in decreased expression of KANK4 mRNA | CTD | PMID:24768652 and PMID:25583101 | Kank4 | Rat | nickel dichloride | affects expression | EXP | | 6480464 | nickel chloride affects the expression of KANK4 mRNA | CTD | PMID:22110744 | Kank4 | Rat | nitrofen | decreases expression | EXP | | 6480464 | nitrofen results in decreased expression of KANK4 mRNA | CTD | PMID:33484710 | Kank4 | Rat | oxaliplatin | increases expression | EXP | | 6480464 | oxaliplatin results in increased expression of KANK4 mRNA | CTD | PMID:25729387 | Kank4 | Rat | oxaliplatin | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in increased expression of KANK4 mRNA | CTD | PMID:25729387 | Kank4 | Rat | ozone | multiple interactions | ISO | Kank4 (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased expression of KANK4 mRNA | CTD | PMID:34911549 | Kank4 | Rat | panobinostat | increases expression | ISO | KANK4 (Homo sapiens) | 6480464 | panobinostat results in increased expression of KANK4 mRNA | CTD | PMID:26272509 | Kank4 | Rat | panobinostat | multiple interactions | ISO | KANK4 (Homo sapiens) | 6480464 | [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KANK4 mRNA | CTD | PMID:27188386 | Kank4 | Rat | phenylmercury acetate | increases expression | ISO | KANK4 (Homo sapiens) | 6480464 | Phenylmercuric Acetate results in increased expression of KANK4 mRNA | CTD | PMID:26272509 | Kank4 | Rat | phenylmercury acetate | multiple interactions | ISO | KANK4 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KANK4 mRNA | CTD | PMID:27188386 | Kank4 | Rat | pioglitazone | multiple interactions | ISO | Kank4 (Mus musculus) | 6480464 | [N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of KANK4 mRNA | CTD | PMID:27935865 | Kank4 | Rat | propanal | decreases expression | ISO | KANK4 (Homo sapiens) | 6480464 | propionaldehyde results in decreased expression of KANK4 mRNA | CTD | PMID:26079696 | Kank4 | Rat | quercetin | decreases expression | ISO | KANK4 (Homo sapiens) | 6480464 | Quercetin results in decreased expression of KANK4 mRNA | CTD | PMID:21632981 | Kank4 | Rat | SB 431542 | multiple interactions | ISO | KANK4 (Homo sapiens) | 6480464 | [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | Kank4 | Rat | silicon dioxide | affects expression | ISO | KANK4 (Homo sapiens) | 6480464 | Silicon Dioxide analog affects the expression of KANK4 mRNA | CTD | PMID:25895662 | Kank4 | Rat | sodium arsenite | affects expression | ISO | KANK4 (Homo sapiens) | 6480464 | sodium arsenite affects the expression of KANK4 mRNA | CTD | PMID:34032870 | Kank4 | Rat | tetraphene | multiple interactions | ISO | Kank4 (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of KANK4 mRNA | CTD | PMID:27858113 | Kank4 | Rat | thapsigargin | increases expression | ISO | KANK4 (Homo sapiens) | 6480464 | Thapsigargin results in increased expression of KANK4 mRNA | CTD | PMID:22378314 | Kank4 | Rat | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of KANK4 mRNA | CTD | PMID:34492290 | Kank4 | Rat | thiram | increases expression | ISO | KANK4 (Homo sapiens) | 6480464 | Thiram results in increased expression of KANK4 mRNA | CTD | PMID:38568856 | Kank4 | Rat | topotecan | increases expression | EXP | | 6480464 | Topotecan results in increased expression of KANK4 mRNA | CTD | PMID:25729387 | Kank4 | Rat | topotecan | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in increased expression of KANK4 mRNA | CTD | PMID:25729387 | Kank4 | Rat | trichloroethene | decreases expression | EXP | | 6480464 | Trichloroethylene results in decreased expression of KANK4 mRNA | CTD | PMID:33387578 | Kank4 | Rat | trichostatin A | increases expression | ISO | KANK4 (Homo sapiens) | 6480464 | trichostatin A results in increased expression of KANK4 mRNA | CTD | PMID:24935251 and PMID:26272509 | Kank4 | Rat | trichostatin A | multiple interactions | ISO | KANK4 (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KANK4 mRNA | CTD | PMID:27188386 | Kank4 | Rat | triptonide | increases expression | ISO | Kank4 (Mus musculus) | 6480464 | triptonide results in increased expression of KANK4 mRNA | CTD | PMID:33045310 | Kank4 | Rat | urethane | decreases expression | ISO | KANK4 (Homo sapiens) | 6480464 | Urethane results in decreased expression of KANK4 mRNA | CTD | PMID:28818685 | Kank4 | Rat | valproic acid | multiple interactions | ISO | KANK4 (Homo sapiens) | 6480464 | [Hydralazine co-treated with Valproic Acid] results in increased expression of KANK4 mRNA more ... | CTD | PMID:17183730 and PMID:27188386 | Kank4 | Rat | valproic acid | affects expression | ISO | Kank4 (Mus musculus) | 6480464 | Valproic Acid affects the expression of KANK4 mRNA | CTD | PMID:17963808 | Kank4 | Rat | valproic acid | affects expression | ISO | KANK4 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of KANK4 mRNA | CTD | PMID:25979313 | Kank4 | Rat | valproic acid | increases expression | ISO | KANK4 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of KANK4 mRNA | CTD | PMID:23179753 more ... | Kank4 | Rat | vinclozolin | decreases methylation | EXP | | 6480464 | vinclozolin results in decreased methylation of KANK4 gene | CTD | PMID:31079544 | Kank4 | Rat | vorinostat | increases expression | ISO | KANK4 (Homo sapiens) | 6480464 | vorinostat results in increased expression of KANK4 mRNA | CTD | PMID:26272509 | Kank4 | Rat | vorinostat | multiple interactions | ISO | KANK4 (Homo sapiens) | 6480464 | [NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KANK4 mRNA | CTD | PMID:27188386 | Kank4 | Rat | XL147 | multiple interactions | ISO | Kank4 (Mus musculus) | 6480464 | [N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of KANK4 mRNA | CTD | PMID:27935865 | |