Bace2 (beta-secretase 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Bace2 (beta-secretase 2) Rattus norvegicus
Analyze
Symbol: Bace2
Name: beta-secretase 2
RGD ID: 1303241
Description: Predicted to enable aspartic-type endopeptidase activity. Involved in astrocyte activation. Located in dense core granule. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human BACE2 (beta-secretase 2); PARTICIPATES IN Alzheimer's disease pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: beta-site amyloid precursor protein cleaving enzyme 2; beta-site APP cleaving enzyme 2; beta-site APP-cleaving enzyme 2; memapsin-1; membrane-associated aspartic protease 1; theta-secretase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81150,176,852 - 50,258,948 (+)NCBIGRCr8
mRatBN7.21136,707,447 - 36,789,550 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1136,707,458 - 36,789,546 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1145,356,116 - 45,437,781 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01138,027,502 - 38,109,167 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01137,187,422 - 37,269,087 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01137,798,397 - 37,880,624 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1137,798,370 - 37,880,821 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01141,305,984 - 41,389,663 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41137,345,568 - 37,428,155 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11137,403,156 - 37,485,744 (+)NCBI
Celera1136,594,056 - 36,676,118 (+)NCBICelera
Cytogenetic Map11q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroprene  (EXP)
cisplatin  (ISO)
clozapine  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
DDE  (EXP)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP)
dicyclanil  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
entinostat  (ISO)
epoxiconazole  (EXP,ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
folic acid  (ISO)
fonofos  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gentamycin  (EXP)
linuron  (EXP)
lovastatin  (EXP,ISO)
mercury dichloride  (ISO)
methapyrilene  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
mitomycin C  (ISO)
mitoxantrone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
parathion  (ISO)
phenylmercury acetate  (ISO)
potassium dichromate  (ISO)
prochloraz  (EXP)
procymidone  (EXP)
resveratrol  (ISO)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
temozolomide  (ISO)
terbufos  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thimerosal  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. BACE2 suppression promotes ß-cell survival and function in a model of type 2 diabetes induced by human islet amyloid polypeptide overexpression. Alcarraz-Vizán G, etal., Cell Mol Life Sci. 2017 Aug;74(15):2827-2838. doi: 10.1007/s00018-017-2505-1. Epub 2017 Mar 23.
2. ß-Secretase activity in rat astrocytes: translational block of BACE1 and modulation of BACE2 expression. Bettegazzi B, etal., Eur J Neurosci. 2011 Jan;33(2):236-43. doi: 10.1111/j.1460-9568.2010.07482.x. Epub 2010 Nov 14.
3. BACE2 is stored in secretory granules of mouse and rat pancreatic beta cells. Finzi G, etal., Ultrastruct Pathol. 2008 Nov-Dec;32(6):246-51. doi: 10.1080/01913120802486217.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. BACE2 expression increases in human neurodegenerative disease. Holler CJ, etal., Am J Pathol. 2012 Jan;180(1):337-50. doi: 10.1016/j.ajpath.2011.09.034. Epub 2011 Nov 7.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Chromosome 21 BACE2 haplotype associates with Alzheimer's disease: a two-stage study. Myllykangas L, etal., J Neurol Sci. 2005 Sep 15;236(1-2):17-24. doi: 10.1016/j.jns.2005.04.008.
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. A genomic analysis of rat proteases and protease inhibitors. Puente XS and Lopez-Otin C, Genome Res 2004 Apr;14(4):609-22.
10. GOA pipeline RGD automated data pipeline
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:10591213   PMID:11423558   PMID:12477932   PMID:12801932   PMID:16757811   PMID:21907142   PMID:25342134  


Genomics

Comparative Map Data
Bace2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81150,176,852 - 50,258,948 (+)NCBIGRCr8
mRatBN7.21136,707,447 - 36,789,550 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1136,707,458 - 36,789,546 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1145,356,116 - 45,437,781 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01138,027,502 - 38,109,167 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01137,187,422 - 37,269,087 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01137,798,397 - 37,880,624 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1137,798,370 - 37,880,821 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01141,305,984 - 41,389,663 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41137,345,568 - 37,428,155 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11137,403,156 - 37,485,744 (+)NCBI
Celera1136,594,056 - 36,676,118 (+)NCBICelera
Cytogenetic Map11q12NCBI
BACE2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382141,168,160 - 41,282,530 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2141,167,801 - 41,282,530 (+)EnsemblGRCh38hg38GRCh38
GRCh372142,540,087 - 42,654,457 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362141,461,598 - 41,570,394 (+)NCBINCBI36Build 36hg18NCBI36
Build 342141,461,597 - 41,570,394NCBI
Celera2127,737,910 - 27,846,710 (+)NCBICelera
Cytogenetic Map21q22.2-q22.3NCBI
HuRef2128,008,619 - 28,123,292 (+)NCBIHuRef
CHM1_12142,100,065 - 42,215,315 (+)NCBICHM1_1
T2T-CHM13v2.02139,556,492 - 39,670,904 (+)NCBIT2T-CHM13v2.0
Bace2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391697,157,928 - 97,244,136 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1697,157,942 - 97,244,136 (+)EnsemblGRCm39 Ensembl
GRCm381697,356,728 - 97,442,936 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1697,356,742 - 97,442,936 (+)EnsemblGRCm38mm10GRCm38
MGSCv371697,578,335 - 97,660,619 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361697,461,672 - 97,543,922 (+)NCBIMGSCv36mm8
Celera1698,415,225 - 98,499,352 (+)NCBICelera
Cytogenetic Map16C4NCBI
cM Map1657.4NCBI
Bace2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540740,792,887 - 40,874,760 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540740,792,089 - 40,879,872 (+)NCBIChiLan1.0ChiLan1.0
BACE2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22237,246,736 - 37,356,607 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12132,101,224 - 32,217,134 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02127,500,453 - 27,612,795 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12140,831,209 - 40,939,253 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2140,831,203 - 40,938,280 (+)Ensemblpanpan1.1panPan2
BACE2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13135,714,003 - 35,760,686 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3135,713,149 - 35,760,681 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3134,835,731 - 34,915,420 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03135,197,633 - 35,277,577 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3135,196,852 - 35,277,649 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13135,095,350 - 35,174,795 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03135,071,879 - 35,151,408 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03135,564,859 - 35,644,622 (+)NCBIUU_Cfam_GSD_1.0
Bace2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497135,055,073 - 35,099,518 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365002,368,334 - 2,449,789 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365002,362,994 - 2,449,783 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BACE2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13204,600,735 - 204,694,836 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113204,600,740 - 204,720,215 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213214,759,157 - 214,846,140 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BACE2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1285,079,404 - 85,194,908 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl285,079,812 - 85,187,944 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605412,931,246 - 13,046,493 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bace2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474528,690,149 - 28,765,588 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474528,690,045 - 28,765,506 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Bace2
411 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:34
Count of miRNA genes:27
Interacting mature miRNAs:34
Transcripts:ENSRNOT00000002679
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113491804179918041Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
10755497Bp388Blood pressure QTL 3882.76arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)111945620576331918Rat
724517Uae18Urinary albumin excretion QTL 183.7urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)111647204744285911Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)112295940367959403Rat
1300130Rf20Renal function QTL 204.44kidney glomerulus integrity trait (VT:0010546)kidney glomerulus diameter (CMO:0001166)112952841860324829Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)11104193166113562Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)112328045668280456Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)112328045668280456Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat
1641927Alcrsp10Alcohol response QTL 10alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)11843667453436674Rat

Markers in Region
D11Got114  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21136,751,210 - 36,751,433 (+)MAPPERmRatBN7.2
Rnor_6.01137,842,323 - 37,842,545NCBIRnor6.0
Rnor_5.01141,349,910 - 41,350,132UniSTSRnor5.0
RGSC_v3.41137,389,771 - 37,389,993UniSTSRGSC3.4
Cytogenetic Map11q12UniSTS
RH133630  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21136,789,218 - 36,789,433 (+)MAPPERmRatBN7.2
Rnor_6.01137,880,506 - 37,880,720NCBIRnor6.0
Rnor_5.01141,388,093 - 41,388,307UniSTSRnor5.0
RGSC_v3.41137,428,037 - 37,428,251UniSTSRGSC3.4
Celera1136,676,000 - 36,676,214UniSTS
RH 3.4 Map11266.6UniSTS
Cytogenetic Map11q12UniSTS
RH134179  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21136,708,457 - 36,708,638 (+)MAPPERmRatBN7.2
Rnor_6.01137,799,382 - 37,799,562NCBIRnor6.0
Rnor_5.01141,306,969 - 41,307,149UniSTSRnor5.0
RGSC_v3.41137,346,553 - 37,346,733UniSTSRGSC3.4
Celera1136,595,041 - 36,595,221UniSTS
RH 3.4 Map11272.3UniSTS
Cytogenetic Map11q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000002679   ⟹   ENSRNOP00000002679
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1136,707,458 - 36,789,546 (+)Ensembl
Rnor_6.0 Ensembl1137,798,370 - 37,880,821 (+)Ensembl
RefSeq Acc Id: NM_001002802   ⟹   NP_001002802
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81150,176,852 - 50,258,948 (+)NCBI
mRatBN7.21136,707,447 - 36,789,550 (+)NCBI
Rnor_6.01137,798,397 - 37,880,624 (+)NCBI
Rnor_5.01141,305,984 - 41,389,663 (+)NCBI
RGSC_v3.41137,345,568 - 37,428,155 (+)RGD
Celera1136,594,056 - 36,676,118 (+)RGD
Sequence:
RefSeq Acc Id: XM_039088202   ⟹   XP_038944130
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81150,223,127 - 50,258,948 (+)NCBI
mRatBN7.21136,753,746 - 36,789,550 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001002802 (Get FASTA)   NCBI Sequence Viewer  
  XP_038944130 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI66597 (Get FASTA)   NCBI Sequence Viewer  
  CAE48373 (Get FASTA)   NCBI Sequence Viewer  
  EDM10962 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000002679.4
GenBank Protein Q6IE75 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001002802   ⟸   NM_001002802
- Peptide Label: precursor
- UniProtKB: B2GVB0 (UniProtKB/Swiss-Prot),   Q6IE75 (UniProtKB/Swiss-Prot),   A6IQF8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000002679   ⟸   ENSRNOT00000002679
RefSeq Acc Id: XP_038944130   ⟸   XM_039088202
- Peptide Label: isoform X1
Protein Domains
Peptidase A1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6IE75-F1-model_v2 AlphaFold Q6IE75 1-514 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698091
Promoter ID:EPDNEW_R8615
Type:multiple initiation site
Name:Bace2_1
Description:beta-site APP-cleaving enzyme 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01137,798,371 - 37,798,431EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303241 AgrOrtholog
BioCyc Gene G2FUF-21686 BioCyc
Ensembl Genes ENSRNOG00000001953 Ensembl, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000002679.8 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.70.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7936295 IMAGE-MGC_LOAD
InterPro Aspartic_peptidase_A1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aspartic_peptidase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BACE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BACE2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Memapsin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PEPTIDASE_A1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_aspartic_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:288227 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:188369 IMAGE-MGC_LOAD
NCBI Gene 288227 ENTREZGENE
PANTHER ASPARTYL PROTEASE-RELATED UniProtKB/TrEMBL
  BETA-SECRETASE 2 UniProtKB/TrEMBL
  PTHR47965 UniProtKB/Swiss-Prot
  PTHR47965:SF40 UniProtKB/Swiss-Prot
Pfam Asp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Bace2 PhenoGen
PRINTS BACE2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BACEFAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PEPSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ASP_PROTEASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PEPTIDASE_A1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001953 RatGTEx
Superfamily-SCOP Acid proteases UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt A6IQF8 ENTREZGENE, UniProtKB/TrEMBL
  B2GVB0 ENTREZGENE
  BACE2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary B2GVB0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-18 Bace2  beta-secretase 2  Bace2  beta-site APP-cleaving enzyme 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Bace2  beta-site APP-cleaving enzyme 2      Symbol and Name status set to approved 1299863 APPROVED
2005-07-14 Bace2  beta-site APP-cleaving enzyme 2      Symbol and Name status set to provisional 70820 PROVISIONAL