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Gene: BACE2 (beta-secretase 2) Homo sapiens
Symbol: BACE2
Name: beta-secretase 2
Description: Exhibits aspartic-type endopeptidase activity. Involved in glucose homeostasis; membrane protein ectodomain proteolysis; and negative regulation of amyloid precursor protein biosynthetic process. Localizes to Golgi apparatus and plasma membrane. Implicated in Alzheimer's disease. Biomarker of Alzheimer's disease and frontotemporal dementia.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 56 kDa aspartic-like protease; AEPLC; ALP56; asp 1; ASP1; ASP21; aspartic-like protease 56 kDa; aspartyl protease 1; BAE2; beta secretase 2; beta-site amyloid beta A4 precursor protein-cleaving enzyme 2; beta-site amyloid precursor protein cleaving enzyme 2; beta-site APP cleaving enzyme 2; beta-site APP-cleaving enzyme 2; CDA13; CEAP1; down region aspartic protease; Down syndrome region aspartic protease; DRAP; memapsin 1; memapsin-1; membrane-associated aspartic protease 1; SLCO3A1/BACE2 fusion; theta-secretase; transmembrane aspartic proteinase Asp1
Mus musculus (house mouse) : Bace2 (beta-site APP-cleaving enzyme 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Bace2 (beta-secretase 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Bace2 (beta-secretase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : BACE2 (beta-secretase 2)
Canis lupus familiaris (dog) : BACE2 (beta-secretase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Bace2 (beta-secretase 2)
Sus scrofa (pig) : BACE2 (beta-secretase 2)
Chlorocebus sabaeus (African green monkey) : BACE2 (beta-secretase 2)
Heterocephalus glaber (naked mole-rat) : Bace2 (beta-secretase 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl2141,167,801 - 41,282,530 (+)EnsemblGRCh38hg38GRCh38
GRCh382141,168,160 - 41,282,530 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372142,539,728 - 42,654,461 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362141,461,598 - 41,570,394 (+)NCBINCBI36hg18NCBI36
Build 342141,461,597 - 41,570,394NCBI
Celera2127,737,910 - 27,846,710 (+)NCBI
Cytogenetic Map21q22.2-q22.3NCBI
HuRef2128,008,619 - 28,123,292 (+)NCBIHuRef
CHM1_12142,100,065 - 42,215,315 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on BACE2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1350115
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-08-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.