Bace2 (beta-secretase 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Bace2 (beta-secretase 2) Heterocephalus glaber
Analyze
Symbol: Bace2
Name: beta-secretase 2
RGD ID: 18926918
Description: ENCODES a protein that exhibits peptidase activity (ortholog); INVOLVED IN astrocyte activation (ortholog); glucose homeostasis (ortholog); melanosome organization (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); autistic disorder (ortholog); frontotemporal dementia (ortholog); FOUND IN dense core granule (ortholog); Golgi apparatus (ortholog); melanosome membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: beta-site APP-cleaving enzyme 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474528,690,149 - 28,765,588 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474528,690,045 - 28,765,506 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Bace2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474528,690,149 - 28,765,588 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474528,690,045 - 28,765,506 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
BACE2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382141,168,160 - 41,282,530 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2141,167,801 - 41,282,530 (+)EnsemblGRCh38hg38GRCh38
GRCh372142,540,087 - 42,654,457 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362141,461,598 - 41,570,394 (+)NCBINCBI36Build 36hg18NCBI36
Build 342141,461,597 - 41,570,394NCBI
Celera2127,737,910 - 27,846,710 (+)NCBICelera
Cytogenetic Map21q22.2-q22.3NCBI
HuRef2128,008,619 - 28,123,292 (+)NCBIHuRef
CHM1_12142,100,065 - 42,215,315 (+)NCBICHM1_1
T2T-CHM13v2.02139,556,492 - 39,670,904 (+)NCBIT2T-CHM13v2.0
Bace2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391697,157,928 - 97,244,136 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1697,157,942 - 97,244,136 (+)EnsemblGRCm39 Ensembl
GRCm381697,356,728 - 97,442,936 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1697,356,742 - 97,442,936 (+)EnsemblGRCm38mm10GRCm38
MGSCv371697,578,335 - 97,660,619 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361697,461,672 - 97,543,922 (+)NCBIMGSCv36mm8
Celera1698,415,225 - 98,499,352 (+)NCBICelera
Cytogenetic Map16C4NCBI
cM Map1657.4NCBI
Bace2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81150,176,852 - 50,258,948 (+)NCBIGRCr8
mRatBN7.21136,707,447 - 36,789,550 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1136,707,458 - 36,789,546 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1145,356,116 - 45,437,781 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01138,027,502 - 38,109,167 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01137,187,422 - 37,269,087 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01137,798,397 - 37,880,624 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1137,798,370 - 37,880,821 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01141,305,984 - 41,389,663 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41137,345,568 - 37,428,155 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11137,403,156 - 37,485,744 (+)NCBI
Celera1136,594,056 - 36,676,118 (+)NCBICelera
Cytogenetic Map11q12NCBI
Bace2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540740,792,887 - 40,874,760 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540740,792,089 - 40,879,872 (+)NCBIChiLan1.0ChiLan1.0
BACE2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22237,246,736 - 37,356,607 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12132,101,224 - 32,217,134 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02127,500,453 - 27,612,795 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12140,831,209 - 40,939,253 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2140,831,203 - 40,938,280 (+)Ensemblpanpan1.1panPan2
BACE2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13135,714,003 - 35,760,686 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3135,713,149 - 35,760,681 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3134,835,731 - 34,915,420 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03135,197,633 - 35,277,577 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3135,196,852 - 35,277,649 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13135,095,350 - 35,174,795 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03135,071,879 - 35,151,408 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03135,564,859 - 35,644,622 (+)NCBIUU_Cfam_GSD_1.0
Bace2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497135,055,073 - 35,099,518 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365002,368,334 - 2,449,789 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365002,362,994 - 2,449,783 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BACE2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13204,600,735 - 204,694,836 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113204,600,740 - 204,720,215 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213214,759,157 - 214,846,140 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BACE2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1285,079,404 - 85,194,908 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl285,079,812 - 85,187,944 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605412,931,246 - 13,046,493 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000009856   ⟹   ENSHGLP00000009748
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462474528,690,149 - 28,765,588 (-)Ensembl
RefSeq Acc Id: XM_004842466   ⟹   XP_004842523
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474528,690,045 - 28,765,486 (-)NCBI
RefSeq Acc Id: XM_021256354   ⟹   XP_021112013
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474528,690,882 - 28,733,741 (-)NCBI
RefSeq Acc Id: XR_002394128
Type: NON-CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474528,691,045 - 28,765,506 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004842523 (Get FASTA)   NCBI Sequence Viewer  
  XP_021112013 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB16742 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000009748
Reference Protein Sequences
RefSeq Acc Id: XP_004842523   ⟸   XM_004842466
- Peptide Label: isoform X1
- UniProtKB: G5C5D1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021112013   ⟸   XM_021256354
- Peptide Label: isoform X2
- UniProtKB: G5C5D1 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000009748   ⟸   ENSHGLT00000009856


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000006993 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000009856 ENTREZGENE
Gene3D-CATH Acid Proteases UniProtKB/TrEMBL
InterPro Aspartic_peptidase_A1 UniProtKB/TrEMBL
  Aspartic_peptidase_AS UniProtKB/TrEMBL
  BACE UniProtKB/TrEMBL
  BACE2 UniProtKB/TrEMBL
  Memapsin-like UniProtKB/TrEMBL
  PEPTIDASE_A1 UniProtKB/TrEMBL
  Peptidase_aspartic_dom_sf UniProtKB/TrEMBL
NCBI Gene Bace2 ENTREZGENE
PANTHER ASPARTYL PROTEASE-RELATED UniProtKB/TrEMBL
  BETA-SECRETASE 2 UniProtKB/TrEMBL
Pfam Asp UniProtKB/TrEMBL
PRINTS BACE2 UniProtKB/TrEMBL
  BACEFAMILY UniProtKB/TrEMBL
  PEPSIN UniProtKB/TrEMBL
PROSITE ASP_PROTEASE UniProtKB/TrEMBL
  PEPTIDASE_A1 UniProtKB/TrEMBL
Superfamily-SCOP Acid proteases UniProtKB/TrEMBL
UniProt G5C5D1 ENTREZGENE, UniProtKB/TrEMBL