BACE2 (beta-secretase 2) - Rat Genome Database

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Gene: BACE2 (beta-secretase 2) Sus scrofa
Analyze
Symbol: BACE2
Name: beta-secretase 2
RGD ID: 14152930
Description: ENCODES a protein that exhibits aspartic-type endopeptidase activity (inferred); hydrolase activity (inferred); peptidase activity (inferred); INVOLVED IN astrocyte activation (ortholog); glucose homeostasis (ortholog); melanosome organization (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); autistic disorder (ortholog); frontotemporal dementia (ortholog); FOUND IN dense core granule (ortholog); Golgi apparatus (ortholog); melanosome membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: beta-site APP-cleaving enzyme 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13204,600,735 - 204,694,836 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113204,600,740 - 204,720,215 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213214,759,157 - 214,846,140 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:14681463   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
BACE2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13204,600,735 - 204,694,836 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113204,600,740 - 204,720,215 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213214,759,157 - 214,846,140 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BACE2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382141,168,160 - 41,282,530 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2141,167,801 - 41,282,530 (+)EnsemblGRCh38hg38GRCh38
GRCh372142,540,087 - 42,654,457 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362141,461,598 - 41,570,394 (+)NCBINCBI36Build 36hg18NCBI36
Build 342141,461,597 - 41,570,394NCBI
Celera2127,737,910 - 27,846,710 (+)NCBICelera
Cytogenetic Map21q22.2-q22.3NCBI
HuRef2128,008,619 - 28,123,292 (+)NCBIHuRef
CHM1_12142,100,065 - 42,215,315 (+)NCBICHM1_1
T2T-CHM13v2.02139,556,492 - 39,670,904 (+)NCBIT2T-CHM13v2.0
Bace2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391697,157,928 - 97,244,136 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1697,157,942 - 97,244,136 (+)EnsemblGRCm39 Ensembl
GRCm381697,356,728 - 97,442,936 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1697,356,742 - 97,442,936 (+)EnsemblGRCm38mm10GRCm38
MGSCv371697,578,335 - 97,660,619 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361697,461,672 - 97,543,922 (+)NCBIMGSCv36mm8
Celera1698,415,225 - 98,499,352 (+)NCBICelera
Cytogenetic Map16C4NCBI
cM Map1657.4NCBI
Bace2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81150,176,852 - 50,258,948 (+)NCBIGRCr8
mRatBN7.21136,707,447 - 36,789,550 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1136,707,458 - 36,789,546 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1145,356,116 - 45,437,781 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01138,027,502 - 38,109,167 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01137,187,422 - 37,269,087 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01137,798,397 - 37,880,624 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1137,798,370 - 37,880,821 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01141,305,984 - 41,389,663 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41137,345,568 - 37,428,155 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11137,403,156 - 37,485,744 (+)NCBI
Celera1136,594,056 - 36,676,118 (+)NCBICelera
Cytogenetic Map11q12NCBI
Bace2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540740,792,887 - 40,874,760 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540740,792,089 - 40,879,872 (+)NCBIChiLan1.0ChiLan1.0
BACE2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22237,246,736 - 37,356,607 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12132,101,224 - 32,217,134 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02127,500,453 - 27,612,795 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12140,831,209 - 40,939,253 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2140,831,203 - 40,938,280 (+)Ensemblpanpan1.1panPan2
BACE2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13135,714,003 - 35,760,686 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3135,713,149 - 35,760,681 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3134,835,731 - 34,915,420 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03135,197,633 - 35,277,577 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3135,196,852 - 35,277,649 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13135,095,350 - 35,174,795 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03135,071,879 - 35,151,408 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03135,564,859 - 35,644,622 (+)NCBIUU_Cfam_GSD_1.0
Bace2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497135,055,073 - 35,099,518 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365002,368,334 - 2,449,789 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365002,362,994 - 2,449,783 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BACE2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1285,079,404 - 85,194,908 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl285,079,812 - 85,187,944 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605412,931,246 - 13,046,493 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bace2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474528,690,149 - 28,765,588 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474528,690,045 - 28,765,506 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in BACE2
6153 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 2 1 2 1 1
Low 8 4 3 4 2 21 2 1
Below cutoff 2 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000013206   ⟹   ENSSSCP00000012854
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl13204,600,735 - 204,694,836 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000075815   ⟹   ENSSSCP00000069580
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl13204,600,735 - 204,695,316 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000076411   ⟹   ENSSSCP00000067159
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl13204,600,735 - 204,694,836 (+)Ensembl
RefSeq Acc Id: XM_005670363   ⟹   XP_005670420
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.113204,600,740 - 204,701,772 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021071002   ⟹   XP_020926661
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.113204,600,740 - 204,701,772 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021071004   ⟹   XP_020926663
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.113204,600,740 - 204,719,243 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021071005   ⟹   XP_020926664
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.113204,600,740 - 204,720,215 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021071006   ⟹   XP_020926665
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.113204,600,740 - 204,720,215 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_020926664   ⟸   XM_021071005
- Peptide Label: isoform X3
- UniProtKB: A0A8D2BZI0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020926665   ⟸   XM_021071006
- Peptide Label: isoform X4
- UniProtKB: A0A8D2BZI0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020926663   ⟸   XM_021071004
- Peptide Label: isoform X2
- UniProtKB: A0A8D2BZI0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020926661   ⟸   XM_021071002
- Peptide Label: isoform X1
- UniProtKB: A0A8D1KYH0 (UniProtKB/TrEMBL),   F1SG69 (UniProtKB/TrEMBL),   A0A8D1BEY8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005670420   ⟸   XM_005670363
- Peptide Label: isoform X5
- UniProtKB: A0A4X1TLE9 (UniProtKB/TrEMBL),   A0A5G2R620 (UniProtKB/TrEMBL),   A0A8D1BGK4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000069580   ⟸   ENSSSCT00000075815
RefSeq Acc Id: ENSSSCP00000067159   ⟸   ENSSSCT00000076411
RefSeq Acc Id: ENSSSCP00000012854   ⟸   ENSSSCT00000013206
Protein Domains
Peptidase A1


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000012074 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00025051257 UniProtKB/TrEMBL
  ENSSSCG00035080463 UniProtKB/TrEMBL
  ENSSSCG00045019171 UniProtKB/TrEMBL
  ENSSSCG00050054093 UniProtKB/TrEMBL
  ENSSSCG00055006872 UniProtKB/TrEMBL
  ENSSSCG00065013260 UniProtKB/TrEMBL
  ENSSSCG00070009888 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000013206 ENTREZGENE
  ENSSSCT00000013206.4 UniProtKB/TrEMBL
  ENSSSCT00000075815 ENTREZGENE
  ENSSSCT00000075815.2 UniProtKB/TrEMBL
  ENSSSCT00000076411.1 UniProtKB/TrEMBL
  ENSSSCT00025070054.1 UniProtKB/TrEMBL
  ENSSSCT00025070283.1 UniProtKB/TrEMBL
  ENSSSCT00035110240.1 UniProtKB/TrEMBL
  ENSSSCT00035110274.1 UniProtKB/TrEMBL
  ENSSSCT00045032655.1 UniProtKB/TrEMBL
  ENSSSCT00045032786.1 UniProtKB/TrEMBL
  ENSSSCT00050073755.1 UniProtKB/TrEMBL
  ENSSSCT00055013337.1 UniProtKB/TrEMBL
  ENSSSCT00055013417.1 UniProtKB/TrEMBL
  ENSSSCT00065017647.1 UniProtKB/TrEMBL
  ENSSSCT00070019217.1 UniProtKB/TrEMBL
  ENSSSCT00070019226.1 UniProtKB/TrEMBL
  ENSSSCT00070019230.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.70.10 UniProtKB/TrEMBL
InterPro Aspartic_peptidase_A1 UniProtKB/TrEMBL
  Aspartic_peptidase_AS UniProtKB/TrEMBL
  BACE UniProtKB/TrEMBL
  BACE2 UniProtKB/TrEMBL
  Memapsin-like UniProtKB/TrEMBL
  PEPTIDASE_A1 UniProtKB/TrEMBL
  Peptidase_aspartic_dom_sf UniProtKB/TrEMBL
KEGG Report ssc:100517374 UniProtKB/TrEMBL
NCBI Gene BACE2 ENTREZGENE
PANTHER PTHR47965 UniProtKB/TrEMBL
  PTHR47965:SF40 UniProtKB/TrEMBL
Pfam Asp UniProtKB/TrEMBL
PRINTS BACE2 UniProtKB/TrEMBL
  BACEFAMILY UniProtKB/TrEMBL
  PEPSIN UniProtKB/TrEMBL
PROSITE ASP_PROTEASE UniProtKB/TrEMBL
  PEPTIDASE_A1 UniProtKB/TrEMBL
Superfamily-SCOP SSF50630 UniProtKB/TrEMBL
UniProt A0A4X1TH80_PIG UniProtKB/TrEMBL
  A0A4X1TLE9 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1TLN4_PIG UniProtKB/TrEMBL
  A0A5G2QQZ1_PIG UniProtKB/TrEMBL
  A0A5G2R620 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1BEY8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1BGK4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1KYH0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D2BZI0 ENTREZGENE, UniProtKB/TrEMBL
  F1SG69 ENTREZGENE, UniProtKB/TrEMBL