PTGS2 (prostaglandin-endoperoxide synthase 2) - Rat Genome Database

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Gene: PTGS2 (prostaglandin-endoperoxide synthase 2) Canis lupus familiaris
Analyze
Symbol: PTGS2
Name: prostaglandin-endoperoxide synthase 2
RGD ID: 12279597
Description: ENCODES a protein that exhibits oxidoreductase activity, acting on single donors with incorporation of molecular oxygen (ortholog); oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen (ortholog); INVOLVED IN cellular response to non-ionic osmotic stress; negative regulation of apoptotic process; negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress; PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); acute kidney failure (ortholog); Acute Liver Failure (ortholog); FOUND IN cytoplasm; caveola (ortholog); protein-containing complex (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; carprofen
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: COX-2; cyclooxygenase 2; cyclooxygenase type 2; prostaglandin G/H synthase 2; prostaglandin G/H synthase-2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1719,668,079 - 19,674,903 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl719,668,082 - 19,674,903 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha719,190,741 - 19,197,565 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0719,405,501 - 19,412,325 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl719,405,504 - 19,412,176 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1719,311,510 - 19,318,356 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0719,420,827 - 19,427,651 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0719,552,954 - 19,559,778 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
JBrowse:




Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
acute kidney failure  (ISO)
Acute Liver Failure  (ISO)
Acute Lung Injury  (ISO)
adenocarcinoma  (ISO)
Adrenal Gland Neoplasms  (ISO)
Albuminuria  (ISO)
Alcohol Withdrawal Delirium  (ISO)
allergic rhinitis  (ISO)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis  (ISO)
Anaphylaxis  (ISO)
Anorexia  (ISO)
arteriosclerosis  (ISO)
asphyxia neonatorum  (ISO)
aspirin-induced respiratory disease  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
autistic disorder  (ISO)
avian influenza  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
B-cell lymphoma  (ISO)
Barrett's esophagus  (ISO)
bipolar disorder  (ISO)
bladder neck obstruction  (ISO)
Bone Fractures  (ISO)
Bone Neoplasms  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
Breast Neoplasms  (ISO)
Burns  (ISO)
Cachexia  (ISO)
Calcification of Aortic Valve  (ISO)
carcinoma  (ISO)
Cardiac Arrhythmias  (ISO)
cardiomyopathy  (ISO)
cardiovascular system disease  (ISO)
Cerebral Hemorrhage  (ISO)
cervix uteri carcinoma in situ  (ISO)
Chagas disease  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cholangiocarcinoma  (ISO)
chronic obstructive pulmonary disease  (ISO)
chronic rhinosinusitis with nasal polyps  (ISO)
cognitive disorder  (ISO)
colitis  (ISO)
Colonic Neoplasms  (ISO)
Colorectal Neoplasms  (ISO)
congestive heart failure  (ISO)
coronary artery disease  (ISO)
Cough  (ISO)
COVID-19  (ISO)
Creutzfeldt-Jakob disease  (ISO)
Crohn's disease  (ISO)
cryptorchidism  (ISO)
cystic fibrosis  (ISO)
cystitis  (ISO)
demyelinating disease  (ISO)
depressive disorder  (ISO)
diabetes mellitus  (ISO)
Diabetic Nephropathies  (ISO)
diabetic neuropathy  (ISO)
disease of cellular proliferation  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
ductal carcinoma in situ  (ISO)
duodenal ulcer  (ISO)
Edema  (ISO)
end stage renal disease  (ISO)
Endometrial Neoplasms  (ISO)
endometriosis  (ISO)
Endotoxemia  (ISO)
Esophageal Neoplasms  (ISO)
esophagitis  (ISO)
esophagus adenocarcinoma  (ISO)
esophagus squamous cell carcinoma  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Neuritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Mammary Neoplasms  (ISO)
Experimental Radiation Injuries  (ISO)
Experimental Seizures  (ISO)
familial adenomatous polyposis  (ISO)
Fetal Growth Retardation  (ISO)
Fever  (ISO)
Fibrosis  (ISO)
Gallbladder Neoplasms  (ISO)
gastric ulcer  (ISO)
gastritis  (ISO)
gastroesophageal reflux disease  (ISO)
glioblastoma  (ISO)
gliosarcoma  (ISO)
granulosa cell tumor  (ISO)
Graves ophthalmopathy  (ISO)
growth hormone secreting pituitary adenoma  (ISO)
head and neck squamous cell carcinoma  (ISO)
hepatocellular carcinoma  (ISO)
high grade glioma  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Human Influenza  (ISO)
Huntington's disease  (ISO)
hydronephrosis  (ISO)
Hyperalgesia  (ISO)
Hyperemia  (ISO)
hyperglycemia  (ISO)
Hyperplasia  (ISO)
hypertension  (ISO)
Hypoxia  (ISO)
idiopathic pulmonary fibrosis  (ISO)
in situ carcinoma  (ISO)
Inflammation  (ISO)
inflammatory bowel disease  (ISO)
intestinal obstruction  (ISO)
Intestinal Polyps  (ISO)
invasive ductal carcinoma  (ISO)
kidney disease  (ISO)
Kidney Neoplasms  (ISO)
Laryngeal Neoplasms  (ISO)
Laryngeal Papillomatosis  (ISO)
Left Ventricular Hypertrophy  (ISO)
leiomyosarcoma  (ISO)
liver cirrhosis  (ISO)
lung cancer  (ISO)
lung disease  (ISO)
lung non-small cell carcinoma  (ISO)
Lymphatic Metastasis  (ISO)
meconium aspiration syndrome  (ISO)
melanoma  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
Metabolic Syndrome  (ISO)
mouth disease  (ISO)
Mouth Neoplasms  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
myocarditis  (ISO)
Nasal Polyps  (ISO)
Neoplasm Metastasis  (ISO)
Neoplasm Recurrence, Local  (ISO)
nephroblastoma  (ISO)
nephrotic syndrome  (ISO)
nervous system disease  (ISO)
Neurogenic Inflammation  (ISO)
obesity  (ISO)
obstructive sleep apnea  (ISO)
occupational asthma  (ISO)
open-angle glaucoma  (ISO)
oral mucosa leukoplakia  (ISO)
oral submucous fibrosis  (ISO)
osteoarthritis  (ISO)
Ovarian Neoplasms  (ISO)
Pain  (ISO)
pancreatic cancer  (ISO)
pancreatic ductal carcinoma  (ISO)
pancreatitis  (ISO)
papilloma  (ISO)
Parkinsonism  (ISO)
pericardial effusion  (ISO)
Peripheral Nerve Injuries  (ISO)
pleurisy  (ISO)
polycystic kidney disease  (ISO)
portal hypertension  (ISO)
pre-malignant neoplasm  (ISO)
Precocious Puberty  (ISO)
Premature Birth  (ISO)
prolactinoma  (ISO)
prostate cancer  (ISO)
prostate carcinoma in situ  (ISO)
prostatic hypertrophy  (ISO)
Prostatic Neoplasms  (ISO)
prostatitis  (ISO)
proteinuria  (ISO)
pulmonary emphysema  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (ISO)
retrograde amnesia  (ISO)
rheumatoid arthritis  (ISO)
sarcoidosis  (ISO)
schizophrenia  (ISO)
secondary hyperparathyroidism  (ISO)
Sepsis-Associated Encephalopathy  (ISO)
skin disease  (ISO)
Skin Neoplasms  (ISO)
Sleep Deprivation  (ISO)
Spinal Cord Injuries  (ISO)
squamous cell carcinoma  (ISO)
status epilepticus  (ISO)
steatotic liver disease  (ISO)
Stomach Neoplasms  (ISO)
stroke  (ISO)
Subarachnoid Hemorrhage  (ISO)
systemic lupus erythematosus  (ISO)
systemic scleroderma  (ISO)
thrombosis  (ISO)
Thyroid Neoplasms  (ISO)
Tongue Neoplasms  (ISO)
transitional cell carcinoma  (ISO)
traumatic brain injury  (ISO)
type 2 diabetes mellitus  (ISO)
ulcerative colitis  (ISO)
urinary bladder cancer  (ISO)
Urologic Neoplasms  (ISO)
Uterine Cervical Neoplasms  (ISO)
Ventilator-Induced Lung Injury  (ISO)
Wernicke encephalopathy  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (ISO)
bone mineralization  (ISO)
brown fat cell differentiation  (IEA)
cellular oxidant detoxification  (IEA)
cellular response to ATP  (ISO)
cellular response to fluid shear stress  (ISO)
cellular response to heat  (ISO)
cellular response to homocysteine  (ISO)
cellular response to hypoxia  (IEA)
cellular response to lead ion  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to non-ionic osmotic stress  (IDA,IEA)
cyclooxygenase pathway  (IBA,IEA,ISO)
decidualization  (ISO)
embryo implantation  (ISO)
fatty acid biosynthetic process  (IEA)
fatty acid metabolic process  (IEA)
hair cycle  (ISO)
learning  (ISO)
lipid metabolic process  (IEA)
maintenance of blood-brain barrier  (ISO)
memory  (ISO)
negative regulation of apoptotic process  (IDA,IEA)
negative regulation of calcium ion transport  (ISO)
negative regulation of cell cycle  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress  (IEA,IMP)
negative regulation of smooth muscle contraction  (ISO)
negative regulation of synaptic transmission, dopaminergic  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of brown fat cell differentiation  (IEA)
positive regulation of cell migration involved in sprouting angiogenesis  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of fever generation  (IEA)
positive regulation of fibroblast growth factor production  (ISO)
positive regulation of nitric oxide biosynthetic process  (ISO)
positive regulation of platelet-derived growth factor production  (ISO)
positive regulation of prostaglandin biosynthetic process  (IDA,IEA)
positive regulation of protein import into nucleus  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of smooth muscle contraction  (ISO)
positive regulation of synaptic plasticity  (ISO)
positive regulation of synaptic transmission, glutamatergic  (ISO)
positive regulation of transforming growth factor beta production  (ISO)
positive regulation of vascular endothelial growth factor production  (ISO)
positive regulation of vasoconstriction  (ISO)
prostaglandin biosynthetic process  (IEA,ISO)
prostaglandin metabolic process  (IEA)
prostaglandin secretion  (ISO)
prostanoid biosynthetic process  (IEA)
regulation of blood pressure  (ISO)
regulation of cell population proliferation  (ISO)
regulation of neuroinflammatory response  (IEA)
response to angiotensin  (ISO)
response to cytokine  (ISO)
response to estradiol  (ISO)
response to fatty acid  (ISO)
response to fructose  (ISO)
response to glucocorticoid  (ISO)
response to lipopolysaccharide  (ISO)
response to manganese ion  (ISO)
response to nematode  (ISO)
response to oxidative stress  (IEA)
response to selenium ion  (ISO)
response to tumor necrosis factor  (ISO)
response to vitamin D  (ISO)
response to xenobiotic stimulus  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acetylsalicylic acid pharmacodynamics pathway  (ISO)
antipyrine drug pathway  (ISO)
arachidonic acid metabolic pathway  (ISO)
celecoxib pharmacodynamics pathway  (ISO)
celecoxib pharmacokinetics pathway   (ISO)
cyclooxygenase mediated pathway of arachidonic acid metabolism  (ISO)
diclofenac pharmacodynamics pathway  (ISO)
diflunisal pharmacodynamics pathway  (ISO)
etodolac pharmacodynamics pathway  (ISO)
etoposide pharmacodynamics pathway  (ISO)
etoposide pharmacokinetics pathway  (ISO)
fenoprofen pharmacodynamics pathway  (ISO)
flurbiprofen pharmacodynamics pathway  (ISO)
ibuprofen pharmacodynamics pathway  (ISO)
ibuprofen pharmacokinetics pathway  (ISO)
indometacin pharmacodynamics pathway  (ISO)
indometacin pharmacodynamics pathway  (ISO)
ketoprofen pharmacodynamics pathway  (ISO)
ketorolac pharmacodynamics pathway  (ISO)
leukotriene C4 synthase deficiency pathway  (ISO)
lornoxicam pharmacodynamics pathway  (ISO)
magnesium salicylate pharmacodynamics pathway  (ISO)
mefenamic acid pharmacodynamics pathway  (ISO)
meloxicam pharmacodynamics pathway  (ISO)
nabumetone pharmacodynamics pathway  (ISO)
naproxen pharmacodynamics pathway   (ISO)
paracetamol drug pathway  (ISO)
piroxicam pharmacodynamics pathway  (ISO)
pro-inflammatory cytokine mediated pathway   (ISO)
prostanoid biosynthetic pathway  (ISO)
salicylic acid pharmacodynamics pathway  (ISO)
sodium salicylate pharmacodynamics pathway  (ISO)
sphingosine 1-phosphate signaling pathway  (ISO)
sulindac pharmacodynamics pathway  (ISO)
tenoxicam pharmacodynamics pathway  (ISO)
tiaprofenic acid pharmacodynamics pathway  (ISO)
tolmetin pharmacodynamics pathway  (ISO)
valdecoxib pharmacodynamics pathway  (ISO)

References
Additional References at PubMed
PMID:11861541   PMID:16538539   PMID:16966442   PMID:17316722   PMID:17708399   PMID:17921331   PMID:18562222   PMID:18717642   PMID:19005164   PMID:19243816   PMID:19274754   PMID:19535119  
PMID:19605908   PMID:19691646   PMID:19795944   PMID:20207364   PMID:22301074   PMID:22731506   PMID:23489848   PMID:23531445   PMID:24060154   PMID:24197070   PMID:24813155   PMID:26549149  
PMID:27892876   PMID:28956485   PMID:29867151   PMID:30032202  


Genomics

Comparative Map Data
PTGS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1719,668,079 - 19,674,903 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl719,668,082 - 19,674,903 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha719,190,741 - 19,197,565 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0719,405,501 - 19,412,325 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl719,405,504 - 19,412,176 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1719,311,510 - 19,318,356 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0719,420,827 - 19,427,651 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0719,552,954 - 19,559,778 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
PTGS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381186,671,791 - 186,680,423 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1186,671,791 - 186,680,922 (-)Ensemblhg38GRCh38
GRCh371186,640,923 - 186,649,555 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361184,907,592 - 184,916,179 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341183,372,625 - 183,381,213NCBI
Celera1159,751,694 - 159,760,309 (-)NCBICelera
Cytogenetic Map1q31.1NCBI
HuRef1157,875,712 - 157,884,327 (-)NCBIHuRef
CHM1_11188,062,673 - 188,071,288 (-)NCBICHM1_1
T2T-CHM13v2.01186,026,616 - 186,035,248 (-)NCBIT2T-CHM13v2.0
Ptgs2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391149,975,851 - 149,983,978 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1149,975,782 - 149,983,978 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381150,100,031 - 150,108,234 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1150,100,031 - 150,108,227 (+)Ensemblmm10GRCm38
MGSCv371151,947,254 - 151,955,147 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361151,862,342 - 151,870,235 (+)NCBIMGSCv36mm8
Celera1152,546,728 - 152,554,611 (+)NCBICelera
Cytogenetic Map1G1NCBI
cM Map163.84NCBI
Ptgs2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81364,714,063 - 64,722,320 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1364,713,619 - 64,722,320 (+)EnsemblGRCr8
mRatBN7.21362,163,936 - 62,172,193 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1362,163,932 - 62,172,188 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1364,798,537 - 64,804,239 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01366,083,346 - 66,089,057 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01363,344,882 - 63,350,588 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01367,351,230 - 67,356,920 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1367,351,087 - 67,359,335 (+)Ensemblrn6Rnor6.0
Rnor_5.01372,315,959 - 72,324,483 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41364,427,288 - 64,432,978 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1362,129,439 - 62,135,131 (+)NCBICelera
RGSC_v3.11364,441,245 - 64,449,480 (+)NCBI
Cytogenetic Map13q21NCBI
Ptgs2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540625,079,945 - 25,086,171 (-)Ensembl
ChiLan1.0NW_00495540625,077,988 - 25,086,259 (-)NCBIChiLan1.0ChiLan1.0
PTGS2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2163,030,462 - 63,041,820 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1162,713,923 - 62,723,110 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01162,205,534 - 162,214,130 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11166,355,845 - 166,364,517 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1166,355,845 - 166,364,519 (-)EnsemblpanPan2panpan1.1
Ptgs2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934485,975,505 - 85,982,237 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364813,822,251 - 3,828,086 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364813,821,564 - 3,828,086 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTGS2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9127,850,015 - 127,858,884 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.19127,850,164 - 127,858,866 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29140,251,667 - 140,260,362 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PTGS2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12542,733,535 - 42,742,463 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2542,734,771 - 42,742,429 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605543,903,786 - 43,913,892 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ptgs2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248146,897,857 - 6,903,728 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248146,897,818 - 6,904,890 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Ptgs2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11029,593,573 - 29,601,879 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in PTGS2
61 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000021841   ⟹   ENSCAFP00000020288
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl719,668,082 - 19,674,903 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845009561   ⟹   ENSCAFP00845007477
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl719,405,504 - 19,412,176 (-)Ensembl
RefSeq Acc Id: NM_001003354   ⟹   NP_001003354
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1719,668,079 - 19,674,903 (-)NCBI
Dog10K_Boxer_Tasha719,190,741 - 19,197,565 (-)NCBI
ROS_Cfam_1.0719,405,501 - 19,412,325 (-)NCBI
UMICH_Zoey_3.1719,311,510 - 19,318,356 (-)NCBI
UNSW_CanFamBas_1.0719,420,827 - 19,427,651 (-)NCBI
UU_Cfam_GSD_1.0719,552,954 - 19,559,778 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038670503   ⟹   XP_038526431
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0719,405,501 - 19,412,186 (-)NCBI
RefSeq Acc Id: NP_001003354   ⟸   NM_001003354
- Peptide Label: precursor
- UniProtKB: Q8SPQ9 (UniProtKB/TrEMBL),   A0A8C0R270 (UniProtKB/TrEMBL),   A0A8P0NFH5 (UniProtKB/TrEMBL),   A0A8C0QK63 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000020288   ⟸   ENSCAFT00000021841
RefSeq Acc Id: XP_038526431   ⟸   XM_038670503
- Peptide Label: isoform X1
- UniProtKB: A0A8C0R270 (UniProtKB/TrEMBL),   Q8SPQ9 (UniProtKB/TrEMBL),   A0A8P0NFH5 (UniProtKB/TrEMBL),   A0A8C0QK63 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845007477   ⟸   ENSCAFT00845009561
Protein Domains
EGF-like

Promoters
RGD ID:13683927
Promoter ID:EPDNEW_C1995
Type:single initiation site
Name:PTGS2_1
Description:prostaglandin-endoperoxide synthase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1719,674,931 - 19,674,991EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000013762 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030000542 UniProtKB/TrEMBL
  ENSCAFG00040005256 UniProtKB/TrEMBL
  ENSCAFG00845005378 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000021841.5 UniProtKB/TrEMBL
  ENSCAFT00030000891.1 UniProtKB/TrEMBL
  ENSCAFT00040009852.1 UniProtKB/TrEMBL
  ENSCAFT00845009561 ENTREZGENE
  ENSCAFT00845009561.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.640.10 UniProtKB/TrEMBL
  Laminin UniProtKB/TrEMBL
InterPro EGF-like_dom UniProtKB/TrEMBL
  Haem_peroxidase_animal UniProtKB/TrEMBL
  Haem_peroxidase_sf UniProtKB/TrEMBL
  Haem_peroxidase_sf_animal UniProtKB/TrEMBL
  Oxylipin_biosynth_metab UniProtKB/TrEMBL
KEGG Report cfa:442942 UniProtKB/TrEMBL
NCBI Gene PTGS2 ENTREZGENE
PANTHER PROSTAGLANDIN G/H SYNTHASE UniProtKB/TrEMBL
  PTHR11903:SF8 UniProtKB/TrEMBL
Pfam An_peroxidase UniProtKB/TrEMBL
  EGF UniProtKB/TrEMBL
PRINTS ANPEROXIDASE UniProtKB/TrEMBL
PROSITE EGF_3 UniProtKB/TrEMBL
  PEROXIDASE_3 UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/TrEMBL
  SSF48113 UniProtKB/TrEMBL
UniProt A0A8C0LV05_CANLF UniProtKB/TrEMBL
  A0A8C0QK63 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0R270 ENTREZGENE
  A0A8P0NFH5 ENTREZGENE, UniProtKB/TrEMBL
  Q8SPQ9 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:45152 ENTREZGENE