| 733162 | Ebp | EBP cholestenol delta-isomerase | This gene encodes a transmembrane protein that localizes to the endoplasmic reticulum. This protein catalyses the conversion of delta8 to delta7 sterols, an important step in sterol biosynthesis. Mutations in this gene are responsible for the mouse tattered mutant phenotype. Tattered males are embry onic lethal, while heterozygous females have developmental defects. Deficiency of the related gene in human causes X-linked dominant chondrodysplasia punctata. [provided by RefSeq, May 2015] | X | 8051568 | 8059751 | Mouse | 277 | symbol , old_gene_name , PhenoGen , name | gene, protein-coding, REVIEWED [RefSeq] |
| 1313991 | Ebna1bp2 | EBNA1 binding protein 2 | Predicted to be involved in rRNA processing and ribosomal large subunit biogenesis. Predicted to be located in chromosome. Predicted to be part of preribosome, large subunit precursor. Predicted to be active in nuclear periphery and nucleolus. Orthologous to human EBNA1BP2 (EBNA1 binding protein 2). [provided by Alliance of Genome Resources, Jul 2025] | 4 | 118477996 | 118484973 | Mouse | 128 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1332087 | Pa2g4 | proliferation-associated 2G4 | Predicted to enable nucleic acid binding activity; transcription corepressor activity; and ubiquitin protein ligase binding activity. Predicted to be involved in negative regulation of apoptotic process and positive regulation of cell differentiation. Predicted to act upstream of or within negative regulation of DNA-templated transcription. Predicted to be located in cytoplasm and nucleolus. Predicted to be part of ribonucleoprotein complex. Is expressed in brain; heart; jaw; limb; and lung mesenchyme. Orthologous to human PA2G4 (proliferation-associated 2G4). [provided by Alliance of Genome Resources, Jul 2025] | 10 | 128393635 | 128401803 | Mouse | 198 | old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 10325 | Cebpa | CCAAT/enhancer binding protein alpha | This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain and recognizes the CCAAT motif in the promoters of target genes. The encoded protein functions in homodimers and also heterodimers with CCAAT/enhancer-binding proteins beta and gamma. Activity of t his protein can modulate the expression of genes involved in cell cycle regulation as well as in body weight homeostasis. The use of alternative in-frame non-AUG (CUG) and AUG start codons results in several protein isoforms with different lengths. Differential translation initiation is mediated by an out-of-frame, upstream open reading frame which is located between the CUG and the first AUG start codons. [provided by RefSeq, Sep 2014] | 7 | 34818718 | 34821353 | Mouse | 902 | symbol , old_gene_name , PhenoGen , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 10328 | Cebpe | CCAAT/enhancer binding protein epsilon | Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Acts upstream of or within macrophage differentiation; phagocytosis; and positive regu lation of gene expression. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be part of RNA polymerase II transcription regulator complex. Is expressed in bone marrow; liver; lung; and spleen. Human ortholog(s) of this gene implicated in immunodeficiency 108. Orthologous to human CEBPE (CCAAT enhancer binding protein epsilon). [provided by Alliance of Genome Resources, Jul 2025] | 14 | 54947823 | 54949604 | Mouse | 156 | symbol , old_gene_name , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 730893 | Nfkb1 | nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 | Enables several functions, including RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; identical protein binding activity; and transcription coregulator activity. Involved in several processes, including B cell receptor signaling pathway; cellular response to virus; and regulation of gene expression. Acts upstream of or within several processes, including cellular response to tumor necrosis factor; regulation of gene expression; and response to muscle stretch. Located in cytosol. Part of NF-kappaB p50/p65 complex and transcription regulator complex. Is active in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and integumental system. Human ortholog(s) of this gene implicated in several diseases, including HTLV-1-associated myelopathy/tropical spastic paraparesis; carcinoma (multiple); common variable immunodeficiency 12; melanoma; and prostate cancer. Orthologous to human NFKB1 (nuclear factor kappa B subunit 1). [provided by Alliance of Genome Resources, Jul 2025] | 3 | 135290416 | 135397422 | Mouse | 1593 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 732281 | Nherf1 | NHERF family PDZ scaffold protein 1 | Enables dopamine receptor binding activity and phosphatase binding activity. Involved in several processes, including bile acid secretion; maintenance of epithelial cell apical/basal polarity; and negative regulation of signal transduction. Acts upstream of or within several processes, including G p rotein-coupled dopamine receptor signaling pathway; auditory receptor cell stereocilium organization; and cerebrospinal fluid circulation. Located in several cellular components, including brush border membrane; sperm midpiece; and stereocilium tip. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; knee joint primordium; and sensory organ. Human ortholog(s) of this gene implicated in hypophosphatemic nephrolithiasis/osteoporosis 2. Orthologous to human NHERF1 (NHERF family PDZ scaffold protein 1). [provided by Alliance of Genome Resources, Apr 2025] | 11 | 115054138 | 115072009 | Mouse | 355 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 11420 | Nkx2-1 | NK2 homeobox 1 | Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and intronic transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including hypothalamus de velopment; positive regulation of circadian rhythm; and regulation of DNA-templated transcription. Acts upstream of or within several processes, including lung development; nervous system development; and regulation of transcription by RNA polymerase II. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; brain; neural ectoderm; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in choreatic disease and papillary thyroid carcinoma. Orthologous to human NKX2-1 (NK2 homeobox 1). [provided by Alliance of Genome Resources, Jul 2025] | 12 | 56578741 | 56583570 | Mouse | 354 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 10329 | Cebpg | CCAAT/enhancer binding protein gamma | Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in hemopoiesis; natural killer cell mediated cytotoxicity; and regulation of gene expression. Acts upstream of or within mRNA metabolic process. Located in nucleus. Is expressed in several structures, in cluding blood; central nervous system; genitourinary system; retina; and yolk sac. Orthologous to human CEBPG (CCAAT enhancer binding protein gamma). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 34745847 | 34755991 | Mouse | 194 | symbol , old_gene_name , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 62396 | Ddit3 | DNA-damage inducible transcript 3 | Enables several functions, including DNA-binding transcription factor binding activity; protein heterodimerization activity; and transcription regulator activator activity. Involved in several processes, including blood vessel development; intracellular signal transduction; and regulation of transcr iption by RNA polymerase II. Acts upstream of or within several processes, including ER overload response; diaphragm contraction; and negative regulation of fat cell differentiation. Located in late endosome and nucleus. Part of CHOP-C/EBP complex. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in myxoid liposarcoma. Orthologous to human DDIT3 (DNA damage inducible transcript 3). [provided by Alliance of Genome Resources, Jul 2025] | 10 | 127126662 | 127132160 | Mouse | 1691 | old_gene_name , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 10326 | Cebpb | CCAAT/enhancer binding protein beta | Enables several functions, including DNA binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and enzyme binding activity. Contributes to RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including li ver development; positive regulation of metabolic process; and response to bacterium. Acts upstream of or within several processes, including mammary gland epithelium development; positive regulation of osteoblast differentiation; and regulation of gene expression. Located in chromosome; cytoplasm; and nuclear matrix. Part of C/EBP complex. Is expressed in several structures, including adrenal gland; connective tissue; extraembryonic component; genitourinary system; and integumental system. Used to study osteochondrodysplasia and viral infectious disease. Orthologous to human CEBPB (CCAAT enhancer binding protein beta). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 167530835 | 167532352 | Mouse | 1011 | symbol , old_gene_name , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 10327 | Cebpd | CCAAT/enhancer binding protein delta | Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including fat cell differentiation; positive regulation of osteoblast differentiation; and regulation of DNA-templated transcription. Located in nucleus. Is expressed in several structures, including alimentary system; early embryo; genitourinary system; integumental system; and lung. Orthologous to human CEBPD (CCAAT enhancer binding protein delta). [provided by Alliance of Genome Resources, Jul 2025] | 16 | 15705150 | 15707409 | Mouse | 371 | symbol , old_gene_name , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 733713 | Atf4 | activating transcription factor 4 | Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; cAMP response element binding protein binding activity; and promoter-specific chromatin binding activity. Contributes to DNA-binding transcription factor activity, RNA polymerase II-specifi c. Involved in several processes, including cellular response to leucine starvation; intracellular signal transduction; and regulation of gene expression. Acts upstream of or within several processes, including gluconeogenesis; positive regulation of sodium-dependent phosphate transport; and positive regulation of vascular associated smooth muscle cell apoptotic process. Located in cytoplasm and nucleus. Part of ATF1-ATF4 transcription factor complex and ATF4-CREB1 transcription factor complex. Is expressed in several structures, including central nervous system; embryo ectoderm; eye; genitourinary system; and long bone. Human ortholog(s) of this gene implicated in prostate carcinoma. Orthologous to human ATF4 (activating transcription factor 4). [provided by Alliance of Genome Resources, Apr 2025] | 15 | 80139385 | 80141746 | Mouse | 1019 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1616773 | Cebpzos | CCAAT/enhancer binding protein zeta, opposite strand | Predicted to be located in mitochondrial membrane. Orthologous to human CEBPZOS (CEBPZ opposite strand). [provided by Alliance of Genome Resources, Jul 2025] | 17 | 79223928 | 79228477 | Mouse | 35 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1312756 | Cebpz | CCAAT/enhancer binding protein zeta | Predicted to enable transcription coactivator activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be part of CCAAT-binding activity factor complex. Predicted to be active in nucleus. Is expressed in several structures, including alimentary sy stem; bone; brain; genitourinary system; and hemolymphoid system gland. Orthologous to human CEBPZ (CCAAT enhancer binding protein zeta). [provided by Alliance of Genome Resources, Apr 2025] | 17 | 79226432 | 79244499 | Mouse | 81 | symbol , old_gene_name , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1312087 | Ebpl | emopamil binding protein-like | Predicted to enable cholestenol delta-isomerase activity. Predicted to be involved in sterol metabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum. Is expressed in central nervous system; retina; retina inner nuclear layer; and retina outer nuclear layer. Orthologous to human EBPL (EBP like). [provided by Alliance of Genome Resources, Jul 2025] | 14 | 61577212 | 61597894 | Mouse | 81 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1552402 | Cldn18 | claudin 18 | This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cel l sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is a downstream target gene regulated by the T/EBP/NKX2.1 homeodomain transcription factor. Four alternatively spliced transcript variants resulted from alternative promoters and alternative splicing have been identified, which encode two lung-specific isoforms and two stomach-specific isoforms respectively. This gene is also expressed in colons, inner ear and skin, and its expression is increased in both experimental colitis and ulcerative colitis. [provided by RefSeq, Aug 2010] | 9 | 99572849 | 99599320 | Mouse | 106 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1553262 | Tbc1d10c | TBC1 domain family, member 10c | Predicted to enable GTPase activator activity. Acts upstream of or within negative regulation of B cell activation; negative regulation of ERK1 and ERK2 cascade; and negative regulation of calcineurin-NFAT signaling cascade. Predicted to be located in filopodium membrane. Is expressed in thymus prim ordium. Orthologous to human TBC1D10C (TBC1 domain family member 10C). [provided by Alliance of Genome Resources, Jul 2025] | 19 | 4234356 | 4241194 | Mouse | 85 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1615771 | Tbc1d10a | TBC1 domain family, member 10a | Predicted to enable GTPase activator activity and PDZ domain binding activity. Predicted to be involved in positive regulation of proteolysis and retrograde transport, endosome to Golgi. Predicted to be located in plasma membrane. Is expressed in renal calyx and vibrissa. Orthologous to human TBC1D1 0A (TBC1 domain family member 10A). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 4136852 | 4167407 | Mouse | 96 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |