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58 records found for search term Zfyve1
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RGD IDSymbolNameDescriptionChrStartStopSpeciesAnnotationsMatchType
1307795Zfyve1zinc finger FYVE-type containing 1ENCODES a protein that exhibits 1-phosphatidylinositol binding (ortholog); phosphatidylinositol-3,4,5-trisphosphate binding (ortholog); phosphatidylinositol-3,4-bisphosphate binding (ortholog); INVOLVED IN cellular response to starvation (ortholog); host-mediated activation of viral genome replicati6108916062108965231Rat144symbol , PhenoGengene, protein-coding, VALIDATED [RefSeq]
1317194ZFYVE1zinc finger FYVE-type containing 1The FYVE domain mediates the recruitment of proteins involved in membrane trafficking and cell signaling to phosphatidylinositol 3-phosphate-containing membranes. This protein contains two zinc-binding FYVE domains in tandem and is reported to localize to the Golgi apparatus. Alternative splicing re147296944573027106Human124symbol , COSMIC , Human Proteome Mapgene, protein-coding, REVIEWED [RefSeq]
1317195Zfyve1zinc finger, FYVE domain containing 1Predicted to enable phosphatidylinositol binding activity and phosphatidylinositol-3,4-bisphosphate binding activity. Involved in lipid droplet formation. Located in several cellular components, including Golgi apparatus; lipid droplet; and mitochondrion. Orthologous to human ZFYVE1128359333083679289Mouse154symbol , PhenoGen , descriptiongene, protein-coding, VALIDATED [RefSeq]
8945522Zfyve1zinc finger FYVE-type containing 1ENCODES a protein that exhibits 1-phosphatidylinositol binding (ortholog); phosphatidylinositol-3,4,5-trisphosphate binding (ortholog); phosphatidylinositol-3,4-bisphosphate binding (ortholog); INVOLVED IN cellular response to starvation (ortholog); host-mediated activation of viral genome replicatiNW_00495552323341752388612Chinchilla31symbolgene, protein-coding, MODEL [RefSeq]
11768699ZFYVE1zinc finger FYVE-type containing 1ENCODES a protein that exhibits 1-phosphatidylinositol binding (inferred); metal ion binding (inferred); phosphatidylinositol-3,4,5-trisphosphate binding (inferred); INVOLVED IN cellular response to starvation (inferred); host-mediated activation of viral genome replication (inferred); lipid droplet145355068853608297Bonobo45symbolgene, protein-coding, MODEL [RefSeq]
12211928ZFYVE1zinc finger FYVE-type containing 1ENCODES a protein that exhibits 1-phosphatidylinositol binding (inferred); metal ion binding (inferred); phosphatidylinositol-3,4,5-trisphosphate binding (inferred); INVOLVED IN cellular response to starvation (inferred); host-mediated activation of viral genome replication (inferred); lipid droplet84635348946407912Dog45symbolgene, protein-coding, MODEL [RefSeq]
12576483Zfyve1zinc finger FYVE-type containing 1ENCODES a protein that exhibits 1-phosphatidylinositol binding (inferred); metal ion binding (inferred); phosphatidylinositol-3,4,5-trisphosphate binding (inferred); INVOLVED IN cellular response to starvation (inferred); host-mediated activation of viral genome replication (inferred); lipid dropletNW_00493648823045212364472Squirrel45symbolgene, protein-coding, MODEL [RefSeq]
14037449ZFYVE1zinc finger FYVE-type containing 1ENCODES a protein that exhibits 1-phosphatidylinositol binding (inferred); metal ion binding (inferred); phosphatidylinositol-3,4,5-trisphosphate binding (inferred); INVOLVED IN cellular response to starvation (inferred); host-mediated activation of viral genome replication (inferred); lipid dropletPig45symbolgene, protein-coding, MODEL [RefSeq]
18599212ZFYVE1zinc finger FYVE-type containing 1ENCODES a protein that exhibits 1-phosphatidylinositol binding (inferred); metal ion binding (inferred); phosphatidylinositol-3,4,5-trisphosphate binding (inferred); INVOLVED IN cellular response to starvation (inferred); host-mediated activation of viral genome replication (inferred); lipid dropletGreen Monkey45symbolgene, protein-coding, MODEL [RefSeq]
18933549Zfyve1zinc finger FYVE-type containing 1ENCODES a protein that exhibits 1-phosphatidylinositol binding (inferred); metal ion binding (inferred); phosphatidylinositol-3,4,5-trisphosphate binding (inferred); INVOLVED IN cellular response to starvation (inferred); host-mediated activation of viral genome replication (inferred); lipid dropletNaked Mole-Rat45symbolgene, protein-coding, MODEL [RefSeq]
155251266zfyve1Tropical Clawed Frogsymbolgene, null
626157447Zfyve1zinc finger FYVE-type containing 1ENCODES a protein that exhibits 1-phosphatidylinositol binding (ortholog); phosphatidylinositol-3,4,5-trisphosphate binding (ortholog); phosphatidylinositol-3,4-bisphosphate binding (ortholog); INVOLVED IN cellular response to starvation (ortholog); host-mediated activation of viral genome replicatiBlack Rat31symbolgene, protein-coding, MODEL [RefSeq]
155242148zfyve1.LAfrican Clawed Frogsymbolgene, null
155258324zfyve1.SAfrican Clawed Frogsymbolgene, null
1322176Mtmr3myotubularin related protein 3Predicted to enable phosphatase activity and protein phosphatase binding activity. Predicted to be involved in several processes, including cellular response to glucose starvation; phosphatidylinositol metabolic process; and regulation of phosphatidylinositol dephosphorylation. Predicted to be locat1144308674544863Mouse118old_gene_symbolgene, protein-coding, VALIDATED [RefSeq]
1321135Mtmr4myotubularin related protein 4Predicted to enable molecular adaptor activity; phosphatase activity; and protein phosphatase binding activity. Predicted to be involved in several processes, including midbody abscission; phosphatidylinositol dephosphorylation; and regulation of phosphatidylinositol dephosphorylation. Predicted to 118748276987507128Mouse148old_gene_symbolgene, protein-coding, VALIDATED [RefSeq]
1323799Plekhf2pleckstrin homology domain containing, family F (with FYVE domain) member 2Predicted to enable phosphatidylinositol binding activity. Predicted to be involved in endosome organization and endosome to lysosome transport. Predicted to be located in transport vesicle. Predicted to be active in early endosome. Is expressed in central nervous system and genitourinary system. Or41098866211007619Mouse92old_gene_symbolgene, protein-coding, VALIDATED [RefSeq]
1312930Rufy1RUN and FYVE domain containing 1Predicted to enable identical protein binding activity; protein domain specific binding activity; and protein-macromolecule adaptor activity. Acts upstream of or within protein transport; regulation of endocytosis; and small GTPase-mediated signal transduction. Located in cytoplasm. Is expressed in 115028011350322101Mouse106old_gene_symbolgene, protein-coding, VALIDATED [RefSeq]
1312075Rufy2RUN and FYVE domain-containing 2Predicted to enable SH3 domain binding activity. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Is expressed in several structures, including central nervous system; respiratory system; sensory organ; skeleton; and skin. Orthologous to human RUFY2 (RUN and FYVE domain conta106281594762852988Mouse83old_gene_symbolgene, protein-coding, VALIDATED [RefSeq]
16562093AC026826.2zinc finger, FYVE domain containing 1 (ZFYVE1) pseudogeneHumannamegene, processed_pseudogene
1348980ZFYVE16zinc finger FYVE-type containing 16This gene encodes an endosomal protein that belongs to the FYVE zinc finger family of proteins. The encoded protein is thought to regulate membrane trafficking in the endosome. This protein functions as a scaffold protein in the transforming growth factor-beta signaling pathway and is involved in po58040761080483379Human127symbol , COSMIC , Human Proteome Mapgene, protein-coding, REVIEWED [RefSeq]
1558542Zfyve16zinc finger, FYVE domain containing 16Predicted to enable 1-phosphatidylinositol binding activity and phosphatidylinositol-3,4,5-trisphosphate binding activity. Predicted to be involved in endosomal transport and protein targeting to lysosome. Predicted to be located in cytosol and early endosome. Predicted to be active in early endosom139262425792667318Mouse124symbol , PhenoGen , descriptiongene, protein-coding, PROVISIONAL [RefSeq]
1564784Zfyve16zinc finger FYVE-type containing 16ENCODES a protein that exhibits 1-phosphatidylinositol binding (ortholog); phosphatidylinositol-3,4,5-trisphosphate binding (ortholog); INVOLVED IN endosomal transport (ortholog); protein targeting to lysosome (ortholog); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; transforming gr22544826425495180Rat116symbol , PhenoGengene, protein-coding, PROVISIONAL [RefSeq]
8874795Zfyve16zinc finger FYVE-type containing 16ENCODES a protein that exhibits 1-phosphatidylinositol binding (ortholog); phosphatidylinositol-3,4,5-trisphosphate binding (ortholog); INVOLVED IN endosomal transport (ortholog); protein targeting to lysosome (ortholog); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; transforming grNW_0049554182935327629403336Chinchilla16symbolgene, protein-coding, MODEL [RefSeq]
11693911ZFYVE16zinc finger FYVE-type containing 16ENCODES a protein that exhibits 1-phosphatidylinositol binding (inferred); metal ion binding (inferred); phosphatidylinositol-3,4,5-trisphosphate binding (inferred); INVOLVED IN endosomal transport (inferred); protein targeting to lysosome (inferred); PARTICIPATES IN Bone morphogenetic proteins sign53483741034910416Bonobo31symbolgene, protein-coding, MODEL [RefSeq]
12357003ZFYVE16zinc finger FYVE-type containing 16ENCODES a protein that exhibits 1-phosphatidylinositol binding (inferred); metal ion binding (inferred); phosphatidylinositol-3,4,5-trisphosphate binding (inferred); INVOLVED IN endosomal transport (inferred); protein targeting to lysosome (inferred); PARTICIPATES IN Bone morphogenetic proteins sign32666275026714184Dog31symbolgene, protein-coding, MODEL [RefSeq]
12552026Zfyve16zinc finger FYVE-type containing 16ENCODES a protein that exhibits phosphatidylinositol-3,4,5-trisphosphate binding (ortholog); INVOLVED IN endosomal transport (inferred); protein targeting to lysosome (inferred); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; transforming growth factor-beta Smad dependent signaling pNW_00493654980824648110116Squirrel22symbolgene, protein-coding, MODEL [RefSeq]
14283211ZFYVE16zinc finger FYVE-type containing 16ENCODES a protein that exhibits 1-phosphatidylinositol binding (inferred); metal ion binding (inferred); phosphatidylinositol-3,4,5-trisphosphate binding (inferred); INVOLVED IN endosomal transport (inferred); protein targeting to lysosome (inferred); PARTICIPATES IN Bone morphogenetic proteins signPig27symbolgene, protein-coding, MODEL [RefSeq]
18568011ZFYVE16zinc finger FYVE-type containing 16ENCODES a protein that exhibits 1-phosphatidylinositol binding (inferred); metal ion binding (inferred); phosphatidylinositol-3,4,5-trisphosphate binding (inferred); INVOLVED IN endosomal transport (inferred); protein targeting to lysosome (inferred); PARTICIPATES IN Bone morphogenetic proteins signGreen Monkey27symbolgene, protein-coding, MODEL [RefSeq]
18909826Zfyve16zinc finger FYVE-type containing 16ENCODES a protein that exhibits phosphatidylinositol-3,4,5-trisphosphate binding (ortholog); INVOLVED IN endosomal transport (inferred); protein targeting to lysosome (inferred); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; transforming growth factor-beta Smad dependent signaling pNaked Mole-Rat22symbolgene, protein-coding, MODEL [RefSeq]
284422542zfyve16Tropical Clawed Frogsymbolgene, null
626057004Zfyve16zinc finger FYVE-type containing 16ENCODES a protein that exhibits 1-phosphatidylinositol binding (ortholog); phosphatidylinositol-3,4,5-trisphosphate binding (ortholog); INVOLVED IN endosomal transport (ortholog); protein targeting to lysosome (ortholog); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; transforming grBlack Rat16symbolgene, protein-coding, MODEL [RefSeq]
1345411ZFYVE19zinc finger FYVE-type containing 19Enables phosphatidylinositol-3-phosphate binding activity. Involved in midbody abscission; mitotic cytokinesis checkpoint signaling; and negative regulation of cytokinesis. Located in centrosome; cleavage furrow; and midbody. Implicated in progressive familial intrahepatic cholestasis. [provided by 154080708940815084Human100symbol , COSMIC , Human Proteome Mapgene, protein-coding, VALIDATED [RefSeq]
1557318Zfyve19zinc finger, FYVE domain containing 19Predicted to enable phosphatidylinositol-3-phosphate binding activity. Predicted to be involved in abscission; midbody abscission; and negative regulation of cell cycle process. Predicted to be located in Flemming body and cytoplasm. Predicted to be active in centrosome; cleavage furrow; and midbody2119039088119047531Mouse102symbol , PhenoGen , descriptiongene, protein-coding, VALIDATED [RefSeq]
1561576Zfyve19zinc finger FYVE-type containing 19ENCODES a protein that exhibits phosphatidylinositol-3-phosphate binding (ortholog); INVOLVED IN midbody abscission (ortholog); mitotic cytokinesis checkpoint signaling (ortholog); negative regulation of cytokinesis (ortholog); ASSOCIATED WITH Progressive Familial Intrahepatic Cholestasis 9 (ortholo3126649625126657812Rat82symbol , PhenoGengene, protein-coding, PROVISIONAL [RefSeq]
9054600Zfyve19zinc finger FYVE-type containing 19ENCODES a protein that exhibits phosphatidylinositol-3-phosphate binding (ortholog); INVOLVED IN midbody abscission (ortholog); mitotic cytokinesis checkpoint signaling (ortholog); negative regulation of cytokinesis (ortholog); ASSOCIATED WITH Progressive Familial Intrahepatic Cholestasis 9 (ortholoNW_00495541676724997679851Chinchilla16symbolgene, protein-coding, MODEL [RefSeq]
11717278ZFYVE19zinc finger FYVE-type containing 19ENCODES a protein that exhibits lipid binding (inferred); metal ion binding (inferred); phosphatidylinositol-3-phosphate binding (inferred); INVOLVED IN abscission (inferred); cell division (inferred); midbody abscission (inferred); ASSOCIATED WITH Progressive Familial Intrahepatic Cholestasis 9 (or151974760619755185Bonobo30symbolgene, protein-coding, MODEL [RefSeq]
12235481ZFYVE19zinc finger FYVE-type containing 19ENCODES a protein that exhibits lipid binding (inferred); metal ion binding (inferred); phosphatidylinositol-3-phosphate binding (inferred); INVOLVED IN cell division (inferred); midbody abscission (inferred); mitotic cytokinesis checkpoint signaling (inferred); ASSOCIATED WITH Progressive Familial 3079453647952751Dog29symbolgene, protein-coding, MODEL [RefSeq]
12572332Zfyve19zinc finger FYVE-type containing 19ENCODES a protein that exhibits phosphatidylinositol-3-phosphate binding (inferred); INVOLVED IN midbody abscission (ortholog); negative regulation of cytokinesis (ortholog); ASSOCIATED WITH Progressive Familial Intrahepatic Cholestasis 9 (ortholog); FOUND IN centrosome (inferred); cleavage furrow (NW_00493647142033914207332Squirrel17symbolgene, protein-coding, MODEL [RefSeq]
14246156ZFYVE19zinc finger FYVE-type containing 19ENCODES a protein that exhibits lipid binding (inferred); metal ion binding (inferred); phosphatidylinositol-3-phosphate binding (inferred); INVOLVED IN cell division (inferred); midbody abscission (inferred); mitotic cytokinesis checkpoint signaling (inferred); ASSOCIATED WITH Progressive Familial Pig30symbolgene, protein-coding, MODEL [RefSeq]
18361838ZFYVE19zinc finger FYVE-type containing 19ENCODES a protein that exhibits lipid binding (inferred); metal ion binding (inferred); phosphatidylinositol-3-phosphate binding (inferred); INVOLVED IN abscission (inferred); cell division (inferred); midbody abscission (inferred); ASSOCIATED WITH Progressive Familial Intrahepatic Cholestasis 9 (orGreen Monkey30symbolgene, protein-coding, MODEL [RefSeq]
18932745Zfyve19zinc finger FYVE-type containing 19ENCODES a protein that exhibits lipid binding (inferred); metal ion binding (inferred); phosphatidylinositol-3-phosphate binding (inferred); INVOLVED IN midbody abscission (ortholog); negative regulation of cytokinesis (ortholog); ASSOCIATED WITH Progressive Familial Intrahepatic Cholestasis 9 (orthNaked Mole-Rat25symbolgene, protein-coding, MODEL [RefSeq]
155239485zfyve19Tropical Clawed Frogsymbolgene, null
626147098Zfyve19zinc finger FYVE-type containing 19ENCODES a protein that exhibits phosphatidylinositol-3-phosphate binding (ortholog); INVOLVED IN midbody abscission (ortholog); mitotic cytokinesis checkpoint signaling (ortholog); negative regulation of cytokinesis (ortholog); ASSOCIATED WITH Progressive Familial Intrahepatic Cholestasis 9 (ortholoBlack Rat16symbolgene, protein-coding, MODEL [RefSeq]
285586728zfyve16.LAfrican Clawed Frogsymbolgene, null
284421671zfyve16.SAfrican Clawed Frogsymbolgene, null
155242756zfyve19.LAfrican Clawed Frogsymbolgene, null
1320021ANKFY1ankyrin repeat and FYVE domain containing 1This gene encodes a cytoplasmic protein that contains a coiled-coil structure and a BTB/POZ domain at its N-terminus, ankyrin repeats in the middle portion, and a FYVE-finger motif at its C-terminus. This protein belongs to a subgroup of double zinc finger proteins which may be involved in vesicle o1741638214263979Human126old_gene_symbolgene, protein-coding, REVIEWED [RefSeq]
1320022Ankfy1ankyrin repeat and FYVE domain containing 1Predicted to enable phosphatidylinositol phosphate binding activity and small GTPase binding activity. Predicted to be involved in cytosolic transport; endosomal vesicle fusion; and positive regulation of pinocytosis. Located in endosome membrane. Is expressed in several structures, including adipos117258082872662972Mouse143old_gene_symbolgene, protein-coding, VALIDATED [RefSeq]
1343929MTMR3myotubularin related protein 3This gene encodes a member of the myotubularin dual specificity protein phosphatase gene family. The encoded protein is structurally similar to myotubularin but in addition contains a FYVE domain and an N-terminal PH-GRAM domain. The protein can self-associate and also form heteromers with another m222988317430030868Human113old_gene_symbolgene, protein-coding, REVIEWED [RefSeq]
1321134MTMR4myotubularin related protein 4Enables several functions, including R-SMAD binding activity; phosphatidylinositol phosphate phosphatase activity; and protein phosphatase binding activity. Involved in several processes, including midbody abscission; negative regulation of transmembrane receptor protein serine/threonine kinase sign175848953758519047Human149old_gene_symbolgene, protein-coding, VALIDATED [RefSeq]
1321508PLEKHF1pleckstrin homology and FYVE domain containing 1Enables phosphatidylinositol-3-phosphate binding activity; phosphatidylinositol-4-phosphate binding activity; and phosphatidylinositol-5-phosphate binding activity. Involved in endosome organization; positive regulation of autophagy; and protein localization to plasma membrane. Located in endosome a192966546129675477Human142old_gene_symbolgene, protein-coding, VALIDATED [RefSeq]
1321509Plekhf1pleckstrin homology domain containing, family F (with FYVE domain) member 1Predicted to enable phosphatidylinositol-3-phosphate binding activity; phosphatidylinositol-4-phosphate binding activity; and phosphatidylinositol-5-phosphate binding activity. Predicted to be involved in several processes, including endosome organization; endosome to lysosome transport; and protein73792007837927418Mouse158old_gene_symbolgene, protein-coding, VALIDATED [RefSeq]
1323798PLEKHF2pleckstrin homology and FYVE domain containing 2Predicted to enable phosphatidylinositol binding activity. Predicted to be involved in endosome organization and endosome to lysosome transport. Located in transport vesicle. [provided by Alliance of Genome Resources, Jul 2025]89513378595156685Human80old_gene_symbolgene, protein-coding, VALIDATED [RefSeq]
1312929RUFY1RUN and FYVE domain containing 1This gene encodes a protein that contains a RUN domain and a FYVE-type zinc finger domain. The encoded protein binds to phosphatidylinositol-3-phosphate (PI3P) and plays a role in early endosomal trafficking, tethering and fusion through interactions with small GTPases including Rab4, Rab5 and Rab145179550554179610012Human102old_gene_symbolgene, protein-coding, REVIEWED [RefSeq]
1312074RUFY2RUN and FYVE domain containing 2Enables SH3 domain binding activity. Predicted to be involved in regulation of endocytosis. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]106834111268407277Human83old_gene_symbolgene, protein-coding, VALIDATED [RefSeq]
1314357WDFY1WD repeat and FYVE domain containing 1The protein encoded by this gene is a phosphatidylinositol 3-phosphate binding protein, which contains a FYVE zinc finger domain and multiple WD-40 repeat domains. When exogenously expressed, it localizes to early endosomes. Mutagenesis analysis demonstrates that this endosomal localization is media2223875348223945335Human105old_gene_symbolgene, protein-coding, REVIEWED [RefSeq]
1620804Wdfy1WD repeat and FYVE domain containing 1Predicted to enable 1-phosphatidylinositol binding activity. Involved in positive regulation of toll-like receptor 3 signaling pathway and positive regulation of toll-like receptor 4 signaling pathway. Located in early endosome. Is expressed in embryo; extraembryonic component; placenta; and skin. O17967997979753764Mouse119old_gene_symbolgene, protein-coding, VALIDATED [RefSeq]