Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17beta-estradiol | decreases expression | ISO | RGD:1321135 | 6480464 | Estradiol results in decreased expression of MTMR4 mRNA | CTD | PMID:19693291 | 8-Br-cAMP | increases expression | EXP | | 6480464 | 8-Bromo Cyclic Adenosine Monophosphate results in increased expression of MTMR4 mRNA | CTD | PMID:20147733 | acrolein | multiple interactions | EXP | | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of MTMR4 mRNA, [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of MTMR4 mRNA | CTD | PMID:32699268 | aflatoxin B1 | affects expression | EXP | | 6480464 | Aflatoxin B1 affects the expression of MTMR4 protein | CTD | PMID:20106945 | aflatoxin B1 | decreases methylation | EXP | | 6480464 | Aflatoxin B1 results in decreased methylation of MTMR4 gene | CTD | PMID:27153756 | aflatoxin B1 | decreases expression | EXP | | 6480464 | Aflatoxin B1 results in decreased expression of MTMR4 mRNA | CTD | PMID:22100608 | all-trans-retinoic acid | increases expression | ISO | RGD:1321135 | 6480464 | Tretinoin results in increased expression of MTMR4 mRNA | CTD | PMID:16169686 | alpha-pinene | multiple interactions | EXP | | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of MTMR4 mRNA, [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of MTMR4 mRNA | CTD | PMID:32699268 | benzo[a]pyrene | decreases expression | EXP | | 6480464 | Benzoapyrene results in decreased expression of MTMR4 mRNA | CTD | PMID:22316170, PMID:32234424 | bisphenol A | decreases expression | ISO | RGD:1310306 | 6480464 | bisphenol A results in decreased expression of MTMR4 mRNA | CTD | PMID:25181051 | bisphenol A | increases expression | ISO | RGD:1310306 | 6480464 | bisphenol A results in increased expression of MTMR4 mRNA | CTD | PMID:30816183 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of MTMR4 mRNA | CTD | PMID:29275510 | carbon nanotube | increases expression | ISO | RGD:1321135 | 6480464 | Nanotubes more ... | CTD | PMID:25620056 | cerium trichloride | increases expression | ISO | RGD:1321135 | 6480464 | cerous chloride results in increased expression of MTMR4 mRNA | CTD | PMID:23573234 | choline | multiple interactions | ISO | RGD:1321135 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of MTMR4 mRNA, [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of MTMR4 gene | CTD | PMID:20938992 | chromium(6+) | affects expression | ISO | RGD:1321135 | 6480464 | chromium hexavalent ion affects the expression of MTMR4 mRNA | CTD | PMID:28472532 | ciglitazone | multiple interactions | EXP | | 6480464 | [ciglitazone binds to PPARG protein alternative form] which results in increased expression of MTMR4 mRNA | CTD | PMID:16197558 | cisplatin | decreases expression | EXP | | 6480464 | Cisplatin results in decreased expression of MTMR4 mRNA | CTD | PMID:27594783 | cisplatin | multiple interactions | EXP | | 6480464 | [Cisplatin co-treated with jinfukang] results in increased expression of MTMR4 mRNA | CTD | PMID:27392435 | cobalt dichloride | decreases expression | EXP | | 6480464 | cobaltous chloride results in decreased expression of MTMR4 mRNA | CTD | PMID:19376846 | copper atom | multiple interactions | EXP | | 6480464 | [NSC 689534 binds to Copper] which results in decreased expression of MTMR4 mRNA | CTD | PMID:20971185 | copper atom | increases expression | ISO | RGD:1310306 | 6480464 | Copper results in increased expression of MTMR4 mRNA | CTD | PMID:30556269 | copper(0) | multiple interactions | EXP | | 6480464 | [NSC 689534 binds to Copper] which results in decreased expression of MTMR4 mRNA | CTD | PMID:20971185 | copper(0) | increases expression | ISO | RGD:1310306 | 6480464 | Copper results in increased expression of MTMR4 mRNA | CTD | PMID:30556269 | coumestrol | multiple interactions | EXP | | 6480464 | [Coumestrol co-treated with 2, 3-bis3'-hydroxybenzylbutyrolactone] results in increased expression of MTMR4 mRNA | CTD | PMID:19167446 | cyclosporin A | decreases expression | EXP | | 6480464 | Cyclosporine results in decreased expression of MTMR4 mRNA | CTD | PMID:20106945 | cyclosporin A | decreases expression | ISO | RGD:1321135 | 6480464 | Cyclosporine results in decreased expression of MTMR4 mRNA | CTD | PMID:19770486 | Enterolactone | multiple interactions | EXP | | 6480464 | [Coumestrol co-treated with 2, 3-bis3'-hydroxybenzylbutyrolactone] results in increased expression of MTMR4 mRNA | CTD | PMID:19167446 | ethanol | affects splicing | ISO | RGD:1321135 | 6480464 | Ethanol affects the splicing of MTMR4 mRNA | CTD | PMID:30319688 | ethyl methanesulfonate | decreases expression | EXP | | 6480464 | Ethyl Methanesulfonate results in decreased expression of MTMR4 mRNA | CTD | PMID:23649840 | folic acid | multiple interactions | ISO | RGD:1321135 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of MTMR4 mRNA, [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of MTMR4 gene | CTD | PMID:20938992 | formaldehyde | decreases expression | EXP | | 6480464 | Formaldehyde results in decreased expression of MTMR4 mRNA | CTD | PMID:23649840 | hydralazine | multiple interactions | EXP | | 6480464 | [Hydralazine co-treated with Valproic Acid] results in increased expression of MTMR4 mRNA | CTD | PMID:17183730 | hydrogen peroxide | affects expression | EXP | | 6480464 | Hydrogen Peroxide affects the expression of MTMR4 mRNA | CTD | PMID:21179406 | irinotecan | affects expression | ISO | RGD:1310306 | 6480464 | Irinotecan affects the expression of MTMR4 mRNA | CTD | PMID:20097248 | L-methionine | multiple interactions | ISO | RGD:1321135 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of MTMR4 mRNA, [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of MTMR4 gene | CTD | PMID:20938992 | leflunomide | decreases expression | EXP | | 6480464 | leflunomide results in decreased expression of MTMR4 mRNA | CTD | PMID:28988120 | methapyrilene | decreases expression | ISO | RGD:1310306 | 6480464 | Methapyrilene results in decreased expression of MTMR4 mRNA | CTD | PMID:30467583 | methoxyacetic acid | affects expression | ISO | RGD:1310306 | 6480464 | methoxyacetic acid affects the expression of MTMR4 mRNA | CTD | PMID:20864626 | methyl methanesulfonate | decreases expression | EXP | | 6480464 | Methyl Methanesulfonate results in decreased expression of MTMR4 mRNA | CTD | PMID:23649840 | nefazodone | increases expression | ISO | RGD:1310306 | 6480464 | nefazodone results in increased expression of MTMR4 mRNA | CTD | PMID:24136188 | O-methyleugenol | decreases expression | EXP | | 6480464 | methyleugenol results in decreased expression of MTMR4 mRNA | CTD | PMID:32234424 | ozone | multiple interactions | EXP | | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of MTMR4 mRNA more ... | CTD | PMID:32699268 | paracetamol | affects expression | ISO | RGD:1321135 | 6480464 | Acetaminophen affects the expression of MTMR4 mRNA | CTD | PMID:17562736 | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of MTMR4 mRNA | CTD | PMID:21420995, PMID:29067470 | perfluorononanoic acid | decreases expression | EXP | | 6480464 | perfluorononanoic acid results in decreased expression of MTMR4 mRNA | CTD | PMID:32588087 | pirinixic acid | increases expression | ISO | RGD:1321135 | 6480464 | pirinixic acid results in increased expression of MTMR4 mRNA | CTD | PMID:18301758 | pirinixic acid | multiple interactions | ISO | RGD:1321135 | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of MTMR4 mRNA | CTD | PMID:19710929 | quercetin | decreases expression | EXP | | 6480464 | Quercetin results in decreased expression of MTMR4 mRNA | CTD | PMID:21632981 | resveratrol | multiple interactions | ISO | RGD:1321135 | 6480464 | Resveratrol inhibits the reaction [titanium dioxide results in increased expression of MTMR4 mRNA] | CTD | PMID:31298478 | silicon dioxide | decreases expression | ISO | RGD:1321135 | 6480464 | Silicon Dioxide results in decreased expression of MTMR4 mRNA | CTD | PMID:19073995 | silicon dioxide | increases expression | EXP | | 6480464 | Silicon Dioxide analog results in increased expression of MTMR4 mRNA | CTD | PMID:23806026 | sodium arsenite | decreases expression | EXP | | 6480464 | sodium arsenite results in decreased expression of MTMR4 mRNA | CTD | PMID:28595984 | Soman | decreases expression | ISO | RGD:1310306 | 6480464 | Soman results in decreased expression of MTMR4 mRNA | CTD | PMID:19281266 | testosterone | decreases expression | ISO | RGD:1321135 | 6480464 | Testosterone results in decreased expression of MTMR4 mRNA | CTD | PMID:19693291 | titanium dioxide | increases expression | ISO | RGD:1321135 | 6480464 | titanium dioxide results in increased expression of MTMR4 mRNA | CTD | PMID:31298478 | titanium dioxide | multiple interactions | ISO | RGD:1321135 | 6480464 | Resveratrol inhibits the reaction [titanium dioxide results in increased expression of MTMR4 mRNA] | CTD | PMID:31298478 | tungsten | decreases expression | ISO | RGD:1321135 | 6480464 | Tungsten results in decreased expression of MTMR4 mRNA | CTD | PMID:30912803 | valproic acid | multiple interactions | EXP | | 6480464 | [Hydralazine co-treated with Valproic Acid] results in increased expression of MTMR4 mRNA | CTD | PMID:17183730 | valproic acid | affects expression | ISO | RGD:1321135 | 6480464 | Valproic Acid affects the expression of MTMR4 mRNA | CTD | PMID:17292431 | valproic acid | affects expression | EXP | | 6480464 | Valproic Acid affects the expression of MTMR4 mRNA | CTD | PMID:25979313 | valproic acid | decreases methylation | EXP | | 6480464 | Valproic Acid results in decreased methylation of MTMR4 gene | CTD | PMID:29154799 | valproic acid | decreases expression | EXP | | 6480464 | Valproic Acid results in decreased expression of MTMR4 mRNA | CTD | 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Gene Ontology Annotations Click to see Annotation Detail View
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Gene Ontology Annotations
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References
References - curated
| 1. | GOA_HUMAN data from the GO Consortium |
| 2. | Plant PJ, etal., Biochem J. 2009 Apr 1;419(1):57-63. doi: 10.1042/BJ20081866. |
| 3. | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
| 4. | RGD automated import pipeline for gene-chemical interactions |
Additional References at PubMed
| PMID:9734811 | PMID:9736772 | PMID:10888877 | PMID:11302699 | PMID:12477932 | PMID:15231748 | PMID:16787938 | PMID:19322201 | PMID:19329342 | PMID:20061380 | PMID:20736309 | PMID:21873635 |
| PMID:21940522 | PMID:22664934 | PMID:23150675 | PMID:25195910 | PMID:25208829 | PMID:25659891 | PMID:26186194 | PMID:26787466 | PMID:27432908 | PMID:27625994 | PMID:27880917 | PMID:27976729 |
| PMID:28514442 | PMID:28675297 | PMID:29117863 | PMID:29507755 | PMID:31586073 | PMID:31723608 |
Genomics
