| 1321471 | SCRIB | scribble planar cell polarity protein | This gene encodes a protein that was identified as being similar to the Drosophila scribble protein. The mammalian protein is involved in tumor suppression pathways. As a scaffold protein involved in cell polarization processes, this protein binds to many other proteins. The encoded protein binds to papillomavirus E6 protein via its PDZ domain and the C-terminus of E6. Two alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2011] | 8 | 143790925 | 143815773 | Human | 218 | symbol , old_gene_name , COSMIC , name , description , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1321472 | Scrib | scribbled planar cell polarity | Predicted to enable protein kinase binding activity and signaling adaptor activity. Involved in several processes, including establishment of T cell polarity; negative regulation of activated T cell proliferation; and synaptic vesicle cycle. Acts upstream of or within several processes, including ne rvous system development; post-anal tail morphogenesis; and wound healing. Located in several cellular components, including basolateral plasma membrane; immunological synapse; and myelin sheath abaxonal region. Is expressed in several structures, including embryo mesenchyme; epithelium; metanephros; nervous system; and skin. Used to study prostate cancer. Orthologous to human SCRIB (scribble planar cell polarity protein). [provided by Alliance of Genome Resources, Jul 2025] | 15 | 75919011 | 75941633 | Mouse | 324 | symbol , old_gene_name , PhenoGen , name , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1565055 | Scrib | scribble planar cell polarity protein | ENCODES a protein that exhibits signaling adaptor activity (ortholog); INVOLVED IN astrocyte cell migration; neurotransmitter receptor transport, endosome to postsynaptic membrane; regulation of postsynaptic neurotransmitter receptor internalization; PARTICIPATES IN Wnt signaling, the planar cell po larity pathway; ASSOCIATED WITH microcephaly (ortholog); neural tube defect (ortholog); FOUND IN cell-cell junction; extrinsic component of postsynaptic density membrane; glutamatergic synapse; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; 6-propyl-2-thiouracil | 7 | 109640034 | 109663354 | Rat | 175 | symbol , old_gene_name , PhenoGen , name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 8871697 | Scrib | scribble planar cell polarity protein | ENCODES a protein that exhibits signaling adaptor activity (ortholog); INVOLVED IN activation of GTPase activity (ortholog); apoptotic process involved in morphogenesis (ortholog); astrocyte cell migration (ortholog); PARTICIPATES IN Wnt signaling, the planar cell polarity pathway; ASSOCIATED WITH m icrocephaly (ortholog); neural tube defect (ortholog); FOUND IN adherens junction (ortholog); basolateral plasma membrane (ortholog); cell junction (ortholog) | NW_004955454 | 2461526 | 2482734 | Chinchilla | 112 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 11940430 | SCRIB | scribble planar cell polarity protein | ENCODES a protein that exhibits protein kinase binding (inferred); signaling adaptor activity (inferred); INVOLVED IN activation of GTPase activity (ortholog); astrocyte cell migration (ortholog); auditory receptor cell morphogenesis (ortholog); PARTICIPATES IN Wnt signaling, the planar cell polarit y pathway; ASSOCIATED WITH microcephaly (ortholog); neural tube defect (ortholog); FOUND IN cell-cell junction (ortholog); extrinsic component of postsynaptic density membrane (ortholog); glutamatergic synapse (ortholog) | 8 | 140544797 | 140571078 | Bonobo | 129 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12108710 | SCRIB | scribble planar cell polarity protein | ENCODES a protein that exhibits signaling adaptor activity (inferred); INVOLVED IN epithelial structure maintenance; positive regulation of epithelial cell migration; activation of GTPase activity (ortholog); PARTICIPATES IN Wnt signaling, the planar cell polarity pathway; ASSOCIATED WITH microcepha ly (ortholog); neural tube defect (ortholog); FOUND IN cell junction; cytoplasm; plasma membrane | 13 | 37356405 | 37374765 | Dog | 82 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12521534 | Scrib | scribble planar cell polarity protein | ENCODES a protein that exhibits protein kinase binding (inferred); signaling adaptor activity (inferred); INVOLVED IN activation of GTPase activity (ortholog); astrocyte cell migration (ortholog); auditory receptor cell morphogenesis (ortholog); PARTICIPATES IN Wnt signaling, the planar cell polarit y pathway; ASSOCIATED WITH microcephaly (ortholog); neural tube defect (ortholog); FOUND IN cell-cell junction (ortholog); extrinsic component of postsynaptic density membrane (ortholog); glutamatergic synapse (ortholog) | NW_004936470 | 8349175 | 8370099 | Squirrel | 129 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 13866495 | SCRIB | scribble planar cell polarity protein | ENCODES a protein that exhibits signaling adaptor activity (inferred); INVOLVED IN activation of GTPase activity (ortholog); astrocyte cell migration (ortholog); auditory receptor cell morphogenesis (ortholog); PARTICIPATES IN Wnt signaling, the planar cell polarity pathway; ASSOCIATED WITH microcep haly (ortholog); neural tube defect (ortholog); FOUND IN cell-cell junction (ortholog); extrinsic component of postsynaptic density membrane (ortholog); glutamatergic synapse (ortholog) | | | | Pig | 124 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 14385322 | scrib | | | | | | Fly | | symbol | gene, null |
| 18398227 | SCRIB | scribble planar cell polarity protein | ENCODES a protein that exhibits protein kinase binding (inferred); signaling adaptor activity (inferred); INVOLVED IN activation of GTPase activity (ortholog); astrocyte cell migration (ortholog); auditory receptor cell morphogenesis (ortholog); PARTICIPATES IN Wnt signaling, the planar cell polarit y pathway; ASSOCIATED WITH microcephaly (ortholog); neural tube defect (ortholog); FOUND IN cell-cell junction (ortholog); extrinsic component of postsynaptic density membrane (ortholog); glutamatergic synapse (ortholog) | | | | Green Monkey | 129 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18918514 | Scrib | scribble planar cell polarity protein | ENCODES a protein that exhibits signaling adaptor activity (ortholog); INVOLVED IN activation of GTPase activity (ortholog); apoptotic process involved in morphogenesis (ortholog); astrocyte cell migration (ortholog); PARTICIPATES IN Wnt signaling, the planar cell polarity pathway; ASSOCIATED WITH m icrocephaly (ortholog); neural tube defect (ortholog); FOUND IN cell leading edge (ortholog); cell-cell contact zone (ortholog); cell-cell junction (ortholog) | | | | Naked Mole-Rat | 124 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 155256960 | scrib | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626099942 | Scrib | scribble planar cell polarity protein | ENCODES a protein that exhibits signaling adaptor activity (ortholog); INVOLVED IN activation of GTPase activity (ortholog); apoptotic process involved in morphogenesis (ortholog); astrocyte cell migration (ortholog); PARTICIPATES IN Wnt signaling, the planar cell polarity pathway; ASSOCIATED WITH m icrocephaly (ortholog); neural tube defect (ortholog); FOUND IN adherens junction (ortholog); basolateral plasma membrane (ortholog); cell junction (ortholog) | | | | Black Rat | 112 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 155256032 | scrib.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155256961 | scrib.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 10166 | Apc | APC, WNT signaling pathway regulator | Enables several functions, including beta-catenin binding activity; dynein complex binding activity; and enzyme binding activity. Involved in insulin receptor signaling pathway; positive regulation of cold-induced thermogenesis; and positive regulation of protein localization to centrosome. Acts ups tream of or within several processes, including negative regulation of epithelial cell proliferation; regionalization; and regulation of apoptotic process. Located in several cellular components, including axonal growth cone; cell projection membrane; and microtubule cytoskeleton. Part of Scrib-APC-beta-catenin complex. Is active in glutamatergic synapse and postsynapse. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and peripheral nervous system ganglion. Used to study breast cancer; familial adenomatous polyposis; gastrointestinal system cancer (multiple); and reproductive organ cancer (multiple). Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); familial adenomatous polyposis 1; gastrointestinal system cancer (multiple); hereditary desmoid disease; and reproductive organ cancer (multiple). Orthologous to human APC (APC regulator of WNT signaling pathway). [provided by Alliance of Genome Resources, Jul 2025] | 18 | 34353350 | 34455243 | Mouse | 1412 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 625976908 | LOC116888918 | protein scribble homolog | | | | | Black Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 733153 | Llgl1 | LLGL1 scribble cell polarity complex component | Predicted to enable GTPase activator activity; enzyme binding activity; and myosin II binding activity. Acts upstream of or within maintenance of apical/basal cell polarity. Located in several cellular components, including basolateral plasma membrane; cytoskeleton; and myelin sheath abaxonal region . Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human LLGL1 (LLGL scribble cell polarity complex component 1). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 60590501 | 60605012 | Mouse | 113 | name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1557962 | Llgl2 | LLGL2 scribble cell polarity complex component | Predicted to enable GTPase activator activity; PDZ domain binding activity; and myosin II binding activity. Acts upstream of or within establishment or maintenance of polarity of embryonic epithelium; labyrinthine layer development; and post-embryonic development. Predicted to be located in cytosol and intracellular membrane-bounded organelle. Predicted to be active in cortical actin cytoskeleton and plasma membrane. Is expressed in several structures, including cardiovascular system; endocrine gland; genitourinary system; gut; and nasal cavity epithelium. Orthologous to human LLGL2 (LLGL scribble cell polarity complex component 2). [provided by Alliance of Genome Resources, Apr 2025] | 11 | 115714855 | 115746606 | Mouse | 140 | old_gene_name , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 3012 | Llgl1 | LLGL scribble cell polarity complex component 1 | ENCODES a protein that exhibits GTPase activator activity; small GTPase binding; protein kinase binding (ortholog); INVOLVED IN axonogenesis; Golgi to plasma membrane transport; cortical actin cytoskeleton organization (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); hydrocephalus (ortholog) ; FOUND IN axon; early endosome membrane; Golgi cis cisterna; INTERACTS WITH 3-chloropropane-1,2-diol; acrylamide; ammonium chloride | 10 | 45878936 | 45893609 | Rat | 95 | old_gene_name , name | gene, protein-coding, VALIDATED [RefSeq] |
| 733152 | LLGL1 | LLGL scribble cell polarity complex component 1 | This gene encodes a protein that is similar to a tumor suppressor in Drosophila. The protein is part of a cytoskeletal network and is associated with nonmuscle myosin II heavy chain and a kinase that specifically phosphorylates this protein at serine residues. The gene is located within the Smith-Ma genis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008] | 17 | 18225635 | 18244875 | Human | 89 | old_gene_name , name | gene, protein-coding, REVIEWED [RefSeq] |
| 8897463 | Llgl1 | LLGL scribble cell polarity complex component 1 | ENCODES a protein that exhibits GTPase activator activity (ortholog); protein kinase binding (ortholog); small GTPase binding (ortholog); INVOLVED IN axonogenesis (ortholog); cortical actin cytoskeleton organization (ortholog); Golgi to plasma membrane transport (ortholog); ASSOCIATED WITH Breast Ne oplasms (ortholog); hydrocephalus (ortholog); FOUND IN axon (ortholog); basolateral plasma membrane (ortholog); cortical actin cytoskeleton (ortholog) | NW_004955478 | 11075399 | 11089818 | Chinchilla | 21 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12043605 | LLGL1 | LLGL scribble cell polarity complex component 1 | ENCODES a protein that exhibits small GTPase binding (ortholog); INVOLVED IN axonogenesis (ortholog); maintenance of apical/basal cell polarity (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); hydrocephalus (ortholog); FOUND IN axon (ortholog); basolateral plasma membrane (ortholog); cytoske leton (ortholog) | 17 | 32770511 | 32789756 | Bonobo | 29 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12162413 | LLGL1 | LLGL scribble cell polarity complex component 1 | ENCODES a protein that exhibits small GTPase binding (ortholog); INVOLVED IN axonogenesis (ortholog); maintenance of apical/basal cell polarity (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); hydrocephalus (ortholog); FOUND IN basolateral plasma membrane (ortholog); Golgi cis cisterna (orth olog); myelin sheath abaxonal region (ortholog) | 5 | 41314807 | 41332687 | Dog | 33 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12610160 | Llgl1 | LLGL scribble cell polarity complex component 1 | ENCODES a protein that exhibits small GTPase binding (ortholog); INVOLVED IN axonogenesis (ortholog); maintenance of apical/basal cell polarity (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); hydrocephalus (ortholog); FOUND IN axon (ortholog); basolateral plasma membrane (ortholog); cytoske leton (ortholog) | NW_004936741 | 1770797 | 1784716 | Squirrel | 29 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 14018864 | LLGL1 | LLGL scribble cell polarity complex component 1 | ENCODES a protein that exhibits small GTPase binding (ortholog); INVOLVED IN axonogenesis (ortholog); maintenance of apical/basal cell polarity (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); hydrocephalus (ortholog); FOUND IN axon (ortholog); basolateral plasma membrane (ortholog); cytoske leton (ortholog) | | | | Pig | 32 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18428378 | LLGL1 | LLGL scribble cell polarity complex component 1 | ENCODES a protein that exhibits small GTPase binding (ortholog); INVOLVED IN axonogenesis (ortholog); maintenance of apical/basal cell polarity (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); hydrocephalus (ortholog); FOUND IN axon (ortholog); basolateral plasma membrane (ortholog); cytoske leton (ortholog) | | | | Green Monkey | 29 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18925122 | Llgl1 | LLGL scribble cell polarity complex component 1 | ENCODES a protein that exhibits protein kinase binding (ortholog); small GTPase binding (ortholog); INVOLVED IN axonogenesis (ortholog); maintenance of apical/basal cell polarity (ortholog); protein-containing complex assembly (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); hydrocephalus (o rtholog); FOUND IN axon (ortholog); basolateral plasma membrane (ortholog); cytoskeleton (ortholog) | | | | Naked Mole-Rat | 26 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 1353110 | LLGL2 | LLGL scribble cell polarity complex component 2 | The lethal (2) giant larvae protein of Drosophila plays a role in asymmetric cell division, epithelial cell polarity, and cell migration. This human gene encodes a protein similar to lethal (2) giant larvae of Drosophila. In fly, the protein's ability to localize cell fate determinants is regulated by the atypical protein kinase C (aPKC). In human, this protein interacts with aPKC-containing complexes and is cortically localized in mitotic cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] | 17 | 75525002 | 75575209 | Human | 121 | old_gene_name , name | gene, protein-coding, REVIEWED [RefSeq] |
| 1560307 | Llgl2 | LLGL scribble cell polarity complex component 2 | ENCODES a protein that exhibits PDZ domain binding (ortholog); INVOLVED IN branching involved in labyrinthine layer morphogenesis (ortholog); establishment or maintenance of polarity of embryonic epithelium (ortholog); L-leucine transport (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); COVI D-19 (ortholog); Neoplasm Metastasis (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; all-trans-retinoic acid; bisphenol A | 10 | 101549911 | 101585466 | Rat | 121 | old_gene_name , name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 8816288 | Llgl2 | LLGL scribble cell polarity complex component 2 | ENCODES a protein that exhibits PDZ domain binding (ortholog); INVOLVED IN branching involved in labyrinthine layer morphogenesis (ortholog); establishment or maintenance of polarity of embryonic epithelium (ortholog); L-leucine transport (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); COVI D-19 (ortholog); Neoplasm Metastasis (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog) | NW_004955553 | 2377640 | 2415152 | Chinchilla | 18 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 11956801 | LLGL2 | LLGL scribble cell polarity complex component 2 | ENCODES a protein that exhibits GTPase activator activity (inferred); myosin II binding (inferred); PDZ domain binding (inferred); INVOLVED IN branching involved in labyrinthine layer morphogenesis (ortholog); establishment or maintenance of polarity of embryonic epithelium (ortholog); labyrinthine layer blood vessel development (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); COVID-19 (ortholog); Neoplasm Metastasis (ortholog); FOUND IN cortical actin cytoskeleton (inferred); cytoplasm (inferred); cytosol (inferred) | 17 | 69474804 | 69524797 | Bonobo | 31 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12372910 | LLGL2 | LLGL scribble cell polarity complex component 2 | ENCODES a protein that exhibits PDZ domain binding (inferred); INVOLVED IN branching involved in labyrinthine layer morphogenesis (ortholog); establishment or maintenance of polarity of embryonic epithelium (ortholog); labyrinthine layer blood vessel development (ortholog); ASSOCIATED WITH Breast Ne oplasms (ortholog); COVID-19 (ortholog); Neoplasm Metastasis (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred) | 9 | 4975309 | 5008383 | Dog | 31 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12438879 | Llgl2 | LLGL scribble cell polarity complex component 2 | ENCODES a protein that exhibits GTPase activator activity (inferred); myosin II binding (inferred); PDZ domain binding (inferred); INVOLVED IN branching involved in labyrinthine layer morphogenesis (ortholog); establishment or maintenance of polarity of embryonic epithelium (ortholog); labyrinthine layer blood vessel development (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); COVID-19 (ortholog); Neoplasm Metastasis (ortholog); FOUND IN cortical actin cytoskeleton (inferred); cytoplasm (inferred); cytosol (inferred) | NW_004936594 | 754140 | 792493 | Squirrel | 29 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 14015634 | LLGL2 | LLGL scribble cell polarity complex component 2 | ENCODES a protein that exhibits PDZ domain binding (inferred); INVOLVED IN branching involved in labyrinthine layer morphogenesis (ortholog); establishment or maintenance of polarity of embryonic epithelium (ortholog); labyrinthine layer blood vessel development (ortholog); ASSOCIATED WITH Breast Ne oplasms (ortholog); COVID-19 (ortholog); Neoplasm Metastasis (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred) | | | | Pig | 31 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18792008 | LLGL2 | LLGL scribble cell polarity complex component 2 | ENCODES a protein that exhibits GTPase activator activity (inferred); myosin II binding (inferred); PDZ domain binding (inferred); INVOLVED IN branching involved in labyrinthine layer morphogenesis (ortholog); establishment or maintenance of polarity of embryonic epithelium (ortholog); labyrinthine layer blood vessel development (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); COVID-19 (ortholog); Neoplasm Metastasis (ortholog); FOUND IN cortical actin cytoskeleton (inferred); cytoplasm (inferred); cytosol (inferred) | | | | Green Monkey | 31 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18909451 | Llgl2 | LLGL scribble cell polarity complex component 2 | ENCODES a protein that exhibits PDZ domain binding (ortholog); INVOLVED IN branching involved in labyrinthine layer morphogenesis (ortholog); establishment or maintenance of polarity of embryonic epithelium (ortholog); L-leucine transport (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); COVI D-19 (ortholog); Neoplasm Metastasis (ortholog); FOUND IN cytosol (ortholog) | | | | Naked Mole-Rat | 29 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 626082693 | Llgl2 | LLGL scribble cell polarity complex component 2 | ENCODES a protein that exhibits PDZ domain binding (ortholog); INVOLVED IN branching involved in labyrinthine layer morphogenesis (ortholog); establishment or maintenance of polarity of embryonic epithelium (ortholog); L-leucine transport (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); COVI D-19 (ortholog); Neoplasm Metastasis (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog) | | | | Black Rat | 18 | name | gene, protein-coding, MODEL [RefSeq] |
| 2505 | Dlg1 | discs large MAGUK scaffold protein 1 | ENCODES a protein that exhibits ionotropic glutamate receptor binding; kinesin binding; PDZ domain binding; INVOLVED IN cell adhesion; cellular response to brain-derived neurotrophic factor stimulus; cerebral cortex development; PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta re ceptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; ASSOCIATED WITH Parkinson's disease; cervix uteri carcinoma in situ (ortholog); cleft palate (ortholog); FOUND IN basal plasma membrane; basolateral plasma membrane; cytosol; INTERACTS WITH 17beta-estradiol; 6-propyl-2-thiouracil; aflatoxin B1 | 11 | 82416853 | 82607797 | Rat | 465 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 731903 | DLG1 | discs large MAGUK scaffold protein 1 | This gene encodes a multi-domain scaffolding protein that is required for normal development. This protein may have a role in septate junction formation, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. A multitude of transcript variants deriving from alternative sp licing and the use of multiple alternate promoter have been observed, including some splice variants that may be specific to brain and other tissues. An upstream uORF may regulate translation at some splice variants of this gene. [provided by RefSeq, Sep 2018] | 3 | 197042560 | 197299321 | Human | 434 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
