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Gene: DLG1 (discs large MAGUK scaffold protein 1) Homo sapiens
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Symbol: DLG1
Name: discs large MAGUK scaffold protein 1
Description: Exhibits several functions, including L27 domain binding activity; enzyme binding activity; and ion channel binding activity. Involved in several processes, including actin cytoskeleton organization; cytoplasmic microtubule organization; and negative regulation of MAPK cascade. Localizes to several cellular components, including MPP7-DLG1-LIN7 complex; bicellular tight junction; and immunological synapse. Predicted to colocalize with ionotropic glutamate receptor complex. Implicated in invasive ductal carcinoma. Biomarker of cervix uteri carcinoma in situ.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: discs large homolog 1; discs large homolog 1, scribble cell polarity complex component; discs, large homolog 1; discs, large homolog 1 (Drosophila) transcript variant 6-v1; discs, large homolog 1 (Drosophila) transcript variant 6-v2; discs, large homolog 1 transcript variant 6-v1; discs, large homolog 1 transcript variant 6-v2; disks large homolog 1; dJ1061C18.1.1; DKFZp761P0818; DKFZp781B0426; DLGH1; hdlg; presynaptic protein SAP97; SAP-97; SAP97; synapse-associated protein 97
Orthologs:
Mus musculus (house mouse) : Dlg1 (discs large MAGUK scaffold protein 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Dlg1 (discs large MAGUK scaffold protein 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dlg1 (discs large MAGUK scaffold protein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : DLG1 (discs large MAGUK scaffold protein 1)
Canis lupus familiaris (dog) : DLG1 (discs large MAGUK scaffold protein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dlg1 (discs large MAGUK scaffold protein 1)
Sus scrofa (pig) : DLG1 (discs large MAGUK scaffold protein 1)
Chlorocebus sabaeus (African green monkey) : DLG1 (discs large MAGUK scaffold protein 1)
Heterocephalus glaber (naked mole-rat) : Dlg1 (discs large MAGUK scaffold protein 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl3197,042,560 - 197,299,330 (-)EnsemblGRCh38hg38GRCh38
GRCh383197,042,560 - 197,299,321 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh373196,769,431 - 197,026,171 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363198,253,828 - 198,509,844 (-)NCBINCBI36hg18NCBI36
Build 343198,259,732 - 198,513,757NCBI
Celera3195,354,807 - 195,610,760 (-)NCBI
Cytogenetic Map3q29NCBI
HuRef3194,068,872 - 194,324,699 (-)NCBIHuRef
CHM1_13196,740,135 - 196,996,969 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on DLG1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731903
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-05-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.