Scrib (scribbled planar cell polarity) - Rat Genome Database

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Gene: Scrib (scribbled planar cell polarity) Mus musculus
Analyze
Symbol: Scrib
Name: scribbled planar cell polarity
RGD ID: 1321472
MGI Page MGI
Description: Involved in several processes, including establishment of T cell polarity; nervous system development; and synaptic vesicle cycle. Localizes to several cellular components, including basolateral plasma membrane; immunological synapse; and myelin sheath abaxonal region. Predicted to colocalize with cell leading edge; ionotropic glutamate receptor complex; and synaptic membrane. Is expressed in several structures, including alimentary system; embryo mesenchyme; ganglia; genitourinary system; and hair follicle. Orthologous to human SCRIB (scribble planar cell polarity protein); PARTICIPATES IN Wnt signaling, the planar cell polarity pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B1; benzo[a]pyrene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI118201; circletail; Cr; Crc; CRIB; KIAA0147; mKIAA0147; PDZ-domain protein scribble; protein scribble homolog; Scr; Scrb1; SCRIB1; scribble homolog 1; scribbled homolog; vartul
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391575,919,011 - 75,941,633 (-)NCBIGRCm39mm39
GRCm39 Ensembl1575,919,007 - 75,941,633 (-)Ensembl
GRCm381576,047,162 - 76,069,784 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1576,047,158 - 76,069,784 (-)EnsemblGRCm38mm10GRCm38
MGSCv371575,877,616 - 75,900,160 (-)NCBIGRCm37mm9NCBIm37
MGSCv361575,874,441 - 75,896,985 (-)NCBImm8
Celera1577,548,113 - 77,570,657 (-)NCBICelera
Cytogenetic Map15D3NCBI
cM Map1535.29NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of GTPase activity  (ISO)
apoptotic process involved in morphogenesis  (ISO)
astrocyte cell migration  (ISO)
auditory receptor cell morphogenesis  (IGI)
auditory receptor cell stereocilium organization  (IGI)
camera-type eye morphogenesis  (TAS)
cell differentiation  (IEA)
cell migration  (IMP,ISO)
cell population proliferation  (ISO)
cell-cell adhesion  (IBA,ISO)
cochlear nucleus development  (IGI)
epithelial cell morphogenesis  (TAS)
establishment of apical/basal cell polarity  (ISO)
establishment of T cell polarity  (IDA)
establishment or maintenance of epithelial cell apical/basal polarity  (IBA,TAS)
inner ear receptor cell stereocilium organization  (IMP)
mammary gland duct morphogenesis  (IMP)
morphogenesis of embryonic epithelium  (IMP)
negative regulation of activated T cell proliferation  (IMP)
negative regulation of mitotic cell cycle  (ISO)
neural tube closure  (IGI,IMP,ISO)
neurotransmitter receptor transport postsynaptic membrane to endosome  (IBA,ISO)
neurotransmitter receptor transport, endosome to postsynaptic membrane  (IBA,ISO)
polarized epithelial cell differentiation  (ISO)
positive chemotaxis  (IMP,ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of interferon-gamma production  (IMP)
positive regulation of receptor recycling  (ISO)
post-anal tail morphogenesis  (IGI,IMP)
protein localization  (IMP)
protein localization to adherens junction  (ISO)
receptor clustering  (IBA)
receptor localization to synapse  (IBA)
regulation of postsynaptic neurotransmitter receptor internalization  (ISO)
synaptic vesicle endocytosis  (IDA,IMP)
synaptic vesicle targeting  (IMP)
vesicle-mediated transport in synapse  (ISO)
wound healing  (IGI)

Molecular Function
protein binding  (IPI,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal abdominal wall morphology  (IAGP)
abnormal bone structure  (IEA)
abnormal cerebral cortex morphology  (IAGP)
abnormal cochlea morphology  (IAGP)
abnormal cochlear inner hair cell morphology  (IAGP)
abnormal cochlear outer hair cell morphology  (IAGP)
abnormal corneal epithelium morphology  (IAGP)
abnormal craniofacial morphology  (IEA)
abnormal developmental patterning  (IAGP)
abnormal embryo size  (IEA)
abnormal embryonic neuroepithelium morphology  (IAGP)
abnormal eye morphology  (IEA)
abnormal eyelid development  (IAGP)
abnormal eyelid morphology  (IAGP)
abnormal forebrain development  (IAGP)
abnormal gonad rudiment morphology  (IAGP)
abnormal hindbrain morphology  (IEA)
abnormal innervation  (IAGP)
abnormal intestine morphology  (IAGP)
abnormal lateral ventricle morphology  (IAGP)
abnormal lens epithelium morphology  (IAGP)
abnormal lens morphology  (IAGP)
abnormal lung lobe morphology  (IAGP)
abnormal midbrain morphology  (IEA)
abnormal neural tube closure  (IEA)
abnormal optic chiasm morphology  (IAGP)
abnormal optic nerve innervation  (IAGP)
abnormal organ of Corti morphology  (IAGP)
abnormal orientation of cochlear hair cell stereociliary bundles  (IAGP)
abnormal orientation of outer hair cell stereociliary bundles  (IAGP)
abnormal pancreas morphology  (IAGP)
abnormal pericardium morphology  (IEA)
abnormal placenta size  (IEA)
abnormal prostate gland physiology  (IAGP)
abnormal reproductive system development  (IAGP)
abnormal retina morphology  (IAGP)
abnormal retinal ganglion layer morphology  (IAGP)
abnormal tail morphology  (IAGP)
absent eyelids  (IAGP)
absent third ventricle  (IAGP)
cataract  (IAGP)
craniorachischisis  (IAGP)
curly tail  (IAGP)
decreased bone mineral content  (IEA)
decreased embryo size  (IAGP)
decreased embryo weight  (IAGP)
decreased fetal size  (IAGP)
decreased grip strength  (IEA)
decreased lean body mass  (IEA)
delayed embryo turning  (IAGP)
embryonic growth retardation  (IEA)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
encephalomeningocele  (IAGP)
exencephaly  (IAGP)
eyelids open at birth  (IAGP)
herniated abdominal wall  (IAGP)
increased carcinoma incidence  (IAGP)
increased lung adenocarcinoma incidence  (IAGP)
increased lung adenoma incidence  (IAGP)
increased lung non-small cell carcinoma incidence  (IAGP)
increased lung tumor incidence  (IAGP)
increased prostate gland adenocarcinoma incidence  (IAGP)
increased prostate gland weight  (IAGP)
increased prostate intraepithelial neoplasia incidence  (IAGP)
increased total retina thickness  (IAGP)
iris hyperplasia  (IAGP)
kinked tail  (IAGP)
lethality throughout fetal growth and development, incomplete penetrance  (IAGP)
lung epithelium hyperplasia  (IAGP)
microphthalmia  (IAGP)
open neural tube  (IAGP)
pale yolk sac  (IEA)
perinatal lethality, complete penetrance  (IAGP)
premature death  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
preweaning lethality, complete penetrance  (IEA)
prostate gland hyperplasia  (IAGP)
short tibia  (IEA)
small lens  (IAGP)
small lung  (IAGP)
spina bifida  (IAGP)
References

Additional References at PubMed
PMID:8889548   PMID:10862153   PMID:11707073   PMID:12112872   PMID:12477932   PMID:12499390   PMID:12724779   PMID:15314648   PMID:15345747   PMID:15489334   PMID:15649318   PMID:15782199  
PMID:15963788   PMID:16402019   PMID:16602821   PMID:16611247   PMID:16687519   PMID:16778019   PMID:17229766   PMID:17556662   PMID:17767158   PMID:18329370   PMID:18339676   PMID:18716323  
PMID:18809908   PMID:18849982   PMID:19041750   PMID:19098995   PMID:19210786   PMID:19363157   PMID:19458197   PMID:19726564   PMID:20215345   PMID:20237282   PMID:20534871   PMID:20643356  
PMID:20660256   PMID:20704721   PMID:20843830   PMID:21146521   PMID:21189299   PMID:21267068   PMID:21350009   PMID:21515572   PMID:21559415   PMID:21701506   PMID:21873635   PMID:21965329  
PMID:22333836   PMID:22586490   PMID:22623728   PMID:23195221   PMID:23362312   PMID:23610450   PMID:23653213   PMID:24094954   PMID:24095903   PMID:24276238   PMID:24852022   PMID:25128525  
PMID:25139745   PMID:25145929   PMID:25330230   PMID:25521757   PMID:25576928   PMID:25704816   PMID:25807062   PMID:26114487   PMID:26205961   PMID:26235047   PMID:26370500   PMID:26371508  
PMID:26376988   PMID:26883626   PMID:27179074   PMID:27321929   PMID:27405641   PMID:27565344   PMID:27582005   PMID:27626380   PMID:27694890   PMID:28007914   PMID:28095473   PMID:28369449  
PMID:28536193   PMID:28583412   PMID:28671696   PMID:28968740   PMID:29107558   PMID:29282252   PMID:29467485   PMID:30026494   PMID:30083817   PMID:30283008   PMID:30305289   PMID:30949676  
PMID:31780662   PMID:32213656   PMID:32253237   PMID:32294451   PMID:32325033   PMID:32511952   PMID:32534038   PMID:33526661  


Genomics

Comparative Map Data
Scrib
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391575,919,011 - 75,941,633 (-)NCBIGRCm39mm39
GRCm39 Ensembl1575,919,007 - 75,941,633 (-)Ensembl
GRCm381576,047,162 - 76,069,784 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1576,047,158 - 76,069,784 (-)EnsemblGRCm38mm10GRCm38
MGSCv371575,877,616 - 75,900,160 (-)NCBIGRCm37mm9NCBIm37
MGSCv361575,874,441 - 75,896,985 (-)NCBImm8
Celera1577,548,113 - 77,570,657 (-)NCBICelera
Cytogenetic Map15D3NCBI
cM Map1535.29NCBI
SCRIB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl8143,790,920 - 143,815,773 (-)EnsemblGRCh38hg38GRCh38
GRCh388143,790,925 - 143,815,773 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh378144,873,095 - 144,897,943 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368144,945,078 - 144,969,537 (-)NCBINCBI36hg18NCBI36
Celera8141,185,992 - 141,210,452 (-)NCBI
Cytogenetic Map8q24.3NCBI
HuRef8140,126,075 - 140,150,540 (-)NCBIHuRef
CHM1_18144,913,332 - 144,937,791 (-)NCBICHM1_1
Scrib
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27107,759,343 - 107,782,364 (-)NCBI
Rnor_6.0 Ensembl7117,105,810 - 117,128,798 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.07117,105,810 - 117,128,802 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.07117,091,481 - 117,114,469 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47114,077,733 - 114,100,721 (-)NCBIRGSC3.4rn4RGSC3.4
Celera7104,116,077 - 104,138,929 (-)NCBICelera
Cytogenetic Map7q34NCBI
Scrib
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554542,461,760 - 2,482,098 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554542,461,526 - 2,482,734 (-)NCBIChiLan1.0ChiLan1.0
SCRIB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.18143,557,479 - 143,582,409 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8143,557,722 - 143,582,353 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v08140,544,797 - 140,571,078 (-)NCBIMhudiblu_PPA_v0panPan3
SCRIB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11337,356,405 - 37,374,765 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1337,356,405 - 37,374,681 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1337,312,750 - 37,331,086 (-)NCBI
ROS_Cfam_1.01337,828,183 - 37,846,535 (-)NCBI
UMICH_Zoey_3.11337,502,286 - 37,520,617 (-)NCBI
UNSW_CanFamBas_1.01337,619,233 - 37,637,560 (-)NCBI
UU_Cfam_GSD_1.01338,100,565 - 38,118,912 (-)NCBI
Scrib
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303923,076 - 943,996 (+)NCBI
SpeTri2.0NW_0049364708,349,175 - 8,370,099 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SCRIB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.14824,925 - 852,360 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SCRIB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18138,008,722 - 138,033,874 (-)NCBI
ChlSab1.1 Ensembl8138,008,579 - 138,033,843 (-)Ensembl
Vero_WHO_p1.0NW_0236660391,843,884 - 1,869,060 (+)NCBI
Scrib
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473512,997,358 - 13,018,765 (+)NCBI

Position Markers
Rbm16  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map15D3UniSTS
Cytogenetic Map17A1UniSTS
cM Map171.96UniSTS
cM Map17 UniSTS
AI118201  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381576,047,331 - 76,047,656UniSTSGRCm38
MGSCv371575,877,761 - 75,878,086UniSTSGRCm37
Celera1577,548,258 - 77,548,583UniSTS
Cytogenetic Map15D3UniSTS
cM Map1543.8UniSTS
Whitehead/MRC_RH15639.7UniSTS
RH141209  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381576,070,355 - 76,070,569UniSTSGRCm38
MGSCv371575,900,785 - 75,900,999UniSTSGRCm37
Celera1577,571,282 - 77,571,496UniSTS
Cytogenetic Map15D3UniSTS
Cytogenetic Map15E1UniSTS
cM Map1543.8UniSTS
STS-H95077  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381576,057,838 - 76,059,429UniSTSGRCm38
MGSCv371575,888,268 - 75,889,859UniSTSGRCm37
Celera1577,558,765 - 77,560,356UniSTS
Cytogenetic Map15D3UniSTS
cM Map1543.8UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141952W3q7_mweight 3 weeks QTL 7 (mouse)Not determined346021278717086Mouse
4142448Tailq6_mtail length QTL 6 (mouse)Not determined346021278717086Mouse
4142252Tailaq4_mtail length adjusted QTL 4 (mouse)Not determined346021278717086Mouse
1357559Scfq2_msubcutaneous fat pad weight QTL 2 (mouse)Not determined15346021278717086Mouse
1357659Epfpq4_mepididymal fat percentage QTL 4 (mouse)Not determined15346021278717086Mouse
27095932Ulnl11_mulna length 11, 16 week (mouse)15610000076500000Mouse
27226717Tibw4_mtibia width 4, proximal, 10 week (mouse)15610000078800000Mouse
27226734Tibmd5_mtibia midshaft diameter 5, 10 week (mouse)15610000086800000Mouse
26884442Sklq6_mskull length QTL 6, 5 week (mouse)156100000100900000Mouse
27226777Tibl8_mtibia length 8, 5 week (mouse)15690000084700000Mouse
1301433Rapop5_mradiation-induced apoptosis 5 (mouse)Not determined15927293679590561Mouse
1357526Hyplip2_mhyperlipidemia 2 (mouse)Not determined1512402117102988123Mouse
26884425Cvht2_mcranial vault height 2, 5 week (mouse)1528800000102100000Mouse
26884392Humsd8_mhumerus midshaft diameter 8, 16 week (mouse)152930000076200000Mouse
1558985Eae32_mexperimental allergic encephalomyelitis susceptibility 32 (mouse)Not determined1532578270103517472Mouse
27226729Tibmd2_mtibia midshaft diameter 2, 5 week (mouse)153800000086800000Mouse
26884402Cvht9_mcranial vault height 9, 16 week (mouse)154230000095600000Mouse
1300644Fob3_mF-line obesity QTL 3 (mouse)11.3Not determined154414443889377036Mouse
1357703Vtbt17_mvertebral trabecular bone trait 17 (mouse)Not determined154468146478681588Mouse
1301568Tria2_mT-cell receptor induced activation 2 (mouse)Not determined154498729278987432Mouse
1357756Alaa4_malopecia areata 4 (mouse)Not determined154651779780517996Mouse
10755515Amzn3_manatomical modifier of Zfp423 3 (mouse)154651779780517996Mouse
1301006Hfib1_mhepatic fibrogenesis 1 (mouse)Not determined154743448581434630Mouse
1301860Gct3_mgranulosa cell tumorigenesis 3 (mouse)Not determined154753774781537842Mouse
26884397Humsd5_mhumerus midshaft diameter 5, 10 week (mouse)154850000098500000Mouse
26884399Humsd1_mhumerus midshaft diameter 1, 5 week (mouse)1548500000101800000Mouse
1301429Pcir3_mperiosteal circumference 3 (mouse)Not determined154859351382593647Mouse
1301779Dpml_mdopamine loss (mouse)Not determined155114129876910293Mouse
4142198Hbtq_mhabituation QTL (mouse)Not determined155128885985288984Mouse
10045637Heal27_mwound healing/regeneration 29 (mouse)Not determined155154651285546662Mouse
10412067Pain2_mpain 2 (mouse)Not determined155177349085773777Mouse
1302080Szs13_mseizure susceptibility 13 (mouse)Not determined155181398385822600Mouse
1301708Cocrb14_mcocaine related behavior 14 (mouse)Not determined155193466685934802Mouse
38501067Tip3_mtuberculosis immunophenotype 3, IFN-g level (mouse)155370000089700000Mouse
13504731Cath5_mcarotid atherosclerosis 5 (mouse)155491728088917280Mouse
1302074Bmd4_mbone mineral density 4 (mouse)Not determined1556323312103517472Mouse
27095936Ulnl4_mulna length 4, 5 week (mouse)155690000087800000Mouse
1300800Ses3_msalmonella enteritidis susceptibility 3 (mouse)Not determined155724515691245304Mouse
1357407Pfat4_mpredicted fat percentage 4 (mouse)8.6Body fat amountpredicted fat percentage155724515691245304Mouse
12880420V25Dq8_mvitamin D inactive form serum level QTL 8 (mouse)156170000095700000Mouse
1301601Faq9_mfluctuating asymmetry QTL 9 (mouse)Not determined156327970297279794Mouse
1558786Msq1_mMAV-1 susceptibility QTL 1 (mouse)Not determined156351779781202235Mouse
1302197Bhr2_mbronchial hyperresponsiveness 2 (mouse)Not determined1564434485103517472Mouse
4141135Cia35_mcollagen induced arthritis 35 (mouse)Not determined156492762598927745Mouse
1301119Drb7_mdopamine receptor binding 7 (mouse)Not determined156545237799456827Mouse
1301171Brm2_mbrachyury modifier 2 (mouse)Not determined156564117599641298Mouse
4141921Pstc3_mperiosteal circumference 3 (mouse)Not determined1567386497101386646Mouse
1300627Sluc26_msusceptibility to lung cancer 26 (mouse)Not determined1570461452104043685Mouse
1300726Pitm4_mprion incubation time 4 (mouse)Not determined1570465070104043685Mouse
1300648Dbsty4_mdiabesity 4 (mouse)Not determined1570465070104043685Mouse
14747011Mancz13_mmandible centroid size 13 (mouse)1572498466104043685Mouse
1300844Emo2_memotionality 2 (mouse)Not determined157250061076910293Mouse
1302002Cocia2_mcocaine induced activation 2 (mouse)Not determined157250061080014977Mouse
12791003Aath8_maortic arch atherosclerosis 8 (mouse)1573545941104043685Mouse
15092079Igly6_mIgG glycosylation 6, GP6 (mouse)157422869182789955Mouse
13442492Mecth2_mmechanosensation threshold 2 (mouse)157479100079503000Mouse
1301472Pain1_mpain 1 (mouse)Not determined157544899790928982Mouse

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir296mmu-miR-296-5pOncomiRDBexternal_infoNANA21643016

Predicted Target Of
Summary Value
Count of predictions:1641
Count of miRNA genes:516
Interacting mature miRNAs:588
Transcripts:ENSMUST00000002603, ENSMUST00000063747, ENSMUST00000109946, ENSMUST00000136390, ENSMUST00000145830, ENSMUST00000148211
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001310542 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001310543 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_134089 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006520238 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006520239 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006520242 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017316354 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017316355 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030248260 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_003951338 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_003951339 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004938777 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004938778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004938779 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004938780 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_875207 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_875208 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC116487 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF271735 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF441233 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK122211 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK205808 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC006859 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC037480 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC049942 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC060689 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC062888 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466545 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ704151 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000002603   ⟹   ENSMUSP00000002603
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1576,047,158 - 76,069,754 (-)Ensembl
RefSeq Acc Id: ENSMUST00000063747   ⟹   ENSMUSP00000068056
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1576,047,158 - 76,069,754 (-)Ensembl
RefSeq Acc Id: ENSMUST00000109946   ⟹   ENSMUSP00000105572
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1576,047,158 - 76,069,784 (-)Ensembl
RefSeq Acc Id: ENSMUST00000136390
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1576,047,158 - 76,062,719 (-)Ensembl
RefSeq Acc Id: ENSMUST00000145830   ⟹   ENSMUSP00000115329
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1576,048,940 - 76,050,786 (-)Ensembl
RefSeq Acc Id: ENSMUST00000148211   ⟹   ENSMUSP00000114573
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1576,049,203 - 76,050,786 (-)Ensembl
RefSeq Acc Id: ENSMUST00000229896
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1576,047,657 - 76,048,637 (-)Ensembl
RefSeq Acc Id: ENSMUST00000229940
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1576,047,299 - 76,047,820 (-)Ensembl
RefSeq Acc Id: ENSMUST00000230104
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1576,048,934 - 76,050,632 (-)Ensembl
RefSeq Acc Id: ENSMUST00000230217
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1576,048,129 - 76,049,232 (-)Ensembl
RefSeq Acc Id: ENSMUST00000230249
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1576,048,515 - 76,049,291 (-)Ensembl
RefSeq Acc Id: ENSMUST00000231218
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1576,047,646 - 76,049,017 (-)Ensembl
RefSeq Acc Id: NM_001310542   ⟹   NP_001297471
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391575,919,012 - 75,941,633 (-)NCBI
GRCm381576,047,163 - 76,069,784 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001310543   ⟹   NP_001297472
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391575,919,012 - 75,941,633 (-)NCBI
GRCm381576,047,163 - 76,069,784 (-)NCBI
Sequence:
RefSeq Acc Id: NM_134089   ⟹   NP_598850
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391575,919,012 - 75,941,633 (-)NCBI
GRCm381576,047,163 - 76,069,784 (-)NCBI
MGSCv371575,877,616 - 75,900,160 (-)RGD
Celera1577,548,113 - 77,570,657 (-)RGD
cM Map15 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006520238   ⟹   XP_006520301
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391575,919,011 - 75,941,610 (-)NCBI
GRCm381576,047,162 - 76,069,761 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006520239   ⟹   XP_006520302
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391575,919,011 - 75,941,610 (-)NCBI
GRCm381576,047,162 - 76,069,771 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006520242   ⟹   XP_006520305
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391575,919,011 - 75,941,610 (-)NCBI
GRCm381576,047,162 - 76,069,761 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017316354   ⟹   XP_017171843
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391575,919,011 - 75,941,610 (-)NCBI
GRCm381576,047,163 - 76,069,771 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017316355   ⟹   XP_017171844
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391575,919,011 - 75,941,610 (-)NCBI
GRCm381576,047,163 - 76,069,771 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030248260   ⟹   XP_030104120
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391575,919,011 - 75,941,620 (-)NCBI
GRCm381576,047,162 - 76,069,771 (-)NCBI
Sequence:
RefSeq Acc Id: XR_003951338
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391575,919,011 - 75,941,610 (-)NCBI
GRCm381576,047,162 - 76,069,771 (-)NCBI
Sequence:
RefSeq Acc Id: XR_003951339
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391575,919,011 - 75,941,610 (-)NCBI
GRCm381576,047,162 - 76,069,771 (-)NCBI
Sequence:
RefSeq Acc Id: XR_004938777
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391575,919,011 - 75,941,610 (-)NCBI
RefSeq Acc Id: XR_004938778
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391575,919,011 - 75,941,610 (-)NCBI
RefSeq Acc Id: XR_004938779
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391575,919,011 - 75,941,610 (-)NCBI
RefSeq Acc Id: XR_004938780
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391575,919,011 - 75,941,610 (-)NCBI
RefSeq Acc Id: XR_875207
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391575,919,011 - 75,941,610 (-)NCBI
GRCm381576,047,162 - 76,069,771 (-)NCBI
Sequence:
RefSeq Acc Id: XR_875208
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391575,919,011 - 75,941,610 (-)NCBI
GRCm381576,047,162 - 76,069,771 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_598850   ⟸   NM_134089
- Peptide Label: isoform 1
- UniProtKB: Q80U72 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006520301   ⟸   XM_006520238
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006520302   ⟸   XM_006520239
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006520305   ⟸   XM_006520242
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_017171844   ⟸   XM_017316355
- Peptide Label: isoform X4
- UniProtKB: Q80U72 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017171843   ⟸   XM_017316354
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: NP_001297472   ⟸   NM_001310543
- Peptide Label: isoform 3
- UniProtKB: Q80U72 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001297471   ⟸   NM_001310542
- Peptide Label: isoform 2
- UniProtKB: Q80U72 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_030104120   ⟸   XM_030248260
- Peptide Label: isoform X6
RefSeq Acc Id: ENSMUSP00000115329   ⟸   ENSMUST00000145830
RefSeq Acc Id: ENSMUSP00000105572   ⟸   ENSMUST00000109946
RefSeq Acc Id: ENSMUSP00000114573   ⟸   ENSMUST00000148211
RefSeq Acc Id: ENSMUSP00000002603   ⟸   ENSMUST00000002603
RefSeq Acc Id: ENSMUSP00000068056   ⟸   ENSMUST00000063747
Protein Domains
PDZ

Promoters
RGD ID:6847257
Promoter ID:MM_ACW:18449
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Lung
Transcripts:SCRIB.KSEP07,   SCRIB.MSEP07-UNSPLICED,   SCRIB.NSEP07,   SCRIB.SSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361575,878,056 - 75,879,647 (-)MPROMDB
RGD ID:6826452
Promoter ID:MM_KWN:18831
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:UC007WIF.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361575,892,776 - 75,893,276 (-)MPROMDB
RGD ID:6826451
Promoter ID:MM_KWN:18832
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000063747,   ENSMUST00000109945,   OTTMUST00000049728,   OTTMUST00000049729
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361575,900,181 - 75,901,087 (-)MPROMDB
RGD ID:8684058
Promoter ID:EPDNEW_M20060
Type:initiation region
Name:Scrib_1
Description:Mus musculus scribbled planar cell polarity , transcript variant3, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381576,069,733 - 76,069,793EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2145950 AgrOrtholog
Ensembl Genes ENSMUSG00000022568 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000002603 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000068056 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000105572 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000114573 UniProtKB/TrEMBL
  ENSMUSP00000115329 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000002603 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000063747 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000109946 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000145830 UniProtKB/TrEMBL
  ENSMUST00000148211 UniProtKB/TrEMBL
Gene3D-CATH 2.30.42.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.80.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Leu-rich_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:105782 UniProtKB/Swiss-Prot
MGD MGI:2145950 ENTREZGENE
NCBI Gene 105782 ENTREZGENE
Pfam LRR_8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Scrib PhenoGen
PROSITE LRR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART LRR_TYP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50156 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt D3YU97_MOUSE UniProtKB/TrEMBL
  D3YVA3_MOUSE UniProtKB/TrEMBL
  Q6P9N3_MOUSE UniProtKB/TrEMBL
  Q80U72 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q6P5H7 UniProtKB/Swiss-Prot
  Q7TPH8 UniProtKB/Swiss-Prot
  Q80VB1 UniProtKB/Swiss-Prot
  Q8CI48 UniProtKB/Swiss-Prot
  Q8VII1 UniProtKB/Swiss-Prot
  Q922S3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-29 Scrib  scribbled planar cell polarity    scribbled homolog (Drosophila)  Symbol and/or name change 5135510 APPROVED