Scrib (scribble planar cell polarity protein) - Rat Genome Database

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Gene: Scrib (scribble planar cell polarity protein) Ictidomys tridecemlineatus
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Symbol: Scrib
Name: scribble planar cell polarity protein
RGD ID: 12521534
Description: INVOLVED IN astrocyte cell migration (ortholog); auditory receptor cell morphogenesis (ortholog); auditory receptor cell stereocilium organization (ortholog); PARTICIPATES IN Wnt signaling, the planar cell polarity pathway; ASSOCIATED WITH Brown-Vialetto-Van Laere syndrome 2 (ortholog); epidermolysis bullosa simplex with muscular dystrophy (ortholog); microcephaly (ortholog); FOUND IN cell leading edge (ortholog); cell-cell junction (ortholog); cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: protein scribble homolog
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303923,076 - 943,996 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364708,349,188 - 8,369,864 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049364708,349,175 - 8,370,099 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of GTPase activity  (IEA)
apoptotic process involved in morphogenesis  (IEA)
astrocyte cell migration  (ISO)
auditory receptor cell morphogenesis  (IEA,ISO)
auditory receptor cell stereocilium organization  (IEA,ISO)
cell migration  (IEA)
cell population proliferation  (IEA)
cell-cell adhesion  (IEA)
cochlear nucleus development  (IEA,ISO)
establishment of apical/basal cell polarity  (IEA)
establishment of T cell polarity  (IEA)
inner ear receptor cell stereocilium organization  (IEA,ISO)
mammary gland duct morphogenesis  (IEA)
morphogenesis of embryonic epithelium  (IEA,ISO)
negative regulation of activated T cell proliferation  (IEA)
negative regulation of mitotic cell cycle  (IEA)
negative regulation of translational initiation  (ISO)
neural tube closure  (IEA,ISO)
neurotransmitter receptor transport postsynaptic membrane to endosome  (ISO)
neurotransmitter receptor transport, endosome to postsynaptic membrane  (ISO)
polarized epithelial cell differentiation  (IEA)
positive chemotaxis  (IEA)
positive regulation of apoptotic process  (IEA)
positive regulation of receptor recycling  (IEA)
positive regulation of type II interferon production  (IEA)
post-anal tail morphogenesis  (IEA,ISO)
protein localization  (IEA,ISO)
protein localization to adherens junction  (IEA)
regulation of postsynaptic neurotransmitter receptor internalization  (ISO)
synaptic vesicle endocytosis  (IEA)
synaptic vesicle targeting  (IEA)
vesicle-mediated transport in synapse  (ISO)
wound healing  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
Scrib
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303923,076 - 943,996 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364708,349,188 - 8,369,864 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049364708,349,175 - 8,370,099 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SCRIB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388143,790,925 - 143,815,773 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl8143,790,920 - 143,815,773 (-)EnsemblGRCh38hg38GRCh38
GRCh378144,873,095 - 144,897,943 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368144,945,078 - 144,969,537 (-)NCBINCBI36Build 36hg18NCBI36
Celera8141,185,992 - 141,210,452 (-)NCBICelera
Cytogenetic Map8q24.3NCBI
HuRef8140,126,075 - 140,150,540 (-)NCBIHuRef
CHM1_18144,913,332 - 144,937,791 (-)NCBICHM1_1
T2T-CHM13v2.08144,947,418 - 144,972,471 (-)NCBIT2T-CHM13v2.0
Scrib
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391575,919,011 - 75,941,633 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1575,919,007 - 75,941,633 (-)EnsemblGRCm39 Ensembl
GRCm381576,047,162 - 76,069,784 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1576,047,158 - 76,069,784 (-)EnsemblGRCm38mm10GRCm38
MGSCv371575,877,616 - 75,900,160 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361575,874,441 - 75,896,985 (-)NCBIMGSCv36mm8
Celera1577,548,113 - 77,570,657 (-)NCBICelera
Cytogenetic Map15D3NCBI
cM Map1535.29NCBI
Scrib
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27107,759,343 - 107,782,364 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7107,759,343 - 107,782,331 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7109,499,717 - 109,522,737 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.07111,723,394 - 111,746,414 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.07111,680,128 - 111,703,152 (-)NCBIRnor_WKY
Rnor_6.07117,105,810 - 117,128,802 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7117,105,810 - 117,128,798 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07117,091,481 - 117,114,469 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47114,077,733 - 114,100,721 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera7104,116,077 - 104,138,929 (-)NCBICelera
Cytogenetic Map7q34NCBI
Scrib
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554542,461,760 - 2,482,098 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554542,461,526 - 2,482,734 (-)NCBIChiLan1.0ChiLan1.0
SCRIB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.18143,557,479 - 143,582,409 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8143,557,722 - 143,582,353 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v08140,544,797 - 140,571,078 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
SCRIB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11337,356,405 - 37,374,765 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1337,356,405 - 37,374,681 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1337,312,750 - 37,331,086 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01337,828,183 - 37,846,535 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1337,828,186 - 37,846,509 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11337,502,286 - 37,520,617 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01337,619,233 - 37,637,560 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01338,100,565 - 38,118,912 (-)NCBIUU_Cfam_GSD_1.0
SCRIB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4825,062 - 852,664 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14824,925 - 852,360 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SCRIB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18138,008,722 - 138,033,874 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl8138,008,579 - 138,033,843 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660391,843,884 - 1,869,060 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Scrib
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473512,997,408 - 13,018,533 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473512,997,358 - 13,018,765 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSSTOT00000003611   ⟹   ENSSTOP00000003235
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049364708,349,188 - 8,369,864 (+)Ensembl
RefSeq Acc Id: ENSSTOT00000037523   ⟹   ENSSTOP00000029917
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049364708,349,188 - 8,369,864 (+)Ensembl
RefSeq Acc Id: XM_040293412   ⟹   XP_040149346
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405303923,076 - 943,996 (+)NCBI
Protein Sequences
Protein RefSeqs XP_040149346 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein KAG3273441 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_040149346   ⟸   XM_040293412
RefSeq Acc Id: ENSSTOP00000003235   ⟸   ENSSTOT00000003611
RefSeq Acc Id: ENSSTOP00000029917   ⟸   ENSSTOT00000037523
Protein Domains
PDZ


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000003571 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSTOP00000003235.3 UniProtKB/TrEMBL
  ENSSTOP00000029917.1 UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000003611.3 UniProtKB/TrEMBL
  ENSSTOT00000037523.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.42.10 UniProtKB/TrEMBL
  3.80.10.10 UniProtKB/TrEMBL
InterPro Leu-rich_rpt UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  PDZ_6 UniProtKB/TrEMBL
  PDZ_sf UniProtKB/TrEMBL
NCBI Gene Scrib ENTREZGENE
Pfam LRR_8 UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  PDZ_6 UniProtKB/TrEMBL
PROSITE LRR UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
SMART LRR_TYP UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
Superfamily-SCOP SSF50156 UniProtKB/TrEMBL
UniProt A0A287D8M4_ICTTR UniProtKB/TrEMBL
  I3M2L5_ICTTR UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-01-15 Scrib  scribble planar cell polarity protein    scribbled planar cell polarity protein  Symbol and/or name change 5135510 APPROVED