| 621163 | Mif | macrophage migration inhibitory factor | ENCODES a protein that exhibits protein-containing complex binding; chemoattractant activity (ortholog); cytokine activity (ortholog); INVOLVED IN brain renin-angiotensin system; cellular response to hydrogen peroxide; cellular response to hypoxia; PARTICIPATES IN alkaptonuria pathway; disulfiram ph armacodynamics pathway; dopamine beta-hydroxylase deficiency pathway; ASSOCIATED WITH acute necrotizing pancreatitis; alcohol-associated liver disease; anti-basement membrane glomerulonephritis; FOUND IN extracellular space; cell surface (ortholog); cytoplasm (ortholog); INTERACTS WITH 1,2,4-trimethylbenzene; 17alpha-ethynylestradiol; 17beta-estradiol | 20 | 12767138 | 12791222 | Rat | 425 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 734203 | MIF | macrophage migration inhibitory factor | This gene encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in integrin signaling pathways. [provided by RefSeq, Jul 2008] | 22 | 23894383 | 23895223 | Human | 498 | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 734204 | Mif | macrophage migration inhibitory factor (glycosylation-inhibiting factor) | Enables cytokine activity; phenylpyruvate tautomerase activity; and protease binding activity. Involved in several processes, including positive regulation of cytokine production; positive regulation of icosanoid secretion; and regulation of signal transduction. Acts upstream of or within DNA damage response, signal transduction by p53 class mediator; cellular senescence; and regulation of cell population proliferation. Located in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in allergic disease; asthma; cystic fibrosis; lung disease (multiple); and obesity. Orthologous to human MIF (macrophage migration inhibitory factor). [provided by Alliance of Genome Resources, Jul 2025] | 10 | 75695187 | 75696111 | Mouse | 490 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 9050430 | Mif | macrophage migration inhibitory factor | ENCODES a protein that exhibits chemoattractant activity (ortholog); cytokine activity (ortholog); cytokine receptor binding (ortholog); INVOLVED IN brain renin-angiotensin system (ortholog); carboxylic acid metabolic process (ortholog); cell surface receptor signaling pathway (ortholog); PARTICIPAT ES IN alkaptonuria pathway; disulfiram pharmacodynamics pathway; dopamine beta-hydroxylase deficiency pathway; ASSOCIATED WITH acute necrotizing pancreatitis (ortholog); alcohol-associated liver disease (ortholog); allergic disease (ortholog); FOUND IN cell surface (ortholog); cytoplasm (ortholog); cytosol (ortholog) | NW_004955455 | 8367566 | 8368460 | Chinchilla | 176 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11848819 | MIF | macrophage migration inhibitory factor | ENCODES a protein that exhibits protease binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN brain renin-angiotensin system (ortholog); cellular response to hydrogen peroxide (ortholog); cellular response to hypoxia (ortholog); PARTICIPATES IN alkaptonuria pathway; disulfi ram pharmacodynamics pathway; dopamine beta-hydroxylase deficiency pathway; ASSOCIATED WITH acute necrotizing pancreatitis (ortholog); alcohol-associated liver disease (ortholog); allergic disease (ortholog); FOUND IN extracellular space (ortholog) | 22 | 4646986 | 4647831 | Bonobo | 182 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12280045 | MIF | macrophage migration inhibitory factor | ENCODES a protein that exhibits protein-containing complex binding (ortholog); INVOLVED IN brain renin-angiotensin system (ortholog); cellular response to hydrogen peroxide (ortholog); cellular response to hypoxia (ortholog); PARTICIPATES IN alkaptonuria pathway; disulfiram pharmacodynamics pathway; dopamine beta-hydroxylase deficiency pathway; ASSOCIATED WITH acute necrotizing pancreatitis (ortholog); alcohol-associated liver disease (ortholog); allergic disease (ortholog); FOUND IN extracellular space (ortholog); INTERACTS WITH bisphenol A | | | | Dog | 184 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12723861 | Mif | macrophage migration inhibitory factor | ENCODES a protein that exhibits protein-containing complex binding (ortholog); INVOLVED IN brain renin-angiotensin system (ortholog); cellular response to hydrogen peroxide (ortholog); cellular response to hypoxia (ortholog); PARTICIPATES IN alkaptonuria pathway; disulfiram pharmacodynamics pathway; dopamine beta-hydroxylase deficiency pathway; ASSOCIATED WITH acute necrotizing pancreatitis (ortholog); alcohol-associated liver disease (ortholog); allergic disease (ortholog); FOUND IN extracellular space (ortholog) | NW_004936619 | 1207058 | 1208010 | Squirrel | 182 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14237543 | MIF | macrophage migration inhibitory factor | ENCODES a protein that exhibits dopachrome isomerase activity (ortholog); protein-containing complex binding (ortholog); INVOLVED IN brain renin-angiotensin system (ortholog); cellular response to hydrogen peroxide (ortholog); cellular response to hypoxia (ortholog); PARTICIPATES IN alkaptonuria pat hway; disulfiram pharmacodynamics pathway; dopamine beta-hydroxylase deficiency pathway; ASSOCIATED WITH acute necrotizing pancreatitis (ortholog); alcohol-associated liver disease (ortholog); allergic disease (ortholog); FOUND IN extracellular space (ortholog) | | | | Pig | 186 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18601080 | MIF | macrophage migration inhibitory factor | ENCODES a protein that exhibits protease binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN brain renin-angiotensin system (ortholog); cellular response to hydrogen peroxide (ortholog); cellular response to hypoxia (ortholog); PARTICIPATES IN alkaptonuria pathway; disulfi ram pharmacodynamics pathway; dopamine beta-hydroxylase deficiency pathway; ASSOCIATED WITH acute necrotizing pancreatitis (ortholog); alcohol-associated liver disease (ortholog); allergic disease (ortholog); FOUND IN extracellular space (ortholog) | | | | Green Monkey | 182 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18900756 | Mif | macrophage migration inhibitory factor | ENCODES a protein that exhibits chemoattractant activity (ortholog); cytokine receptor binding (ortholog); identical protein binding (ortholog); INVOLVED IN brain renin-angiotensin system (ortholog); carboxylic acid metabolic process (ortholog); cell surface receptor signaling pathway (ortholog); PA RTICIPATES IN alkaptonuria pathway; disulfiram pharmacodynamics pathway; dopamine beta-hydroxylase deficiency pathway; ASSOCIATED WITH acute necrotizing pancreatitis (ortholog); alcohol-associated liver disease (ortholog); allergic disease (ortholog); FOUND IN cell surface (ortholog); cytosol (ortholog); extracellular space (ortholog) | | | | Naked Mole-Rat | 182 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 155248438 | mif | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625972908 | Mif | macrophage migration inhibitory factor | ENCODES a protein that exhibits chemoattractant activity (ortholog); cytokine activity (ortholog); cytokine receptor binding (ortholog); INVOLVED IN brain renin-angiotensin system (ortholog); carboxylic acid metabolic process (ortholog); cell surface receptor signaling pathway (ortholog); PARTICIPAT ES IN alkaptonuria pathway; disulfiram pharmacodynamics pathway; dopamine beta-hydroxylase deficiency pathway; ASSOCIATED WITH acute necrotizing pancreatitis (ortholog); alcohol-associated liver disease (ortholog); allergic disease (ortholog); FOUND IN cell surface (ortholog); cytoplasm (ortholog); cytosol (ortholog) | | | | Black Rat | 176 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14385670 | mif-1 | | | | | | Roundworm | | symbol | gene, null |
| 14380154 | mif-2 | | | | | | Roundworm | | symbol | gene, null |
| 25825258 | mif-3 | | | | | | Roundworm | | symbol | gene, null |
| 155252295 | mif.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 2294064 | Mif-ps | macrophage migration inhibitory factor, pseudogene | | 7 | 29664522 | 29665080 | Mouse | | symbol , ensembl_gene_symbol , PhenoGen , old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 9479125 | MIF-AS1 | MIF antisense RNA 1 | INTERACTS WITH acrylamide; aristolochic acid A; sodium arsenite | 22 | 23893710 | 23898930 | Human | 3 | symbol , COSMIC , name , Human Proteome Map , old_gene_symbol | gene, ncrna, VALIDATED [RefSeq] |
| 1561007 | Mif-ps1 | macrophage migration inhibitory factor, pseudogene 1 | | 14 | 108653952 | 108654637 | Rat | | symbol , PhenoGen | gene, pseudo, INFERRED [RefSeq] |
| 1594382 | Mif-ps2 | macrophage migration inhibitory factor, pseudogene 2 | | 2 | 32715389 | 32715734 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 15037406 | Mif-ps2 | macrophage migration inhibitory factor, pseudogene 2 | | | | | Mouse | | symbol , PhenoGen | gene, pseudo |
| 1593026 | Mif-ps3 | macrophage migration inhibitory factor, pseudogene 3 | | 19 | 32434476 | 32436019 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 1616318 | Mif-ps3 | macrophage migration inhibitory factor, pseudogene 3 | | 3 | 91931795 | 91932340 | Mouse | | symbol , PhenoGen | gene, pseudo, INFERRED [RefSeq] |
| 41009377 | Mif-ps4 | macrophage migration inhibitory factor, pseudogene 4 | | 16 | 50790739 | 50791722 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 7710320 | Mif-ps5 | macrophage migration inhibitory factor, pseudogene 5 | | 5 | 155713068 | 155718599 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 15039156 | Mif-ps5 | macrophage migration inhibitory factor, pseudogene 5 | | | | | Mouse | | symbol , PhenoGen | gene, pseudo |
| 15554191 | Mif-ps6 | macrophage migration inhibitory factor, pseudogene 6 | | | | | Mouse | | symbol , PhenoGen | gene, processed_pseudogene |
| 41141102 | Mif-ps6 | macrophage migration inhibitory factor, pseudogene 6 | | 13 | 54478825 | 54488333 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 9587173 | Mif-ps7 | macrophage migration inhibitory factor, pseudogene 7 | | 12 | 109064113 | 109064601 | Mouse | | symbol , PhenoGen | gene, pseudo, INFERRED [RefSeq] |
| 1583787 | Mif-ps8 | macrophage migration inhibitory factor, pseudogene 8 | | 1 | 136187101 | 136187540 | Rat | | symbol , old_gene_name , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 1587602 | Mif-ps9 | macrophage migration inhibitory factor, pseudogene 9 | | 13 | 86495532 | 86496022 | Rat | | symbol , old_gene_name , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 1593321 | Mif-ps10 | macrophage migration inhibitory factor, pseudogene 10 | | 6 | 145536843 | 145537189 | Rat | | symbol , old_gene_name , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 5138324 | Mif-ps10 | macrophage migration inhibitory factor, pseudogene 10 | | 18 | 28735532 | 28736170 | Mouse | | symbol , PhenoGen | gene, pseudo, INFERRED [RefSeq] |
| 2310763 | Mif-ps11 | macrophage migration inhibitory factor, pseudogene 11 | | 4 | 28486030 | 28486510 | Mouse | | symbol , PhenoGen | gene, pseudo, INFERRED [RefSeq] |
| 2310540 | Mif-ps12 | macrophage migration inhibitory factor, pseudogene 12 | | 5 | 23348721 | 23349051 | Mouse | | symbol , PhenoGen | gene, pseudo, VALIDATED [RefSeq] |
| 15018012 | Mif-ps13 | macrophage migration inhibitory factor, pseudogene 13 | | X | 163788518 | 163789097 | Mouse | | symbol , PhenoGen | gene, pseudo, INFERRED [RefSeq] |
| 736161 | AMH | anti-Mullerian hormone | This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate N- and C-terminal cleavage products that homodimerize and associate to form a biologically active noncovalent complex. This complex binds to the anti-Mullerian hormone receptor type 2 and causes the regression of Mullerian ducts in the male embryo that would otherwise differentiate into the uterus and fallopian tubes. This protein also plays a role in Leydig cell differentiation and function and follicular development in adult females. Mutations in this gene result in persistent Mullerian duct syndrome. [provided by RefSeq, Jul 2016] | 19 | 2249323 | 2252073 | Human | 241 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 10044040 | Gm4924 | predicted gene 4924 | Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in cytoplasm. [provide d by Alliance of Genome Resources, Jul 2025] | 10 | 82190087 | 82215477 | Mouse | 29 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1349531 | S100A8 | S100 calcium binding protein A8 | The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progressi on and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and as a cytokine. Altered expression of this protein is associated with the disease cystic fibrosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016] | 1 | 153390032 | 153422583 | Human | 428 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1352981 | S100A9 | S100 calcium binding protein A9 | The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progressi on and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and altered expression of this protein is associated with the disease cystic fibrosis. This antimicrobial protein exhibits antifungal and antibacterial activity. [provided by RefSeq, Nov 2014] | 1 | 153357854 | 153361023 | Human | 441 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1620899 | Gm5228 | predicted gene 5228 | | 17 | 48247011 | 48247489 | Mouse | | ensembl_gene_symbol , old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 1620274 | Gm6990 | predicted pseudogene 6990 | | 19 | 56743310 | 56743862 | Mouse | | ensembl_gene_symbol , old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 617244302 | Gm8762 | predicted gene 8762 | | 1 | 136716806 | 136717310 | Mouse | | old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 1353002 | DDT | D-dopachrome tautomerase | D-dopachrome tautomerase converts D-dopachrome into 5,6-dihydroxyindole. The DDT gene is related to the migration inhibitory factor (MIF) in terms of sequence, enzyme activity, and gene structure. DDT and MIF are closely lin ked on chromosome 22. [provided by RefSeq, Jul 2008] | 22 | 23971370 | 23980504 | Human | 128 | description , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 407443972 | Gm16379 | predicted pseudogene 16379 | | 9 | 14756540 | 14757065 | Mouse | | old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 13801140 | ODC1-DT | ODC1 divergent transcript | INTERACTS WITH sodium arsenite | 2 | 10449728 | 10455552 | Human | 1 | old_gene_symbol | gene, ncrna, VALIDATED [RefSeq] |
| 16555692 | AL451062.1 | SMT3 suppressor of mif two 3 (yeast) family pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 14077691 | SUMO4 | SMT3 suppressor of mif two 3 homolog 4 (S. cerevisiae) | FOUND IN nucleus (inferred) | | | | Pig | 5 | name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 16552765 | AL390728.3 | SMT3 suppressor of mif two 3 homolog 3 (yeast) (SUMO3) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 16556153 | AL008629.1 | pseudogene similar to part of SMT3 suppressor of mif two 3 (yeast) | | | | | Human | | name | gene, processed_pseudogene |
| 16554250 | AL009048.1 | SMT3 suppressor of mif two 3 homolog 1 (yeast) (SMT3H1) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 16557791 | FO393419.3 | SMT3 suppressor of mif two 3 homolog 2 (yeast) (SMT3H2) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 1619203 | Smt3h1-ps | SMT3 suppressor of mif two 3 homolog 1, pseudogene (S. cerevisiae) | | X | 152566238 | 152567830 | Mouse | | name | gene, pseudo, INFERRED [RefSeq] |
| 2314439 | Smt3h2-ps | SMT3 suppressor of mif two 3 homolog 2, pseudogene (S. cerevisiae) | | X | 7618287 | 7619435 | Mouse | | old_gene_name , name | gene, pseudo, INFERRED [RefSeq] |
| 1621399 | Smt3h2-ps2 | SMT3 suppressor of mif two 3 homolog 2, pseudogene 2 (S. cerevisiae) | INTERACTS WITH chrysene | 7 | 126997057 | 126998195 | Mouse | 1 | old_gene_name , name | gene, pseudo, VALIDATED [RefSeq] |
| 1621398 | Smt3h2-ps3 | SMT3 suppressor of mif two 3 homolog 2, pseudogene 3 (S. cerevisiae) | | 10 | 129500744 | 129501731 | Mouse | | old_gene_name , name | gene, pseudo, VALIDATED [RefSeq] |
| 1622153 | Smt3h2-ps4 | SMT3 suppressor of mif two 3 homolog 2, pseudogene 4 (S. cerevisiae) | | 1 | 14909491 | 14910497 | Mouse | | name | gene, pseudo, INFERRED [RefSeq] |
| 16564852 | AC012254.4 | SUMO2 SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae), pseudogene | | 18 | 47136915 | 47137284 | Human | | name | gene, pseudo, MODEL [RefSeq] |
| 16553824 | AC002542.1 | SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae) (SUMO2) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 16561713 | AC006349.1 | SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae) (SUMO2) pseudogene | | | | | Human | | name | gene, transcribed_processed_pseudogene |
| 16552054 | AC010493.1 | SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae) (SUMO1) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 16555232 | AC011233.1 | SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae) (SUMO3) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 16560180 | AC025755.1 | SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae) (SUMO2) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 16562456 | AC034105.2 | SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae) (SUMO3) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 16562763 | AC074050.1 | SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae) (SUMO2) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 16552797 | AC079809.1 | SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae) (SUMO2) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 16562130 | AC084759.1 | SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae) (SUMO2) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 16561702 | AL121603.1 | SMT3 suppressor of mif two 3 homolog 4 (S. cerevisiae) (SUMO4) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 16552450 | AL121834.1 | SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae) (SUMO2) pseudogene | | | | | Human | | name | gene, transcribed_processed_pseudogene |
| 16552405 | AL451046.2 | SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae) (SUMO1) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 16560494 | AP003168.1 | SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae) (SUMO1) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 9078820 | LOC103692684 | small ubiquitin-related modifier 2 pseudogene | | 6 | 119045628 | 119045907 | Rat | | old_gene_name | gene, pseudo, MODEL [RefSeq] |
| 731866 | Sumo2 | small ubiquitin-like modifier 2 | Enables SUMO transferase activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II and protein sumoylation. Is active in several cellular components, including hippocampal mossy fiber to CA3 synapse; postsynaptic cytosol; and presynaptic cytosol. Is expressed in several structures, including branchial arch; central nervous system; early conceptus; eye; and heart. Orthologous to human SUMO2 (small ubiquitin like modifier 2). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 115413935 | 115427056 | Mouse | 149 | old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1306919 | Sumo1 | small ubiquitin-like modifier 1 | ENCODES a protein that exhibits enzyme binding (ortholog); potassium channel regulator activity (ortholog); protein tag activity (ortholog); INVOLVED IN cellular response to hypoxia; cellular response to cadmium ion (ortholog); cellular response to heat (ortholog); PARTICIPATES IN sumoylation pathwa y; RNA transport pathway; ASSOCIATED WITH cleft lip (ortholog); cleft palate (ortholog); Neoplasm Invasiveness (ortholog); FOUND IN dendrite; fibrillar center; heterochromatin; INTERACTS WITH 2,4-dinitrotoluene; 2,6-dinitrotoluene; 3H-1,2-dithiole-3-thione | 9 | 68572901 | 68602803 | Rat | 220 | old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1315807 | SUMO1 | small ubiquitin like modifier 1 | This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degr adation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last four amino acids of the carboxy-terminus have been cleaved off. Several pseudogenes have been reported for this gene. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008] | 2 | 202206171 | 202238597 | Human | 300 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 1315808 | Sumo1 | small ubiquitin-like modifier 1 | Predicted to enable enzyme binding activity; potassium channel regulator activity; and protein tag activity. Involved in several processes, including positive regulation of ATPase-coupled calcium transmembrane transporter activity; regulation of cardiac muscle cell contraction; and regulation of pro tein stability. Acts upstream of or within several processes, including PML body organization; protein localization to nuclear pore; and protein sumoylation. Located in XY body and nuclear body. Is active in glutamatergic synapse; postsynaptic cytosol; and presynaptic cytosol. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; eye; and genitourinary system. Human ortholog(s) of this gene implicated in orofacial cleft 10. Orthologous to human SUMO1 (small ubiquitin like modifier 1). [provided by Alliance of Genome Resources, Apr 2025] | 1 | 59678593 | 59709993 | Mouse | 260 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 11761043 | SUMO1 | small ubiquitin like modifier 1 | ENCODES a protein that exhibits enzyme binding (ortholog); potassium channel regulator activity (ortholog); protein tag activity (ortholog); INVOLVED IN cellular response to cadmium ion (ortholog); cellular response to heat (ortholog); cellular response to hypoxia (ortholog); PARTICIPATES IN sumoyla tion pathway; ASSOCIATED WITH cleft lip (ortholog); cleft palate (ortholog); Neoplasm Invasiveness (ortholog); FOUND IN dendrite (ortholog); fibrillar center (ortholog); glutamatergic synapse (ortholog) | 2B | 89461773 | 89493879 | Bonobo | 126 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12347260 | SUMO1 | small ubiquitin like modifier 1 | ENCODES a protein that exhibits enzyme binding (ortholog); potassium channel regulator activity (ortholog); small protein activating enzyme binding (ortholog); INVOLVED IN cellular response to cadmium ion (ortholog); cellular response to heat (ortholog); cellular response to hypoxia (ortholog); PART ICIPATES IN sumoylation pathway; ASSOCIATED WITH cleft lip (ortholog); cleft palate (ortholog); Neoplasm Invasiveness (ortholog); FOUND IN dendrite (ortholog); fibrillar center (ortholog); glutamatergic synapse (ortholog) | 37 | 11199937 | 11229743 | Dog | 129 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 14191750 | SUMO1 | small ubiquitin like modifier 1 | ENCODES a protein that exhibits potassium channel regulator activity (ortholog); transporter activator activity (ortholog); ubiquitin protein ligase binding (ortholog); INVOLVED IN cellular response to cadmium ion (ortholog); cellular response to heat (ortholog); cellular response to hypoxia (orthol og); PARTICIPATES IN sumoylation pathway; ASSOCIATED WITH cleft lip (ortholog); cleft palate (ortholog); Neoplasm Invasiveness (ortholog); FOUND IN dendrite (ortholog); fibrillar center (ortholog); glutamatergic synapse (ortholog); INTERACTS WITH ochratoxin A | | | | Pig | 76 | old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 621761 | Sumo2 | small ubiquitin-like modifier 2 | ENCODES a protein that exhibits nuclear retinoid X receptor binding; SUMO transferase activity (ortholog); ubiquitin protein ligase binding (ortholog); INVOLVED IN intracellular protein localization; negative regulation of DNA-templated transcription; positive regulation of protein sumoylation; PART ICIPATES IN RNA transport pathway; FOUND IN GABA-ergic synapse (ortholog); glutamatergic synapse (ortholog); hippocampal mossy fiber to CA3 synapse (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 4,4'-sulfonyldiphenol | 10 | 101270899 | 101283458 | Rat | 133 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1346569 | SUMO2 | small ubiquitin like modifier 2 | This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degr adation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last two amino acids of the carboxy-terminus have been cleaved off. Numerous pseudogenes have been reported for this gene. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] | 17 | 75165586 | 75182959 | Human | 145 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 12001716 | SUMO2 | small ubiquitin like modifier 2 | ENCODES a protein that exhibits nuclear retinoid X receptor binding (ortholog); SUMO transferase activity (ortholog); ubiquitin protein ligase binding (ortholog); INVOLVED IN intracellular protein localization (ortholog); negative regulation of DNA-templated transcription (ortholog); positive regula tion of proteasomal ubiquitin-dependent protein catabolic process (ortholog); FOUND IN GABA-ergic synapse (ortholog); glutamatergic synapse (ortholog); hippocampal mossy fiber to CA3 synapse (ortholog) | 17 | 69115433 | 69130065 | Bonobo | 44 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12218193 | SUMO2 | small ubiquitin like modifier 2 | ENCODES a protein that exhibits nuclear retinoid X receptor binding (ortholog); SUMO transferase activity (ortholog); ubiquitin protein ligase binding (ortholog); INVOLVED IN intracellular protein localization (ortholog); negative regulation of DNA-templated transcription (ortholog); positive regula tion of proteasomal ubiquitin-dependent protein catabolic process (ortholog); FOUND IN GABA-ergic synapse (ortholog); glutamatergic synapse (ortholog); hippocampal mossy fiber to CA3 synapse (ortholog) | 9 | 5298315 | 5311184 | Dog | 51 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 13970885 | SUMO2 | small ubiquitin like modifier 2 | ENCODES a protein that exhibits nuclear retinoid X receptor binding (ortholog); ubiquitin protein ligase binding (ortholog); INVOLVED IN intracellular protein localization (ortholog); negative regulation of DNA-templated transcription (ortholog); positive regulation of protein sumoylation (ortholog) ; FOUND IN PML body (ortholog) | | | | Pig | 53 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1346388 | SUMO3 | small ubiquitin like modifier 3 | This gene encodes a member of the small ubiquitin-related modifier (SUMO) family of eukaryotic proteins. The encoded protein is covalently conjugated to other proteins via a post-translation modification known as sumoylation. Sumoylation may play a role in a wide variety of cellular processes, inclu ding nuclear transport, DNA replication and repair, mitosis, transcriptional regulation, and signal transduction. Alternatively spliced transcript variants encoding distinct proteins have been described. [provided by RefSeq, Feb 2014] | 21 | 44805617 | 44818062 | Human | 108 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 1557723 | Sumo3 | small ubiquitin-like modifier 3 | This gene encodes a member of the small ubiquitin-like modifier family. The encoded protein may regulate a variety of proteins in many pathways via a post-translational modification, known as SUMOylation. This activity may play a role in a wide variety of cellular processes, including nuclear transp ort, DNA replication and repair, mitosis, transcriptional regulation, and signal transduction. Disruption of some of these processes has been associated with cerebral ischemia, neural dysfunction, and heart disease. A pseudogene of this gene has been defined on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014] | 10 | 77441931 | 77454165 | Mouse | 111 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 1561022 | Sumo3 | small ubiquitin-like modifier 3 | ENCODES a protein that exhibits protein tag activity (ortholog); SUMO transferase activity (ortholog); INVOLVED IN positive regulation of ubiquitin-dependent protein catabolic process (ortholog); protein localization to nucleus (ortholog); protein sumoylation (ortholog); PARTICIPATES IN RNA transpor t pathway; FOUND IN glutamatergic synapse (ortholog); nuclear body (ortholog); nucleoplasm (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol; ammonium chloride | 20 | 11009730 | 11020502 | Rat | 105 | old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1349888 | SUMO4 | small ubiquitin like modifier 4 | This gene is a member of the SUMO gene family. This family of genes encode small ubiquitin-related modifiers that are attached to proteins and control the target proteins' subcellular localization, stability, or activity. The protein described in this record is located in the cytoplasm and specifica lly modifies IKBA, leading to negative regulation of NF-kappa-B-dependent transcription of the IL12B gene. A specific polymorphism in this SUMO gene, which leads to the M55V substitution, has been associated with type I diabetes. The RefSeq contains this polymorphism. [provided by RefSeq, Jul 2008] | 6 | 149400262 | 149401278 | Human | 34 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 11804015 | SUMO4 | small ubiquitin like modifier 4 | INVOLVED IN cellular response to oxidative stress (ortholog); negative regulation of DNA-templated transcription (ortholog); protein sumoylation (ortholog); ASSOCIATED WITH type 1 diabetes mellitus 5 (ortholog); FOUND IN nuclear body (ortholog); nucleoplasm (ortholog); SUMO ligase complex (ortholog) | 6 | 147219279 | 147221125 | Bonobo | 9 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 1595256 | Sumo4 | small ubiquitin-like modifier 4 | | 5 | 19896946 | 19897930 | Rat | 4 | old_gene_name | gene, pseudo, INFERRED [RefSeq] |
| 4144231 | SUMO2P7 | SUMO2 pseudogene 7 | | 17 | 50235749 | 50236350 | Human | | old_gene_name | gene, pseudo, INFERRED [RefSeq] |
| 1559921 | Mifl3 | macrophage migration inhibitory factor like 3 | INTERACTS WITH bisphenol A | 6 | 105002879 | 105003802 | Rat | 1 | symbol , old_gene_name , PhenoGen | gene, protein-coding, MODEL [RefSeq] |
| 1584794 | Mifl2 | macrophage migration inhibitory factor like 2 | ENCODES a protein that exhibits cytokine activity (inferred); dopachrome isomerase activity (inferred); isomerase activity (inferred); INVOLVED IN immune system process (inferred); inflammatory response (inferred); innate immune response (inferred); FOUND IN cytoplasm (inferred); extracellular regio n (inferred); extracellular space (inferred) | 1 | 86560607 | 86561609 | Rat | 15 | symbol , old_gene_name , PhenoGen | gene, protein-coding, MODEL [RefSeq] |
| 14377546 | mIF2 | | | | | | Fly | | symbol | gene, null |
| 14379829 | MIF2 | | | | | | Yeast | | symbol | gene, null |
| 14389719 | mIF3 | | | | | | Fly | | symbol | gene, null |
| 9400372 | Mifl1 | macrophage migration inhibitory factor like 1 | | 4 | 12858722 | 12861498 | Rat | | symbol , PhenoGen | gene, protein-coding, MODEL [RefSeq] |
| 1565459 | Mifl4 | macrophage migration inhibitory factor like 4 | INTERACTS WITH ammonium chloride; bisphenol A | 10 | 94688691 | 94696405 | Rat | 2 | symbol , PhenoGen | gene, protein-coding, MODEL [RefSeq] |
| 1309685 | Mif4gd | MIF4G domain containing | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN cap-dependent translational initiation (ortholog); FOUND IN cytosol (ortholog); nucleolus (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; alpha-Zearalanol | 10 | 101346120 | 101350584 | Rat | 93 | symbol , old_gene_name , PhenoGen , name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1320163 | Mif4gd | MIF4G domain containing | Predicted to enable identical protein binding activity and translation activator activity. Predicted to be involved in cap-dependent translational initiation and regulation of translational initiation. Predicted to be located in Golgi apparatus and nucleolus. Predicted to be part of histone mRNA ste m-loop binding activity complex. Predicted to be active in cytosol. Is expressed in several structures, including aorta; brain; connective tissue; endocrine gland; and genitourinary system. Orthologous to human MIF4GD (MIF4G domain containing). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 115498744 | 115503795 | Mouse | 112 | symbol , old_gene_name , PhenoGen , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1606529 | MIF4GD | MIF4G domain containing | This gene encodes a protein which interacts with the N-terminus of the stem-loop binding protein (SLBP) and the 3' end of histone mRNA. This interaction facilitates the activation of histone mRNA translation. Alternative splicing results in multiple transcript variants encoding different isoforms. [ provided by RefSeq, Jun 2011] | 17 | 75266228 | 75271292 | Human | 100 | symbol , old_gene_name , COSMIC , name , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 8704659 | Mif4gd | MIF4G domain containing | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN cap-dependent translational initiation (ortholog); FOUND IN cytosol (ortholog); nucleolus (ortholog) | NW_004955553 | 2128410 | 2133519 | Chinchilla | 18 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 11669162 | MIF4GD | MIF4G domain containing | ENCODES a protein that exhibits identical protein binding (inferred); RNA binding (inferred); translation activator activity (inferred); INVOLVED IN cap-dependent translational initiation (inferred); positive regulation of translation (inferred); regulation of translation (inferred); FOUND IN cytopl asm (inferred); cytosol (inferred); histone mRNA stem-loop binding complex (inferred) | 17 | 69213313 | 69218324 | Bonobo | 28 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 12160474 | MIF4GD | MIF4G domain containing | ENCODES a protein that exhibits identical protein binding (inferred); RNA binding (inferred); INVOLVED IN cap-dependent translational initiation (inferred); positive regulation of translation (inferred); regulation of translation (inferred); FOUND IN cytoplasm (inferred); cytosol (inferred); histone mRNA stem-loop binding complex (inferred) | 9 | 5225683 | 5231709 | Dog | 28 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12655023 | Mif4gd | MIF4G domain containing | ENCODES a protein that exhibits identical protein binding (inferred); RNA binding (inferred); translation activator activity (inferred); INVOLVED IN cap-dependent translational initiation (inferred); positive regulation of translation (inferred); regulation of translation (inferred); FOUND IN cytopl asm (inferred); cytosol (inferred); histone mRNA stem-loop binding complex (inferred) | NW_004936594 | 551946 | 556124 | Squirrel | 28 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 14156493 | MIF4GD | MIF4G domain containing | ENCODES a protein that exhibits identical protein binding (inferred); phosphatidylinositol binding (inferred); RNA binding (inferred); INVOLVED IN cap-dependent translational initiation (inferred); intracellular protein transport (inferred); positive regulation of translation (inferred); FOUND IN cy toplasm (inferred); cytosol (inferred); early endosome membrane (inferred) | | | | Pig | 37 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18752818 | MIF4GD | MIF4G domain containing | ENCODES a protein that exhibits identical protein binding (inferred); RNA binding (inferred); translation activator activity (inferred); INVOLVED IN cap-dependent translational initiation (inferred); positive regulation of translation (inferred); regulation of translation (inferred); FOUND IN cytopl asm (inferred); cytosol (inferred); histone mRNA stem-loop binding complex (inferred) | | | | Green Monkey | 28 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18910846 | Mif4gd | MIF4G domain containing | ENCODES a protein that exhibits identical protein binding (inferred); RNA binding (inferred); translation activator activity (inferred); INVOLVED IN cap-dependent translational initiation (ortholog); FOUND IN nucleolus (ortholog) | | | | Naked Mole-Rat | 26 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 155241149 | mif4gd | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626112407 | Mif4gd | MIF4G domain containing | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN cap-dependent translational initiation (ortholog); FOUND IN cytosol (ortholog); nucleolus (ortholog) | | | | Black Rat | 18 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 155259856 | mif4gd.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155243628 | mif4gd.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 16563810 | MIF4GD-DT | MIF4GD divergent transcript | | 17 | 75271299 | 75273895 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 1354407 | CENPC | centromere protein C | Centromere protein C 1 is a centromere autoantigen and a component of the inner kinetochore plate. The protein is required for maintaining proper kinetochore size and a timely transition to anaphase. A putative pseudogene exists on chromosome 12. [provided by RefSeq, Jul 2008] | 4 | 67468762 | 67545503 | Human | 99 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1618978 | Fcrl1 | Fc receptor-like 1 | Predicted to enable coreceptor activity. Predicted to be involved in B cell activation. Predicted to be located in cell surface. Orthologous to several human genes including FCRL1 (Fc receptor like 1). [provided by Alliance of Genome Resources, Apr 2025] | 3 | 87283656 | 87311274 | Mouse | 23 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1624404 | Fcrl6 | Fc receptor-like 6 | Enables protein phosphatase binding activity. Predicted to be involved in cell surface receptor signaling pathway and immune response. Located in external side of plasma membrane. Is expressed in testis and thyroid gland. Orthologous to human FCRL6 (Fc receptor like 6). [provided by Alliance of Geno me Resources, Jul 2025] | 1 | 172423081 | 172445889 | Mouse | 34 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 733943 | HERPUD1 | homocysteine inducible ER protein with ubiquitin like domain 1 | The accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggers the ER stress response. This response includes the inhibition of translation to prevent further accumulation of unfolded proteins, the increased expression of proteins involved in polypeptide folding, known as the unfol ded protein response (UPR), and the destruction of misfolded proteins by the ER-associated protein degradation (ERAD) system. This gene may play a role in both UPR and ERAD. Its expression is induced by UPR and it has an ER stress response element in its promoter region while the encoded protein has an N-terminal ubiquitin-like domain which may interact with the ERAD system. This protein has been shown to interact with presenilin proteins and to increase the level of amyloid-beta protein following its overexpression. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms. The full-length nature of all transcript variants has not been determined. [provided by RefSeq, Jan 2013] | 16 | 56932142 | 56944864 | Human | 294 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 733944 | Herpud1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | Enables ubiquitin-like ligase-substrate adaptor activity. Involved in protein targeting to ER; regulation of ERAD pathway; and regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway. Acts upstream of or within endoplasmic reticulum unfolded protein response; regulat ion of protein ubiquitination; and ubiquitin-dependent protein catabolic process. Located in endoplasmic reticulum membrane and endoplasmic reticulum quality control compartment. Is expressed in several structures, including clavicle; craniocervical region bone; early conceptus; and olfactory epithelium. Orthologous to human HERPUD1 (homocysteine inducible ER protein with ubiquitin like domain 1). [provided by Alliance of Genome Resources, Jul 2025] | 8 | 95113057 | 95121999 | Mouse | 306 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 736447 | HSPA5 | heat shock protein family A (Hsp70) member 5 | The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. This protein localizes to the lumen of the endoplasmic reticulum (ER) where it operates as a typical HSP70 chaperone involved in the folding and assembly of proteins in the ER and is a master regulator of ER ho meostasis. During cellular stress, as during viral infection or tumorogenesis, this protein interacts with the transmembrane stress sensor proteins PERK (protein kinase R-like endoplasmic reticulum kinase), IRE1 (inositol-requiring kinase 1), and ATF6 (activating transcription factor 6) where it acts as a repressor of the unfolded protein response (UPR) and also plays a role in cellular apoptosis and senescence. Elevated expression and atypical translocation of this protein to the cell surface has been reported in viral infections and some types of cancer cells. At the cell surface this protein may facilitate viral attachment and entry to host cells. This gene is a therapeutic target for the treatment of coronavirus diseases and chemoresistant cancers. [provided by RefSeq, Jul 2020] | 9 | 125234853 | 125241343 | Human | 1403 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 620201 | Mmp23 | matrix metallopeptidase 23 | ENCODES a protein that exhibits metalloendopeptidase activity (ortholog); INVOLVED IN proteolysis (inferred); ASSOCIATED WITH COVID-19 (ortholog); FOUND IN endoplasmic reticulum membrane (inferred); extracellular matrix (inferred); membrane (inferred); INTERACTS WITH 1,1,1-Trichloro-2-(o-chloropheny l)-2-(p-chlorophenyl)ethane; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine | 5 | 171521905 | 171525007 | Rat | 107 | old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1602337 | MMP23A | matrix metallopeptidase 23A (pseudogene) | This locus represents the partially duplicated copy of the MMP23B gene, and therefore considered a pseudogene. This pseudogene is part of a duplicated region of chromosome 1p36.3. It belongs to the more centromeric copy of the duplicated region. [provided by RefSeq, Jul 2008] | 1 | 1699939 | 1701808 | Human | 6 | old_gene_symbol | gene, pseudo, PROVISIONAL [RefSeq] |
| 1344169 | MMP23B | matrix metallopeptidase 23B | This gene (MMP23B) encodes a member of the matrix metalloproteinase (MMP) family, and it is part of a duplicated region of chromosome 1p36.3. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryon ic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. This gene belongs to the more telomeric copy of the duplicated region. [provided by RefSeq, Jul 2008] | 1 | 1632173 | 1634654 | Human | 209 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1319727 | Ift20 | intraflagellar transport 20 | Enables opsin binding activity. Involved in regulation of organelle assembly; regulation of platelet-derived growth factor receptor-alpha signaling pathway; and spermatogenesis. Acts upstream of or within several processes, including morphogenesis of a polarized epithelium; plasma membrane bounded c ell projection organization; and protein transport. Located in several cellular components, including ciliary base; microtubule cytoskeleton; and photoreceptor cell cilium. Part of intraciliary transport particle B. Is expressed in cranium. Orthologous to human IFT20 (intraflagellar transport 20). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 78427187 | 78432558 | Mouse | 214 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1319839 | BNIPL | BCL2 interacting protein like | The protein encoded by this gene interacts with several other proteins, such as BCL2, ARHGAP1, MIF and GFER. It may function as a bridge molecule between BCL2 and ARHGAP1/CDC42 in promoting cell death. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011] | 1 | 151036586 | 151047720 | Human | 50 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1350471 | CD74 | CD74 molecule | The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF eight:700;'>MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011] | 5 | 150401639 | 150412910 | Human | 377 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 18900994 | LOC101726551 | MIF4G domain-containing protein-like | ENCODES a protein that exhibits identical protein binding (inferred); RNA binding (inferred); translation activator activity (inferred); INVOLVED IN positive regulation of translation (inferred); regulation of translation (inferred); regulation of translational initiation (inferred); FOUND IN cytopl asm (inferred); cytosol (inferred); histone mRNA stem-loop binding complex (inferred) | | | | Naked Mole-Rat | 10 | name | gene, protein-coding, MODEL [RefSeq] |
| 12424145 | LOC611596 | MIF4G domain-containing protein-like | | 13 | 54050845 | 54052112 | Dog | | name | gene, pseudo, MODEL [RefSeq] |
| 1345070 | NOM1 | nucleolar protein with MIF4G domain 1 | Proteins that contain MIF4G (middle of eIF4G (MIM 600495)) and/or MA3 domains, such as NOM1, function in protein translation. These domains include binding sites for members of the EIF4A family of ATP-dependent DEAD box RNA helicases (see EIF4A1; MIM 602641) (Si mmons et al., 2005 [PubMed 15715967]).[supplied by OMIM, Mar 2008] | 7 | 156949712 | 156973176 | Human | 49 | old_gene_name , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1588109 | Nom1 | nucleolar protein with MIF4G domain 1 | ENCODES a protein that exhibits RNA binding (inferred); INVOLVED IN hair follicle maturation (ortholog); ASSOCIATED WITH diffuse large B-cell lymphoma (ortholog); FOUND IN nucleolus (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; flutamide | 4 | 6562931 | 6586093 | Rat | 47 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 1616357 | Nom1 | nucleolar protein with MIF4G domain 1 | Predicted to enable RNA binding activity. Acts upstream of or within hair follicle maturation. Predicted to be active in nucleolus. Is expressed in several structures, including bladder; dorsal root ganglion; limb; skeleton; and ventral grey horn. Orthologous to human NOM1 (nucleolar protein with ... (more)pan style='font-weight:700;'>MIF4G domain 1). [provided by Alliance of Genome Resources, Apr 2025] | 5 | 29637338 | 29658504 | Mouse | 51 | old_gene_name , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8806287 | Nom1 | nucleolar protein with MIF4G domain 1 | INVOLVED IN hair follicle maturation (ortholog); ASSOCIATED WITH diffuse large B-cell lymphoma (ortholog); FOUND IN nucleolus (ortholog) | NW_004955579 | 27206 | 42137 | Chinchilla | 6 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 11886249 | NOM1 | nucleolar protein with MIF4G domain 1 | ENCODES a protein that exhibits RNA binding (inferred); INVOLVED IN hair follicle maturation (ortholog); ASSOCIATED WITH diffuse large B-cell lymphoma (ortholog); FOUND IN nucleolus (inferred) | 7 | 148568075 | 148588155 | Bonobo | 11 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12204417 | NOM1 | nucleolar protein with MIF4G domain 1 | ENCODES a protein that exhibits RNA binding (inferred); INVOLVED IN hair follicle maturation (ortholog); ASSOCIATED WITH diffuse large B-cell lymphoma (ortholog); FOUND IN nucleolus (inferred) | 16 | 19477187 | 19491714 | Dog | 11 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12632611 | Nom1 | nucleolar protein with MIF4G domain 1 | ENCODES a protein that exhibits RNA binding (inferred); INVOLVED IN hair follicle maturation (ortholog); ASSOCIATED WITH diffuse large B-cell lymphoma (ortholog); FOUND IN nucleolus (inferred) | NW_004936797 | 644431 | 661606 | Squirrel | 11 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 13880241 | NOM1 | nucleolar protein with MIF4G domain 1 | ENCODES a protein that exhibits RNA binding (inferred); INVOLVED IN hair follicle maturation (ortholog); ASSOCIATED WITH diffuse large B-cell lymphoma (ortholog); FOUND IN nucleolus (inferred) | | | | Pig | 11 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18670911 | NOM1 | nucleolar protein with MIF4G domain 1 | ENCODES a protein that exhibits RNA binding (inferred); INVOLVED IN hair follicle maturation (ortholog); ASSOCIATED WITH diffuse large B-cell lymphoma (ortholog); FOUND IN nucleolus (inferred) | | | | Green Monkey | 10 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18901881 | Nom1 | nucleolar protein with MIF4G domain 1 | ENCODES a protein that exhibits RNA binding (inferred); INVOLVED IN hair follicle maturation (ortholog); ASSOCIATED WITH diffuse large B-cell lymphoma (ortholog); FOUND IN nucleolus (inferred) | | | | Naked Mole-Rat | 11 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 626016177 | Nom1 | nucleolar protein with MIF4G domain 1 | INVOLVED IN hair follicle maturation (ortholog); ASSOCIATED WITH diffuse large B-cell lymphoma (ortholog); FOUND IN nucleolus (ortholog) | | | | Black Rat | 6 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 14133734 | LOC100621528 | nucleolar MIF4G domain-containing protein 1 pseudogene | | | | | Pig | | name | gene, pseudo, MODEL [RefSeq] |
| 13923643 | LOC100739237 | nucleolar MIF4G domain-containing protein 1 pseudogene | | | | | Pig | | name | gene, pseudo, MODEL [RefSeq] |
| 14199035 | LOC102161499 | nucleolar MIF4G domain-containing protein 1 pseudogene | | | | | Pig | | name | gene, pseudo, MODEL [RefSeq] |
| 14096887 | LOC106507281 | nucleolar MIF4G domain-containing protein 1 pseudogene | | | | | Pig | | name | gene, pseudo, MODEL [RefSeq] |
| 14040217 | LOC110259052 | nucleolar MIF4G domain-containing protein 1 pseudogene | | | | | Pig | | name | gene, pseudo, MODEL [RefSeq] |
| 2295267 | Cwc22rt1 | CWC22 spliceosome-associated protein, retrotransposed 1 | Predicted to enable RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be located in cytosol and nuclear speck. Predicted to be part of U2-type catalytic step 1 spliceosome; U2-type catalytic step 2 spliceosome; and U2-type precatalytic spliceosome. Orthol ogous to human CWC22 (CWC22 spliceosome associated protein homolog). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 83785949 | 83789002 | Mouse | | old_gene_name | gene, pseudo, INFERRED [RefSeq] |
| 2295187 | Cwc22rt2 | CWC22 spliceosome-associated protein, retrotransposed 2 | Predicted to enable RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be located in cytosol and nuclear speck. Predicted to be part of U2-type catalytic step 1 spliceosome; U2-type catalytic step 2 spliceosome; and U2-type precatalytic spliceosome. Orthol ogous to human CWC22 (CWC22 spliceosome associated protein homolog). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 83791759 | 83794812 | Mouse | | old_gene_name | gene, pseudo, INFERRED [RefSeq] |
| 2295186 | Cwc22rt4 | CWC22 spliceosome-associated protein, retrotransposed 4 | Predicted to enable RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be located in cytosol and nuclear speck. Predicted to be part of U2-type catalytic step 1 spliceosome; U2-type catalytic step 2 spliceosome; and U2-type precatalytic spliceosome. Orthol ogous to human CWC22 (CWC22 spliceosome associated protein homolog). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 83803379 | 83806432 | Mouse | | old_gene_name | gene, pseudo, INFERRED [RefSeq] |
| 2295185 | Cwc22rt5 | CWC22 spliceosome-associated protein, retrotransposed 5 | Predicted to enable RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be located in cytosol and nuclear speck. Predicted to be part of U2-type catalytic step 1 spliceosome; U2-type catalytic step 2 spliceosome; and U2-type precatalytic spliceosome. Orthol ogous to human CWC22 (CWC22 spliceosome associated protein homolog). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 83809189 | 83812242 | Mouse | 17 | old_gene_name | gene, pseudo, INFERRED [RefSeq] |
| 2295182 | Cwc22rt6 | CWC22 spliceosome-associated protein, retrotransposed 6 | Predicted to enable RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be located in cytosol and nuclear speck. Predicted to be part of U2-type catalytic step 1 spliceosome; U2-type catalytic step 2 spliceosome; and U2-type precatalytic spliceosome. Orthol ogous to human CWC22 (CWC22 spliceosome associated protein homolog). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 83820809 | 83823862 | Mouse | 3 | old_gene_name | gene, pseudo, INFERRED [RefSeq] |
| 2295184 | Cwc22rt7 | CWC22 spliceosome-associated protein, retrotransposed 7 | Predicted to enable RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be located in cytosol and nuclear speck. Predicted to be part of U2-type catalytic step 1 spliceosome; U2-type catalytic step 2 spliceosome; and U2-type precatalytic spliceosome. Orthol ogous to human CWC22 (CWC22 spliceosome associated protein homolog). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 83814999 | 83818052 | Mouse | | old_gene_name | gene, pseudo, INFERRED [RefSeq] |