| 2827 | Hras | HRas proto-oncogene, GTPase | ENCODES a protein that exhibits protein-containing complex binding; GDP binding (ortholog); GTP binding (ortholog); INVOLVED IN cellular senescence; insulin-like growth factor receptor signaling pathway; liver development; PARTICIPATES IN adenosine signaling pathway; endothelin signaling pathway; ep hrin - ephrin receptor bidirectional signaling axis; ASSOCIATED WITH abnormal retina apoptosis; ASSOCIATED WITH diabetic retinopathy; Experimental Diabetes Mellitus; Experimental Mammary Neoplasms; FOUND IN plasma membrane; cytosol (ortholog); glutamatergic synapse (ortholog); INTERACTS WITH (S)-nicotine; 1,2-dichlorobenzene; 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile | 1 | 205712625 | 205729406 | Rat | 672 | symbol , old_gene_name , PhenoGen , name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 10730 | Hras | Hras proto-oncogene, GTPase | Enables GTP binding activity and protein-membrane adaptor activity. Involved in several processes, including Ras protein signal transduction; insulin receptor signaling pathway; and nervous system development. Acts upstream of or within several processes, including defense response to protozoan; int racellular signal transduction; and oncogene-induced cell senescence. Predicted to be located in Golgi apparatus; cytosol; and nucleoplasm. Predicted to be part of GTPase complex. Predicted to be active in glutamatergic synapse and plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; early embryo; genitourinary system; and sensory organ. Used to study Costello syndrome; high grade glioma; and malignant astrocytoma. Human ortholog(s) of this gene implicated in several diseases, including Costello syndrome; autistic disorder; carcinoma (multiple); epidermal nevus; and large congenital melanocytic nevus. Orthologous to human HRAS (HRas proto-oncogene, GTPase). [provided by Alliance of Genome Resources, Apr 2025] | 7 | 140770839 | 140773938 | Mouse | 723 | symbol , old_gene_name , PhenoGen , name , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 730881 | HRAS | HRas proto-oncogene, GTPase | This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protei n undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, cognitive disability, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene. [provided by RefSeq, Jul 2008] | 11 | 532242 | 535576 | Human | 936 | symbol , old_gene_name , COSMIC , name , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 8952216 | Hras | HRas proto-oncogene, GTPase | ENCODES a protein that exhibits GDP binding (ortholog); GTP binding (ortholog); GTPase activity (ortholog); INVOLVED IN adipose tissue development (ortholog); cellular response to gamma radiation (ortholog); cellular senescence (ortholog); PARTICIPATES IN adenosine signaling pathway; endothelin sign aling pathway; ephrin - ephrin receptor bidirectional signaling axis; ASSOCIATED WITH acute myeloid leukemia (ortholog); adenoid cystic carcinoma (ortholog); Alzheimer's disease (ortholog); FOUND IN cytosol (ortholog); glutamatergic synapse (ortholog); Golgi apparatus (ortholog) | NW_004955476 | 11508446 | 11510333 | Chinchilla | 279 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 11716276 | HRAS | HRas proto-oncogene, GTPase | ENCODES a protein that exhibits protein-containing complex binding (ortholog); INVOLVED IN cellular senescence (ortholog); defense response to protozoan (ortholog); endocytosis (ortholog); PARTICIPATES IN adenosine signaling pathway; endothelin signaling pathway; ephrin - ephrin receptor bidirection al signaling axis; ASSOCIATED WITH acute myeloid leukemia (ortholog); adenoid cystic carcinoma (ortholog); Alzheimer's disease (ortholog); FOUND IN Golgi apparatus (ortholog) | 11 | 537488 | 540810 | Bonobo | 282 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12284930 | HRAS | HRas proto-oncogene, GTPase | ENCODES a protein that exhibits protein-containing complex binding (ortholog); INVOLVED IN cellular senescence (ortholog); defense response to protozoan (ortholog); endocytosis (ortholog); PARTICIPATES IN adenosine signaling pathway; endothelin signaling pathway; ephrin - ephrin receptor bidirection al signaling axis; ASSOCIATED WITH acute myeloid leukemia (ortholog); adenoid cystic carcinoma (ortholog); Alzheimer's disease (ortholog); FOUND IN Golgi apparatus (ortholog) | 18 | 25642844 | 25644717 | Dog | 286 | symbol , old_gene_name , name | gene, protein-coding, INFERRED [RefSeq] |
| 12619795 | Hras | HRas proto-oncogene, GTPase | ENCODES a protein that exhibits protein-containing complex binding (ortholog); INVOLVED IN cellular senescence (ortholog); defense response to protozoan (ortholog); endocytosis (ortholog); PARTICIPATES IN adenosine signaling pathway; endothelin signaling pathway; ephrin - ephrin receptor bidirection al signaling axis; ASSOCIATED WITH acute myeloid leukemia (ortholog); adenoid cystic carcinoma (ortholog); Alzheimer's disease (ortholog); FOUND IN Golgi apparatus (ortholog) | NW_004936888 | 375372 | 378125 | Squirrel | 281 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 14262040 | HRAS | HRas proto-oncogene, GTPase | ENCODES a protein that exhibits protein-containing complex binding (ortholog); INVOLVED IN cellular senescence (ortholog); defense response to protozoan (ortholog); endocytosis (ortholog); PARTICIPATES IN adenosine signaling pathway; endothelin signaling pathway; ephrin - ephrin receptor bidirection al signaling axis; ASSOCIATED WITH acute myeloid leukemia (ortholog); adenoid cystic carcinoma (ortholog); Alzheimer's disease (ortholog); FOUND IN Golgi apparatus (ortholog) | | | | Pig | 286 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18521743 | HRAS | HRas proto-oncogene, GTPase | ENCODES a protein that exhibits protein-containing complex binding (ortholog); INVOLVED IN cellular senescence (ortholog); defense response to protozoan (ortholog); endocytosis (ortholog); PARTICIPATES IN adenosine signaling pathway; endothelin signaling pathway; ephrin - ephrin receptor bidirection al signaling axis; ASSOCIATED WITH acute myeloid leukemia (ortholog); adenoid cystic carcinoma (ortholog); Alzheimer's disease (ortholog); FOUND IN Golgi apparatus (ortholog) | | | | Green Monkey | 282 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18907110 | Hras | HRas proto-oncogene, GTPase | ENCODES a protein that exhibits GDP binding (ortholog); phospholipase C activator activity (ortholog); protein-containing complex binding (ortholog); INVOLVED IN adipose tissue development (ortholog); cellular response to gamma radiation (ortholog); cellular senescence (ortholog); PARTICIPATES IN ad enosine signaling pathway; endothelin signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; ASSOCIATED WITH acute myeloid leukemia (ortholog); adenoid cystic carcinoma (ortholog); Alzheimer's disease (ortholog); FOUND IN cytosol (ortholog); glutamatergic synapse (ortholog); Golgi apparatus (ortholog) | | | | Naked Mole-Rat | 281 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 155248420 | hras | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625969554 | Hras | HRas proto-oncogene, GTPase | ENCODES a protein that exhibits GDP binding (ortholog); GTP binding (ortholog); GTPase activity (ortholog); INVOLVED IN adipose tissue development (ortholog); cellular response to gamma radiation (ortholog); cellular senescence (ortholog); PARTICIPATES IN adenosine signaling pathway; endothelin sign aling pathway; ephrin - ephrin receptor bidirectional signaling axis; ASSOCIATED WITH acute myeloid leukemia (ortholog); adenoid cystic carcinoma (ortholog); Alzheimer's disease (ortholog); FOUND IN cytosol (ortholog); glutamatergic synapse (ortholog); Golgi apparatus (ortholog) | | | | Black Rat | 240 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 155244294 | hras.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 14296540 | NRAS | NRAS proto-oncogene, GTPase | ENCODES a protein that exhibits GTPase activity (ortholog); INVOLVED IN defense response to protozoan (ortholog); myoblast differentiation (ortholog); negative regulation of skeletal muscle tissue development (ortholog); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; epiderma l growth factor/neuregulin signaling pathway; Fc epsilon receptor mediated signaling pathway; ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); acute myeloid leukemia (ortholog); acute promyelocytic leukemia (ortholog); FOUND IN Golgi apparatus (inferred); Golgi membrane (inferred); membrane (inferred) | | | | Pig | 131 | old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 12233356 | LOC106557512 | GTPase HRas-like | | 27 | 35292215 | 35296659 | Dog | | name | gene, pseudo, MODEL [RefSeq] |
| 625875092 | LOC116887962 | GTPase HRas-like | | | | | Black Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 18907995 | LOC101712273 | HRAS-like suppressor 3 | ENCODES a protein that exhibits A2-type glycerophospholipase activity (inferred); catalytic activity (inferred); glycerophospholipid phospholipase A1 activity (inferred); INVOLVED IN lipid metabolic process (inferred); N-acylphosphatidylethanolamine metabolic process (inferred); FOUND IN cytoplasm ( inferred) | | | | Naked Mole-Rat | 9 | name | gene, protein-coding, MODEL [RefSeq] |
| 18922539 | LOC101713128 | HRAS-like suppressor 2 | ENCODES a protein that exhibits A2-type glycerophospholipase activity (inferred); catalytic activity (inferred); glycerophospholipid phospholipase A1 activity (inferred); INVOLVED IN lipid metabolic process (inferred); N-acylphosphatidylethanolamine metabolic process (inferred); FOUND IN cytoplasm ( inferred) | | | | Naked Mole-Rat | 9 | name | gene, protein-coding, MODEL [RefSeq] |
| 8835106 | LOC102003033 | HRAS-like suppressor 3 | | NW_004955422 | 21415634 | 21440465 | Chinchilla | | name | gene, protein-coding, MODEL [RefSeq] |
| 9022670 | LOC102003559 | HRAS-like suppressor 2 | | NW_004955422 | 21458082 | 21474996 | Chinchilla | | name , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 1583762 | Hrasl1 | HRas proto-oncogene, GTPase like 1 | ENCODES a protein that exhibits G protein activity (inferred); GTP binding (inferred); GTPase activity (inferred); INVOLVED IN signal transduction (inferred); FOUND IN membrane (inferred); plasma membrane (inferred) | X | 72587494 | 72588640 | Rat | 14 | symbol , old_gene_name , PhenoGen , name | gene, protein-coding, INFERRED [RefSeq] |
| 40894559 | LOC119620193 | GTPase KRas pseudogene | | | | | Green Monkey | | old_gene_name | gene, pseudo, MODEL [RefSeq] |
| 1309485 | Plaat1 | phospholipase A and acyltransferase 1 | ENCODES a protein that exhibits glycerophospholipase activity; A2-type glycerophospholipase activity (ortholog); glycerophospholipid phospholipase A1 activity (ortholog); INVOLVED IN ether lipid metabolic process (ortholog); lens fiber cell differentiation (ortholog); N-acylphosphatidylethanolamine metabolic process (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); endoplasmic reticulum (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl | 11 | 85022297 | 85041999 | Rat | 112 | old_gene_name , old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1319850 | PLAAT1 | phospholipase A and acyltransferase 1 | Enables acyltransferase activity, transferring groups other than amino-acyl groups and phospholipase activity. Involved in N-acylphosphatidylethanolamine metabolic process and phosphatidylcholine metabolic process. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025 ] | 3 | 193240606 | 193281426 | Human | 105 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1553234 | Plaat1 | phospholipase A and acyltransferase 1 | Enables phospholipase activity. Acts upstream of or within ether lipid metabolic process and peroxisome organization. Located in nuclear envelope lumen and peroxisome. Orthologous to human PLAAT1 (phospholipase A and acyltransferase 1). [provided by Alliance of Genome Resources, Jul 2025] | 16 | 29027883 | 29049283 | Mouse | 133 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 9026843 | Plaat1 | phospholipase A and acyltransferase 1 | ENCODES a protein that exhibits A2-type glycerophospholipase activity (ortholog); glycerophospholipase activity (ortholog); glycerophospholipid phospholipase A1 activity (ortholog); INVOLVED IN ether lipid metabolic process (ortholog); N-acylphosphatidylethanolamine metabolic process (ortholog); per oxisome organization (ortholog); FOUND IN cytoplasm (ortholog); nuclear envelope lumen (ortholog); nucleus (ortholog) | NW_004955420 | 15305901 | 15326444 | Chinchilla | 17 | old_gene_name , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 11767369 | PLAAT1 | phospholipase A and acyltransferase 1 | ENCODES a protein that exhibits glycerophospholipase activity (ortholog); O-acyltransferase activity (ortholog); INVOLVED IN ether lipid metabolic process (ortholog); peroxisome organization (ortholog); phosphatidylcholine metabolic process (ortholog); FOUND IN nuclear envelope lumen (ortholog); nuc leus (ortholog); peroxisome (ortholog) | 3 | 190536749 | 190577714 | Bonobo | 23 | old_gene_name , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 12092753 | PLAAT1 | phospholipase A and acyltransferase 1 | ENCODES a protein that exhibits glycerophospholipase activity (ortholog); INVOLVED IN ether lipid metabolic process (ortholog); peroxisome organization (ortholog); FOUND IN nuclear envelope lumen (ortholog); peroxisome (ortholog) | 34 | 24751404 | 24770690 | Dog | 23 | old_gene_name , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 12571751 | Plaat1 | phospholipase A and acyltransferase 1 | ENCODES a protein that exhibits glycerophospholipase activity (ortholog); INVOLVED IN ether lipid metabolic process (ortholog); peroxisome organization (ortholog); FOUND IN nuclear envelope lumen (ortholog); peroxisome (ortholog) | NW_004936711 | 1389664 | 1422781 | Squirrel | 23 | old_gene_name , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 14078086 | PLAAT1 | phospholipase A and acyltransferase 1 | ENCODES a protein that exhibits glycerophospholipase activity (ortholog); INVOLVED IN ether lipid metabolic process (ortholog); peroxisome organization (ortholog); FOUND IN nuclear envelope lumen (ortholog); peroxisome (ortholog) | | | | Pig | 23 | old_gene_name , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 18756481 | PLAAT1 | phospholipase A and acyltransferase 1 | ENCODES a protein that exhibits A2-type glycerophospholipase activity (ortholog); glycerophospholipase activity (ortholog); glycerophospholipid phospholipase A1 activity (ortholog); INVOLVED IN ether lipid metabolic process (ortholog); N-acylphosphatidylethanolamine metabolic process (ortholog); per oxisome organization (ortholog); FOUND IN cytoplasm (ortholog); nuclear envelope lumen (ortholog); nucleus (ortholog) | | | | Green Monkey | 17 | old_gene_name , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 18926424 | Plaat1 | phospholipase A and acyltransferase 1 | ENCODES a protein that exhibits glycerophospholipase activity (ortholog); O-acyltransferase activity (ortholog); INVOLVED IN ether lipid metabolic process (ortholog); peroxisome organization (ortholog); phosphatidylcholine metabolic process (ortholog); FOUND IN nuclear envelope lumen (ortholog); nuc leus (ortholog); peroxisome (ortholog) | | | | Naked Mole-Rat | 19 | old_gene_name , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 2829 | Plaat3 | phospholipase A and acyltransferase 3 | ENCODES a protein that exhibits A2-type glycerophospholipase activity; glycerophospholipid phospholipase A1 activity; acyltransferase activity (ortholog); INVOLVED IN negative regulation of cell cycle; ether lipid metabolic process (ortholog); lens fiber cell differentiation (ortholog); ASSOCIATED W ITH Breast Neoplasms (ortholog); Familial Partial Lipodystrophy Type 9 (ortholog); seminoma (ortholog); FOUND IN cytosol (ortholog); endoplasmic reticulum (ortholog); lysosome (ortholog); INTERACTS WITH (+)-schisandrin B; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine | 1 | 214211755 | 214245551 | Rat | 211 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 737532 | PLAAT3 | phospholipase A and acyltransferase 3 | Enables N-acyltransferase activity; lipid binding activity; and phospholipase activity. Involved in N-acylphosphatidylethanolamine metabolic process. Predicted to be located in several cellular components, including lysosome; nuclear envelope; and peroxisome. Predicted to be active in cytoplasm. Bio marker of seminoma. [provided by Alliance of Genome Resources, Jul 2025] | 11 | 63574462 | 63616927 | Human | 264 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 12587315 | LOC101955561 | phospholipase A and acyltransferase 2-like | | NW_004936879 | 632982 | 641385 | Squirrel | | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 1344464 | PLAAT2 | phospholipase A and acyltransferase 2 | The protein encoded by this gene has both phospholipase and acyltransferase activities and acts as a tumor suppressor. The encoded protein can hydrolyze dipalmitoylated phosphatidylcholine (PC) to palmitic acid and lyso-PC. In addition, this protein can catalyze the N-acylation of phosphatidylethano lamine and can catalyze the O-acylation of lyso-PC to form PC. [provided by RefSeq, Jul 2016] | 11 | 63552770 | 63565070 | Human | 45 | old_gene_name , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 11980677 | PLAAT2 | phospholipase A and acyltransferase 2 | ENCODES a protein that exhibits A2-type glycerophospholipase activity (inferred); glycerophospholipid phospholipase A1 activity (inferred); hydrolase activity (inferred); INVOLVED IN lipid metabolic process (inferred); N-acylphosphatidylethanolamine metabolic process (inferred); FOUND IN cytoplasm ( inferred) | 11 | 58905049 | 58920353 | Bonobo | 17 | old_gene_name , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 18411401 | PLAAT2 | phospholipase A and acyltransferase 2 | ENCODES a protein that exhibits A2-type glycerophospholipase activity (inferred); glycerophospholipid phospholipase A1 activity (inferred); hydrolase activity (inferred); INVOLVED IN lipid metabolic process (inferred); N-acylphosphatidylethanolamine metabolic process (inferred); FOUND IN cytoplasm ( inferred) | | | | Green Monkey | 17 | old_gene_name , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 734412 | Plaat3 | phospholipase A and acyltransferase 3 | Enables phospholipase A1 activity and phospholipase A2 activity. Involved in several processes, including ether lipid metabolic process; lens fiber cell differentiation; and regulation of adipose tissue development. Acts upstream of or within response to bacterium. Located in several cellular compon ents, including nuclear envelope; perinuclear region of cytoplasm; and peroxisome. Orthologous to human PLAAT3 (phospholipase A and acyltransferase 3). [provided by Alliance of Genome Resources, Jul 2025] | 19 | 7534824 | 7565914 | Mouse | 251 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 11679988 | PLAAT3 | phospholipase A and acyltransferase 3 | ENCODES a protein that exhibits acyltransferase activity (ortholog); lipid binding (ortholog); INVOLVED IN negative regulation of cell cycle (ortholog); response to bacterium (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); Familial Partial Lipodystrophy Type 9 (ortholog); seminoma (ortholog ); FOUND IN cytoplasm (inferred); cytosol (inferred); endoplasmic reticulum (inferred) | 11 | 58931593 | 58971269 | Bonobo | 47 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12087628 | PLAAT3 | phospholipase A and acyltransferase 3 | ENCODES a protein that exhibits acyltransferase activity (ortholog); glycerophospholipase activity (ortholog); lipid binding (ortholog); INVOLVED IN ether lipid metabolic process (ortholog); lipid catabolic process (ortholog); membrane disassembly (ortholog); ASSOCIATED WITH Breast Neoplasms (orthol og); Familial Partial Lipodystrophy Type 9 (ortholog); seminoma (ortholog); FOUND IN cytosol (ortholog); endoplasmic reticulum (ortholog); lysosome (ortholog) | 18 | 53367441 | 53412165 | Dog | 42 | old_gene_name , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 12483813 | Plaat3 | phospholipase A and acyltransferase 3 | ENCODES a protein that exhibits acyltransferase activity (ortholog); lipid binding (ortholog); INVOLVED IN negative regulation of cell cycle (ortholog); response to bacterium (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); Familial Partial Lipodystrophy Type 9 (ortholog); seminoma (ortholog ); FOUND IN cytoplasm (inferred); cytosol (inferred); endoplasmic reticulum (inferred) | NW_004936599 | 5509723 | 5524837 | Squirrel | 44 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 14228574 | PLAAT3 | phospholipase A and acyltransferase 3 | ENCODES a protein that exhibits acyltransferase activity (ortholog); lipid binding (ortholog); INVOLVED IN negative regulation of cell cycle (ortholog); response to bacterium (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); Familial Partial Lipodystrophy Type 9 (ortholog); seminoma (ortholog ); FOUND IN cytosol (inferred); endoplasmic reticulum (inferred); lysosome (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 46 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 18652808 | PLAAT3 | phospholipase A and acyltransferase 3 | ENCODES a protein that exhibits A2-type glycerophospholipase activity (ortholog); acyltransferase activity (ortholog); glycerophospholipase activity (ortholog); INVOLVED IN ether lipid metabolic process (ortholog); lens fiber cell differentiation (ortholog); lipid catabolic process (ortholog); ASSOC IATED WITH Breast Neoplasms (ortholog); Familial Partial Lipodystrophy Type 9 (ortholog); seminoma (ortholog); FOUND IN cytosol (ortholog); endoplasmic reticulum (ortholog); lysosome (ortholog) | | | | Green Monkey | 41 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 1342575 | PLAAT4 | phospholipase A and acyltransferase 4 | Retinoids exert biologic effects such as potent growth inhibitory and cell differentiation activities and are used in the treatment of hyperproliferative dermatological diseases. These effects are mediated by specific nuclear receptor proteins that are members of the steroid and thyroid hormone rece ptor superfamily of transcriptional regulators. RARRES1, RARRES2, and RARRES3 are genes whose expression is upregulated by the synthetic retinoid tazarotene. RARRES3 is thought act as a tumor suppressor or growth regulator. [provided by RefSeq, Jul 2008] | 11 | 63536808 | 63546458 | Human | 97 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1308376 | Plaat5 | phospholipase A and acyltransferase 5 | ENCODES a protein that exhibits N-acyltransferase activity; A2-type glycerophospholipase activity (ortholog); glycerophospholipid phospholipase A1 activity (ortholog); INVOLVED IN N-acylphosphatidylethanolamine metabolic process; FOUND IN cytosol (inferred); INTERACTS WITH 1-naphthyl isothiocyanate; 6-propyl-2-thiouracil; acetamide | 1 | 214276553 | 214307600 | Rat | 61 | old_gene_name , old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1318109 | Plaat5 | phospholipase A and acyltransferase 5 | Enables N-acyltransferase activity. Acts upstream of or within N-acylphosphatidylethanolamine metabolic process. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to human PLAAT5 (phospholipase A and acyltransferase 5). [provided by Alliance of Genome Resources, Ju l 2025] | 19 | 7589902 | 7618405 | Mouse | 70 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1606473 | PLAAT5 | phospholipase A and acyltransferase 5 | Enables N-acyltransferase activity; phospholipase A1 activity; and phospholipase A2 activity. Acts upstream of or within N-acylphosphatidylethanolamine metabolic process. Predicted to be located in cytosol. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025] | 11 | 63461404 | 63491167 | Human | 62 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 18927754 | Plaat5 | phospholipase A and acyltransferase 5 | ENCODES a protein that exhibits A2-type glycerophospholipase activity (inferred); catalytic activity (inferred); glycerophospholipid phospholipase A1 activity (inferred); INVOLVED IN N-acylphosphatidylethanolamine metabolic process (ortholog); FOUND IN cytoplasm (inferred) | | | | Naked Mole-Rat | 15 | old_gene_name , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 12485028 | LOC101956431 | phospholipase A and acyltransferase 2-like | | NW_004936879 | 769757 | 770060 | Squirrel | | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 8913123 | Plaat5 | phospholipase A and acyltransferase 5 | ENCODES a protein that exhibits A2-type glycerophospholipase activity (ortholog); glycerophospholipid phospholipase A1 activity (ortholog); N-acyltransferase activity (ortholog); INVOLVED IN N-acylphosphatidylethanolamine metabolic process (ortholog) | NW_004955599 | 217365 | 247914 | Chinchilla | 12 | old_gene_name , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 12028596 | PLAAT5 | phospholipase A and acyltransferase 5 | ENCODES a protein that exhibits A2-type glycerophospholipase activity (inferred); glycerophospholipid phospholipase A1 activity (inferred); hydrolase activity (inferred); INVOLVED IN N-acylphosphatidylethanolamine metabolic process (ortholog); FOUND IN cytoplasm (inferred) | 11 | 58814588 | 58844376 | Bonobo | 21 | old_gene_name , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 12374809 | PLAAT5 | phospholipase A and acyltransferase 5 | ENCODES a protein that exhibits A2-type glycerophospholipase activity (inferred); catalytic activity (inferred); glycerophospholipid phospholipase A1 activity (inferred); INVOLVED IN N-acylphosphatidylethanolamine metabolic process (ortholog) | 18 | 53451302 | 53465375 | Dog | 18 | old_gene_name , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 12680048 | Plaat5 | phospholipase A and acyltransferase 5 | ENCODES a protein that exhibits A2-type glycerophospholipase activity (inferred); catalytic activity (inferred); glycerophospholipid phospholipase A1 activity (inferred); INVOLVED IN N-acylphosphatidylethanolamine metabolic process (ortholog); FOUND IN cytoplasm (inferred) | NW_004936879 | 510429 | 536934 | Squirrel | 18 | old_gene_name , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 14120527 | PLAAT5 | phospholipase A and acyltransferase 5 | ENCODES a protein that exhibits A2-type glycerophospholipase activity (inferred); catalytic activity (inferred); glycerophospholipid phospholipase A1 activity (inferred); INVOLVED IN N-acylphosphatidylethanolamine metabolic process (ortholog) | | | | Pig | 18 | old_gene_name , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 18727387 | PLAAT5 | phospholipase A and acyltransferase 5 | ENCODES a protein that exhibits A2-type glycerophospholipase activity (inferred); glycerophospholipid phospholipase A1 activity (inferred); hydrolase activity (inferred); INVOLVED IN N-acylphosphatidylethanolamine metabolic process (ortholog); FOUND IN cytoplasm (inferred) | | | | Green Monkey | 21 | old_gene_name , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 3015 | Lox | lysyl oxidase | ENCODES a protein that exhibits copper ion binding; protein-lysine 6-oxidase activity; collagen binding (ortholog); INVOLVED IN cell chemotaxis; collagen fibril organization; elastic fiber assembly; PARTICIPATES IN hypertension pathway; ASSOCIATED WITH abdominal aortic aneurysm; arteriosclerosis; co ronary artery disease; FOUND IN extracellular matrix; collagen trimer (ortholog); extracellular region (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine | 18 | 48162889 | 48175640 | Rat | 410 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 15037630 | Hras1-ps1 | Harvey rat sarcoma virus oncogene, pseudogene 1 | | | | | Mouse | | symbol , PhenoGen , old_gene_symbol | gene, pseudo |
| 1345319 | ERAS | ES cell expressed Ras | This gene encodes a constitutively active member of the small GTPase Ras protein family. The encoded protein activates the phosphatidylinositol 3-kinase signal transduction pathway in undifferentiated stem cells, but is not expressed in differentiated cells. This gene may be involved in cancer and c hemotherapy resistance. [provided by RefSeq, Dec 2012] | X | 48826513 | 48829869 | Human | 31 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1556987 | Eras | ES cell-expressed Ras | Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Predicted to be involved in Ras protein signal transduction. Predicted to be active in plasma membrane. Is expressed in several structures, including blastocyst; early embryo; genitourinary system; gut; and hemolymp hoid system gland. Orthologous to human ERAS (ES cell expressed Ras). [provided by Alliance of Genome Resources, Apr 2025] | X | 7790515 | 7794846 | Mouse | 31 | old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1314751 | RASSF7 | Ras association domain family member 7 | Predicted to be involved in apoptotic process and signal transduction. Located in centriolar satellite. [provided by Alliance of Genome Resources, Jul 2025] | 11 | 560970 | 564025 | Human | 78 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 69137 | RASGRP1 | RAS guanyl releasing protein 1 | This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activat es the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE). [provided by RefSeq, Jul 2008] | 15 | 38488103 | 38564814 | Human | 265 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1321350 | DIRAS1 | DIRAS family GTPase 1 | DIRAS1 belongs to a distinct branch of the functionally diverse Ras (see HRAS; MIM 190020) superfamily of monomeric GTPases.[supplied by OMIM, Apr 2004] | 19 | 2714567 | 2721372 | Human | 73 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1313693 | DIRAS2 | DIRAS family GTPase 2 | DIRAS2 belongs to a distinct branch of the functionally diverse Ras (see HRAS; MIM 190020) superfamily of monomeric GTPases.[supplied by OMIM, Apr 2004] | 9 | 90609832 | 90642824 | Human | 81 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 735722 | RAB10 | RAB10, member RAS oncogene family | RAB10 belongs to the RAS (see HRAS; MIM 190020) superfamily of small GTPases. RAB proteins localize to exocytic and endocytic compartments and regulate intracellular vesicle trafficking (Bao et al., 1998 [PubMed 9918381]).[supplied by OMIM, Mar 2009] | 2 | 26033285 | 26137454 | Human | 193 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 737281 | RALBP1 | ralA binding protein 1 | RALBP1 plays a role in receptor-mediated endocytosis and is a downstream effector of the small GTP-binding protein RAL (see RALA; MIM 179550). Small G proteins, such as RAL, have GDP-bound inactive and GTP-bound active forms, which shift from the inactive to the active state through the action of RA LGDS (MIM 601619), which in turn is activated by RAS (see HRAS; MIM 190020) (summary by Feig, 2003 [PubMed 12888294]).[supplied by OMIM, Nov 2010] | 18 | 9475009 | 9538114 | Human | 180 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1315047 | RAPGEF2 | Rap guanine nucleotide exchange factor 2 | Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF2, serve as RAS a ctivators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008] | 4 | 159103079 | 159360173 | Human | 218 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1343059 | RAPGEF5 | Rap guanine nucleotide exchange factor 5 | Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF5, serve as RAS a ctivators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008] | 7 | 22118236 | 22357154 | Human | 114 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1312152 | RASGRP3 | RAS guanyl releasing protein 3 | The protein encoded by this gene is a guanine nucleotide exchange factor that activates the oncogenes HRAS and RAP1A. Defects in this gene have been associated with systemic lupus erythematosus and several cancers. [provided by RefSeq, Mar 2017] | 2 | 33436348 | 33564731 | Human | 142 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1316971 | RIT2 | Ras like without CAAX 2 | RIN belongs to the RAS (HRAS; MIM 190020) superfamily of small GTPases (Shao et al., 1999 [PubMed 10545207]).[supplied by OMIM, Mar 2008] | 18 | 42743227 | 43115685 | Human | 109 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1348132 | ZDHHC9 | zDHHC palmitoyltransferase 9 | This gene encodes an integral membrane protein that is a member of the zinc finger DHHC domain-containing protein family. The encoded protein forms a complex with golgin subfamily A member 7 and functions as a palmitoyltransferase. This protein specifically palmitoylates HRAS ;'>HRAS and NRAS. Mutations in this gene are associated with X-linked cognitive disability. Alternate splicing results in multiple transcript variants that encode the same protein.[provided by RefSeq, May 2010] | X | 129803288 | 129843886 | Human | 172 | description | gene, protein-coding, REVIEWED [RefSeq] |