Eras (ES cell-expressed Ras) - Rat Genome Database

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Gene: Eras (ES cell-expressed Ras) Mus musculus
Analyze
Symbol: Eras
Name: ES cell-expressed Ras
RGD ID: 1556987
MGI Page MGI
Description: Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Predicted to be involved in Ras protein signal transduction. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including blastocyst; early embryo; embryo ectoderm; gut; and hemolymphoid system gland. Orthologous to human ERAS (ES cell expressed Ras).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: E-Ras; ecat; ecat5; embryonic stem cell-expressed Ras; GTPase ERas; H; Ha-; Ha-Ras2; HR; HRAS2; HRasp; small GTPase E-Ras
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X7,790,515 - 7,794,846 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX7,790,515 - 7,794,846 (-)EnsemblGRCm39 Ensembl
GRCm38X7,924,276 - 7,928,607 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX7,924,276 - 7,928,607 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X7,501,402 - 7,505,733 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X7,081,235 - 7,085,566 (-)NCBIMGSCv36mm8
CeleraX3,540,725 - 3,545,056 (+)NCBICelera
Cytogenetic MapXA1.1NCBI
cM MapX3.58NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:12774123   PMID:12787504   PMID:14610273   PMID:16046393   PMID:16141072   PMID:16141073  
PMID:17967808   PMID:18174262   PMID:18799693   PMID:19266163   PMID:20007774   PMID:21267068   PMID:21731673   PMID:21873635   PMID:23765875   PMID:26269429   PMID:28117393   PMID:30158566  
PMID:31143371  


Genomics

Comparative Map Data
Eras
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X7,790,515 - 7,794,846 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX7,790,515 - 7,794,846 (-)EnsemblGRCm39 Ensembl
GRCm38X7,924,276 - 7,928,607 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX7,924,276 - 7,928,607 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X7,501,402 - 7,505,733 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X7,081,235 - 7,085,566 (-)NCBIMGSCv36mm8
CeleraX3,540,725 - 3,545,056 (+)NCBICelera
Cytogenetic MapXA1.1NCBI
cM MapX3.58NCBI
ERAS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X48,826,513 - 48,829,869 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX48,826,513 - 48,830,138 (+)EnsemblGRCh38hg38GRCh38
GRCh37X48,684,923 - 48,688,279 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X48,572,227 - 48,573,492 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X48,443,531 - 48,444,797NCBI
CeleraX52,974,981 - 52,976,246 (-)NCBICelera
Cytogenetic MapXp11.23NCBI
HuRefX46,344,561 - 46,347,994 (+)NCBIHuRef
CHM1_1X48,716,067 - 48,719,421 (+)NCBICHM1_1
T2T-CHM13v2.0X48,237,009 - 48,240,364 (+)NCBIT2T-CHM13v2.0
Eras
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X17,245,915 - 17,250,301 (+)NCBIGRCr8
mRatBN7.2X14,573,987 - 14,578,455 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX14,573,987 - 14,578,374 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX19,387,537 - 19,391,924 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X20,691,188 - 20,695,575 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X16,956,357 - 16,960,744 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X15,318,215 - 15,322,601 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX15,321,713 - 15,322,396 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 EnsemblX15,419,028 - 15,423,414 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X16,098,270 - 16,102,842 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X26,608,537 - 26,612,923 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX14,658,743 - 14,663,129 (+)NCBICelera
Cytogenetic MapXq12NCBI
Eras
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955543381,756 - 383,093 (+)NCBIChiLan1.0ChiLan1.0
ERAS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X50,317,880 - 50,319,208 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X50,321,353 - 50,322,574 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X41,125,895 - 41,127,757 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X48,984,189 - 48,987,653 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX48,986,812 - 48,987,513 (+)Ensemblpanpan1.1panPan2
ERAS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X42,024,867 - 42,029,649 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX42,028,711 - 42,029,412 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX16,401,245 - 16,405,081 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X42,162,000 - 42,165,837 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX42,164,899 - 42,165,600 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X42,148,247 - 42,152,082 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X42,136,523 - 42,140,359 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X42,230,679 - 42,234,515 (+)NCBIUU_Cfam_GSD_1.0
Eras
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X34,539,541 - 34,543,018 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936721782,525 - 783,208 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936721782,343 - 783,591 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ERAS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX42,941,664 - 42,946,524 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X42,942,033 - 42,946,715 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X47,883,777 - 47,888,037 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ERAS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X45,955,444 - 45,957,170 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX45,955,803 - 45,956,504 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607611,434,706 - 11,436,678 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Eras
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624893631,033 - 632,244 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Eras
86 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:59
Count of miRNA genes:54
Interacting mature miRNAs:58
Transcripts:ENSMUST00000033500
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302195Pbwg10_mpostnatal body weight growth 10 (mouse)Not determinedX126202173Mouse
1357433Dbts2_mdiabetes 2 (mouse)Not determinedX7226295150107038Mouse

Markers in Region
AF006603  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X7,930,290 - 7,930,393UniSTSGRCm38
MGSCv37X7,507,416 - 7,507,519UniSTSGRCm37
CeleraX3,538,938 - 3,539,041UniSTS
Cytogenetic MapXA1.1UniSTS
Whitehead/MRC_RHX39.85UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000033500   ⟹   ENSMUSP00000033500
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX7,790,515 - 7,794,846 (-)Ensembl
GRCm38.p6 EnsemblX7,924,276 - 7,928,607 (-)Ensembl
RefSeq Acc Id: NM_181548   ⟹   NP_853526
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X7,790,515 - 7,794,846 (-)NCBI
GRCm38X7,924,276 - 7,928,607 (-)NCBI
MGSCv37X7,501,402 - 7,505,733 (-)RGD
CeleraX3,540,725 - 3,545,056 (+)RGD
cM MapX ENTREZGENE
Sequence:
RefSeq Acc Id: NP_853526   ⟸   NM_181548
- UniProtKB: Q7TN89 (UniProtKB/Swiss-Prot),   Q0VEC9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000033500   ⟸   ENSMUST00000033500

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q7TN89-F1-model_v2 AlphaFold Q7TN89 1-227 view protein structure

Promoters
RGD ID:6845681
Promoter ID:MM_KWN:59457
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:ES_Cell
Transcripts:NM_181548
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36X7,505,076 - 7,505,576 (-)MPROMDB
RGD ID:13680014
Promoter ID:EPDNEW_M24156
Type:multiple initiation site
Name:Eras_1
Description:Mus musculus ES cell-expressed Ras , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38X7,928,515 - 7,928,575EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2665023 AgrOrtholog
Ensembl Genes ENSMUSG00000031160 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000033500 ENTREZGENE
  ENSMUST00000033500.5 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTP-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTPase_Ras-type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:353283 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:2665023 ENTREZGENE
NCBI Gene 353283 ENTREZGENE
PANTHER GTPASE ERAS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR24070 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ras UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Eras PhenoGen
PRINTS RASTRNSFRMNG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE RAB UniProtKB/TrEMBL
  RAS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART RAB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RAS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RHO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt Q0VEC9 ENTREZGENE, UniProtKB/TrEMBL
  Q7TN89 ENTREZGENE, UniProtKB/Swiss-Prot