| 1348155 | EDA | ectodysplasin A | The protein encoded by this gene is a type II membrane protein that can be cleaved by furin to produce a secreted form. The encoded protein, which belongs to the tumor necrosis factor family, acts as a homotrimer and may be involved in cell-cell signaling during the development of ectodermal organs. Defects in this gene are a cause of ectodermal dysplasia, anhidrotic, which is also known as X-linked hypohidrotic ectodermal dysplasia. Several transcript variants encoding many different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] | X | 69616113 | 70039472 | Human | 395 | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1557590 | Eda | ectodysplasin-A | Predicted to enable cytokine activity; death receptor agonist activity; and death receptor binding activity. Acts upstream of or within several processes, including hair follicle placode formation; positive regulation of signal transduction; and trachea gland development. Located in apical part of c ell; endoplasmic reticulum membrane; and plasma membrane. Is expressed in several structures, including embryo ectoderm; exocrine system; facial prominence; nasal gland epithelium; and oral region epithelium. Used to study hypohidrotic ectodermal dysplasia. Human ortholog(s) of this gene implicated in ectodermal dysplasia 1 and tooth agenesis. Orthologous to human EDA (ectodysplasin A). [provided by Alliance of Genome Resources, Jul 2025] | X | 99019212 | 99444366 | Mouse | 286 | symbol , old_gene_name , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1563178 | Eda | ectodysplasin-A | ENCODES a protein that exhibits cytokine activity (ortholog); death receptor agonist activity (ortholog); death receptor binding (ortholog); INVOLVED IN cell-matrix adhesion (ortholog); cytokine-mediated signaling pathway (ortholog); gene expression (ortholog); PARTICIPATES IN cytokine mediated sign aling pathway; ASSOCIATED WITH anodontia (ortholog); Clouston syndrome (ortholog); craniofrontonasal syndrome (ortholog); FOUND IN apical part of cell (ortholog); endoplasmic reticulum membrane (ortholog); plasma membrane (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acetamide | X | 69118577 | 69520274 | Rat | 130 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 8916256 | Eda | ectodysplasin A | ENCODES a protein that exhibits cytokine activity (ortholog); death receptor agonist activity (ortholog); death receptor binding (ortholog); INVOLVED IN cell-matrix adhesion (ortholog); cytokine-mediated signaling pathway (ortholog); gene expression (ortholog); ASSOCIATED WITH anodontia (ortholog); Clouston syndrome (ortholog); craniofrontonasal syndrome (ortholog); FOUND IN apical part of cell (ortholog); endoplasmic reticulum membrane (ortholog); plasma membrane (ortholog) | NW_004955475 | 9177911 | 9592150 | Chinchilla | 49 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11736349 | EDA | ectodysplasin A | ENCODES a protein that exhibits cytokine activity (ortholog); death receptor agonist activity (ortholog); death receptor binding (ortholog); INVOLVED IN cell-matrix adhesion (ortholog); cytokine-mediated signaling pathway (ortholog); gene expression (ortholog); ASSOCIATED WITH anodontia (ortholog); Clouston syndrome (ortholog); craniofrontonasal syndrome (ortholog); FOUND IN apical part of cell (ortholog); endoplasmic reticulum membrane (ortholog); plasma membrane (ortholog) | X | 58881660 | 59308451 | Bonobo | 49 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12147212 | EDA | ectodysplasin A | ENCODES a protein that exhibits death receptor agonist activity (ortholog); death receptor binding (ortholog); INVOLVED IN cell-matrix adhesion (ortholog); gene expression (ortholog); hair follicle development (ortholog); ASSOCIATED WITH Clouston syndrome; anodontia (ortholog); craniofrontonasal syn drome (ortholog); FOUND IN apical part of cell (inferred); endoplasmic reticulum membrane (inferred); extracellular region (inferred) | X | 54078694 | 54515535 | Dog | 65 | symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 12621844 | Eda | ectodysplasin A | ENCODES a protein that exhibits cytokine activity (inferred); death receptor agonist activity (inferred); death receptor binding (inferred); INVOLVED IN cell-matrix adhesion (ortholog); gene expression (ortholog); hair follicle development (ortholog); ASSOCIATED WITH anodontia (ortholog); Clouston s yndrome (ortholog); craniofrontonasal syndrome (ortholog); FOUND IN apical part of cell (inferred); endoplasmic reticulum membrane (inferred); extracellular region (inferred) | NW_004936777 | 1545293 | 1561109 | Squirrel | 63 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13873993 | EDA | ectodysplasin A | ENCODES a protein that exhibits death receptor agonist activity (ortholog); death receptor binding (ortholog); INVOLVED IN cell-matrix adhesion (ortholog); gene expression (ortholog); hair follicle development (ortholog); ASSOCIATED WITH anodontia (ortholog); Clouston syndrome (ortholog); craniofron tonasal syndrome (ortholog); FOUND IN apical part of cell (inferred); endoplasmic reticulum membrane (inferred); extracellular region (inferred) | | | | Pig | 65 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18435621 | EDA | ectodysplasin A | ENCODES a protein that exhibits cytokine activity (ortholog); death receptor agonist activity (ortholog); death receptor binding (ortholog); INVOLVED IN cell-matrix adhesion (ortholog); cytokine-mediated signaling pathway (ortholog); gene expression (ortholog); ASSOCIATED WITH anodontia (ortholog); Clouston syndrome (ortholog); craniofrontonasal syndrome (ortholog); FOUND IN apical part of cell (ortholog); endoplasmic reticulum membrane (ortholog); plasma membrane (ortholog) | | | | Green Monkey | 49 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18915510 | Eda | ectodysplasin A | ENCODES a protein that exhibits signaling receptor binding (ortholog); INVOLVED IN cell-matrix adhesion (ortholog); cytokine-mediated signaling pathway (ortholog); gene expression (ortholog); ASSOCIATED WITH anodontia (ortholog); Clouston syndrome (ortholog); craniofrontonasal syndrome (ortholog); F OUND IN apical part of cell (ortholog); endoplasmic reticulum membrane (ortholog) | | | | Naked Mole-Rat | 59 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 20866794 | EDA | ectodysplasin A | ENCODES a protein that exhibits cytokine activity (inferred); death receptor agonist activity (inferred); death receptor binding (inferred); INVOLVED IN animal organ development (inferred); cell differentiation (inferred); cell surface receptor signaling pathway (inferred); FOUND IN apical part of c ell (inferred); endoplasmic reticulum membrane (inferred); extracellular region (inferred) | | | | Green Monkey | 27 | symbol | gene, protein-coding |
| 286404835 | eda | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625922669 | Eda | ectodysplasin A | ENCODES a protein that exhibits cytokine activity (ortholog); death receptor agonist activity (ortholog); death receptor binding (ortholog); INVOLVED IN cell-matrix adhesion (ortholog); cytokine-mediated signaling pathway (ortholog); gene expression (ortholog); ASSOCIATED WITH anodontia (ortholog); Clouston syndrome (ortholog); craniofrontonasal syndrome (ortholog); FOUND IN apical part of cell (ortholog); endoplasmic reticulum membrane (ortholog); plasma membrane (ortholog) | | | | Black Rat | 50 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 405857164 | eda.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405860458 | eda.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405860520 | eda.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405862086 | eda.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 626468243 | eda.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 626468335 | eda.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 626468452 | eda.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405859351 | eda.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405861522 | eda.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405861603 | eda.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405865412 | eda.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 626468403 | eda.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1332378 | Hemgn | hemogen | Predicted to be involved in regulation of osteoblast differentiation. Located in nucleoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and liver. Orthologous to human HEMGN (hemogen). [provided by Alliance of Genome Resources, Jul 2025] | 4 | 46393989 | 46404183 | Mouse | 59 | old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1344270 | EDA2R | ectodysplasin A2 receptor | The protein encoded by this gene is a type III transmembrane protein of the TNFR (tumor necrosis factor receptor) superfamily, and contains cysteine-rich repeats and a single transmembrane domain. This protein binds to the EDA-A2 isoform of ectodysplasin, which plays an important role in maintenance of hair and teeth. Alternatively spliced transcript variants encodes distinct protein isoforms. [provided by RefSeq, Apr 2016] | X | 66595637 | 66639269 | Human | 129 | symbol , old_gene_name , COSMIC , description , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1344202 | EDAR | ectodysplasin A receptor | This gene encodes a member of the tumor necrosis factor receptor family. The encoded transmembrane protein is a receptor for the soluble ligand ectodysplasin A, and can activate the nuclear factor-kappaB, JNK, and caspase-independent cell death pathways. It is required for the development of hair, t eeth, and other ectodermal derivatives. Mutations in this gene result in autosomal dominant and recessive forms of hypohidrotic ectodermal dysplasia. [provided by RefSeq, Jul 2008] | 2 | 108894471 | 108989220 | Human | 134 | symbol , old_gene_name , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1557662 | Edar | ectodysplasin-A receptor | Enables signaling receptor activity. Involved in cytokine-mediated signaling pathway and positive regulation of canonical NF-kappaB signal transduction. Acts upstream of or within several processes, including hair follicle development; positive regulation of non-canonical NF-kappaB signal transducti on; and salivary gland cavitation. Located in apical part of cell and plasma membrane. Is expressed in several structures, including embryo ectoderm; integumental system; male accessory gland; sensory organ; and tooth. Used to study hypohidrotic ectodermal dysplasia. Human ortholog(s) of this gene implicated in ectodermal dysplasia 10A and ectodermal dysplasia 10B. Orthologous to human EDAR (ectodysplasin A receptor). [provided by Alliance of Genome Resources, Jul 2025] | 10 | 58436602 | 58511518 | Mouse | 169 | symbol , old_gene_name , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 16571219 | AL158141.1 | novel transcript, antisense to EDA | | | | | Human | | name | gene, lncrna |
| 1557218 | Eda2r | ectodysplasin A2 receptor | Predicted to enable transmembrane signaling receptor activity. Acts upstream of or within intrinsic apoptotic signaling pathway by p53 class mediator. Predicted to be active in plasma membrane. Is expressed in several structures, including adrenal gland; genitourinary system; gut; hemolymphoid syste m gland; and integumental system. Orthologous to human EDA2R (ectodysplasin A2 receptor). [provided by Alliance of Genome Resources, Apr 2025] | X | 96375936 | 96420786 | Mouse | 120 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1564025 | Eda2r | ectodysplasin A2 receptor | ENCODES a protein that exhibits transmembrane signaling receptor activity (ortholog); INVOLVED IN cytokine-mediated signaling pathway (ortholog); intrinsic apoptotic signaling pathway by p53 class mediator (ortholog); positive regulation of canonical NF-kappaB signal transduction (ortholog); PARTICI PATES IN cytokine mediated signaling pathway; ASSOCIATED WITH anodontia (ortholog); ectodermal dysplasia 1 (ortholog); tooth agenesis (ortholog); FOUND IN plasma membrane (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B1; bisphenol A | X | 66225557 | 66280674 | Rat | 112 | symbol , old_gene_name , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1561714 | Edar | ectodysplasin-A receptor | ENCODES a protein that exhibits signaling receptor activity (ortholog); transmembrane signaling receptor activity (ortholog); INVOLVED IN cytokine-mediated signaling pathway (ortholog); hair follicle development (ortholog); odontogenesis of dentin-containing tooth (ortholog); PARTICIPATES IN cytokin e mediated signaling pathway; ASSOCIATED WITH anodontia (ortholog); ectodermal dysplasia (ortholog); ectodermal dysplasia 10A (ortholog); FOUND IN apical part of cell (ortholog); plasma membrane (ortholog); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 6-propyl-2-thiouracil | 20 | 27130934 | 27209672 | Rat | 94 | symbol , old_gene_name , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 8811959 | Edar | ectodysplasin A receptor | ENCODES a protein that exhibits signaling receptor activity (ortholog); transmembrane signaling receptor activity (ortholog); INVOLVED IN cytokine-mediated signaling pathway (ortholog); hair follicle development (ortholog); odontogenesis of dentin-containing tooth (ortholog); ASSOCIATED WITH anodont ia (ortholog); ectodermal dysplasia (ortholog); ectodermal dysplasia 10A (ortholog); FOUND IN apical part of cell (ortholog); plasma membrane (ortholog) | NW_004955470 | 12310680 | 12362555 | Chinchilla | 24 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 11801462 | EDAR | ectodysplasin A receptor | ENCODES a protein that exhibits signaling receptor activity (inferred); transmembrane signaling receptor activity (inferred); INVOLVED IN hair follicle development (ortholog); odontogenesis of dentin-containing tooth (ortholog); pigmentation (ortholog); ASSOCIATED WITH anodontia (ortholog); ectoderm al dysplasia (ortholog); ectodermal dysplasia 10A (ortholog); FOUND IN apical part of cell (inferred); membrane (inferred); plasma membrane (inferred) | 2A | 95132396 | 95172218 | Bonobo | 36 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12232627 | EDAR | ectodysplasin A receptor | ENCODES a protein that exhibits signaling receptor activity (inferred); transmembrane signaling receptor activity (inferred); INVOLVED IN hair follicle development (ortholog); odontogenesis of dentin-containing tooth (ortholog); pigmentation (ortholog); ASSOCIATED WITH anodontia (ortholog); ectoderm al dysplasia (ortholog); ectodermal dysplasia 10A (ortholog); FOUND IN apical part of cell (inferred); membrane (inferred); plasma membrane (inferred) | 10 | 34873311 | 34943140 | Dog | 36 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12691688 | Edar | ectodysplasin A receptor | ENCODES a protein that exhibits signaling receptor activity (inferred); transmembrane signaling receptor activity (inferred); INVOLVED IN hair follicle development (ortholog); odontogenesis of dentin-containing tooth (ortholog); pigmentation (ortholog); ASSOCIATED WITH anodontia (ortholog); ectoderm al dysplasia (ortholog); ectodermal dysplasia 10A (ortholog); FOUND IN apical part of cell (inferred); membrane (inferred); plasma membrane (inferred) | NW_004936829 | 429667 | 458943 | Squirrel | 36 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 13842957 | EDAR | ectodysplasin A receptor | ENCODES a protein that exhibits signaling receptor activity (inferred); transmembrane signaling receptor activity (inferred); INVOLVED IN hair follicle development (ortholog); odontogenesis of dentin-containing tooth (ortholog); pigmentation (ortholog); ASSOCIATED WITH anodontia (ortholog); ectoderm al dysplasia (ortholog); ectodermal dysplasia 10A (ortholog); FOUND IN apical part of cell (inferred); membrane (inferred); plasma membrane (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 37 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18436275 | EDAR | ectodysplasin A receptor | ENCODES a protein that exhibits signaling receptor activity (inferred); transmembrane signaling receptor activity (inferred); INVOLVED IN hair follicle development (ortholog); odontogenesis of dentin-containing tooth (ortholog); pigmentation (ortholog); ASSOCIATED WITH anodontia (ortholog); ectoderm al dysplasia (ortholog); ectodermal dysplasia 10A (ortholog); FOUND IN apical part of cell (inferred); membrane (inferred); plasma membrane (inferred) | | | | Green Monkey | 36 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18934885 | Edar | ectodysplasin A receptor | ENCODES a protein that exhibits transmembrane signaling receptor activity (ortholog); INVOLVED IN hair follicle development (ortholog); odontogenesis of dentin-containing tooth (ortholog); pigmentation (ortholog); ASSOCIATED WITH anodontia (ortholog); ectodermal dysplasia (ortholog); ectodermal dysp lasia 10A (ortholog); FOUND IN apical part of cell (ortholog) | | | | Naked Mole-Rat | 33 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 155233194 | edar | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626095568 | Edar | ectodysplasin A receptor | ENCODES a protein that exhibits signaling receptor activity (ortholog); transmembrane signaling receptor activity (ortholog); INVOLVED IN cytokine-mediated signaling pathway (ortholog); hair follicle development (ortholog); odontogenesis of dentin-containing tooth (ortholog); ASSOCIATED WITH anodont ia (ortholog); ectodermal dysplasia 10A (ortholog); ectodermal dysplasia 10B (ortholog); FOUND IN apical part of cell (ortholog); plasma membrane (ortholog) | | | | Black Rat | 23 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 8987674 | Eda2r | ectodysplasin A2 receptor | ENCODES a protein that exhibits transmembrane signaling receptor activity (ortholog); INVOLVED IN cytokine-mediated signaling pathway (ortholog); intrinsic apoptotic signaling pathway by p53 class mediator (ortholog); positive regulation of canonical NF-kappaB signal transduction (ortholog); ASSOCIA TED WITH anodontia (ortholog); ectodermal dysplasia 1 (ortholog); tooth agenesis (ortholog); FOUND IN plasma membrane (ortholog) | NW_004955475 | 6080153 | 6143339 | Chinchilla | 13 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11703671 | EDA2R | ectodysplasin A2 receptor | ENCODES a protein that exhibits signaling receptor activity (inferred); transmembrane signaling receptor activity (inferred); tumor necrosis factor receptor activity (inferred); INVOLVED IN intrinsic apoptotic signaling pathway by p53 class mediator (ortholog); ASSOCIATED WITH anodontia (ortholog); ectodermal dysplasia 1 (ortholog); tooth agenesis (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred) | X | 55786361 | 55830798 | Bonobo | 24 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12575892 | Eda2r | ectodysplasin A2 receptor | ENCODES a protein that exhibits signaling receptor activity (inferred); transmembrane signaling receptor activity (inferred); tumor necrosis factor receptor activity (inferred); INVOLVED IN intrinsic apoptotic signaling pathway by p53 class mediator (ortholog); ASSOCIATED WITH anodontia (ortholog); ectodermal dysplasia 1 (ortholog); tooth agenesis (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred) | NW_004936635 | 1303855 | 1335766 | Squirrel | 24 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14248004 | EDA2R | ectodysplasin A2 receptor | ENCODES a protein that exhibits transmembrane signaling receptor activity (ortholog); INVOLVED IN cytokine-mediated signaling pathway (ortholog); intrinsic apoptotic signaling pathway by p53 class mediator (ortholog); positive regulation of canonical NF-kappaB signal transduction (ortholog); ASSOCIA TED WITH anodontia (ortholog); ectodermal dysplasia 1 (ortholog); tooth agenesis (ortholog); FOUND IN plasma membrane (ortholog) | | | | Pig | 13 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18392646 | EDA2R | ectodysplasin A2 receptor | ENCODES a protein that exhibits signaling receptor activity (inferred); transmembrane signaling receptor activity (inferred); tumor necrosis factor receptor activity (inferred); INVOLVED IN intrinsic apoptotic signaling pathway by p53 class mediator (ortholog); ASSOCIATED WITH anodontia (ortholog); ectodermal dysplasia 1 (ortholog); tooth agenesis (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred) | | | | Green Monkey | 24 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18919721 | Eda2r | ectodysplasin A2 receptor | ENCODES a protein that exhibits transmembrane signaling receptor activity (ortholog); INVOLVED IN cytokine-mediated signaling pathway (ortholog); intrinsic apoptotic signaling pathway by p53 class mediator (ortholog); ASSOCIATED WITH anodontia (ortholog); ectodermal dysplasia 1 (ortholog); tooth age nesis (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred) | | | | Naked Mole-Rat | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 286681048 | eda2r | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625883520 | Eda2r | ectodysplasin A2 receptor | ENCODES a protein that exhibits transmembrane signaling receptor activity (ortholog); INVOLVED IN cytokine-mediated signaling pathway (ortholog); intrinsic apoptotic signaling pathway by p53 class mediator (ortholog); positive regulation of canonical NF-kappaB signal transduction (ortholog); ASSOCIA TED WITH anodontia (ortholog); ectodermal dysplasia 1 (ortholog); tooth agenesis (ortholog); FOUND IN plasma membrane (ortholog) | | | | Black Rat | 13 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155247578 | edar.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155242528 | edar.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 286681748 | eda2r.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 1351297 | EDARADD | EDAR associated via death domain | This gene was identified by its association with ectodermal dysplasia, a genetic disorder characterized by defective development of hair, teeth, and eccrine sweat glands. The protein encoded by this gene is a death domain-containing protein, and is found to interact with EDA ;'>EDAR, a death domain receptor known to be required for the development of hair, teeth and other ectodermal derivatives. This protein and EDAR are coexpressed in epithelial cells during the formation of hair follicles and teeth. Through its interaction with EDAR, this protein acts as an adaptor, and links the receptor to downstream signaling pathways. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] | 1 | 236348259 | 236484930 | Human | 239 | symbol , old_gene_name , COSMIC , name , description , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1558198 | Edaradd | EDAR associated via death domain | Predicted to enable death receptor binding activity. Acts upstream of or within hair follicle development; odontogenesis of dentin-containing tooth; and trachea gland development. Predicted to be located in cytoplasm. Is expressed in several structures, including alimentary system; metanephros; nari s; skin; and ureter. Human ortholog(s) of this gene implicated in ectodermal dysplasia 11A and ectodermal dysplasia 11B. Orthologous to human EDARADD (EDAR associated via death domain). [provided by Alliance of Genome Resources, Jul 2025] | 13 | 12486090 | 12535413 | Mouse | 146 | symbol , old_gene_name , PhenoGen , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1564010 | Edaradd | EDAR associated via death domain | INVOLVED IN positive regulation of non-canonical NF-kappaB signal transduction; hair follicle development (ortholog); odontogenesis of dentin-containing tooth (ortholog); ASSOCIATED WITH abnormal awl hair morphology; abnormal hair texture; abnormal mammary gland alveolus morphology; ASSOCIATED WITH hypohidrotic ectodermal dysplasia; otitis media; ectodermal dysplasia (ortholog); FOUND IN cytoplasm (inferred); INTERACTS WITH 17beta-estradiol; bisphenol A; 1,2-dimethylhydrazine (ortholog) | 17 | 92850791 | 92894808 | Rat | 81 | symbol , old_gene_name , PhenoGen , name | gene, protein-coding, VALIDATED [RefSeq] |
| 8928726 | Edaradd | EDAR associated via death domain | INVOLVED IN hair follicle development (ortholog); odontogenesis of dentin-containing tooth (ortholog); positive regulation of non-canonical NF-kappaB signal transduction (ortholog); ASSOCIATED WITH ectodermal dysplasia (ortholog); ectodermal dysplasia 10A (ortholog); ectodermal dysplasia 10B (orthol og) | NW_004955492 | 3709819 | 3777506 | Chinchilla | 19 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 11696464 | EDARADD | EDAR associated via death domain | INVOLVED IN hair follicle development (ortholog); odontogenesis of dentin-containing tooth (ortholog); positive regulation of non-canonical NF-kappaB signal transduction (ortholog); ASSOCIATED WITH ectodermal dysplasia (ortholog); ectodermal dysplasia 10A (ortholog); ectodermal dysplasia 10B (orthol og); FOUND IN cytoplasm (inferred) | 1 | 211973108 | 212043142 | Bonobo | 22 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12106137 | EDARADD | EDAR associated death domain | INVOLVED IN hair follicle development (ortholog); odontogenesis of dentin-containing tooth (ortholog); positive regulation of non-canonical NF-kappaB signal transduction (ortholog); ASSOCIATED WITH ectodermal dysplasia (ortholog); ectodermal dysplasia 10A (ortholog); ectodermal dysplasia 10B (orthol og); FOUND IN cytoplasm (inferred) | 4 | 3608545 | 3659357 | Dog | 22 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 12448215 | Edaradd | EDAR associated via death domain | INVOLVED IN hair follicle development (ortholog); odontogenesis of dentin-containing tooth (ortholog); positive regulation of non-canonical NF-kappaB signal transduction (ortholog); ASSOCIATED WITH ectodermal dysplasia (ortholog); ectodermal dysplasia 10A (ortholog); ectodermal dysplasia 10B (orthol og); FOUND IN cytoplasm (inferred) | NW_004936484 | 16394753 | 16446102 | Squirrel | 22 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 14260764 | EDARADD | EDAR associated death domain | INVOLVED IN hair follicle development (ortholog); odontogenesis of dentin-containing tooth (ortholog); positive regulation of non-canonical NF-kappaB signal transduction (ortholog); ASSOCIATED WITH ectodermal dysplasia (ortholog); ectodermal dysplasia 10A (ortholog); ectodermal dysplasia 10B (orthol og); FOUND IN cytoplasm (inferred) | | | | Pig | 22 | symbol , name | gene, protein-coding, VALIDATED [RefSeq] |
| 18733119 | EDARADD | EDAR associated via death domain | INVOLVED IN hair follicle development (ortholog); odontogenesis of dentin-containing tooth (ortholog); positive regulation of non-canonical NF-kappaB signal transduction (ortholog); ASSOCIATED WITH ectodermal dysplasia (ortholog); ectodermal dysplasia 10A (ortholog); ectodermal dysplasia 10B (orthol og); FOUND IN cytoplasm (inferred) | | | | Green Monkey | 22 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18921637 | Edaradd | EDAR associated via death domain | INVOLVED IN hair follicle development (ortholog); odontogenesis of dentin-containing tooth (ortholog); positive regulation of non-canonical NF-kappaB signal transduction (ortholog); ASSOCIATED WITH ectodermal dysplasia (ortholog); ectodermal dysplasia 10A (ortholog); ectodermal dysplasia 10B (orthol og); FOUND IN cytoplasm (inferred) | | | | Naked Mole-Rat | 22 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 284812906 | edaradd | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625936109 | Edaradd | EDAR associated via death domain | INVOLVED IN hair follicle development (ortholog); odontogenesis of dentin-containing tooth (ortholog); positive regulation of non-canonical NF-kappaB signal transduction (ortholog); ASSOCIATED WITH ectodermal dysplasia (ortholog); ectodermal dysplasia 10A (ortholog); ectodermal dysplasia 10B (orthol og) | | | | Black Rat | 18 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 284673953 | edaradd.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 628359631 | edaradd.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 14398765 | EdaraddswhKyo | EDAR-associated death domain;swh Kyo mutant | ASSOCIATED WITH abnormal awl hair morphology; abnormal hair texture; abnormal mammary gland alveolus morphology; ASSOCIATED WITH hypohidrotic ectodermal dysplasia | | | | Rat | 16 | symbol , name , description | gene, allele |
| 1351335 | HEMGN | hemogen | Predicted to be involved in regulation of osteoblast differentiation. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025] | 9 | 97926791 | 97944852 | Human | 49 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 621569 | Hemgn | hemogen | INVOLVED IN regulation of osteoblast differentiation; ASSOCIATED WITH nephronophthisis (ortholog); FOUND IN nucleoplasm (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; ammonium chloride | 5 | 65475228 | 65495384 | Rat | 50 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1347094 | IKBKG | inhibitor of nuclear factor kappa B kinase regulatory subunit gamma | This gene encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome. [provided by RefSeq, Mar 2016] | X | 154541238 | 154565046 | Human | 551 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 735440 | NFKBIA | NFKB inhibitor alpha | This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease. [provided by RefSeq, Aug 2011] | 14 | 35401513 | 35404749 | Human | 1843 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1318163 | UBE2V2 | ubiquitin conjugating enzyme E2 V2 | Ubiquitin-conjugating enzyme E2 variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene also shares homology with ubiquitin-conjugating enzyme E2 variant 1 and yeast MMS2 gene product. It may be involved in the differentiation of monocytes and enterocytes. [provided by RefSeq, Jul 2008] | 8 | 47997437 | 48064708 | Human | 104 | old_gene_name , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 12215478 | SELP | selectin P | ENCODES a protein that exhibits calcium ion binding (inferred); calcium-dependent protein binding (inferred); carbohydrate binding (inferred); INVOLVED IN cell-cell adhesion (ortholog); heterophilic cell-cell adhesion (ortholog); inflammatory response (ortholog); PARTICIPATES IN interleukin-4 signal ing pathway; ASSOCIATED WITH acute necrotizing pancreatitis (ortholog); allergic disease (ortholog); Alzheimer's disease (ortholog); FOUND IN external side of plasma membrane (ortholog); extracellular space (ortholog); INTERACTS WITH edaravone; Thrombin | 7 | 28956428 | 28997266 | Dog | 114 | description | gene, protein-coding, VALIDATED [RefSeq] |
