Edaradd (EDAR associated via death domain) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Edaradd (EDAR associated via death domain) Rattus norvegicus
Analyze
Symbol: Edaradd
Name: EDAR associated via death domain (Ensembl:EDAR-associated death domain)
RGD ID: 1564010
Description: Involved in positive regulation of non-canonical NF-kappaB signal transduction. Used to study hypohidrotic ectodermal dysplasia and otitis media. Human ortholog(s) of this gene implicated in ectodermal dysplasia 11A and ectodermal dysplasia 11B. Orthologous to human EDARADD (EDAR associated via death domain); INTERACTS WITH 17beta-estradiol; bisphenol A; 1,2-dimethylhydrazine (ortholog).
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ectodysplasin-A receptor-associated adapter protein; EDAR (ectodysplasin-A receptor)-associated death domain; EDAR-associated death domain; LOC498769; RGD1564010; similar to crinkled
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: EdaraddswhKyo  
Genetic Models: WTC-swh/Kyo
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81792,850,791 - 92,894,808 (-)NCBIGRCr8
mRatBN7.21785,866,629 - 85,910,612 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1785,656,905 - 85,910,447 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01790,802,280 - 90,843,476 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1790,802,393 - 90,843,485 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01792,462,305 - 92,503,399 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41767,056,373 - 67,143,933 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1785,700,726 - 85,744,668 (+)NCBICelera
Cytogenetic Map17q12.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Role of ectodysplasin signalling in middle ear and nasal pathology in rat and mouse models of hypohidrotic ectodermal dysplasia. Del-Pozo J, etal., Dis Model Mech. 2019 Apr 25;12(4). pii: 12/4/dmm037804. doi: 10.1242/dmm.037804.
2. A rat model of hypohidrotic ectodermal dysplasia carries a missense mutation in the Edaradd gene. Kuramoto T, etal., BMC Genet. 2011 Oct 21;12:91. doi: 10.1186/1471-2156-12-91.
3. Sparse and wavy hair: a new model for hypoplasia of hair follicle and mammary glands on rat chromosome 17. Kuramoto T, etal., J Hered. 2005 Jul-Aug;96(4):339-45. Epub 2005 Apr 13.
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:544312   PMID:5893447   PMID:14699584   PMID:15973734   PMID:21873635  


Genomics

Comparative Map Data
Edaradd
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81792,850,791 - 92,894,808 (-)NCBIGRCr8
mRatBN7.21785,866,629 - 85,910,612 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1785,656,905 - 85,910,447 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01790,802,280 - 90,843,476 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1790,802,393 - 90,843,485 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01792,462,305 - 92,503,399 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41767,056,373 - 67,143,933 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1785,700,726 - 85,744,668 (+)NCBICelera
Cytogenetic Map17q12.3NCBI
EDARADD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381236,348,259 - 236,484,930 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1236,348,257 - 236,502,915 (+)EnsemblGRCh38hg38GRCh38
GRCh371236,557,586 - 236,648,230 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361234,624,303 - 234,714,631 (+)NCBINCBI36Build 36hg18NCBI36
Build 341232,883,720 - 232,974,049NCBI
Celera1209,804,771 - 209,895,082 (+)NCBICelera
Cytogenetic Map1q42.3-q43NCBI
HuRef1207,012,849 - 207,103,467 (+)NCBIHuRef
CHM1_11237,829,988 - 237,920,874 (+)NCBICHM1_1
T2T-CHM13v2.01235,750,587 - 235,884,698 (+)NCBIT2T-CHM13v2.0
Edaradd
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391312,486,090 - 12,535,413 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1312,487,513 - 12,535,319 (-)EnsemblGRCm39 Ensembl
GRCm381312,471,209 - 12,520,535 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1312,472,632 - 12,520,438 (-)EnsemblGRCm38mm10GRCm38
MGSCv371312,569,175 - 12,612,715 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361312,531,162 - 12,574,879 (-)NCBIMGSCv36mm8
Celera1312,393,096 - 12,436,757 (-)NCBICelera
Cytogenetic Map13A1NCBI
cM Map134.77NCBI
Edaradd
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554923,711,549 - 3,777,528 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554923,709,819 - 3,777,506 (-)NCBIChiLan1.0ChiLan1.0
EDARADD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2112,702,380 - 12,787,405 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1112,914,211 - 12,999,256 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01211,973,108 - 212,043,142 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11217,042,359 - 217,043,804 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1216,960,418 - 217,044,046 (+)NCBIpanpan1.1panPan2
PanPan1.1 Ensembl1216,960,418 - 217,044,046 (+)Ensemblpanpan1.1panPan2
EDARADD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.143,608,545 - 3,659,357 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl43,610,079 - 3,669,789 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha43,654,946 - 3,715,144 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.043,629,190 - 3,689,391 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl43,629,181 - 3,690,451 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.143,641,762 - 3,701,937 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.043,758,964 - 3,819,177 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.043,979,463 - 4,039,647 (-)NCBIUU_Cfam_GSD_1.0
Edaradd
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934440,226,404 - 40,281,250 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648416,395,935 - 16,446,146 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648416,394,753 - 16,446,102 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EDARADD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1454,925,771 - 54,990,848 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11454,924,156 - 54,992,206 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21458,899,859 - 58,965,928 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EDARADD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12573,537,185 - 73,625,338 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2573,538,944 - 73,626,038 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605575,628,044 - 75,715,344 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Edaradd
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477514,132,710 - 14,191,423 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477514,132,455 - 14,191,604 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Edaradd
439 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:79
Count of miRNA genes:74
Interacting mature miRNAs:75
Transcripts:ENSRNOT00000003535
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2317045Aia11Adjuvant induced arthritis QTL 114.06joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)176078142686533673Rat
4889894Eae33Experimental allergic encephalomyelitis QTL 335.20.0001nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)175090909986022412Rat
7411577Bw141Body weight QTL 1410.001body mass (VT:0001259)body weight gain (CMO:0000420)176261951686533673Rat
7411575Bw140Body weight QTL 14030.20.001body mass (VT:0001259)body weight gain (CMO:0000420)174856093586533673Rat
8694181Bw151Body weight QTL 1514.360.001body mass (VT:0001259)body weight gain (CMO:0000420)174856093586533673Rat
1358295Aocep1Aortic cell protein QTL 16.10.00000071thoracic aorta cellular protein amount (VT:0010598)aortic cell percentage174099000585990005Rat
2303580Gluco49Glucose level QTL 492blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)175004027186533673Rat
2317038Ginf3Gastrointestinal inflammation QTL 32.890.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)174992015486533673Rat

Markers in Region
D17Got212  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21785,953,147 - 85,953,291 (-)MAPPERmRatBN7.2
Rnor_6.01790,760,248 - 90,760,391NCBIRnor6.0
Rnor_5.01792,420,273 - 92,420,416UniSTSRnor5.0
RGSC_v3.41767,060,452 - 67,060,595UniSTSRGSC3.4
Celera1785,656,431 - 85,656,574UniSTS
Cytogenetic Map17q12.1UniSTS
RH143797  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21785,956,944 - 85,957,044 (-)MAPPERmRatBN7.2
Rnor_6.01790,756,495 - 90,756,594NCBIRnor6.0
Rnor_5.01792,416,520 - 92,416,619UniSTSRnor5.0
RGSC_v3.41767,056,699 - 67,056,798UniSTSRGSC3.4
Celera1785,652,677 - 85,652,776UniSTS
Cytogenetic Map17q12.1UniSTS


Genetic Models
This gene Edaradd is modified in the following models/strains:
WTC-swh/Kyo    


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 1
Low 3 13 34 19 18 19 7 7 52 35 40 11 7
Below cutoff 30 22 22 22 1 4 22 1 1

Sequence


RefSeq Acc Id: ENSRNOT00000003535   ⟹   ENSRNOP00000003535
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1785,656,905 - 85,910,447 (-)Ensembl
Rnor_6.0 Ensembl1790,802,393 - 90,843,485 (+)Ensembl
RefSeq Acc Id: XM_574055   ⟹   XP_574055
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81792,850,791 - 92,894,808 (-)NCBI
mRatBN7.21785,866,629 - 85,910,612 (-)NCBI
Rnor_6.01790,802,280 - 90,843,476 (+)NCBI
Rnor_5.01792,462,305 - 92,503,399 (+)NCBI
RGSC_v3.41767,056,373 - 67,143,933 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs XP_574055 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL83158 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000003535
  ENSRNOP00000003535.5
RefSeq Acc Id: XP_574055   ⟸   XM_574055
- UniProtKB: F1LYE0 (UniProtKB/TrEMBL),   A6KTE4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000003535   ⟸   ENSRNOT00000003535
Protein Domains
Death

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LYE0-F1-model_v2 AlphaFold F1LYE0 1-205 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1564010 AgrOrtholog
BioCyc Gene G2FUF-8454 BioCyc
Ensembl Genes ENSRNOG00000002624 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000003535.7 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/TrEMBL
InterPro Death UniProtKB/TrEMBL
  DEATH-like UniProtKB/TrEMBL
  EDARADD UniProtKB/TrEMBL
KEGG Report rno:498769 UniProtKB/TrEMBL
NCBI Gene 498769 ENTREZGENE
PANTHER ECTODYSPLASIN-A RECEPTOR-ASSOCIATED ADAPTER PROTEIN UniProtKB/TrEMBL
  PTHR28469 UniProtKB/TrEMBL
Pfam Death UniProtKB/TrEMBL
PhenoGen Edaradd PhenoGen
RatGTEx ENSRNOG00000002624 RatGTEx
Superfamily-SCOP DEATH_like UniProtKB/TrEMBL
UniProt A6KTE4 ENTREZGENE, UniProtKB/TrEMBL
  F1LYE0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-17 Edaradd  EDAR-associated death domain  Edaradd  EDAR (ectodysplasin-A receptor)-associated death domain  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-06 Edaradd  EDAR (ectodysplasin-A receptor)-associated death domain  RGD1564010_predicted  similar to crinkled (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1564010_predicted  similar to crinkled (predicted)  LOC498769  similar to crinkled  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC498769  similar to crinkled      Symbol and Name status set to provisional 70820 PROVISIONAL