RGD Reference Report - Sparse and wavy hair: a new model for hypoplasia of hair follicle and mammary glands on rat chromosome 17. - Rat Genome Database

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Sparse and wavy hair: a new model for hypoplasia of hair follicle and mammary glands on rat chromosome 17.

Authors: Kuramoto, T  Morimura, K  Nomoto, T  Namiki, C  Hamada, S  Fukushima, S  Sugimura, T  Serikawa, T  Ushijima, T 
Citation: Kuramoto T, etal., J Hered. 2005 Jul-Aug;96(4):339-45. Epub 2005 Apr 13.
RGD ID: 2304219
Pubmed: PMID:15829729   (View Abstract at PubMed)
DOI: DOI:10.1093/jhered/esi053   (Journal Full-text)

Mutant animals in the skin and hair have been used to identify important genes in biomedical research. We describe a new mutant rat, sparse and wavy hair (swh), that spontaneously arose in a colony of inbred WTC rats. The mutant phenotype was characterized by sparse and wavy hair, which was most prominent at age 3-4 weeks, and was inherited in an autosomal recessive manner. The swh/swh rats showed impaired gain of body weight, and their hair follicles were reduced both in number and size, associated with hypoplasia of the sebaceous glands and the subcutaneous fat tissue. Female swh/swh rats were unable to suckle their offspring. Their mammary glands were hypoplastic, and differentiation of mammary epithelial and myoepithelial cells was impaired. Linkage analysis of 579 backcross rats localized the swh locus to a .35-cM region between D17Rat131 and D17Rat50 in the distal end of rat Chr 17. The swh locus spanned the 3.7-Mb genomic region where 24 genes have been mapped and corresponded to the centromere region of the mouse Chr 2 or the region of the human Chr 10p11.1-p14. None of the genes or loci described in mouse or human hair and skin diseases mapped to these regions. These findings suggest that the rat swh is a novel mutation associated with impaired development of the skin appendages, such as hair follicles, sebaceous glands, and mammary glands, and will provide an experimental model to clarify a gene and mechanisms for development of skin appendages.



Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
EdaraddRatabnormal hair texture  IAGP compared to heterozygous animalsRGD 
EdaraddswhKyoRatabnormal hair texture  IAGP compared to heterozygous animalsRGD 
WTC-swh/KyoRatabnormal hair texture  IAGP compared to heterozygous animalsRGD 
EdaraddRatdecreased body weight  IAGP compared to heterozygous animalsRGD 
EdaraddswhKyoRatdecreased body weight  IAGP compared to heterozygous animalsRGD 
WTC-swh/KyoRatdecreased body weight  IAGP compared to heterozygous animalsRGD 
EdaraddRatdecreased hair follicle number  IAGP compared to heterozygous animalsRGD 
EdaraddswhKyoRatdecreased hair follicle number  IAGP compared to heterozygous animalsRGD 
WTC-swh/KyoRatdecreased hair follicle number  IAGP compared to heterozygous animalsRGD 
EdaraddRatmammary gland hypoplasia  IAGP in females and compared to heterozygous animalsRGD 
EdaraddswhKyoRatmammary gland hypoplasia  IAGP in females and compared to heterozygous animalsRGD 
WTC-swh/KyoRatmammary gland hypoplasia  IAGP in females and compared to heterozygous animalsRGD 
EdaraddRatsmall hair follicles  IAGP compared to heterozygous animalsRGD 
EdaraddswhKyoRatsmall hair follicles  IAGP compared to heterozygous animalsRGD 
WTC-swh/KyoRatsmall hair follicles  IAGP compared to heterozygous animalsRGD 
EdaraddRatsparse hair  IAGP compared to heterozygous animalsRGD 
EdaraddswhKyoRatsparse hair  IAGP compared to heterozygous animalsRGD 
WTC-swh/KyoRatsparse hair  IAGP compared to heterozygous animalsRGD 
EdaraddRatwaved hair  IAGP compared to heterozygous animalsRGD 
EdaraddswhKyoRatwaved hair  IAGP compared to heterozygous animalsRGD 
WTC-swh/KyoRatwaved hair  IAGP compared to heterozygous animalsRGD 
Objects Annotated

Genes (Rattus norvegicus)
Edaradd  (EDAR associated via death domain)
EdaraddswhKyo  (EDAR-associated death domain;swh Kyo mutant)

Strains
WTC-swh/Kyo  (NA)


Additional Information