Eda (ectodysplasin-A) - Rat Genome Database

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Gene: Eda (ectodysplasin-A) Mus musculus
Analyze
Symbol: Eda
Name: ectodysplasin-A
RGD ID: 1557590
MGI Page MGI
Description: Predicted to enable death receptor agonist activity and death receptor binding activity. Acts upstream of or within several processes, including hair follicle placode formation; positive regulation of signal transduction; and trachea gland development. Located in apical part of cell and endoplasmic reticulum membrane. Is integral component of plasma membrane. Is expressed in several structures, including alimentary system; brain; future brain; nasal gland epithelium; and skin. Used to study hypohidrotic ectodermal dysplasia. Human ortholog(s) of this gene implicated in ectodermal dysplasia 1 and tooth agenesis. Orthologous to human EDA (ectodysplasin A).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Ed1; EDA protein homolog; Eda-; Eda-A1; Eda-A2; EDA1; HED; Ta; tabby; Tnlg7c; tumor necrosis factor ligand 7c; XLHED
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X99,019,212 - 99,444,366 (+)NCBIGRCm39mm39
GRCm39 EnsemblX99,019,212 - 99,444,368 (+)Ensembl
GRCm38X99,975,606 - 100,400,760 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX99,975,606 - 100,400,762 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X97,170,945 - 97,596,099 (+)NCBIGRCm37mm9NCBIm37
MGSCv36X82,816,290 - 83,239,228 (+)NCBImm8
MGSCv36X96,178,325 - 96,603,479 (+)NCBImm8
CeleraX86,912,424 - 87,326,326 (+)NCBICelera
Cytogenetic MapXC3NCBI
cM MapX43.59NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal autopod morphology  (IAGP)
abnormal awl hair morphology  (IAGP)
abnormal coat appearance  (IAGP)
abnormal coat/ hair morphology  (IAGP)
abnormal coat/hair pigmentation  (IAGP)
abnormal cornea morphology  (IAGP)
abnormal corneal epithelium morphology  (IAGP)
abnormal cranium size  (IAGP)
abnormal enamel morphology  (IAGP)
abnormal exocrine gland morphology  (IEA)
abnormal eye morphology  (IAGP)
abnormal eyelid margin morphology  (IAGP)
abnormal eyelid morphology  (IAGP)
abnormal gland morphology  (IAGP)
abnormal guard hair morphology  (IAGP)
abnormal hair follicle development  (IAGP)
abnormal hair follicle melanocyte morphology  (IAGP)
abnormal hair follicle pheomelanosome pheomelanin content  (IAGP)
abnormal hair growth  (IAGP)
abnormal hair texture  (IAGP)
abnormal incisor morphology  (IAGP)
abnormal lateral nasal gland morphology  (IAGP)
abnormal male preputial gland morphology  (IAGP)
abnormal molar crown morphology  (IAGP)
abnormal molar cusp morphology  (IAGP)
abnormal molar morphology  (IAGP)
abnormal molar root morphology  (IAGP)
abnormal nasal cavity morphology  (IAGP)
abnormal nasal gland morphology  (IAGP)
abnormal nose morphology  (IAGP)
abnormal palatal rugae morphology  (IAGP)
abnormal respiratory mucosa morphology  (IAGP)
abnormal respiratory system morphology  (IAGP)
abnormal skeleton morphology  (IAGP)
abnormal skin morphology  (IAGP)
abnormal skin pigmentation  (IAGP)
abnormal tail morphology  (IEA)
abnormal tail ring morphology  (IAGP)
abnormal tail tip morphology  (IAGP)
abnormal tooth development  (IEA)
abnormal tooth eruption  (IEA)
abnormal tooth morphology  (IAGP)
abnormal vibrissa number  (IAGP)
absent auchene hairs  (IAGP)
absent eccrine glands  (IAGP)
absent guard hair  (IAGP)
absent hair follicle pheomelanosome pheomelanin  (IAGP)
absent incisors  (IAGP)
absent male preputial gland  (IAGP)
absent Meibomian glands  (IAGP)
absent sweat gland  (IAGP)
absent vibrissae  (IAGP)
absent zigzag hairs  (IAGP)
alopecia  (IAGP)
anhidrosis  (IAGP)
blepharitis  (IAGP)
blindness  (IAGP)
coarse hair  (IEA)
conjunctivitis  (IAGP)
corneal limbitis  (IAGP)
corneal opacity  (IAGP)
corneal vascularization  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased molar number  (IAGP)
decreased zigzag hair amount  (IAGP)
delayed hair appearance  (IAGP)
disheveled coat  (IAGP)
domed cranium  (IAGP)
exencephaly  (IAGP)
eye inflammation  (IAGP)
eyelids fail to open  (IEA)
eyelids open at birth  (IEA)
female infertility  (IEA)
focal hair loss  (IAGP)
hairless  (IEA)
hairless tail  (IAGP)
increased curvature of hairs  (IEA)
increased incidence of corneal inflammation  (IAGP)
increased sebocyte number  (IAGP)
increased sebum secretion  (IAGP)
irregular coat pigmentation  (IAGP)
kinked tail  (IAGP)
male pseudohermaphroditism  (IAGP)
narrow eye opening  (IAGP)
neonatal lethality, incomplete penetrance  (IAGP)
polydactyly  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
sebaceous gland hyperplasia  (IAGP)
sebaceous gland hypertrophy  (IAGP)
short hair  (IAGP)
short incisors  (IAGP)
small molars  (IAGP)
sparse hair  (IEA)
striated fur  (IAGP)
supernumerary incisors  (IAGP)
syndactyly  (IAGP)
thin epidermis  (IAGP)
thin skin  (IAGP)
transverse fur striping  (IAGP)
yellow coat color  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Role of ectodysplasin signalling in middle ear and nasal pathology in rat and mouse models of hypohidrotic ectodermal dysplasia. Del-Pozo J, etal., Dis Model Mech. 2019 Apr 25;12(4). pii: 12/4/dmm037804. doi: 10.1242/dmm.037804.
2. A candidate spermatogenesis gene on the mouse Y chromosome is homologous to ubiquitin-activating enzyme E1. Kay GF, etal., Nature 1991 Dec 12;354(6353):486-9.
3. X-linked anhidrotic (hypohidrotic) ectodermal dysplasia is caused by mutation in a novel transmembrane protein. Kere J, etal., Nat Genet. 1996 Aug;13(4):409-16.
4. Order of loci on the X-chromosome of the mouse. Lyon MF Genet Res 1966 Feb;7(1):130-3.
5. MGDs mouse GO annotations MGD data from the GO Consortium
6. MGD IEA MGD IEA
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. Mouse MP Annotation Import Pipeline RGD automated import pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:127839   PMID:188049   PMID:205481   PMID:359407   PMID:478295   PMID:544312   PMID:1675191   PMID:1685478   PMID:1740345   PMID:1772416   PMID:1797229   PMID:1974879  
PMID:2034278   PMID:2055107   PMID:2113569   PMID:2230077   PMID:2272505   PMID:2296595   PMID:2332613   PMID:2348861   PMID:2351074   PMID:2364893   PMID:2448136   PMID:2721933  
PMID:2882509   PMID:2899541   PMID:3004966   PMID:3243423   PMID:3299748   PMID:3600793   PMID:3600794   PMID:4399067   PMID:4399988   PMID:4420168   PMID:4435359   PMID:4561716  
PMID:4726088   PMID:5361553   PMID:5361554   PMID:5361555   PMID:5452809   PMID:5470481   PMID:5548211   PMID:5893447   PMID:5959976   PMID:6373499   PMID:6583703   PMID:6774258  
PMID:7365241   PMID:7391545   PMID:7544943   PMID:7590750   PMID:7805729   PMID:7857878   PMID:7983247   PMID:8118102   PMID:8254285   PMID:8269866   PMID:8517925   PMID:8625802  
PMID:8647934   PMID:8824310   PMID:8829919   PMID:8896602   PMID:8902505   PMID:9226037   PMID:9285798   PMID:9371801   PMID:9698438   PMID:9698443   PMID:9736774   PMID:9832315  
PMID:9988272   PMID:10349636   PMID:10534613   PMID:10594919   PMID:10610025   PMID:10619357   PMID:10642790   PMID:10932191   PMID:11023871   PMID:11035039   PMID:11042159   PMID:11076861  
PMID:11203701   PMID:11217851   PMID:11239407   PMID:11356688   PMID:11360932   PMID:11570810   PMID:11591646   PMID:11751679   PMID:11758785   PMID:11945012   PMID:11973284   PMID:12095918  
PMID:12165674   PMID:12230506   PMID:12416535   PMID:12416536   PMID:12466851   PMID:12477932   PMID:12629675   PMID:12812793   PMID:12932438   PMID:12972005   PMID:13103353   PMID:13227156  
PMID:14248461   PMID:14502575   PMID:14506134   PMID:14656435   PMID:14749376   PMID:15031115   PMID:15136142   PMID:15139292   PMID:15312246   PMID:15371307   PMID:15538367   PMID:15721148  
PMID:15721153   PMID:15723861   PMID:15972955   PMID:15973734   PMID:16141072   PMID:16141073   PMID:16423472   PMID:16481354   PMID:16524929   PMID:16738056   PMID:16769906   PMID:17102627  
PMID:17164417   PMID:17248765   PMID:17362907   PMID:17376426   PMID:17673451   PMID:18022614   PMID:18028050   PMID:18037901   PMID:18256193   PMID:18287559   PMID:18499648   PMID:18508042  
PMID:18651655   PMID:18676816   PMID:18689798   PMID:18848976   PMID:18923450   PMID:19051250   PMID:19087265   PMID:19110031   PMID:19270025   PMID:19340299   PMID:19500387   PMID:19619491  
PMID:19657145   PMID:20386733   PMID:20803597   PMID:20969842   PMID:21267068   PMID:21541253   PMID:21566665   PMID:21652647   PMID:21677750   PMID:21873635   PMID:21917808   PMID:21926481  
PMID:22451941   PMID:22833125   PMID:23123965   PMID:23293290   PMID:23403291   PMID:23431057   PMID:23441037   PMID:23891883   PMID:24051719   PMID:25207818   PMID:25249463   PMID:25514040  
PMID:25847135   PMID:26011242   PMID:26581094   PMID:26626448   PMID:26646413   PMID:26829034   PMID:26952977   PMID:27378689   PMID:27414798   PMID:27590203   PMID:27621364   PMID:27864382  
PMID:28392504   PMID:28655773   PMID:28698625   PMID:28782908   PMID:28813629   PMID:29106399   PMID:29186686   PMID:29913094   PMID:30037996   PMID:30089653   PMID:31221639   PMID:32634219  
PMID:33329029   PMID:33594251   PMID:34995520  


Genomics

Comparative Map Data
Eda
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X99,019,212 - 99,444,366 (+)NCBIGRCm39mm39
GRCm39 EnsemblX99,019,212 - 99,444,368 (+)Ensembl
GRCm38X99,975,606 - 100,400,760 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX99,975,606 - 100,400,762 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X97,170,945 - 97,596,099 (+)NCBIGRCm37mm9NCBIm37
MGSCv36X82,816,290 - 83,239,228 (+)NCBImm8
MGSCv36X96,178,325 - 96,603,479 (+)NCBImm8
CeleraX86,912,424 - 87,326,326 (+)NCBICelera
Cytogenetic MapXC3NCBI
cM MapX43.59NCBI
EDA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X69,616,113 - 70,039,472 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 EnsemblX69,616,067 - 70,039,472 (+)EnsemblGRCh38hg38GRCh38
GRCh37X68,835,957 - 69,259,322 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X68,752,636 - 69,176,047 (+)NCBINCBI36hg18NCBI36
Build 34X68,618,931 - 69,042,340NCBI
CeleraX69,189,229 - 69,612,705 (+)NCBI
Cytogenetic MapXq13.1NCBI
HuRefX62,655,756 - 63,080,124 (+)NCBIHuRef
CHM1_1X68,729,282 - 69,152,930 (+)NCBICHM1_1
T2T-CHM13v2.0X68,049,526 - 68,472,825 (+)NCBI
Eda
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X65,078,454 - 65,480,172 (+)NCBImRatBN7.2
mRatBN7.2 EnsemblX65,078,673 - 65,480,172 (+)Ensembl
Rnor_6.0X69,730,123 - 70,222,693 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX69,730,242 - 70,220,329 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X70,602,479 - 71,095,806 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X87,982,303 - 88,390,680 (+)NCBIRGSC3.4rn4RGSC3.4
CeleraX65,441,737 - 65,840,991 (+)NCBICelera
Cytogenetic MapXq22NCBI
Eda
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554759,178,234 - 9,588,440 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554759,177,911 - 9,592,150 (+)NCBIChiLan1.0ChiLan1.0
EDA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X68,946,036 - 69,371,175 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0X58,881,660 - 59,308,451 (+)NCBIMhudiblu_PPA_v0panPan3
EDA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X54,078,694 - 54,515,535 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX54,078,966 - 54,515,535 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX44,906,268 - 45,341,896 (+)NCBI
ROS_Cfam_1.0X55,046,702 - 55,482,183 (+)NCBI
ROS_Cfam_1.0 EnsemblX55,046,981 - 55,482,183 (+)Ensembl
UMICH_Zoey_3.1X53,014,333 - 53,451,228 (+)NCBI
UNSW_CanFamBas_1.0X54,343,122 - 54,782,021 (+)NCBI
UU_Cfam_GSD_1.0X54,267,090 - 54,709,181 (+)NCBI
Eda
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X47,673,194 - 47,996,323 (-)NCBI
SpeTri2.0NW_0049367771,545,293 - 1,561,109 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EDA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX55,771,240 - 56,103,265 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X55,770,958 - 56,103,296 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X62,968,935 - 63,300,549 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EDA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X59,453,157 - 59,861,555 (+)NCBIChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660651,311,650 - 1,730,565 (+)NCBIVero_WHO_p1.0
Eda
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462489158,991 - 488,788 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462489155,310 - 489,072 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
mHAa21e2.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X100,379,276 - 100,379,465UniSTSGRCm38
MGSCv37X97,574,615 - 97,574,804UniSTSGRCm37
CeleraX87,305,029 - 87,305,218UniSTS
Cytogenetic MapXC3UniSTS
cM MapX37.0UniSTS
Whitehead_YACX UniSTS
AF016628  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X100,397,272 - 100,397,393UniSTSGRCm38
MGSCv37X97,592,611 - 97,592,732UniSTSGRCm37
CeleraX87,322,559 - 87,322,680UniSTS
Cytogenetic MapXC3UniSTS
cM MapX37.0UniSTS
Whitehead/MRC_RHX1113.25UniSTS
px-7h4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X100,285,241 - 100,285,368UniSTSGRCm38
MGSCv37X97,480,580 - 97,480,707UniSTSGRCm37
CeleraX87,213,173 - 87,213,300UniSTS
Cytogenetic MapXC3UniSTS
cM MapX37.0UniSTS
PMC24264P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X99,975,756 - 99,976,344UniSTSGRCm38
MGSCv37X97,171,095 - 97,171,683UniSTSGRCm37
CeleraX86,912,574 - 86,913,162UniSTS
Cytogenetic MapXC3UniSTS
cM MapX37.0UniSTS
PMC24264P2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X100,309,994 - 100,310,332UniSTSGRCm38
MGSCv37X97,505,333 - 97,505,671UniSTSGRCm37
CeleraX87,235,714 - 87,236,052UniSTS
Cytogenetic MapXC3UniSTS
cM MapX37.0UniSTS
PMC24264P3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X100,309,994 - 100,310,105UniSTSGRCm38
MGSCv37X97,505,333 - 97,505,444UniSTSGRCm37
CeleraX87,235,714 - 87,235,825UniSTS
Cytogenetic MapXC3UniSTS
cM MapX37.0UniSTS
PMC24264P4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X100,396,925 - 100,397,070UniSTSGRCm38
MGSCv37X97,592,264 - 97,592,409UniSTSGRCm37
CeleraX87,322,212 - 87,322,357UniSTS
Cytogenetic MapXC3UniSTS
cM MapX37.0UniSTS
Eda  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic MapXC3UniSTS
cM MapX37.0UniSTS


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357433Dbts2_mdiabetes 2 (mouse)Not determinedX7226295150107038Mouse
4141630Gct6_mgranulosa cell tumorigenesis 6 (mouse)Not determined47179121129764756Mouse
13824980Ferq1_mgenetic fertility QTL 1 (mouse)X54045360148782996Mouse
4141665Mhysq2_mmale hybrid sterility QTL 2 (mouse)Not determined71453852139203212Mouse
12879918Shm4_msperm head morphology 4 (mouse)X72072050102062720Mouse
1357500Mdmsc6_mmodifier of muscularity 6 (mouse)Not determinedX75306671109306758Mouse
1302054Gct4_mgranulosa cell tumorigenesis 4 (mouse)Not determinedX76124336102062720Mouse
11075102Modc2_mmodifier of Odc2 (mouse)X80189914114190059Mouse
4141803Lmr30_mleishmaniasis resistance 30 (mouse)Not determined85062606119062720Mouse
13208552Wght12_mweight 12 (mouse)X94043606149782996Mouse
13208556Lgth14_mbody length 14 (mouse)X94043606149782996Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:14925
Count of miRNA genes:1011
Interacting mature miRNAs:1505
Transcripts:ENSMUST00000071453, ENSMUST00000113775, ENSMUST00000113776, ENSMUST00000113777, ENSMUST00000113778, ENSMUST00000113779, ENSMUST00000113780, ENSMUST00000113781, ENSMUST00000113783, ENSMUST00000123547, ENSMUST00000134582, ENSMUST00000145063
Prediction methods:Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001177937 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001177938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001177939 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001177940 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001177941 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001177942 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001177943 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001177944 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_010099 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF004434 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF004435 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF016627 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF016628 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF016629 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF016630 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF016631 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF016632 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ243657 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ243658 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK028502 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK040754 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK137551 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL671299 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL671979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL773561 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC125387 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC144790 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC144791 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX005452 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX890547 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ207760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ168876 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ168877 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ168878 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ168879 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ168880 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ168881 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LN874402 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y13438 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000071453   ⟹   ENSMUSP00000071397
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX99,019,387 - 99,440,762 (+)Ensembl
GRCm38.p6 EnsemblX99,975,781 - 100,397,156 (+)Ensembl
RefSeq Acc Id: ENSMUST00000113775   ⟹   ENSMUSP00000109405
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX99,019,212 - 99,444,366 (+)Ensembl
GRCm38.p6 EnsemblX99,975,606 - 100,400,760 (+)Ensembl
RefSeq Acc Id: ENSMUST00000113776   ⟹   ENSMUSP00000109406
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX99,019,212 - 99,444,366 (+)Ensembl
GRCm38.p6 EnsemblX99,975,606 - 100,400,760 (+)Ensembl
RefSeq Acc Id: ENSMUST00000113777   ⟹   ENSMUSP00000109407
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX99,019,387 - 99,439,418 (+)Ensembl
GRCm38.p6 EnsemblX99,975,781 - 100,395,812 (+)Ensembl
RefSeq Acc Id: ENSMUST00000113778   ⟹   ENSMUSP00000109408
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX99,019,212 - 99,444,368 (+)Ensembl
GRCm38.p6 EnsemblX99,975,606 - 100,400,762 (+)Ensembl
RefSeq Acc Id: ENSMUST00000113779   ⟹   ENSMUSP00000109409
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX99,019,212 - 99,444,366 (+)Ensembl
GRCm38.p6 EnsemblX99,975,606 - 100,400,760 (+)Ensembl
RefSeq Acc Id: ENSMUST00000113780   ⟹   ENSMUSP00000109410
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX99,019,212 - 99,444,368 (+)Ensembl
GRCm38.p6 EnsemblX99,975,606 - 100,400,762 (+)Ensembl
RefSeq Acc Id: ENSMUST00000113781   ⟹   ENSMUSP00000109411
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX99,019,212 - 99,444,365 (+)Ensembl
GRCm38.p6 EnsemblX99,975,606 - 100,400,759 (+)Ensembl
RefSeq Acc Id: ENSMUST00000113783   ⟹   ENSMUSP00000109413
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX99,019,212 - 99,444,365 (+)Ensembl
GRCm38.p6 EnsemblX99,975,606 - 100,400,759 (+)Ensembl
RefSeq Acc Id: ENSMUST00000123547
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX99,430,861 - 99,438,642 (+)Ensembl
GRCm38.p6 EnsemblX100,387,255 - 100,395,036 (+)Ensembl
RefSeq Acc Id: ENSMUST00000134582
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX99,019,212 - 99,354,905 (+)Ensembl
GRCm38.p6 EnsemblX99,975,606 - 100,311,299 (+)Ensembl
RefSeq Acc Id: ENSMUST00000145063
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX99,428,749 - 99,438,044 (+)Ensembl
GRCm38.p6 EnsemblX100,385,143 - 100,394,438 (+)Ensembl
RefSeq Acc Id: NM_001177937   ⟹   NP_001171408
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X99,019,212 - 99,444,366 (+)NCBI
GRCm38X99,975,606 - 100,400,760 (+)NCBI
MGSCv37X97,170,945 - 97,596,099 (+)RGD
CeleraX86,912,424 - 87,326,326 (+)RGD
cM MapX ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001177938   ⟹   NP_001171409
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X99,019,212 - 99,444,366 (+)NCBI
GRCm38X99,975,606 - 100,400,760 (+)NCBI
MGSCv37X97,170,945 - 97,596,099 (+)RGD
CeleraX86,912,424 - 87,326,326 (+)RGD
cM MapX ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001177939   ⟹   NP_001171410
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X99,019,212 - 99,444,366 (+)NCBI
GRCm38X99,975,606 - 100,400,760 (+)NCBI
MGSCv37X97,170,945 - 97,596,099 (+)RGD
CeleraX86,912,424 - 87,326,326 (+)RGD
cM MapX ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001177940   ⟹   NP_001171411
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X99,019,212 - 99,444,366 (+)NCBI
GRCm38X99,975,606 - 100,400,760 (+)NCBI
MGSCv37X97,170,945 - 97,596,099 (+)RGD
CeleraX86,912,424 - 87,326,326 (+)RGD
cM MapX ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001177941   ⟹   NP_001171412
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X99,019,212 - 99,444,366 (+)NCBI
GRCm38X99,975,606 - 100,400,760 (+)NCBI
MGSCv37X97,170,945 - 97,596,099 (+)RGD
CeleraX86,912,424 - 87,326,326 (+)RGD
cM MapX ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001177942   ⟹   NP_001171413
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X99,019,212 - 99,444,366 (+)NCBI
GRCm38X99,975,606 - 100,400,760 (+)NCBI
MGSCv37X97,170,945 - 97,596,099 (+)RGD
CeleraX86,912,424 - 87,326,326 (+)RGD
cM MapX ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001177943   ⟹   NP_001171414
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X99,019,212 - 99,444,366 (+)NCBI
GRCm38X99,975,606 - 100,400,760 (+)NCBI
MGSCv37X97,170,945 - 97,596,099 (+)RGD
CeleraX86,912,424 - 87,326,326 (+)RGD
cM MapX ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001177944   ⟹   NP_001171415
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X99,019,212 - 99,444,366 (+)NCBI
GRCm38X99,975,606 - 100,400,760 (+)NCBI
MGSCv37X97,170,945 - 97,596,099 (+)RGD
CeleraX86,912,424 - 87,326,326 (+)RGD
cM MapX ENTREZGENE
Sequence:
RefSeq Acc Id: NM_010099   ⟹   NP_034229
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X99,019,212 - 99,444,366 (+)NCBI
GRCm38X99,975,606 - 100,400,760 (+)NCBI
MGSCv37X97,170,945 - 97,596,099 (+)RGD
CeleraX86,912,424 - 87,326,326 (+)RGD
cM MapX ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_001171408 (Get FASTA)   NCBI Sequence Viewer  
  NP_001171409 (Get FASTA)   NCBI Sequence Viewer  
  NP_001171410 (Get FASTA)   NCBI Sequence Viewer  
  NP_001171411 (Get FASTA)   NCBI Sequence Viewer  
  NP_001171412 (Get FASTA)   NCBI Sequence Viewer  
  NP_001171413 (Get FASTA)   NCBI Sequence Viewer  
  NP_001171414 (Get FASTA)   NCBI Sequence Viewer  
  NP_001171415 (Get FASTA)   NCBI Sequence Viewer  
  NP_034229 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB88121 (Get FASTA)   NCBI Sequence Viewer  
  AAB88122 (Get FASTA)   NCBI Sequence Viewer  
  AAB95202 (Get FASTA)   NCBI Sequence Viewer  
  AAB95203 (Get FASTA)   NCBI Sequence Viewer  
  AAB95204 (Get FASTA)   NCBI Sequence Viewer  
  AAB95205 (Get FASTA)   NCBI Sequence Viewer  
  AAB95206 (Get FASTA)   NCBI Sequence Viewer  
  AAI25388 (Get FASTA)   NCBI Sequence Viewer  
  AAI44791 (Get FASTA)   NCBI Sequence Viewer  
  AAI44792 (Get FASTA)   NCBI Sequence Viewer  
  ABB59616 (Get FASTA)   NCBI Sequence Viewer  
  ABB59617 (Get FASTA)   NCBI Sequence Viewer  
  ABB59618 (Get FASTA)   NCBI Sequence Viewer  
  ABB59619 (Get FASTA)   NCBI Sequence Viewer  
  ABB59620 (Get FASTA)   NCBI Sequence Viewer  
  ABB59621 (Get FASTA)   NCBI Sequence Viewer  
  BAE23404 (Get FASTA)   NCBI Sequence Viewer  
  CAA73849 (Get FASTA)   NCBI Sequence Viewer  
  CAB52696 (Get FASTA)   NCBI Sequence Viewer  
  CAB52697 (Get FASTA)   NCBI Sequence Viewer  
  CTQ86167 (Get FASTA)   NCBI Sequence Viewer  
  EDL14185 (Get FASTA)   NCBI Sequence Viewer  
  EDL14186 (Get FASTA)   NCBI Sequence Viewer  
  O54693 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_034229   ⟸   NM_010099
- Peptide Label: isoform 1
- UniProtKB: O54693 (UniProtKB/Swiss-Prot),   Q3UV69 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001171408   ⟸   NM_001177937
- Peptide Label: isoform 2
- UniProtKB: O54693 (UniProtKB/Swiss-Prot),   Q3UV69 (UniProtKB/TrEMBL),   A0A0U5J8Q0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001171409   ⟸   NM_001177938
- Peptide Label: isoform 3
- UniProtKB: Q1L2E0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001171410   ⟸   NM_001177939
- Peptide Label: isoform 4
- UniProtKB: O54693 (UniProtKB/Swiss-Prot),   Q3UV69 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001171411   ⟸   NM_001177940
- Peptide Label: isoform 5
- UniProtKB: Q1L2D9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001171412   ⟸   NM_001177941
- Peptide Label: isoform 6
- UniProtKB: Q1L2D8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001171413   ⟸   NM_001177942
- Peptide Label: isoform 7
- UniProtKB: O54693 (UniProtKB/Swiss-Prot),   Q3UV69 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001171414   ⟸   NM_001177943
- Peptide Label: isoform 8
- UniProtKB: Q1L2D6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001171415   ⟸   NM_001177944
- Peptide Label: isoform 8
- UniProtKB: Q1L2D6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000071397   ⟸   ENSMUST00000071453
RefSeq Acc Id: ENSMUSP00000109405   ⟸   ENSMUST00000113775
RefSeq Acc Id: ENSMUSP00000109407   ⟸   ENSMUST00000113777
RefSeq Acc Id: ENSMUSP00000109406   ⟸   ENSMUST00000113776
RefSeq Acc Id: ENSMUSP00000109409   ⟸   ENSMUST00000113779
RefSeq Acc Id: ENSMUSP00000109408   ⟸   ENSMUST00000113778
RefSeq Acc Id: ENSMUSP00000109413   ⟸   ENSMUST00000113783
RefSeq Acc Id: ENSMUSP00000109410   ⟸   ENSMUST00000113780
RefSeq Acc Id: ENSMUSP00000109411   ⟸   ENSMUST00000113781
Protein Domains
Collagen-like   TNF_2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O54693-F1-model_v2 AlphaFold O54693 1-391 view protein structure

Promoters
RGD ID:6845638
Promoter ID:MM_KWN:61261
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver,   Lung,   MEF_B4
Transcripts:ENSMUST00000113775,   ENSMUST00000113776,   ENSMUST00000113777,   ENSMUST00000113778,   ENSMUST00000113780,   ENSMUST00000113783,   NM_010099,   OTTMUST00000043826,   UC009TVO.1,   UC009TVR.1,   UC009TVU.1,   UC009TVV.1,   UC009TVW.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36X97,170,851 - 97,171,351 (+)MPROMDB
RGD ID:13681022
Promoter ID:EPDNEW_M24660
Type:initiation region
Name:Eda_1
Description:Mus musculus ectodysplasin-A , transcript variant 5, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38X99,975,635 - 99,975,695EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1195272 AgrOrtholog
Ensembl Genes ENSMUSG00000059327 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000071397 ENTREZGENE
  ENSMUSP00000071397.3 UniProtKB/TrEMBL
  ENSMUSP00000109405 ENTREZGENE
  ENSMUSP00000109405.2 UniProtKB/TrEMBL
  ENSMUSP00000109406 ENTREZGENE
  ENSMUSP00000109406.2 UniProtKB/TrEMBL
  ENSMUSP00000109407.2 UniProtKB/TrEMBL
  ENSMUSP00000109408 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000109409 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000109410 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000109411 ENTREZGENE
  ENSMUSP00000109411.2 UniProtKB/TrEMBL
  ENSMUSP00000109413.2 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000071453 ENTREZGENE
  ENSMUST00000071453.3 UniProtKB/TrEMBL
  ENSMUST00000113775 ENTREZGENE
  ENSMUST00000113775.8 UniProtKB/TrEMBL
  ENSMUST00000113776 ENTREZGENE
  ENSMUST00000113776.8 UniProtKB/TrEMBL
  ENSMUST00000113777.8 UniProtKB/TrEMBL
  ENSMUST00000113778 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000113779 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000113780 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000113781 ENTREZGENE
  ENSMUST00000113781.8 UniProtKB/TrEMBL
  ENSMUST00000113783.8 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro TNF_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tumour_necrosis_fac-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:13607 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1195272 ENTREZGENE
NCBI Gene 13607 ENTREZGENE
Pfam TNF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Eda PhenoGen
PROSITE TNF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49842 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0U5J8Q0 ENTREZGENE, UniProtKB/TrEMBL
  EDA_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q1L2D6 ENTREZGENE, UniProtKB/TrEMBL
  Q1L2D8 ENTREZGENE, UniProtKB/TrEMBL
  Q1L2D9 ENTREZGENE, UniProtKB/TrEMBL
  Q1L2E0 ENTREZGENE, UniProtKB/TrEMBL
  Q3UV69 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary B7ZMT7 UniProtKB/Swiss-Prot
  O35705 UniProtKB/Swiss-Prot
  Q9QWJ8 UniProtKB/Swiss-Prot
  Q9QZ01 UniProtKB/Swiss-Prot
  Q9QZ02 UniProtKB/Swiss-Prot