SELP (selectin P) - Rat Genome Database

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Gene: SELP (selectin P) Canis lupus familiaris
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Symbol: SELP
Name: selectin P
RGD ID: 12215478
Description: ENCODES a protein that exhibits calcium ion binding (inferred); calcium-dependent protein binding (inferred); carbohydrate binding (inferred); INVOLVED IN cell-cell adhesion (ortholog); heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (ortholog); inflammatory response (ortholog); PARTICIPATES IN interleukin-4 signaling pathway; ASSOCIATED WITH 1q24 Deletion Syndrome (ortholog); acute necrotizing pancreatitis (ortholog); allergic disease (ortholog); FOUND IN external side of plasma membrane (ortholog); extracellular space (ortholog); INTERACTS WITH edaravone; Thrombin
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cell adhesion molecule; GMP140; P-selectin
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1728,956,428 - 28,997,266 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl728,958,486 - 28,996,313 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha728,490,155 - 28,527,988 (+)NCBI
ROS_Cfam_1.0728,758,392 - 28,799,283 (+)NCBI
ROS_Cfam_1.0 Ensembl728,760,327 - 28,798,333 (+)Ensembl
UMICH_Zoey_3.1728,608,516 - 28,646,330 (+)NCBI
UNSW_CanFamBas_1.0728,644,251 - 28,682,064 (+)NCBI
UU_Cfam_GSD_1.0728,881,019 - 28,918,852 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
edaravone  (EXP)
Thrombin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:25673909  


Genomics

Comparative Map Data
SELP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1728,956,428 - 28,997,266 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl728,958,486 - 28,996,313 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha728,490,155 - 28,527,988 (+)NCBI
ROS_Cfam_1.0728,758,392 - 28,799,283 (+)NCBI
ROS_Cfam_1.0 Ensembl728,760,327 - 28,798,333 (+)Ensembl
UMICH_Zoey_3.1728,608,516 - 28,646,330 (+)NCBI
UNSW_CanFamBas_1.0728,644,251 - 28,682,064 (+)NCBI
UU_Cfam_GSD_1.0728,881,019 - 28,918,852 (+)NCBI
SELP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381169,588,849 - 169,630,124 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1169,588,849 - 169,630,193 (-)EnsemblGRCh38hg38GRCh38
GRCh371169,558,087 - 169,599,362 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361167,824,711 - 167,866,001 (-)NCBINCBI36hg18NCBI36
Build 341166,289,747 - 166,331,065NCBI
Celera1142,667,866 - 142,709,161 (-)NCBI
Cytogenetic Map1q24.2NCBI
HuRef1140,780,771 - 140,822,069 (-)NCBIHuRef
CHM1_11170,980,248 - 171,021,531 (-)NCBICHM1_1
T2T-CHM13v2.01168,944,736 - 168,986,000 (-)NCBI
Selp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391163,942,833 - 163,977,595 (+)NCBIGRCm39mm39
GRCm39 Ensembl1163,942,833 - 163,977,595 (+)Ensembl
GRCm381164,115,264 - 164,150,026 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1164,115,264 - 164,150,026 (+)EnsemblGRCm38mm10GRCm38
MGSCv371166,045,509 - 166,079,876 (+)NCBIGRCm37mm9NCBIm37
MGSCv361165,952,053 - 165,986,420 (+)NCBImm8
MGSCv361165,306,067 - 165,340,774 (+)NCBImm8
Celera1166,568,384 - 166,587,846 (+)NCBICelera
Cytogenetic Map1H2.2NCBI
cM Map171.42NCBI
Selp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21376,476,229 - 76,511,846 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1376,476,295 - 76,511,845 (+)Ensembl
Rnor_6.01382,428,914 - 82,464,629 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1382,429,063 - 82,464,628 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01387,308,435 - 87,344,164 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41379,886,614 - 79,922,180 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11379,910,278 - 79,936,368 (+)NCBI
Celera1376,209,805 - 76,244,685 (+)NCBICelera
RH 3.4 Map13482.6RGD
Cytogenetic Map13q23NCBI
Selp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554627,652,437 - 7,693,994 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554627,658,371 - 7,692,870 (+)NCBIChiLan1.0ChiLan1.0
SELP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11148,793,677 - 148,834,701 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1148,793,677 - 148,834,701 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01145,071,094 - 145,112,851 (-)NCBIMhudiblu_PPA_v0panPan3
LOC101970607
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934499,229,898 - 99,265,758 (+)NCBI
SpeTri2.0NW_00493648117,076,660 - 17,112,501 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SELP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl481,365,740 - 81,399,955 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1481,376,804 - 81,401,240 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2489,001,468 - 89,025,903 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103230618
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12559,420,910 - 59,465,140 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2559,433,333 - 59,462,598 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605561,082,227 - 61,140,767 (+)NCBIVero_WHO_p1.0
Selp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248267,511,646 - 7,537,924 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046248267,510,039 - 7,544,332 (-)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 1
Low 5 9 6 5 8 6
Below cutoff 5 13 6 6 1 6 12 8 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000037981   ⟹   ENSCAFP00000033637
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl728,958,486 - 28,996,313 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000037985   ⟹   ENSCAFP00000033641
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl728,967,277 - 28,996,313 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000081953   ⟹   ENSCAFP00000052124
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl728,958,486 - 28,996,313 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000084980   ⟹   ENSCAFP00000064894
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl728,958,486 - 28,996,313 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000092651   ⟹   ENSCAFP00000056871
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl728,958,486 - 28,996,313 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845003913   ⟹   ENSCAFP00845003119
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl728,760,327 - 28,792,592 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845003938   ⟹   ENSCAFP00845003139
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl728,760,505 - 28,798,333 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845003967   ⟹   ENSCAFP00845003168
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl728,760,505 - 28,798,333 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845004015   ⟹   ENSCAFP00845003211
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl728,760,505 - 28,798,333 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845004036   ⟹   ENSCAFP00845003230
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl728,760,505 - 28,798,333 (+)Ensembl
RefSeq Acc Id: NM_001287149   ⟹   NP_001274078
RefSeq Status: VALIDATED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1728,958,486 - 28,996,313 (+)NCBI
Dog10K_Boxer_Tasha728,490,155 - 28,527,988 (+)NCBI
ROS_Cfam_1.0728,760,505 - 28,798,333 (+)NCBI
UMICH_Zoey_3.1728,608,516 - 28,646,330 (+)NCBI
UNSW_CanFamBas_1.0728,644,251 - 28,682,064 (+)NCBI
UU_Cfam_GSD_1.0728,881,019 - 28,918,852 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038670496   ⟹   XP_038526424
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0728,760,288 - 28,799,283 (+)NCBI
RefSeq Acc Id: XM_038670497   ⟹   XP_038526425
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0728,758,392 - 28,799,283 (+)NCBI
RefSeq Acc Id: XM_038670498   ⟹   XP_038526426
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0728,760,287 - 28,799,283 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001274078 (Get FASTA)   NCBI Sequence Viewer  
  XP_038526424 (Get FASTA)   NCBI Sequence Viewer  
  XP_038526425 (Get FASTA)   NCBI Sequence Viewer  
  XP_038526426 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA63789 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001274078   ⟸   NM_001287149
- UniProtKB: Q28290 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000064894   ⟸   ENSCAFT00000084980
RefSeq Acc Id: ENSCAFP00000056871   ⟸   ENSCAFT00000092651
RefSeq Acc Id: ENSCAFP00000052124   ⟸   ENSCAFT00000081953
RefSeq Acc Id: ENSCAFP00000033637   ⟸   ENSCAFT00000037981
RefSeq Acc Id: ENSCAFP00000033641   ⟸   ENSCAFT00000037985
RefSeq Acc Id: XP_038526425   ⟸   XM_038670497
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038526426   ⟸   XM_038670498
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038526424   ⟸   XM_038670496
- Peptide Label: isoform X1
RefSeq Acc Id: ENSCAFP00845003119   ⟸   ENSCAFT00845003913
RefSeq Acc Id: ENSCAFP00845003139   ⟸   ENSCAFT00845003938
RefSeq Acc Id: ENSCAFP00845003230   ⟸   ENSCAFT00845004036
RefSeq Acc Id: ENSCAFP00845003168   ⟸   ENSCAFT00845003967
RefSeq Acc Id: ENSCAFP00845003211   ⟸   ENSCAFT00845004015
Protein Domains
C-type lectin   EGF-like   Sushi

Damaging Variants


Assembly: CanFam3.1

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
7 28969536 28969537 C A snv West Highland White Terrier (WW558), Basset (BH003), Cairn Terrier (CE073), West Highland White Terrier (WW364), West Highland White Terrier (WW361), West Highland White Terrier (WW362), West Highland White Terrier (WW363), West Highland White Terrier (WW174)
7 28969712 28969713 A C snv Australian Cattle dog (AC046), Australian Cattle dog (AC065), Border Collie (BC0480), Chinese indigenous dogs (YJ7), Border Collie (BC272), Border Collie (BC273), Border Collie (BC485), Border Collie (BC555), Border Collie (BC597), Bearded Collie (BD052), Bearded Collie (BD089), Bearded Collie (BD091), Bullmastiff (BU002), Chinese indigenous dogs (DQ1), Chinese indigenous dogs (DQ2), Chinese indigenous dogs (DQ5), German Shepherd/Mixed breed (DS041), German Shepherd/Mixed breed (DS042), German Shepherd (DS053), German Shepherd (DS064), Eurasier (EU008), Eurasier (EU035), German Shepherd (GS1), German Shepherd (GS2), German Shepherd (GS3), German Shepherd (GS4), German Shepherd (GS5), German Shepherd (GS6), German Shepherd (GS8), German Shepherd (GS9), Irish Terrier (IT0390), Siberian Husky (KKH2684), Kunming Dog (KM2), Kunming Dog (KM5), Kunming Dog (KM6), Leonberger (LB111), Chinese indigenous dogs (LJ1), Chinese indigenous dogs (LJ10), Chinese indigenous dogs (LJ2), Chinese indigenous dogs (LJ3), Chinese indigenous dogs (LJ4), Chinese indigenous dogs (LJ5), Chinese indigenous dogs (LJ6), Chinese indigenous dogs (LJ7), Chinese indigenous dogs (LJ8), Chinese indigenous dogs (LJ9), Border Collie (LN47), Malinois (MA008), Malinois (MA0163), Malinois (MA152), Rhodesian Ridgeback (RR123), Saluki (SL006), Iranian Wolf (SRS661488), Portuguese Wolf (SRS661492), Pembroke Welsh Corgi (SRS732551), Shetland Sheepdog (SRS932138), Alaskan Husky (SY001), Siberian Husky (SY046), Tibetan Mastiff (TM1), Tibetan Mastiff (TM2), Tibetan Mastiff (TM4), Wolf (WO001_895), Chinese indigenous dogs (YJ4), Chinese indigenous dogs (YJ5)
7 28991450 28991451 G C snv Basenji (BJ005), Basenji (BJ003), Basenji (BJ002), Basenji (BJ001)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000015180 Ensembl
  ENSCAFG00030024528 UniProtKB/TrEMBL
  ENSCAFG00040000799 UniProtKB/TrEMBL
  ENSCAFG00845002229 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00030039446.1 UniProtKB/TrEMBL
  ENSCAFP00030039465.1 UniProtKB/TrEMBL
  ENSCAFP00030039470.1 UniProtKB/TrEMBL
  ENSCAFP00040001287 UniProtKB/TrEMBL
  ENSCAFP00040001313 UniProtKB/TrEMBL
  ENSCAFP00040001339 UniProtKB/TrEMBL
  ENSCAFP00040001354 UniProtKB/TrEMBL
  ENSCAFP00040001364 UniProtKB/TrEMBL
  ENSCAFP00845003119.1 UniProtKB/TrEMBL
  ENSCAFP00845003139 ENTREZGENE
  ENSCAFP00845003139.1 UniProtKB/TrEMBL
  ENSCAFP00845003168 ENTREZGENE
  ENSCAFP00845003168.1 UniProtKB/TrEMBL
  ENSCAFP00845003211 ENTREZGENE
  ENSCAFP00845003211.1 UniProtKB/TrEMBL
  ENSCAFP00845003230.1 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00030045183.1 UniProtKB/TrEMBL
  ENSCAFT00030045204.1 UniProtKB/TrEMBL
  ENSCAFT00030045209.1 UniProtKB/TrEMBL
  ENSCAFT00040001509 UniProtKB/TrEMBL
  ENSCAFT00040001547 UniProtKB/TrEMBL
  ENSCAFT00040001584 UniProtKB/TrEMBL
  ENSCAFT00040001604 UniProtKB/TrEMBL
  ENSCAFT00040001615 UniProtKB/TrEMBL
  ENSCAFT00845003913.1 UniProtKB/TrEMBL
  ENSCAFT00845003938 ENTREZGENE
  ENSCAFT00845003938.1 UniProtKB/TrEMBL
  ENSCAFT00845003967 ENTREZGENE
  ENSCAFT00845003967.1 UniProtKB/TrEMBL
  ENSCAFT00845004015 ENTREZGENE
  ENSCAFT00845004015.1 UniProtKB/TrEMBL
  ENSCAFT00845004036.1 UniProtKB/TrEMBL
Gene3D-CATH 3.10.100.10 UniProtKB/TrEMBL
InterPro C-type_lectin-like UniProtKB/TrEMBL
  C-type_lectin-like/link_sf UniProtKB/TrEMBL
  C-type_lectin_CS UniProtKB/TrEMBL
  CTDL_fold UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/TrEMBL
  Selectin_superfamily UniProtKB/TrEMBL
  Sushi/SCR/CCP_sf UniProtKB/TrEMBL
  Sushi_SCR_CCP_dom UniProtKB/TrEMBL
KEGG Report cfa:403994 UniProtKB/TrEMBL
NCBI Gene SELP ENTREZGENE
Pfam EGF UniProtKB/TrEMBL
  Lectin_C UniProtKB/TrEMBL
  Sushi UniProtKB/TrEMBL
PRINTS SELECTIN UniProtKB/TrEMBL
PROSITE C_TYPE_LECTIN_1 UniProtKB/TrEMBL
  C_TYPE_LECTIN_2 UniProtKB/TrEMBL
  EGF_1 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  SUSHI UniProtKB/TrEMBL
SMART CCP UniProtKB/TrEMBL
  CLECT UniProtKB/TrEMBL
  EGF UniProtKB/TrEMBL
Superfamily-SCOP SSF56436 UniProtKB/TrEMBL
  SSF57535 UniProtKB/TrEMBL
UniProt A0A8C0PRQ0_CANLF UniProtKB/TrEMBL
  A0A8C0PTS8_CANLF UniProtKB/TrEMBL
  A0A8C0PW87_CANLF UniProtKB/TrEMBL
  A0A8C0Q3D2_CANLF UniProtKB/TrEMBL
  A0A8C0RSQ3_CANLF UniProtKB/TrEMBL
  A0A8C0RSQ7_CANLF UniProtKB/TrEMBL
  A0A8I3MFN1_CANLF UniProtKB/TrEMBL
  A0A8I3MIC7_CANLF UniProtKB/TrEMBL
  A0A8I3MKI2_CANLF UniProtKB/TrEMBL
  A0A8I3RQK1_CANLF UniProtKB/TrEMBL
  A0A8I3RQL3_CANLF UniProtKB/TrEMBL
  Q28290 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:45985 ENTREZGENE