Edar (ectodysplasin-A receptor) - Rat Genome Database

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Gene: Edar (ectodysplasin-A receptor) Mus musculus
Analyze
Symbol: Edar
Name: ectodysplasin-A receptor
RGD ID: 1557662
MGI Page MGI
Description: Predicted to have transmembrane signaling receptor activity. Involved in several processes, including animal organ development; positive regulation of NIK/NF-kappaB signaling; and positive regulation of gene expression. Localizes to apical part of cell and plasma membrane. Is expressed in several structures, including embryo ectoderm; exocrine gland; integumental system; sensory organ; and tooth. Used to study hypohidrotic ectodermal dysplasia. Human ortholog(s) of this gene implicated in ectodermal dysplasia 10A and ectodermal dysplasia 10B. Orthologous to human EDAR (ectodysplasin A receptor); INTERACTS WITH 3,4-methylenedioxymethamphetamine; benzo[a]pyrene; bis(2-chloroethyl) sulfide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: anhidrotic ectodysplasin receptor 1; dl; downless; ectodermal dysplasia receptor; ED1R; ED3; ED5; EDA-A1R; EDA3; tumor necrosis factor receptor superfamily member EDAR
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391058,436,602 - 58,511,518 (-)NCBIGRCm39mm39
GRCm39 Ensembl1058,436,611 - 58,511,476 (-)Ensembl
GRCm381058,600,780 - 58,675,696 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1058,600,789 - 58,675,654 (-)EnsemblGRCm38mm10GRCm38
MGSCv371058,063,536 - 58,138,444 (-)NCBIGRCm37mm9NCBIm37
MGSCv361058,582,058 - 58,656,978 (-)NCBImm8
MGSCv361057,996,146 - 58,071,053 (-)NCBImm8
Cytogenetic Map10B4NCBI
cM Map1029.37NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal auchene hair morphology  (IAGP)
abnormal awl hair morphology  (IAGP)
abnormal branching of the mammary ductal tree  (IAGP)
abnormal circumvallate papillae morphology  (IAGP)
abnormal coat appearance  (IAGP)
abnormal coat/ hair morphology  (IAGP)
abnormal coat/hair pigmentation  (IAGP)
abnormal enamel knot morphology  (IAGP)
abnormal hair cycle  (IAGP)
abnormal hair follicle development  (IAGP)
abnormal hair follicle morphology  (IAGP)
abnormal hair growth  (IAGP)
abnormal hair texture  (IAGP)
abnormal incisor morphology  (IAGP)
abnormal mammary fat pad morphology  (IAGP)
abnormal minor salivary gland morphology  (IAGP)
abnormal molar cusp morphology  (IAGP)
abnormal molar morphology  (IAGP)
abnormal molar root morphology  (IAGP)
abnormal tail position or orientation  (IEA)
abnormal tooth morphology  (IAGP)
abnormal vibrissa number  (IAGP)
absent anterior lingual gland  (IAGP)
absent auchene hairs  (IAGP)
absent duvet hair  (IAGP)
absent guard hair  (IAGP)
absent hair follicles  (IAGP)
absent incisors  (IAGP)
absent Meibomian glands  (IAGP)
absent molars  (IAGP)
absent palatine gland  (IAGP)
absent sweat gland  (IAGP)
absent zigzag hairs  (IAGP)
cataract  (IAGP)
darkened coat color  (IAGP)
decreased eccrine gland number  (IAGP)
decreased mean platelet volume  (IEA)
decreased molar number  (IAGP)
enlarged heart  (IEA)
focal hair loss  (IAGP)
greasy coat  (IAGP)
hairless tail  (IAGP)
increased apoptosis  (IAGP)
increased eccrine gland number  (IAGP)
irregular coat pigmentation  (IEA)
kinked tail  (IAGP)
preweaning lethality, complete penetrance  (IEA)
preweaning lethality, incomplete penetrance  (IEA)
shiny fur  (IAGP)
small incisors  (IAGP)
small molars  (IAGP)
sparse hair  (IAGP)
supernumerary teeth  (IAGP)
References

Additional References at PubMed
PMID:270322   PMID:544312   PMID:678292   PMID:892445   PMID:1733847   PMID:2622338   PMID:4420168   PMID:4789444   PMID:5361554   PMID:5361555   PMID:7983247   PMID:8034315  
PMID:9799834   PMID:10349636   PMID:10431242   PMID:10721709   PMID:11023871   PMID:11042159   PMID:11076861   PMID:11203701   PMID:11239407   PMID:11371349   PMID:11570810   PMID:11585809  
PMID:11780064   PMID:11973284   PMID:12015971   PMID:12060722   PMID:12230506   PMID:12477932   PMID:12629675   PMID:12702649   PMID:12805214   PMID:12812793   PMID:12972005   PMID:14729942  
PMID:15013427   PMID:15031115   PMID:15136142   PMID:15305290   PMID:15366021   PMID:15371307   PMID:15538367   PMID:15978571   PMID:16141072   PMID:16141073   PMID:16179481   PMID:16423472  
PMID:16481354   PMID:16524929   PMID:16769906   PMID:16813530   PMID:17121988   PMID:17148670   PMID:17164417   PMID:17360773   PMID:17362907   PMID:18256193   PMID:18508042   PMID:18561327  
PMID:18651655   PMID:18676816   PMID:18689798   PMID:19270025   PMID:19340299   PMID:19387480   PMID:19427408   PMID:19500387   PMID:19591819   PMID:19619491   PMID:19855838   PMID:20709958  
PMID:20803597   PMID:20969842   PMID:21267068   PMID:21652647   PMID:21677750   PMID:21873635   PMID:21905163   PMID:21982707   PMID:22434869   PMID:22666322   PMID:22898663   PMID:23123965  
PMID:23190887   PMID:23293290   PMID:23415220   PMID:23431057   PMID:23441037   PMID:24051719   PMID:24194600   PMID:24309208   PMID:25066162   PMID:25207818   PMID:25249463   PMID:25422376  
PMID:25514040   PMID:26105758   PMID:26581094   PMID:26829034   PMID:26926045   PMID:26952977   PMID:27193062   PMID:27378689   PMID:27414798   PMID:27626380   PMID:28698625   PMID:28942365  
PMID:29855541   PMID:30063206   PMID:30220568   PMID:30595533   PMID:30595537   PMID:30730874   PMID:30745437   PMID:31221639  


Genomics

Comparative Map Data
Edar
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391058,436,602 - 58,511,518 (-)NCBIGRCm39mm39
GRCm39 Ensembl1058,436,611 - 58,511,476 (-)Ensembl
GRCm381058,600,780 - 58,675,696 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1058,600,789 - 58,675,654 (-)EnsemblGRCm38mm10GRCm38
MGSCv371058,063,536 - 58,138,444 (-)NCBIGRCm37mm9NCBIm37
MGSCv361058,582,058 - 58,656,978 (-)NCBImm8
MGSCv361057,996,146 - 58,071,053 (-)NCBImm8
Cytogenetic Map10B4NCBI
cM Map1029.37NCBI
EDAR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2108,894,471 - 108,989,372 (-)EnsemblGRCh38hg38GRCh38
GRCh382108,894,471 - 108,989,256 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372109,510,927 - 109,605,676 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362108,877,361 - 108,972,260 (-)NCBINCBI36hg18NCBI36
Build 342108,969,448 - 109,064,346NCBI
Celera2103,820,860 - 103,915,790 (-)NCBI
Cytogenetic Map2q13NCBI
HuRef2103,109,351 - 103,204,259 (-)NCBIHuRef
CHM1_12109,515,194 - 109,610,098 (-)NCBICHM1_1
Edar
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22026,587,836 - 26,666,543 (-)NCBI
Rnor_6.0 Ensembl2028,179,140 - 28,263,037 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.02028,179,132 - 28,263,092 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02029,996,972 - 30,079,875 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42037,135,534 - 37,164,197 (+)NCBIRGSC3.4rn4RGSC3.4
Celera2028,038,358 - 28,066,702 (-)NCBICelera
Cytogenetic Map20q11NCBI
Edar
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547012,309,048 - 12,362,570 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495547012,310,680 - 12,362,555 (-)NCBIChiLan1.0ChiLan1.0
EDAR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A110,146,499 - 110,241,556 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A110,146,499 - 110,234,398 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02A95,132,396 - 95,172,218 (-)NCBIMhudiblu_PPA_v0panPan3
EDAR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11034,873,311 - 34,943,140 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1034,848,526 - 34,940,784 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1034,772,071 - 34,866,543 (+)NCBI
ROS_Cfam_1.01035,700,824 - 35,795,378 (+)NCBI
UMICH_Zoey_3.11035,430,446 - 35,524,880 (+)NCBI
UNSW_CanFamBas_1.01035,712,643 - 35,807,092 (+)NCBI
UU_Cfam_GSD_1.01035,901,219 - 35,995,761 (+)NCBI
Edar
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629291,938,934 - 91,970,049 (+)NCBI
SpeTri2.0NW_004936829429,667 - 458,943 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EDAR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl347,396,327 - 47,465,791 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1347,396,303 - 47,466,234 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2349,558,908 - 49,626,194 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EDAR
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11412,430,405 - 12,527,160 (-)NCBI
ChlSab1.1 Ensembl1412,433,418 - 12,468,841 (-)Ensembl
Edar
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474911,981,782 - 11,998,933 (-)NCBI

Position Markers
AF160502  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381058,601,776 - 58,601,888UniSTSGRCm38
MGSCv371058,064,524 - 58,064,636UniSTSGRCm37
Cytogenetic Map10B3UniSTS
cM Map1029.0UniSTS
Whitehead/MRC_RH10681.07UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302092Ath11_matherosclerosis 11 (mouse)Not determined10620194558857699Mouse
1357740Obsty3_mobesity 3 (mouse)Not determined108359714116355075Mouse
1301386Sysbp1_msystolic blood pressure 1 (mouse)Not determined101023252187565233Mouse
1357825Kidpq2_mkidney weight percentage QTL 2 (mouse)Not determined101282830784243920Mouse
1357656Hrtq3_mheart weight QTL 3 (mouse)Not determined101282830784243920Mouse
1357864Scfpq1_msubcutaneous fat pad percentage QTL 1 (mouse)Not determined101282830784243920Mouse
1357893Lvrq4_mliver weight QTL 4 (mouse)Not determined101282830784243920Mouse
4142380W3q11_mweight 3 weeks QTL 11 (mouse)Not determined1282830784243920Mouse
4141943W6q6_mweight 6 weeks QTL 6 (mouse)Not determined1282830784243920Mouse
4141956Egq7_mearly growth QTL 7 (mouse)Not determined1282830784243920Mouse
4142272W10q5_mweight 10 weeks QTL 5 (mouse)Not determined1282830784243920Mouse
39128215Lwq17_mliver weight QTL 17 (mouse)101282830784243920Mouse
1302067Scc9_mcolon tumor susceptibility 9 (mouse)Not determined1018383585125739363Mouse
27226772Tibl13_mtibia length 13, 10 week (mouse)1019000000129800000Mouse
1558757Eae34_mexperimental allergic encephalomyelitis susceptibility 34 (mouse)Not determined1021532255114381325Mouse
1301003Lmblgq4_mlimb length QTL 4 (mouse)Not determined102171529368255809Mouse
26884403Cvht8_mcranial vault height 8, 16 week (mouse)102300000091200000Mouse
26884426Cvht1_mcranial vault height 1, 5 week (mouse)1024800000121200000Mouse
1300898Cfid_mcystic fibrosis intestinal distress (mouse)Not determined102984430763844387Mouse
10045632Heal16_mwound healing/regeneration 16 (mouse)Not determined103109840365098534Mouse
1357558Bmch4_mbone mechanical trait 4 (mouse)Not determined103170104065701188Mouse
27095920Pglq9_mpelvic girdle length QTL 9, 10 week (mouse)103390000071000000Mouse
27095911Pglq15_mpelvic girdle length QTL 15, 16 week (mouse)1039300000129800000Mouse
27226764Tibl19_mtibia length 19, 16 week (mouse)1039300000129800000Mouse
4141070Ltgq1_mliver triglyceride QTL 1 (mouse)Not determined4140150475401504Mouse
26884411Bzwq8_mbi-zygomatic width QTL 8, 10 week (mouse)1045000000116100000Mouse
26884407Bzwq14_mbi-zygomatic width QTL 14, 16 wee (mouse)1045600000120800000Mouse
26884421Cvht5_mcranial vault height 5, 10 week (mouse)104570000069300000Mouse
26884400Huml5_mhumerus length 5, 16 week (mouse)104640000069400000Mouse
4142313Angvq1_mangiogenesis by VEGF QTL 1 (mouse)Not determined4684430782655287Mouse
4141159Phl2_mprogressive hearing loss 2 (mouse)Not determined104809840370276821Mouse
1302150Bbaa18_mB.burgdorferi-associated arthritis 18 (mouse)Not determined104950223383502378Mouse
4142169Pbwg16_mpostnatal body weight growth 16 (mouse)Not determined105001240884012633Mouse
1300597Skull14_mskull morphology 14 (mouse)Not determined105001240884012633Mouse
10045641Jckm3_mjuvenile cystic kidney modifier 3 (mouse)Not determined105001240884012633Mouse
1301966Lifespan2_mlife span 2 (mouse)Not determined105001244384012618Mouse
1357737Hpcr2_mhepatocarcinogen resistance 2 (mouse)Not determined105001244384012618Mouse
1300882Ath17_matherosclerosis 17 (mouse)Not determined105125566085255809Mouse
1301502Eae17_msusceptibility to experimental allergic encephalomyelitis 17 (mouse)Not determined105125566085255809Mouse
1301380Cia8_mcollagen induced arthritis QTL 8 (mouse)Not determined105161730482655287Mouse
14746991Manh68_mmandible shape 68 (mouse)105244466786444667Mouse
12904011Cfq11_mconditioned fear QTL 11 (mouse)105660406061105062Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:610
Count of miRNA genes:445
Interacting mature miRNAs:499
Transcripts:ENSMUST00000003312
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000003312   ⟹   ENSMUSP00000003312
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1058,600,789 - 58,675,654 (-)Ensembl
RefSeq Acc Id: NM_010100   ⟹   NP_034230
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391058,436,610 - 58,511,518 (-)NCBI
GRCm381058,600,788 - 58,675,696 (-)NCBI
MGSCv371058,063,536 - 58,138,444 (-)RGD
cM Map10 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006513204   ⟹   XP_006513267
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391058,436,602 - 58,489,139 (-)NCBI
GRCm381058,600,780 - 58,653,319 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006513205   ⟹   XP_006513268
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391058,436,602 - 58,489,136 (-)NCBI
GRCm381058,600,780 - 58,653,317 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006513206   ⟹   XP_006513269
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391058,436,602 - 58,489,133 (-)NCBI
GRCm381058,600,780 - 58,653,314 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030244869   ⟹   XP_030100729
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391058,436,602 - 58,465,951 (-)NCBI
GRCm381058,600,780 - 58,630,129 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_034230   ⟸   NM_010100
- Peptide Label: precursor
- UniProtKB: Q9R187 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006513267   ⟸   XM_006513204
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006513268   ⟸   XM_006513205
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006513269   ⟸   XM_006513206
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_030100729   ⟸   XM_030244869
- Peptide Label: isoform X4
RefSeq Acc Id: ENSMUSP00000003312   ⟸   ENSMUST00000003312
Protein Domains
Death

Promoters
RGD ID:8672062
Promoter ID:EPDNEW_M14041
Type:initiation region
Name:Edar_1
Description:Mus musculus ectodysplasin-A receptor , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381058,675,697 - 58,675,757EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1343498 AgrOrtholog
Ensembl Genes ENSMUSG00000003227 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000003312 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000003312 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro DEATH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EDAR_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:13608 UniProtKB/Swiss-Prot
MGD MGI:1343498 ENTREZGENE
NCBI Gene 13608 ENTREZGENE
PhenoGen Edar PhenoGen
Superfamily-SCOP SSF47986 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt EDAR_MOUSE UniProtKB/Swiss-Prot
  Q6NV51_MOUSE UniProtKB/TrEMBL
  Q9R187 ENTREZGENE
UniProt Secondary Q9DC43 UniProtKB/Swiss-Prot