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75 records found for search term C4b
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RGD IDSymbolNameDescriptionChrStartStopSpeciesAnnotationsMatchType
10257C4bcomplement C4B (Chido blood group)Predicted to enable carbohydrate binding activity and complement component C1q complex binding activity. Acts upstream of or within complement activation and immunoglobulin mediated immune response. Located in extracellular space. Is expressed in several structures, including hemolymphoid system; li173494724934962876Mouse209symbol , PhenoGen , name , descriptiongene, protein-coding, VALIDATED [RefSeq]
1591983C4bcomplement C4BENCODES a protein that exhibits antigen binding (ortholog); carbohydrate binding (ortholog); complement binding (ortholog); INVOLVED IN complement activation (ortholog); complement activation, classical pathway (ortholog); complement activation, GZMK pathway (ortholog); PARTICIPATES IN coagulation c2042019794216292Rat214symbol , old_gene_name , PhenoGen , namegene, protein-coding, VALIDATED [RefSeq]
1605129C4Bcomplement C4B (Chido/Rodgers blood group)This gene encodes the basic form of complement factor 4, and together with the C4A gene, is part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer pr63201479532035418Human278symbol , old_gene_name , COSMIC , name , Human Proteome Map , old_gene_symbolgene, protein-coding, REVIEWED [RefSeq]
10399720C4B-AS1C4B antisense RNA 1Humansymbol , COSMIC , name , Human Proteome Mapgene, ncrna
620005C4acomplement C4A (Rodgers blood group)ENCODES a protein that exhibits antigen binding (ortholog); complement component C1q complex binding (ortholog); INVOLVED IN complement activation (ortholog); complement activation, classical pathway (ortholog); complement activation, GZMK pathway (ortholog); PARTICIPATES IN classical complement pat2040103064024707Rat140old_gene_symbolgene, protein-coding, VALIDATED [RefSeq]
1615407C4acomplement C4A (Rodgers blood group)Predicted to enable carbohydrate binding activity and complement component C1q complex binding activity. Acts upstream of or within complement activation. Located in extracellular space. Human ortholog(s) of this gene implicated in autistic disorder; autoimmune disease (multiple); complement deficie173502806935042436Mouse134description , old_gene_symbolgene, protein-coding, VALIDATED [RefSeq]
11956560LOC100984709C4b-binding protein alpha chainINVOLVED IN binding of sperm to zona pellucida (ortholog); single fertilization (ortholog); ASSOCIATED WITH COVID-19 (ortholog); Radiation Pneumonitis (ortholog); FOUND IN acrosomal matrix (ortholog); acrosomal vesicle (ortholog); cell body (ortholog)1182707221182747878Bonobo30name , old_gene_symbolgene, protein-coding, MODEL [RefSeq]
18936547LOC101721321C4b-binding protein alpha chainINVOLVED IN complement activation, classical pathway (inferred); immune system process (inferred); innate immune response (inferred)Naked Mole-Rat3namegene, protein-coding, MODEL [RefSeq]
12472340LOC101973539C4b-binding protein alpha chainINVOLVED IN complement activation, classical pathway (inferred); immune system process (inferred); innate immune response (inferred); FOUND IN extracellular space (inferred)NW_00493655755113725535158Squirrel8name , old_gene_symbolgene, protein-coding, MODEL [RefSeq]
2399Cr1lcomplement C3b/C4b receptor 1 likeINVOLVED IN negative regulation of complement activation; cellular response to hypoxia (ortholog); complement activation (ortholog); PARTICIPATES IN coagulation cascade pathway; complement system pathway; FOUND IN basolateral plasma membrane (ortholog); cell surface (ortholog); external side of plas13109138132109189068Rat100namegene, protein-coding, REVIEWED [RefSeq]
732956Cr1lcomplement C3b/C4b receptor 1 likePredicted to enable complement receptor activity and opsonin binding activity. Acts upstream of or within several processes, including cellular response to hypoxia; complement activation; and negative regulation of complement activation. Located in basolateral plasma membrane and external side of pl1194781019194813878Mouse131name , descriptiongene, protein-coding, VALIDATED [RefSeq]
1348835CR1Lcomplement C3b/C4b receptor 1 likeActs upstream of or within regulation of complement activation and regulation of complement-dependent cytotoxicity. Part of receptor complex. [provided by Alliance of Genome Resources, Jul 2025]1207645133207723703Human96old_gene_name , namegene, protein-coding, VALIDATED [RefSeq]
11925800CR1Lcomplement C3b/C4b receptor 1 likeINVOLVED IN cellular response to hypoxia (ortholog); complement activation (ortholog); in utero embryonic development (ortholog); FOUND IN basolateral plasma membrane (ortholog); external side of plasma membrane (ortholog)1183224415183303268Bonobo27namegene, protein-coding, MODEL [RefSeq]
18642056CR1Lcomplement C3b/C4b receptor 1 likeINVOLVED IN cellular response to hypoxia (ortholog); complement activation (ortholog); in utero embryonic development (ortholog); FOUND IN basolateral plasma membrane (ortholog); cell surface (ortholog); external side of plasma membrane (ortholog)Green Monkey13namegene, protein-coding
12149199LOC100855476C4b-binding protein alpha chain-like221960966119611758Dogold_gene_name , namegene, protein-coding, MODEL [RefSeq]
8791048LOC102008817C4b-binding protein alpha chain-likeNW_0049554064270935942715864Chinchillanamegene, protein-coding, MODEL [RefSeq]
1603411CR1complement C3b/C4b receptor 1 (Knops blood group)This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The genome is polymorphic at this locus with allele-specific splice variants encoding different isoforms, based on the presence/absence of long homologous repeats 1207496157207641765Human109old_gene_name , name , old_gene_symbolgene, protein-coding, REVIEWED [RefSeq]
11780137CR1complement C3b/C4b receptor 1 (Knops blood group)ENCODES a protein that exhibits complement component C3b binding (ortholog); complement component C3b receptor activity (ortholog); complement component C4b binding (ortholog); INVOLVED IN ATP export (ortholog); complement activation (ortholog); complement activ1183094601183246957Bonobo41name , descriptiongene, protein-coding, MODEL [RefSeq]
14180015CR1complement C3b/C4b receptor 1 (Knops blood group)ENCODES a protein that exhibits complement component C3b binding (ortholog); complement component C3b receptor activity (ortholog); complement component C4b binding (ortholog); INVOLVED IN ATP export (ortholog); complement activation (ortholog); complement activPig41name , descriptiongene, protein-coding, MODEL [RefSeq]
18514618CR1complement C3b/C4b receptor 1 (Knops blood group)ENCODES a protein that exhibits complement component C3b binding (ortholog); complement component C3b receptor activity (ortholog); complement component C4b binding (ortholog); INVOLVED IN ATP export (ortholog); complement activation (ortholog); complement activGreen Monkey41name , descriptiongene, protein-coding, MODEL [RefSeq]
38641344LOC100422434complement C3b/C4b receptor 1 (Knops blood group) pseudogene1207710382207712868Humannamegene, pseudo, INFERRED [RefSeq]
10258C4bpcomplement component 4 binding proteinPredicted to be involved in several processes, including negative regulation of complement activation, classical pathway; regulation of opsonization; and response to symbiotic bacterium. Predicted to be located in extracellular region. Predicted to be active in extracellular space and plasma membran1130562510130589365Mouse70symbol , old_gene_name , PhenoGen , description , old_gene_symbolgene, protein-coding, VALIDATED [RefSeq]
620429Cficomplement factor IENCODES a protein that exhibits hydrolase activity (inferred); metal ion binding (inferred); peptidase activity (inferred); INVOLVED IN cellular response to interleukin-6; complement activation (ortholog); proteolysis (ortholog); PARTICIPATES IN coagulation cascade pathway; complement system pathway2221062206221104790Rat210old_gene_namegene, protein-coding, PROVISIONAL [RefSeq]
732319Cficomplement component factor iThis gene encodes a serine protease that plays an important role in the classical and alternative complement pathways where it cleaves C4b and C3b components of C3 and C5 convertases. The encoded preproprotein undergoes proteolytic processing to generate an acti3129630432129668978Mouse222old_gene_name , descriptiongene, protein-coding, VALIDATED [RefSeq]
736809CFIcomplement factor IThis gene encodes a serine proteinase that is essential for regulating the complement cascade. The encoded preproprotein is cleaved to produce both heavy and light chains, which are linked by disulfide bonds to form a heterodimeric glycoprotein. This heterodimer can cleave and inactivate the complem4109730982109801999Human483old_gene_name , descriptiongene, protein-coding, REVIEWED [RefSeq]
2236C4bpbcomplement component 4 binding protein, betaINVOLVED IN negative regulation of complement activation, classical pathway (ortholog); positive regulation of protein catabolic process (ortholog); regulation of opsonization (ortholog); PARTICIPATES IN forkhead class A signaling pathway; coagulation cascade pathway; complement system pathway; ASSO134467306444683781Rat92symbol , old_gene_name , PhenoGen , old_gene_symbolgene, protein-coding, PROVISIONAL [RefSeq]
736875C4BPBcomplement component 4 binding protein betaThis gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. A single, unique beta-chain encoded by this gene assembles with seven identical alpha-chains into the predominant isoform of C4b1207088860207099993Human90symbol , old_gene_name , COSMIC , description , Human Proteome Map , old_gene_symbolgene, protein-coding, REVIEWED [RefSeq]
8709568C4bpbcomplement component 4 binding protein betaINVOLVED IN negative regulation of complement activation, classical pathway (ortholog); positive regulation of protein catabolic process (ortholog); regulation of opsonization (ortholog); PARTICIPATES IN forkhead class A signaling pathway; ASSOCIATED WITH COVID-19 (ortholog); FOUND IN extracellular NW_0049554064260116442608912Chinchilla8symbol , old_gene_namegene, protein-coding, MODEL [RefSeq]
11799915C4BPBcomplement component 4 binding protein betaINVOLVED IN negative regulation of complement activation, classical pathway (inferred); positive regulation of protein catabolic process (inferred); regulation of opsonization (inferred); PARTICIPATES IN forkhead class A signaling pathway; ASSOCIATED WITH COVID-19 (ortholog); FOUND IN extracellular 1182691574182703004Bonobo9symbol , old_gene_namegene, protein-coding, MODEL [RefSeq]
12423475C4BPBcomplement component 4 binding protein betaINVOLVED IN negative regulation of complement activation, classical pathway (inferred); positive regulation of protein catabolic process (inferred); regulation of opsonization (inferred); PARTICIPATES IN forkhead class A signaling pathway; ASSOCIATED WITH COVID-19 (ortholog); FOUND IN extracellular 762249626236925Dog8symbol , old_gene_namegene, protein-coding, MODEL [RefSeq]
12538885C4bpbcomplement component 4 binding protein betaINVOLVED IN negative regulation of complement activation, classical pathway (ortholog); positive regulation of protein catabolic process (ortholog); regulation of opsonization (ortholog); PARTICIPATES IN forkhead class A signaling pathway; ASSOCIATED WITH COVID-19 (ortholog); FOUND IN extracellular NW_00493655755466925561531Squirrel8symbol , old_gene_namegene, protein-coding, MODEL [RefSeq]
13876687C4BPBcomplement component 4 binding protein betaINVOLVED IN negative regulation of complement activation, classical pathway (inferred); positive regulation of protein catabolic process (inferred); regulation of opsonization (inferred); PARTICIPATES IN forkhead class A signaling pathway; ASSOCIATED WITH COVID-19 (ortholog); FOUND IN extracellular Pig8symbol , old_gene_namegene, protein-coding, MODEL [RefSeq]
18386212C4BPBcomplement component 4 binding protein betaINVOLVED IN negative regulation of complement activation, classical pathway (inferred); positive regulation of protein catabolic process (inferred); regulation of opsonization (inferred); PARTICIPATES IN forkhead class A signaling pathway; ASSOCIATED WITH COVID-19 (ortholog); FOUND IN extracellular Green Monkey9symbol , old_gene_namegene, protein-coding, MODEL [RefSeq]
18928518C4bpbcomplement component 4 binding protein betaINVOLVED IN negative regulation of complement activation, classical pathway (inferred); positive regulation of protein catabolic process (inferred); regulation of opsonization (inferred); PARTICIPATES IN forkhead class A signaling pathway; ASSOCIATED WITH COVID-19 (ortholog); FOUND IN extracellular Naked Mole-Rat8symbol , old_gene_namegene, protein-coding, MODEL [RefSeq]
625962321C4bpbcomplement component 4 binding protein betaINVOLVED IN negative regulation of complement activation, classical pathway (ortholog); positive regulation of protein catabolic process (ortholog); regulation of opsonization (ortholog); PARTICIPATES IN forkhead class A signaling pathway; ASSOCIATED WITH COVID-19 (ortholog); FOUND IN extracellular Black Rat8symbol , old_gene_namegene, protein-coding, MODEL [RefSeq]
2235C4bpacomplement component 4 binding protein, alphaENCODES a protein that exhibits complement binding (inferred); INVOLVED IN binding of sperm to zona pellucida (ortholog); negative regulation of complement activation, classical pathway (ortholog); positive regulation of protein catabolic process (ortholog); PARTICIPATES IN coagulation cascade pathw134462795944663552Rat138symbol , old_gene_name , PhenoGen , old_gene_symbolgene, protein-coding, PROVISIONAL [RefSeq]
736103C4BPAcomplement component 4 binding protein alphaThis gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. Along with a single, unique beta-chain, seven identical alpha-chains encoded by this gene assemble into the predominant isoform of C4b1207104233207144972Human139symbol , old_gene_name , COSMIC , description , Human Proteome Map , old_gene_symbolgene, protein-coding, REVIEWED [RefSeq]
8710848C4bpacomplement component 4 binding protein alphaINVOLVED IN binding of sperm to zona pellucida (ortholog); negative regulation of complement activation, classical pathway (ortholog); positive regulation of protein catabolic process (ortholog); ASSOCIATED WITH COVID-19 (ortholog); Radiation Pneumonitis (ortholog); FOUND IN acrosomal matrix (ortholNW_0049554064261365942641918Chinchilla24symbol , old_gene_namegene, protein-coding, MODEL [RefSeq]
12236375C4BPAcomplement component 4 binding protein alphaINVOLVED IN binding of sperm to zona pellucida (ortholog); positive regulation of protein catabolic process (ortholog); regulation of opsonization (ortholog); ASSOCIATED WITH COVID-19 (ortholog); Radiation Pneumonitis (ortholog); FOUND IN acrosomal matrix (ortholog); acrosomal vesicle (ortholog); ce762390366268934Dog27symbol , old_gene_namegene, protein-coding, MODEL [RefSeq]
13855995C4BPAcomplement component 4 binding protein alphaINVOLVED IN binding of sperm to zona pellucida (ortholog); single fertilization (ortholog); ASSOCIATED WITH COVID-19 (ortholog); Radiation Pneumonitis (ortholog); FOUND IN acrosomal matrix (ortholog); acrosomal vesicle (ortholog); cell body (ortholog); INTERACTS WITH deoxynivalenol; zearalenonePig30symbol , old_gene_namegene, protein-coding, MODEL [RefSeq]
18730844C4BPAcomplement component 4 binding protein alphaINVOLVED IN binding of sperm to zona pellucida (ortholog); negative regulation of complement activation, classical pathway (ortholog); positive regulation of protein catabolic process (ortholog); ASSOCIATED WITH COVID-19 (ortholog); Radiation Pneumonitis (ortholog); FOUND IN acrosomal matrix (ortholGreen Monkey24symbol , old_gene_namegene, protein-coding, MODEL [RefSeq]
625838559C4bpacomplement component 4 binding protein alphaINVOLVED IN binding of sperm to zona pellucida (ortholog); negative regulation of complement activation, classical pathway (ortholog); positive regulation of protein catabolic process (ortholog); ASSOCIATED WITH COVID-19 (ortholog); Radiation Pneumonitis (ortholog); FOUND IN acrosomal matrix (ortholBlack Rat24symbol , old_gene_namegene, protein-coding, MODEL [RefSeq]
12250166LOC490269complement receptor type 2ENCODES a protein that exhibits complement component C3b binding (ortholog); complement component C3b receptor activity (ortholog); complement component C4b binding (ortholog); INVOLVED IN ATP export (ortholog); complement activation (ortholog); complement activ764562386480672Dog50old_gene_name , descriptiongene, protein-coding, MODEL [RefSeq]
18674727LOC103247303zona pellucida sperm-binding protein 3 receptor-likeGreen Monkeyold_gene_namegene, protein-coding, MODEL [RefSeq]
40896228LOC119622828zona pellucida sperm-binding protein 3 receptor-likeGreen Monkeyold_gene_namegene, protein-coding, MODEL [RefSeq]
12984244Cr2complement C3d receptor 2ENCODES a protein that exhibits complement binding (ortholog); complement receptor activity (ortholog); DNA binding (ortholog); INVOLVED IN B cell activation (ortholog); B cell differentiation (ortholog); B cell proliferation (ortholog); ASSOCIATED WITH common variable immunodeficiency (ortholog); cNW_00493655752467705256608Squirrel47old_gene_namegene, protein-coding, MODEL [RefSeq]
12492411LOC101964865complement receptor type 1ENCODES a protein that exhibits complement component C3b binding (ortholog); complement component C3b receptor activity (ortholog); complement component C4b binding (ortholog); INVOLVED IN ATP export (ortholog); complement activation (ortholog); complement activNW_00493655751858315284999Squirrel41old_gene_name , descriptiongene, protein-coding, MODEL [RefSeq]
7207322C4B_2complement component 4B (Chido/Rodgers blood group), copy 2This gene encodes the basic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction beHuman43symbol , COSMIC , description , Human Proteome Mapgene, protein-coding, REVIEWED [RefSeq]
14150937C4BPAcomplement component 4 binding protein, alphaINVOLVED IN lipid transport (inferred); negative regulation of complement activation, classical pathway (inferred); positive regulation of protein catabolic process (inferred); FOUND IN extracellular region (inferred); extracellular space (inferred)Pig11symbolgene, protein-coding, PROVISIONAL [RefSeq]
20867131C4BPAcomplement component 4 binding protein alphaINVOLVED IN negative regulation of complement activation, classical pathway (inferred); positive regulation of protein catabolic process (inferred); regulation of immune response (inferred); FOUND IN extracellular space (inferred)Green Monkey6symbolgene, protein-coding
155244190c4bpaTropical Clawed Frogsymbolgene, null
155244189c4bpa.LAfrican Clawed Frogsymbolgene, null
1342759C4BPAP1C4BPA pseudogene 1INTERACTS WITH sodium arsenite1207165495207184061Human1symbol , COSMIC , name , Human Proteome Map , old_gene_symbolgene, pseudo, INFERRED [RefSeq]
1345971C4BPAP2C4BPA pseudogene 21207225798207229202Humansymbol , COSMIC , name , Human Proteome Map , old_gene_symbolgene, pseudo, INFERRED [RefSeq]
9999364C4BPAP3C4BPA pseudogene 31207194789207195307Humansymbol , GTEx , COSMIC , name , Human Proteome Mapgene, pseudo, INFERRED [RefSeq]
10259C4bp-ps1complement component 4 binding protein, pseudogene 1PARTICIPATES IN forkhead class A signaling pathway; INTERACTS WITH arsenous acid; bis(2-ethylhexyl) phthalate; bisphenol F1130597939130609308Mouse7symbol , PhenoGen , old_gene_symbolgene, pseudo, VALIDATED [RefSeq]
18919795LOC101720618zona pellucida sperm-binding protein 3 receptorNaked Mole-Ratold_gene_symbolgene, protein-coding, MODEL [RefSeq]
1314030Agpat31-acylglycerol-3-phosphate O-acyltransferase 3Enables lysophosphatidic acid acyltransferase activity. Predicted to be involved in CDP-diacylglycerol biosynthetic process. Located in endoplasmic reticulum. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Ortholo107810500878188335Mouse169UniProt , old_protein_id , UniProt Secondarygene, protein-coding, VALIDATED [RefSeq]
1320452LIG3DNA ligase 3This gene is a member of the DNA ligase family. Each member of this family encodes a protein that catalyzes the joining of DNA ends but they each have a distinct role in DNA metabolism. The protein encoded by this gene is involved in excision repair and is located in both the mitochondria and nucleu173498051235010872Human253UniProtgene, protein-coding, REVIEWED [RefSeq]
1604624METTL13methyltransferase 13, eEF1A N-terminus and K55Enables protein-lysine N-methyltransferase activity. Predicted to be involved in methylation. Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]1171781660171797716Human65UniProtgene, protein-coding, VALIDATED [RefSeq]
1316069REV3LREV3 like, DNA directed polymerase zeta catalytic subunitThe protein encoded by this gene represents the catalytic subunit of DNA polymerase zeta, which functions in translesion DNA synthesis. The encoded protein can be found in mitochondria, where it protects DNA from damage. Defects in this gene are a cause of Mobius syndrome. [provided by RefSeq, Jan 26111299033111483711Human201UniProtgene, protein-coding, REVIEWED [RefSeq]
68964SLC4A4solute carrier family 4 member 4This gene encodes a sodium bicarbonate cotransporter (NBC) involved in the regulation of bicarbonate secretion and absorption and intracellular pH. Mutations in this gene are associated with proximal renal tubular acidosis. Multiple transcript variants encoding different isoforms have been found for47106266071572083Human277UniProt , old_protein_id , UniProt Secondarygene, protein-coding, REVIEWED [RefSeq]
1347040SPG11SPG11 vesicle trafficking associated, spatacsinThe protein encoded by this gene is a potential transmembrane protein that is phosphorylated upon DNA damage. Defects in this gene are a cause of spastic paraplegia type 11 (SPG11). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]154456269644663662Human939UniProtgene, protein-coding, REVIEWED [RefSeq]
736066SPP1secreted phosphoprotein 1The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. The encoded protein is secreted and binds hydroxyapatite with high affinity. The osteoclast vitronectin receptor is found in the cell membrane and may be involved in the binding to this prot48797571487983411Human990UniProtgene, protein-coding, REVIEWED [RefSeq]
1318479TRIM31tripartite motif containing 31This gene encodes a protein that functions as an E3 ubiquitin-protein ligase. This gene shows altered expression in certain tumors and may be a negative regulator of cell growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]63010289730113090Human87UniProtgene, protein-coding, REVIEWED [RefSeq]
1346662CD46CD46 moleculeThe protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from 1207752038207795516Human260descriptiongene, protein-coding, REVIEWED [RefSeq]
1553528Masp2MBL associated serine protease 2Predicted to enable several functions, including calcium-dependent protein binding activity; complement component C4b binding activity; and serine-type endopeptidase activity. Predicted to be involved in complement activation, lectin pathway. Predicted to be loc4148679079148699939Mouse142descriptiongene, protein-coding, VALIDATED [RefSeq]
8736837Masp2MBL associated serine protease 2ENCODES a protein that exhibits calcium-dependent protein binding (ortholog); complement component C4b binding (ortholog); identical protein binding (ortholog); INVOLVED IN cell surface pattern recognition receptor signaling pathway (ortholog); complement activaNW_00495548626417302655125Chinchilla34descriptiongene, protein-coding, MODEL [RefSeq]
18792826MASP2MBL associated serine protease 2ENCODES a protein that exhibits calcium-dependent protein binding (ortholog); complement component C4b binding (ortholog); identical protein binding (ortholog); INVOLVED IN cell surface pattern recognition receptor signaling pathway (ortholog); complement activaGreen Monkey34descriptiongene, protein-coding, MODEL [RefSeq]
18925959Masp2MBL associated serine protease 2ENCODES a protein that exhibits calcium-dependent protein binding (ortholog); complement component C4b binding (ortholog); identical protein binding (ortholog); INVOLVED IN cell surface pattern recognition receptor signaling pathway (ortholog); complement activaNaked Mole-Rat44descriptiongene, protein-coding, MODEL [RefSeq]
20865651MASP2MBL associated serine protease 2ENCODES a protein that exhibits calcium-dependent protein binding (inferred); complement component C4b binding (inferred); peptidase activity (inferred); INVOLVED IN complement activation, lectin pathway (inferred); immune system process (inferred); innate immunGreen Monkey13descriptiongene, protein-coding
626016977Masp2MBL associated serine protease 2ENCODES a protein that exhibits calcium-dependent protein binding (ortholog); complement component C4b binding (ortholog); identical protein binding (ortholog); INVOLVED IN cell surface pattern recognition receptor signaling pathway (ortholog); complement activaBlack Rat34descriptiongene, protein-coding, MODEL [RefSeq]
1342781PROS1protein SThis gene encodes a vitamin K-dependent plasma protein that functions as a cofactor for the anticoagulant protease, activated protein C (APC) to inhibit blood coagulation. It is found in plasma in both a free, functionally active form and also in an inactive form complexed with C4b39387305193973896Human508descriptiongene, protein-coding, REVIEWED [RefSeq]
16567541AL445493.3novel transcript, antisense to C4BPAHumannamegene, lncrna
1550604Zp3rzona pellucida 3 receptorInvolved in binding activity of sperm to zona pellucida. Acts upstream of or within single fertilization. Located in acrosomal vesicle; cell body; and plasma membrane. Part of zona pellucida receptor complex. Human ortholog(s) of this gene implicated in COVID-19. Orthologous to human C4B1130474847130557371Mouse136descriptiongene, protein-coding, VALIDATED [RefSeq]