Kcnh1 (potassium voltage-gated channel subfamily H member 1) - Rat Genome Database

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Gene: Kcnh1 (potassium voltage-gated channel subfamily H member 1) Rattus norvegicus
Analyze
Symbol: Kcnh1
Name: potassium voltage-gated channel subfamily H member 1
RGD ID: 68398
Description: Enables several functions, including 14-3-3 protein binding activity; calmodulin binding activity; and delayed rectifier potassium channel activity. Involved in cellular response to calcium ion; potassium ion transmembrane transport; and startle response. Located in several cellular components, including axolemma; neuronal cell body; and nuclear inner membrane. Part of potassium channel complex. Is active in postsynaptic density membrane and presynaptic membrane. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma. Orthologous to human KCNH1 (potassium voltage-gated channel subfamily H member 1); INTERACTS WITH 6-propyl-2-thiouracil; alpha-Zearalanol; amitrole.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: EAG channel 1; EAG1; ether-a-go-go potassium channel 1; potassium channel, voltage gated eag related subfamily H, member 1; potassium voltage-gated channel, subfamily H (eag-related), member 1; r-eag; voltage-gated delayed rectifier potassium channel KCNH1; voltage-gated potassium channel subunit Kv10.1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr813106,253,101 - 106,555,712 (+)NCBIGRCr8
mRatBN7.213103,722,140 - 104,024,762 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl13103,722,245 - 104,024,740 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx13106,242,159 - 106,544,653 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.013107,626,002 - 107,928,502 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.013104,840,996 - 105,143,620 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.013110,920,712 - 111,232,291 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13110,920,737 - 111,232,269 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013115,478,526 - 115,789,705 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.413108,129,617 - 108,407,815 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.113108,318,724 - 108,596,919 (+)NCBI
Celera13103,160,967 - 103,461,850 (+)NCBICelera
Cytogenetic Map13q27NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
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Reference
Notes
Source
Original Reference(s)
Kcnh1Ratcolorectal adenocarcinoma severityISOKCNH1 (Homo sapiens)9693694DNA:amplification: (human)RGD 
Kcnh1Rathepatocellular carcinoma  ISOKCNH1 (Homo sapiens)9693723protein:increased expression:liver (human)RGD 
Kcnh1Ratrenal cell carcinoma  ISOKCNH1 (Homo sapiens)9693695protein:increased expression:kidney (human)RGD 
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Original Reference(s)
Kcnh1RatDevelopmental Disease  ISOKCNH1 (Homo sapiens)8554872ClinVar Annotator: match by term: Developmental disorderClinVarPMID:25741868
Kcnh1Ratepilepsy  ISOKCNH1 (Homo sapiens)8554872ClinVar Annotator: match by term: SeizureClinVarPMID:23020937 more ...
Kcnh1Ratgastrointestinal stromal tumor  ISOKCNH1 (Homo sapiens)8554872ClinVar Annotator: match by term: Gastrointestinal stromal tumorClinVarPMID:28492532
Kcnh1Ratgenetic disease  ISOKCNH1 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:23020937 more ...
Kcnh1Ratintellectual disability  ISOKCNH1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:25741868 more ...
Kcnh1Ratintellectual disability  ISOKCNH1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:23020937 more ...
Kcnh1RatNeurodevelopmental Disorders  ISOKCNH1 (Homo sapiens)8554872ClinVar Annotator: match by term: Neurodevelopmental disorderClinVarPMID:25741868
Kcnh1Ratparathyroid carcinoma  ISOKCNH1 (Homo sapiens)8554872ClinVar Annotator: match by term: Parathyroid carcinomaClinVarPMID:28492532
Kcnh1RatTemple-Baraitser syndrome  ISOKCNH1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:18203178 more ...
Kcnh1RatZimmerman Laband Syndrome  ISOKCNH1 (Homo sapiens)8554872ClinVar Annotator: match by term: Laband syndromeClinVarPMID:23020937 more ...
Kcnh1RatZimmermann-Laband Syndrome 1  ISOKCNH1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:18541964 more ...
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Original Reference(s)
Kcnh1RatBreast Neoplasms  ISOKCNH1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17520698
Kcnh1Ratepilepsy  ISOKCNH1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25420144 and PMID:29942082
Kcnh1RatNeurodevelopmental Disorders  ISOKCNH1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:29942082
Kcnh1Ratosteosarcoma  ISOKCNH1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:22248279
Kcnh1RatTemple-Baraitser syndrome  ISOKCNH1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25420144
Kcnh1RatZimmerman Laband Syndrome  ISOKCNH1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25915598
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Original Reference(s)
Kcnh1RatTemple-Baraitser syndrome  ISOKCNH1 (Homo sapiens)7240710 OMIM 
Kcnh1RatZimmermann-Laband Syndrome 1  ISOKCNH1 (Homo sapiens)7240710 OMIM 

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Original Reference(s)
Kcnh1Rat17beta-estradiol increases expressionISOKCNH1 (Homo sapiens)6480464Estradiol results in increased expression of KCNH1 mRNACTDPMID:19351862
Kcnh1Rat17beta-estradiol multiple interactionsISOKCNH1 (Homo sapiens)6480464[Estradiol co-treated with ESR1 protein] results in increased expression of KCNH1 mRNA more ...CTDPMID:19351862
Kcnh1Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOKcnh1 (Mus musculus)6480464Tetrachlorodibenzodioxin results in decreased expression of KCNH1 mRNACTDPMID:19933214 and PMID:21354282
Kcnh1Rat3,4-methylenedioxymethamphetamine increases expressionISOKcnh1 (Mus musculus)6480464N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of KCNH1 mRNACTDPMID:20188158
Kcnh1Rat3-[1-[4-(4-fluorophenyl)-4-oxobutyl]-4-piperidinyl]-1H-benzimidazol-2-one multiple interactionsISOKCNH1 (Homo sapiens)6480464Benperidol binds to and results in decreased activity of KCNH1 proteinCTDPMID:17982510
Kcnh1Rat4,4'-sulfonyldiphenol increases expressionISOKcnh1 (Mus musculus)6480464bisphenol S results in increased expression of KCNH1 mRNACTDPMID:30951980
Kcnh1Rat4-hydroxyphenyl retinamide increases expressionISOKcnh1 (Mus musculus)6480464Fenretinide results in increased expression of KCNH1 mRNACTDPMID:28973697
Kcnh1Rat6-propyl-2-thiouracil decreases expressionEXP 6480464Propylthiouracil results in decreased expression of KCNH1 mRNACTDPMID:30047161
Kcnh1Rataflatoxin B1 decreases methylationISOKCNH1 (Homo sapiens)6480464Aflatoxin B1 results in decreased methylation of KCNH1 geneCTDPMID:27153756
Kcnh1Rataldehydo-D-glucose multiple interactionsISOKcnh1 (Mus musculus)6480464[lard co-treated with Cholesterol more ...CTDPMID:37567420
Kcnh1Ratall-trans-retinoic acid multiple interactionsISOKcnh1 (Mus musculus)6480464[mono-(2-ethylhexyl)phthalate co-treated with Tretinoin] results in decreased expression of KCNH1 mRNACTDPMID:36189433
Kcnh1Ratall-trans-retinoic acid decreases expressionISOKcnh1 (Mus musculus)6480464Tretinoin results in decreased expression of KCNH1 mRNACTDPMID:36189433
Kcnh1Ratalpha-Zearalanol multiple interactionsEXP 6480464[Zeranol co-treated with perfluorooctanoic acid] results in increased expression of KCNH1 mRNACTDPMID:35163327
Kcnh1Ratamitrole decreases expressionEXP 6480464Amitrole results in decreased expression of KCNH1 mRNACTDPMID:30047161
Kcnh1Ratammonium chloride affects expressionEXP 6480464Ammonium Chloride affects the expression of KCNH1 mRNACTDPMID:16483693
Kcnh1Ratastemizole decreases activityISOKCNH1 (Homo sapiens)6480464Astemizole results in decreased activity of KCNH1 proteinCTDPMID:14985237 more ...
Kcnh1Ratastemizole affects bindingISOKCNH1 (Homo sapiens)6480464Astemizole binds to KCNH1 proteinCTDPMID:18471075
Kcnh1Ratastemizole multiple interactionsISOKCNH1 (Homo sapiens)6480464Astemizole binds to and results in decreased activity of KCNH1 protein and Astemizole inhibits the reaction [IGF1 protein results in increased activity of KCNH1 protein]CTDPMID:17520698 and PMID:18497958
Kcnh1Ratatrazine affects methylationEXP 6480464Atrazine affects the methylation of KCNH1 geneCTDPMID:28931070 and PMID:35440735
Kcnh1Ratbarium(0) decreases activityISOKCNH1 (Homo sapiens)6480464Barium results in decreased activity of KCNH1 proteinCTDPMID:10896755

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Biological Process
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Original Reference(s)
Kcnh1Ratcellular response to calcium ion  IDA 9693720 RGD 
Kcnh1Ratcellular response to calcium ion involved_inISOKCNH1 (Homo sapiens)1624291 PMID:27005320 and PMID:27325704RGDPMID:27005320 and PMID:27325704
Kcnh1Ratcellular response to calcium ion involved_inIDA 11533419PMID:27516594UniProt 
Kcnh1Ratmonoatomic ion transmembrane transport  IDA 9693685 RGD 
Kcnh1Ratmonoatomic ion transmembrane transport involved_inIEAUniProtKB-KW:KW-0407 and UniProtKB-KW:KW-08511600115GO_REF:0000043UniProtGO_REF:0000043
Kcnh1Ratmonoatomic ion transport involved_inIEAInterPro:IPR0058211600115GO_REF:0000002InterProGO_REF:0000002
Kcnh1Ratmonoatomic ion transport involved_inIEAUniProtKB-KW:KW-04061600115GO_REF:0000043UniProtGO_REF:0000043
Kcnh1Ratpotassium ion transmembrane transport  IDA 68271 RGD 
Kcnh1Ratpotassium ion transmembrane transport involved_inIBAMGI:1341721 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Kcnh1Ratpotassium ion transmembrane transport involved_inISOKcnh1 (Mus musculus)1624291 PMID:19671703RGDPMID:19671703
Kcnh1Ratpotassium ion transmembrane transport involved_inIEAUniProtKB-KW:KW-06311600115GO_REF:0000043UniProtGO_REF:0000043
Kcnh1Ratpotassium ion transmembrane transport involved_inISSUniProtKB:O952591600115GO_REF:0000024UniProtGO_REF:0000024
Kcnh1Ratpotassium ion transmembrane transport involved_inISOKCNH1 (Homo sapiens)1624291 PMID:22732247 more ...RGDPMID:22732247 more ...
Kcnh1Ratpotassium ion transmembrane transport  IDA 1299478 RGD 
Kcnh1Ratpotassium ion transport involved_inIDA 405866186PMID:31490124UniProt 
Kcnh1Ratpotassium ion transport involved_inIEAUniProtKB-KW:KW-06331600115GO_REF:0000043UniProtGO_REF:0000043
Kcnh1Ratpotassium ion transport involved_inIEAInterPro:IPR003938 and InterPro:IPR0039491600115GO_REF:0000002InterProGO_REF:0000002
Kcnh1Ratpotassium ion transport involved_inISOKCNH1 (Homo sapiens)1624291 PMID:11943152RGDPMID:11943152
Kcnh1Ratregulation of cell population proliferation involved_inISOKCNH1 (Homo sapiens)1624291 PMID:23881642RGDPMID:23881642
Kcnh1Ratregulation of cell population proliferation involved_inISSUniProtKB:O952591600115GO_REF:0000024UniProtGO_REF:0000024
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Cellular Component
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Original Reference(s)
Kcnh1Rataxolemma  IDA 9693719 RGD 
Kcnh1Rataxon  IDA 9693685 RGD 
Kcnh1Rataxon located_inIEAUniProtKB-SubCell:SL-02791600115GO_REF:0000044UniProtGO_REF:0000044
Kcnh1Ratcell projection located_inIEAUniProtKB-KW:KW-09661600115GO_REF:0000043UniProtGO_REF:0000043
Kcnh1Ratcell surface  IDA 9693690 RGD 
Kcnh1Ratdendrite  IDA 9693685 RGD 
Kcnh1Ratdendrite located_inIEAUniProtKB-SubCell:SL-02831600115GO_REF:0000044UniProtGO_REF:0000044
Kcnh1Ratearly endosome membrane located_inISSUniProtKB:O952591600115GO_REF:0000024UniProtGO_REF:0000024
Kcnh1Ratearly endosome membrane located_inIEAUniProtKB-SubCell:SL-00931600115GO_REF:0000044UniProtGO_REF:0000044
Kcnh1Ratearly endosome membrane located_inISOKCNH1 (Homo sapiens)1624291 PMID:22841712RGDPMID:22841712
Kcnh1Ratendosome located_inIEAUniProtKB-KW:KW-09671600115GO_REF:0000043UniProtGO_REF:0000043
Kcnh1Ratintracellular membrane-bounded organelle located_inISOKCNH1 (Homo sapiens) more ...1624291 RGDGO_REF:0000052
Kcnh1Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Kcnh1Ratmembrane located_inIEAUniProtKB-SubCell:SL-01621600115GO_REF:0000044UniProtGO_REF:0000044
Kcnh1Ratmembrane located_inIEAInterPro:IPR003938 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Kcnh1Ratmonoatomic ion channel complex part_ofIEAUniProtKB-KW:KW-08511600115GO_REF:0000043UniProtGO_REF:0000043
Kcnh1Ratneuronal cell body  IDA 9693685 RGD 
Kcnh1Ratnuclear inner membrane  IDA 9693693 RGD 
Kcnh1Ratnuclear inner membrane located_inIEAUniProtKB-SubCell:SL-01791600115GO_REF:0000044UniProtGO_REF:0000044
Kcnh1Ratnucleus located_inIEAUniProtKB-KW:KW-05391600115GO_REF:0000043UniProtGO_REF:0000043
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Molecular Function
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Original Reference(s)
Kcnh1Rat14-3-3 protein binding  IPIYwhaq (Rattus norvegicus)9693692 RGD 
Kcnh1Ratcalmodulin binding enablesIDA 11533419PMID:27516594UniProt 
Kcnh1Ratcalmodulin binding enablesIEAUniProtKB-KW:KW-01121600115GO_REF:0000043UniProtGO_REF:0000043
Kcnh1Ratcyclic nucleotide binding NOT|enablesISSUniProtKB:Q606031600115GO_REF:0000024UniProtGO_REF:0000024
Kcnh1Ratcyclic nucleotide binding NOT|enablesISOKcnh1 (Mus musculus)1624291 PMID:19671703RGDPMID:19671703
Kcnh1Ratdelayed rectifier potassium channel activity enablesIDA 405866186PMID:31490124UniProt 
Kcnh1Ratdelayed rectifier potassium channel activity enablesIBAMGI:1341721 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Kcnh1Ratdelayed rectifier potassium channel activity enablesIEAARBA:ARBA000472491600115GO_REF:0000117UniProtGO_REF:0000117
Kcnh1Ratdelayed rectifier potassium channel activity enablesISSUniProtKB:O952591600115GO_REF:0000024UniProtGO_REF:0000024
Kcnh1Ratdelayed rectifier potassium channel activity enablesISOKcnh1 (Mus musculus)1624291 PMID:19671703RGDPMID:19671703
Kcnh1Ratdelayed rectifier potassium channel activity enablesIDA 11533419PMID:27516594UniProt 
Kcnh1Ratdelayed rectifier potassium channel activity enablesISOKCNH1 (Homo sapiens)1624291 PMID:11943152 more ...RGDPMID:11943152 more ...
Kcnh1Ratidentical protein binding  IDA 9693690 RGD 
Kcnh1Ratlipid binding enablesIEAUniProtKB-KW:KW-04461600115GO_REF:0000043UniProtGO_REF:0000043
Kcnh1Ratmonoatomic ion channel activity enablesIEAInterPro:IPR0058211600115GO_REF:0000002InterProGO_REF:0000002
Kcnh1Ratphosphatidylinositol bisphosphate binding enablesISSUniProtKB:O952591600115GO_REF:0000024UniProtGO_REF:0000024
Kcnh1Ratphosphatidylinositol bisphosphate binding enablesISOKCNH1 (Homo sapiens)1624291 PMID:27005320RGDPMID:27005320
Kcnh1Ratpotassium channel activity enablesIEAUniProtKB-KW:KW-06311600115GO_REF:0000043UniProtGO_REF:0000043
Kcnh1Ratprotein binding  IPIEpn1 (Rattus norvegicus)9693722 RGD 
Kcnh1Ratprotein binding enablesISOKCNH1 (Homo sapiens) and UniProtKB:O95259-21624291UniProtKB:P02638 and PMID:20708613RGDPMID:20708613
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#
Reference Title
Reference Citation
1. Regulation of an ERG K+ current by Src tyrosine kinase. Cayabyab FS and Schlichter LC, J Biol Chem 2002 Apr 19;277(16):13673-81.
2. Distal end of carboxyl terminus is not essential for the assembly of rat Eag1 potassium channels. Chen IH, etal., J Biol Chem. 2011 Aug 5;286(31):27183-96. doi: 10.1074/jbc.M111.233825. Epub 2011 Jun 6.
3. Functional K(v)10.1 channels localize to the inner nuclear membrane. Chen Y, etal., PLoS One. 2011 May 3;6(5):e19257. doi: 10.1371/journal.pone.0019257.
4. The punctate localization of rat Eag1 K+ channels is conferred by the proximal post-CNBHD region. Chuang CC, etal., BMC Neurosci. 2014 Feb 4;15:23. doi: 10.1186/1471-2202-15-23.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Characterization of Eag1 channel lateral mobility in rat hippocampal cultures by single-particle-tracking with quantum dots. Gomez-Varela D, etal., PLoS One. 2010 Jan 25;5(1):e8858. doi: 10.1371/journal.pone.0008858.
8. Overexpression of Eag1 potassium channels in clinical tumours. Hemmerlein B, etal., Mol Cancer. 2006 Oct 5;5:41.
9. KCR1, a membrane protein that facilitates functional expression of non-inactivating K+ currents associates with rat EAG voltage-dependent K+ channels. Hoshi N, etal., J Biol Chem 1998 Sep 4;273(36):23080-5.
10. 14-3-3theta is a binding partner of rat Eag1 potassium channels. Hsu PH, etal., PLoS One. 2012;7(7):e41203. doi: 10.1371/journal.pone.0041203. Epub 2012 Jul 20.
11. Hippocampal ether-a-go-go1 potassium channels blockade: effects in the startle reflex and prepulse inhibition. Issy AC, etal., Neurosci Lett. 2014 Jan 24;559:13-7. doi: 10.1016/j.neulet.2013.11.026. Epub 2013 Nov 24.
12. The subfamily-specific assembly of Eag and Erg K+ channels is determined by both the amino and the carboxyl recognition domains. Lin TF, etal., J Biol Chem. 2014 Aug 15;289(33):22815-34. doi: 10.1074/jbc.M114.574814. Epub 2014 Jul 9.
13. Functional expression of a rat homologue of the voltage gated either a go-go potassium channel reveals differences in selectivity and activation kinetics between the Drosophila channel and its mammalian counterpart. Ludwig J, etal., EMBO J 1994 Oct 3;13(19):4451-8.
14. Eag1 potassium channel immunohistochemistry in the CNS of adult rat and selected regions of human brain. Martin S, etal., Neuroscience. 2008 Aug 26;155(3):833-44. doi: 10.1016/j.neuroscience.2008.05.019. Epub 2008 Jul 22.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. KV 10.1 opposes activity-dependent increase in Ca²¿ influx into the presynaptic terminal of the parallel fibre-Purkinje cell synapse. Mortensen LS, etal., J Physiol. 2015 Jan 1;593(1):181-96. doi: 10.1113/jphysiol.2014.281600. Epub 2014 Nov 25.
17. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. Physical and functional interaction of KV10.1 with Rabaptin-5 impacts ion channel trafficking. Ninkovic M, etal., FEBS Lett. 2012 Sep 21;586(19):3077-84. doi: 10.1016/j.febslet.2012.07.055. Epub 2012 Jul 25.
19. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
20. Expression of voltage-gated potassium channels in human and mouse colonic carcinoma. Ousingsawat J, etal., Clin Cancer Res. 2007 Feb 1;13(3):824-31.
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PMID:9400421   PMID:10718922   PMID:15706225   PMID:18063306   PMID:19671703   PMID:20662937   PMID:22048886   PMID:22732247   PMID:23881642   PMID:27005320   PMID:27325704   PMID:33647316  
PMID:36717938  



Kcnh1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr813106,253,101 - 106,555,712 (+)NCBIGRCr8
mRatBN7.213103,722,140 - 104,024,762 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl13103,722,245 - 104,024,740 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx13106,242,159 - 106,544,653 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.013107,626,002 - 107,928,502 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.013104,840,996 - 105,143,620 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.013110,920,712 - 111,232,291 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13110,920,737 - 111,232,269 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013115,478,526 - 115,789,705 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.413108,129,617 - 108,407,815 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.113108,318,724 - 108,596,919 (+)NCBI
Celera13103,160,967 - 103,461,850 (+)NCBICelera
Cytogenetic Map13q27NCBI
KCNH1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381210,678,314 - 211,134,148 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1210,676,823 - 211,134,165 (-)EnsemblGRCh38hg38GRCh38
GRCh371210,851,656 - 211,307,490 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361208,923,178 - 209,374,080 (-)NCBINCBI36Build 36hg18NCBI36
Build 341207,244,949 - 207,695,852NCBI
Celera1184,078,007 - 184,534,030 (-)NCBICelera
Cytogenetic Map1q32.2NCBI
HuRef1181,528,354 - 181,984,466 (-)NCBIHuRef
CHM1_11212,124,419 - 212,580,029 (-)NCBICHM1_1
T2T-CHM13v2.01209,920,145 - 210,379,828 (-)NCBIT2T-CHM13v2.0
Kcnh1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391191,871,759 - 192,192,467 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1191,873,082 - 192,192,467 (+)EnsemblGRCm39 Ensembl
GRCm381192,189,144 - 192,510,159 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1192,190,774 - 192,510,159 (+)EnsemblGRCm38mm10GRCm38
MGSCv371194,014,754 - 194,334,040 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361193,891,596 - 194,210,882 (+)NCBIMGSCv36mm8
Celera1199,081,917 - 199,396,846 (+)NCBICelera
Cytogenetic Map1H6NCBI
cM Map197.33NCBI
Kcnh1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554891,179,053 - 1,545,355 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554891,176,615 - 1,549,880 (+)NCBIChiLan1.0ChiLan1.0
KCNH1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2138,274,955 - 38,737,394 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1138,239,979 - 38,703,633 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01186,233,881 - 186,696,509 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11191,102,299 - 191,561,879 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1191,107,256 - 191,562,766 (-)Ensemblpanpan1.1panPan2
KCNH1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.179,317,804 - 9,631,144 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl79,252,488 - 9,631,150 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha78,829,600 - 9,206,958 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.078,949,600 - 9,333,811 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl78,954,637 - 9,334,074 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.178,881,430 - 9,257,585 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.078,973,450 - 9,359,036 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.079,110,853 - 9,483,089 (-)NCBIUU_Cfam_GSD_1.0
Kcnh1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934464,893,289 - 65,249,587 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365572,133,564 - 2,493,155 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365572,133,596 - 2,493,170 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNH1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9131,960,480 - 132,334,953 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19131,960,566 - 132,336,029 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29145,245,936 - 145,368,735 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KCNH1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12518,353,356 - 18,788,472 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2518,353,482 - 18,783,592 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605518,890,057 - 19,338,331 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnh1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248071,056,313 - 1,388,491 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248071,019,347 - 1,392,433 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Kcnh1
2226 total Variants

Predicted Target Of
Summary Value
Count of predictions:576
Count of miRNA genes:249
Interacting mature miRNAs:318
Transcripts:ENSRNOT00000005209
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1366451204106807694Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1380753256106807694Rat

D13Rat90  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.013110,987,474 - 110,987,854NCBIRnor6.0
Rnor_5.013115,544,837 - 115,545,217UniSTSRnor5.0
RGSC_v3.413108,161,587 - 108,161,830RGDRGSC3.4
RGSC_v3.413108,161,588 - 108,161,830UniSTSRGSC3.4
RGSC_v3.113108,350,605 - 108,350,962RGD
Celera13103,218,254 - 103,218,496UniSTS
FHH x ACI Map1359.9799UniSTS
FHH x ACI Map1359.9799RGD
Cytogenetic Map13q27UniSTS
RH133640  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr813106,555,328 - 106,555,528 (+)Marker Load Pipeline
mRatBN7.213104,024,378 - 104,024,578 (+)MAPPERmRatBN7.2
Rnor_6.013111,231,908 - 111,232,107NCBIRnor6.0
Rnor_5.013115,789,322 - 115,789,521UniSTSRnor5.0
RGSC_v3.413108,407,454 - 108,407,653UniSTSRGSC3.4
Celera13103,461,489 - 103,461,688UniSTS
Cytogenetic Map13q27UniSTS
BF387220  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.213103,953,993 - 103,954,181 (+)MAPPERmRatBN7.2
Rnor_6.013111,161,533 - 111,161,720NCBIRnor6.0
Rnor_5.013115,718,896 - 115,719,083UniSTSRnor5.0
RGSC_v3.413108,337,021 - 108,337,208UniSTSRGSC3.4
Celera13103,391,977 - 103,392,164UniSTS
RH 3.4 Map13750.8UniSTS
Cytogenetic Map13q27UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 42 113 80 79 48 25 48 6 200 90 93 45 60 31



Ensembl Acc Id: ENSRNOT00000005209   ⟹   ENSRNOP00000005209
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl13103,722,245 - 104,024,740 (+)Ensembl
Rnor_6.0 Ensembl13110,920,737 - 111,232,269 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000076362   ⟹   ENSRNOP00000068448
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl13110,920,830 - 111,228,836 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000077014   ⟹   ENSRNOP00000068394
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl13110,920,830 - 111,228,836 (+)Ensembl
RefSeq Acc Id: NM_031742   ⟹   NP_113930
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr813106,253,216 - 106,555,712 (+)NCBI
mRatBN7.213103,722,248 - 104,024,762 (+)NCBI
Rnor_6.013110,920,737 - 111,232,269 (+)NCBI
Rnor_5.013115,478,526 - 115,789,705 (+)NCBI
RGSC_v3.413108,129,617 - 108,407,815 (+)RGD
Celera13103,160,967 - 103,461,850 (+)RGD
Sequence:
RefSeq Acc Id: XM_017598933   ⟹   XP_017454422
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr813106,253,101 - 106,555,712 (+)NCBI
mRatBN7.213103,722,140 - 104,024,762 (+)NCBI
Rnor_6.013110,920,712 - 111,232,291 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039091086   ⟹   XP_038947014
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr813106,392,198 - 106,555,712 (+)NCBI
mRatBN7.213103,877,572 - 104,024,762 (+)NCBI
RefSeq Acc Id: XM_063272592   ⟹   XP_063128662
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr813106,305,469 - 106,555,712 (+)NCBI
RefSeq Acc Id: XM_063272593   ⟹   XP_063128663
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr813106,322,768 - 106,555,712 (+)NCBI
1 to 11 of 11 rows
Protein RefSeqs NP_113930 (Get FASTA)   NCBI Sequence Viewer  
  XP_017454422 (Get FASTA)   NCBI Sequence Viewer  
  XP_038947014 (Get FASTA)   NCBI Sequence Viewer  
  XP_063128662 (Get FASTA)   NCBI Sequence Viewer  
  XP_063128663 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA84018 (Get FASTA)   NCBI Sequence Viewer  
  EDL95016 (Get FASTA)   NCBI Sequence Viewer  
  EDL95017 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000005209
  ENSRNOP00000110242
GenBank Protein Q63472 (Get FASTA)   NCBI Sequence Viewer  
1 to 11 of 11 rows
RefSeq Acc Id: NP_113930   ⟸   NM_031742
- UniProtKB: Q63472 (UniProtKB/Swiss-Prot),   A6JH11 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017454422   ⟸   XM_017598933
- Peptide Label: isoform X1
- UniProtKB: A0A8L2Q1G4 (UniProtKB/TrEMBL),   A6JH10 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000068394   ⟸   ENSRNOT00000077014
Ensembl Acc Id: ENSRNOP00000005209   ⟸   ENSRNOT00000005209
Ensembl Acc Id: ENSRNOP00000068448   ⟸   ENSRNOT00000076362
Cyclic nucleotide-binding   PAC   PAS

Name Modeler Protein Id AA Range Protein Structure
AF-Q63472-F1-model_v2 AlphaFold Q63472 1-962 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 40 of 43 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-16807 BioCyc
Ensembl Genes ENSRNOG00000003841 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000005209 ENTREZGENE
  ENSRNOT00000147245 ENTREZGENE
Gene3D-CATH 1.10.1200.260 UniProtKB/Swiss-Prot
  1.10.287.70 UniProtKB/Swiss-Prot
  2.60.120.10 UniProtKB/Swiss-Prot
  PAS domain UniProtKB/Swiss-Prot
InterPro cNMP-bd-like UniProtKB/Swiss-Prot
  cNMP-bd_dom UniProtKB/Swiss-Prot
  Ion_trans_dom UniProtKB/Swiss-Prot
  K_chnl_volt-dep_EAG UniProtKB/Swiss-Prot
  K_chnl_volt-dep_EAG/ELK/ERG UniProtKB/Swiss-Prot
  KCNH_channel UniProtKB/Swiss-Prot
  PAC UniProtKB/Swiss-Prot
  PAS UniProtKB/Swiss-Prot
  PAS-assoc_C UniProtKB/Swiss-Prot
  PAS-like_dom_sf UniProtKB/Swiss-Prot
  RmlC-like_jellyroll UniProtKB/Swiss-Prot
KEGG Report rno:65198 UniProtKB/Swiss-Prot
NCBI Gene 65198 ENTREZGENE
PANTHER PTHR10217:SF530 UniProtKB/Swiss-Prot
  VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL UniProtKB/Swiss-Prot
Pfam cNMP_binding UniProtKB/Swiss-Prot
  Ion_trans UniProtKB/Swiss-Prot
  PAS_9 UniProtKB/Swiss-Prot
PhenoGen Kcnh1 PhenoGen
PRINTS EAGCHANLFMLY UniProtKB/Swiss-Prot
  EAGCHANNEL UniProtKB/Swiss-Prot
PROSITE CNMP_BINDING_3 UniProtKB/Swiss-Prot
  PAC UniProtKB/Swiss-Prot
  PAS UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000003841 RatGTEx
SMART cNMP UniProtKB/Swiss-Prot
  PAC UniProtKB/Swiss-Prot
Superfamily-SCOP SSF51206 UniProtKB/Swiss-Prot
  SSF55785 UniProtKB/Swiss-Prot
  Voltage-gated potassium channels UniProtKB/Swiss-Prot
TIGR TC218785
UniProt A0A8L2Q1G4 ENTREZGENE, UniProtKB/TrEMBL
1 to 40 of 43 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-09 Kcnh1  potassium voltage-gated channel subfamily H member 1  Kcnh1  potassium channel, voltage gated eag related subfamily H, member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-26 Kcnh1  potassium channel, voltage gated eag related subfamily H, member 1  Kcnh1  potassium voltage-gated channel, subfamily H (eag-related), member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Kcnh1  potassium voltage-gated channel, subfamily H (eag-related), member 1      Name updated 70584 APPROVED

Note Type Note Reference
gene_expression expressed in the central nervous system 68271