Cyp3a23-3a1 (cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1) - Rat Genome Database

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Gene: Cyp3a23-3a1 (cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Cyp3a23-3a1
Name: cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1
RGD ID: 628626
Description: Enables demethylase activity and testosterone 6-beta-hydroxylase activity. Involved in several processes, including oxidative demethylation; response to dexamethasone; and response to genistein. Located in endoplasmic reticulum membrane. Used to study alcohol dependence. Biomarker of cholestasis and depressive disorder. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma; acute lymphoblastic leukemia; chronic myeloid leukemia; and essential hypertension. Orthologous to several human genes including CYP3A5 (cytochrome P450 family 3 subfamily A member 5); PARTICIPATES IN tamoxifen pharmacokinetics pathway; linoleic acid metabolic pathway; phase I biotransformation pathway via cytochrome P450; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1,2,4-trichlorobenzene; 1,2-dichloroethene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: AABR07035343.1; cDEX; CYP; Cyp3a1; CYP3A23; Cyp3a23/3a1; Cyp3a3; CYPIIIA1; cytochrome P-450; cytochrome P-450PCN (PNCN inducible); cytochrome P450 3A1; cytochrome P450 3A1-like; cytochrome P450, family 3, subfamily a, polypeptide 1; cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 1; cytochrome P450, subfamily 3A, polypeptide 3; Cytochrome P450, subfamily IIIA, polypeptide 3; cytochrome P450-PCN1; cytochrome P450/6 beta B; LOC100910877; MGC108757; P450 IIIA; P450-PCN1; RL33
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Allele / Splice: Cyp3a23-3a1em1Myliu  
Genetic Models: SD-Cyp3a23/3a1em1Myliu,Cyp3a2em1Myliu
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81214,369,950 - 14,398,803 (-)NCBIGRCr8
mRatBN7.2129,256,159 - 9,285,020 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl129,254,475 - 9,285,030 (-)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl129,015,383 - 9,285,008 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1210,058,901 - 10,087,682 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01210,682,086 - 10,710,867 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0129,705,516 - 9,734,297 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01211,053,888 - 11,082,742 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1211,655,402 - 11,733,136 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01213,145,742 - 13,174,596 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4129,567,120 - 9,595,974 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1129,596,712 - 9,625,890 (-)NCBI
Celera1211,063,015 - 11,090,937 (-)NCBICelera
RH 3.4 Map12117.0RGD
Cytogenetic Map12p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cyp3a23-3a1Ratalcohol dependence  IDA 405650696 RGD 
Cyp3a23-3a1Ratcholestasis disease_progressionIEP 13782189 RGD 
Cyp3a23-3a1Ratdepressive disorder  IEP 4892242 RGD 
Cyp3a23-3a1RatInflammation  IEP 1625398mRNA:decreased expression:liverRGD 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cyp3a23-3a1Ratacute kidney failure  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:20623750
Cyp3a23-3a1RatChemical and Drug Induced Liver Injury  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:20623750
Cyp3a23-3a1Rathepatocellular adenoma  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:10959800
Cyp3a23-3a1RatInflammation  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:21467745
Cyp3a23-3a1Rattype 2 diabetes mellitus  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:22244987

1 to 20 of 322 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cyp3a23-3a1Rat1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane affects expressionEXP 6480464o and p'-DDT affects the expression of CYP3A23-3A1 mRNACTDPMID:17984292
Cyp3a23-3a1Rat1,2,4-trichlorobenzene increases metabolic processingEXP 6480464CYP3A23-3A1 protein results in increased metabolism of 1 more ...CTDPMID:2017752
Cyp3a23-3a1Rat1,2-dichloroethene decreases activityEXP 64804641 and 2-dichloroethylene results in decreased activity of CYP3A23-3A1 proteinCTDPMID:9493318
Cyp3a23-3a1Rat1,2-dichloroethene decreases expressionEXP 64804641 and 2-dichloroethylene results in decreased expression of CYP3A23-3A1 proteinCTDPMID:9493318
Cyp3a23-3a1Rat1-naphthyl isothiocyanate increases expressionEXP 64804641-Naphthylisothiocyanate results in increased expression of CYP3A23-3A1 mRNACTDPMID:12883083
Cyp3a23-3a1Rat17beta-estradiol increases expressionEXP 6480464Estradiol results in increased expression of CYP3A23-3A1 mRNACTDPMID:10707959
Cyp3a23-3a1Rat17beta-estradiol decreases expressionEXP 6480464Estradiol results in decreased expression of CYP3A23-3A1 mRNACTDPMID:32145629
Cyp3a23-3a1Rat2,2',4,4',5,5'-hexachlorobiphenyl increases expressionEXP 64804642 more ...CTDPMID:23770461
Cyp3a23-3a1Rat2,2',4,4',5,5'-hexachlorobiphenyl multiple interactionsEXP 6480464[2 more ...CTDPMID:23770461 and PMID:24878560
Cyp3a23-3a1Rat2,2',4,4'-Tetrabromodiphenyl ether increases expressionEXP 64804642 more ...CTDPMID:16107549 more ...
Cyp3a23-3a1Rat2,2',4,4'-Tetrabromodiphenyl ether multiple interactionsEXP 6480464[CYP3A23-3A1 protein results in increased oxidation of 2 more ...CTDPMID:21673328
Cyp3a23-3a1Rat2,2',4,4'-Tetrabromodiphenyl ether increases oxidationEXP 6480464CYP3A23-3A1 protein results in increased oxidation of 2 more ...CTDPMID:21673328
Cyp3a23-3a1Rat2,2',5,5'-tetrachlorobiphenyl multiple interactionsEXP 6480464NR1I3 gene mutant form inhibits the reaction [2 more ...CTDPMID:23770461
Cyp3a23-3a1Rat2,2',5,5'-tetrachlorobiphenyl increases expressionEXP 64804642 more ...CTDPMID:23770461
Cyp3a23-3a1Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of CYP3A23-3A1 mRNACTDPMID:16054898
Cyp3a23-3a1Rat2,4-dibromophenyl 2,4,5-tribromophenyl ether multiple interactionsEXP 6480464[CYP3A23-3A1 protein results in increased oxidation of 2 more ...CTDPMID:21673328
Cyp3a23-3a1Rat2,4-dibromophenyl 2,4,5-tribromophenyl ether increases oxidationEXP 6480464CYP3A23-3A1 protein results in increased oxidation of 2 more ...CTDPMID:21673328
Cyp3a23-3a1Rat2,4-dibromophenyl 2,4,5-tribromophenyl ether increases expressionEXP 64804642 more ...CTDPMID:16107549
Cyp3a23-3a1Rat2-acetamidofluorene increases expressionEXP 64804642-Acetylaminofluorene results in increased expression of CYP3A23-3A1 mRNA and 2-Acetylaminofluorene results in increased expression of CYP3A23-3A1 proteinCTDPMID:12504080
Cyp3a23-3a1Rat2-acetamidofluorene multiple interactionsEXP 6480464[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in decreased expression of CYP3A23-3A1 mRNA more ...CTDPMID:12504080 more ...

1 to 20 of 322 rows

Biological Process
1 to 12 of 12 rows

  
1 to 12 of 12 rows

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cyp3a23-3a1Ratendoplasmic reticulum located_inIEAUniProtKB-KW:KW-02561600115GO_REF:0000043UniProtGO_REF:0000043
Cyp3a23-3a1Ratendoplasmic reticulum membrane located_inIEAUniProtKB-SubCell:SL-00971600115GO_REF:0000044UniProtGO_REF:0000044
Cyp3a23-3a1Ratendoplasmic reticulum membrane  IDA 1298226 RGD 
Cyp3a23-3a1Ratendoplasmic reticulum membrane located_inIEAUniRule:UR0015287611600115GO_REF:0000104UniProtGO_REF:0000104
Cyp3a23-3a1Ratintracellular membrane-bounded organelle located_inIEAUniProtKB-KW:KW-04921600115GO_REF:0000043UniProtGO_REF:0000043
Cyp3a23-3a1Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043

Molecular Function
1 to 20 of 27 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cyp3a23-3a1Ratdemethylase activity  IDA 2301699 RGD 
Cyp3a23-3a1Ratdemethylase activity  IDA 5129544 RGD 
Cyp3a23-3a1Ratheme binding enablesIEAInterPro:IPR001128 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Cyp3a23-3a1Ratheme binding enablesIEAInterPro:IPR001128 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Cyp3a23-3a1Ratheme binding enablesIEAUniRule:UR0015287611600115GO_REF:0000104UniProtGO_REF:0000104
Cyp3a23-3a1Ratheme binding enablesIEAInterPro:IPR001128 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Cyp3a23-3a1Ratheme binding enablesIEAInterPro:IPR001128 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Cyp3a23-3a1Ratiron ion binding enablesIEAInterPro:IPR001128 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Cyp3a23-3a1Ratiron ion binding enablesIEAInterPro:IPR001128 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Cyp3a23-3a1Ratiron ion binding enablesIEAUniRule:UR0015287611600115GO_REF:0000104UniProtGO_REF:0000104
Cyp3a23-3a1Ratiron ion binding enablesIEAInterPro:IPR001128 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Cyp3a23-3a1Ratiron ion binding enablesIEAInterPro:IPR001128 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Cyp3a23-3a1Ratmetal ion binding enablesIEAUniProtKB-KW:KW-04791600115GO_REF:0000043UniProtGO_REF:0000043
Cyp3a23-3a1Ratmonooxygenase activity enablesIEAUniProtKB-KW:KW-05031600115GO_REF:0000043UniProtGO_REF:0000043
Cyp3a23-3a1Ratmonooxygenase activity enablesIEAInterPro:IPR001128 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Cyp3a23-3a1Ratmonooxygenase activity enablesIEAInterPro:IPR001128 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Cyp3a23-3a1Ratmonooxygenase activity enablesIEAInterPro:IPR001128 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Cyp3a23-3a1Ratmonooxygenase activity enablesIEAInterPro:IPR001128 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Cyp3a23-3a1Ratoxidoreductase activity enablesIEAUniProtKB-KW:KW-05601600115GO_REF:0000043UniProtGO_REF:0000043
Cyp3a23-3a1Ratoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen enablesIEAInterPro:IPR001128 more ...1600115GO_REF:0000002InterProGO_REF:0000002
1 to 20 of 27 rows

RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cyp3a23-3a1Rattamoxifen pharmacokinetics pathway   IDA 5129544 RGD 

Imported Annotations - KEGG (archival)


1 to 20 of 24 rows
#
Reference Title
Reference Citation
1. The influence of soybean extract on the expression level of selected drug transporters, transcription factors and cytochrome P450 genes encoding phase I drug-metabolizing enzymes. Bogacz A, etal., Ginekol Pol. 2014 May;85(5):348-53. doi: 10.17772/gp/1741.
2. Pregnane X receptor and constitutive androstane receptor modulate differently CYP3A-mediated metabolism in early- and late-stage cholestasis. Gabbia D, etal., World J Gastroenterol. 2017 Nov 14;23(42):7519-7530. doi: 10.3748/wjg.v23.i42.7519.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Complete cDNA and protein sequence of a pregnenolone 16 alpha-carbonitrile-induced cytochrome P-450. A representative of a new gene family. Gonzalez FJ, etal., J Biol Chem 1985 Jun 25;260(12):7435-41.
5. Role of Glucocorticoid Receptor and Pregnane X Receptor in Dexamethasone Induction of Rat Hepatic Aryl Hydrocarbon Receptor Nuclear Translocator and NADPH-Cytochrome P450 Oxidoreductase. Hunter SR, etal., Drug Metab Dispos. 2017 Feb;45(2):118-129. doi: 10.1124/dmd.116.073833. Epub 2016 Nov 16.
6. Alpha-hydroxylation of tamoxifen and toremifene by human and rat cytochrome P450 3A subfamily enzymes. Kim SY, etal., Chem Res Toxicol. 2003 Sep;16(9):1138-44.
7. Comparative study on nobiletin metabolism with liver microsomes from rats, Guinea pigs and hamsters and rat cytochrome p450. Koga N, etal., Biol Pharm Bull. 2007 Dec;30(12):2317-23.
8. Hepatic drug metabolizing profile of Flinders Sensitive Line rat model of depression. Kotsovolou O, etal., Prog Neuropsychopharmacol Biol Psychiatry. 2010 Aug 16;34(6):1075-84. Epub 2010 Jun 4.
9. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
10. Autoantibodies against cytochromes P-4502E1 and P-4503A in alcoholics. Lytton SD, etal., Mol Pharmacol. 1999 Feb;55(2):223-33. doi: 10.1124/mol.55.2.223.
11. Using real-time quantitative TaqMan RT-PCR to evaluate the role of dexamethasone in gene regulation of rat P-glycoproteins mdr1a/1b and cytochrome P450 3A1/2. Mei Q, etal., J Pharm Sci. 2004 Oct;93(10):2488-96.
12. Structure and expression of the rat CYP3A1 gene: isolation of the gene (P450/6betaB) and characterization of the recombinant protein. Nagata K, etal., Arch Biochem Biophys. 1999 Feb 15;362(2):242-53.
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. Profile of territrem metabolism and cytochrome P-450 3A expression in liver microsomes from Wistar rats of both genders as a function of age. Peng FC, etal., J Toxicol Environ Health A. 2005 Nov 12;68(21):1871-88.
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. Effects of chronic exposure to cadmium on renal cytochrome P450-dependent monooxygenase system in rats. Plewka A, etal., Arch Toxicol. 2004 Apr;78(4):194-200. Epub 2003 Nov 1.
17. Selective downregulation of hepatic cytochrome P450 expression and activity in a rat model of inflammatory pain. Projean D, etal., Pharm Res. 2005 Jan;22(1):62-70.
18. Role of temperature on protein and mRNA cytochrome P450 3A (CYP3A) isozymes expression and midazolam oxidation by cultured rat precision-cut liver slices. Rekka E, etal., Biochem Pharmacol 2002 Aug 15;64(4):633-43.
19. GOA pipeline RGD automated data pipeline
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
1 to 20 of 24 rows
PMID:1298226   PMID:1372436   PMID:1417000   PMID:1731631   PMID:2398038   PMID:3875783   PMID:7528203   PMID:7681660   PMID:8274011   PMID:11901229   PMID:12477932   PMID:15979568  
PMID:16461430   PMID:19435144   PMID:19504095   PMID:19848203   PMID:20599767   PMID:22159698   PMID:22822673   PMID:23235327   PMID:23762486   PMID:24212381   PMID:25302309   PMID:25989892  
PMID:26900149   PMID:27899252   PMID:28532222   PMID:29381299   PMID:30811654   PMID:34461081  



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Variants in Cyp3a23-3a1
109 total Variants

Predicted Target Of
Summary Value
Count of predictions:181
Count of miRNA genes:139
Interacting mature miRNAs:156
Transcripts:ENSRNOT00000075671
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 32 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
2312418Kidm41Kidney mass QTL 413.70.0001kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)12119611090Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12852542328064601Rat
1581516Cm56Cardiac mass QTL 564.20.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)12129333307Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat

1 to 10 of 32 rows
RH94398  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2129,255,993 - 9,256,161 (+)MAPPERmRatBN7.2
Rnor_6.01211,703,772 - 11,703,939NCBIRnor6.0
Rnor_6.01211,053,723 - 11,053,890NCBIRnor6.0
Rnor_5.01213,145,577 - 13,145,744UniSTSRnor5.0
Rnor_5.01213,766,697 - 13,766,864UniSTSRnor5.0
RGSC_v3.4129,566,955 - 9,567,122UniSTSRGSC3.4
Celera1211,062,850 - 11,063,017UniSTS
Cytogenetic Map12p11UniSTS
RH132534  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2129,256,029 - 9,256,241 (+)MAPPERmRatBN7.2
Rnor_6.01211,703,808 - 11,704,019NCBIRnor6.0
Rnor_6.01211,053,759 - 11,053,970NCBIRnor6.0
Rnor_5.01213,766,733 - 13,766,944UniSTSRnor5.0
Rnor_5.01213,145,613 - 13,145,824UniSTSRnor5.0
RGSC_v3.4129,566,991 - 9,567,202UniSTSRGSC3.4
Celera1211,062,886 - 11,063,097UniSTS
RH 3.4 Map12102.2UniSTS
Cytogenetic Map12p11UniSTS
RH142381  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2129,285,598 - 9,285,757 (+)MAPPERmRatBN7.2
Rnor_6.01211,733,681 - 11,733,839NCBIRnor6.0
Rnor_6.01211,083,321 - 11,083,479NCBIRnor6.0
Rnor_5.01213,796,606 - 13,796,764UniSTSRnor5.0
Rnor_5.01213,175,175 - 13,175,333UniSTSRnor5.0
RGSC_v3.4129,596,553 - 9,596,711UniSTSRGSC3.4
Celera1211,091,516 - 11,091,674UniSTS
RH 3.4 Map12117.0UniSTS
Cytogenetic Map12p11UniSTS


This gene Cyp3a23-3a1 is modified in the following models/strains:
SD-Cyp3a23/3a1em1Myliu,Cyp3a2em1Myliu    




appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
5 4 18 47 50 37 13 37 74 22 13 10 20 13


1 to 16 of 16 rows
RefSeq Transcripts NM_013105 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB008388 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC088163 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D13912 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D29967 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210339 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211106 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L24207 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M10161 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M28452 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M86850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X62086 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X64401 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X96721 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 16 of 16 rows

Ensembl Acc Id: ENSRNOT00000051244   ⟹   ENSRNOP00000041138
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl129,015,383 - 9,285,008 (-)Ensembl
Rnor_6.0 Ensembl1211,703,598 - 11,733,099 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000071669   ⟹   ENSRNOP00000084956
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl129,015,383 - 9,285,008 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000087257   ⟹   ENSRNOP00000068625
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl129,207,980 - 9,230,043 (-)Ensembl
Rnor_6.0 Ensembl1211,655,402 - 11,733,136 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000099867   ⟹   ENSRNOP00000094020
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl129,207,980 - 9,230,043 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100533   ⟹   ENSRNOP00000082425
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl129,254,475 - 9,285,030 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000104663   ⟹   ENSRNOP00000084206
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl129,254,475 - 9,283,058 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000118926   ⟹   ENSRNOP00000088335
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl129,254,475 - 9,282,915 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000119539   ⟹   ENSRNOP00000087895
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl129,254,475 - 9,283,058 (-)Ensembl
RefSeq Acc Id: NM_013105   ⟹   NP_037237
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81214,369,950 - 14,398,803 (-)NCBI
mRatBN7.2129,256,159 - 9,285,020 (-)NCBI
Rnor_6.01211,053,888 - 11,082,742 (-)NCBI
Rnor_5.01213,145,742 - 13,174,596 (-)NCBI
RGSC_v3.4129,567,120 - 9,595,974 (-)RGD
Celera1211,063,015 - 11,090,937 (-)RGD
Sequence:
RefSeq Acc Id: NP_037237   ⟸   NM_013105
- UniProtKB: A0A8I5ZUW6 (UniProtKB/TrEMBL),   A6K1D8 (UniProtKB/TrEMBL),   Q06884 (UniProtKB/TrEMBL),   Q6LEQ2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000068625   ⟸   ENSRNOT00000087257
Ensembl Acc Id: ENSRNOP00000041138   ⟸   ENSRNOT00000051244
Ensembl Acc Id: ENSRNOP00000084206   ⟸   ENSRNOT00000104663
Ensembl Acc Id: ENSRNOP00000082425   ⟸   ENSRNOT00000100533

Name Modeler Protein Id AA Range Protein Structure
AF-P04800-F1-model_v2 AlphaFold P04800 1-504 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 39 of 39 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-20067 BioCyc
Ensembl Genes ENSRNOG00000032560 Ensembl
  ENSRNOG00000062027 Ensembl
  ENSRNOG00000067532 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000100533 ENTREZGENE
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7370410 IMAGE-MGC_LOAD
InterPro Cyt_P450 UniProtKB/Swiss-Prot
  Cyt_P450_CS UniProtKB/Swiss-Prot
  Cyt_P450_E_CYP3A UniProtKB/Swiss-Prot
  Cyt_P450_E_grp-II UniProtKB/Swiss-Prot
  Cyt_P450_sf UniProtKB/Swiss-Prot
  Cytochrome_P450_3A UniProtKB/Swiss-Prot
MGC_CLONE MGC:108757 IMAGE-MGC_LOAD
NCBI Gene Cyp3a23-3a1 ENTREZGENE
PANTHER CYTOCHROME P450 3A-RELATED UniProtKB/Swiss-Prot
  CYTOCHROME P450 FAMILY 3 UniProtKB/Swiss-Prot
Pfam p450 UniProtKB/Swiss-Prot
PharmGKB CYP3A4 RGD
PhenoGen Cyp3a23-3a1 PhenoGen
PRINTS EP450II UniProtKB/Swiss-Prot
  EP450IICYP3A UniProtKB/Swiss-Prot
  P450 UniProtKB/Swiss-Prot
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000032560 RatGTEx
  ENSRNOG00000062027 RatGTEx
  ENSRNOG00000067532 RatGTEx
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot
TIGR TC205966
UniProt A0A8I5ZUW6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZZ45_RAT UniProtKB/TrEMBL
  A0A8I6A1G5_RAT UniProtKB/TrEMBL
  A0A8I6AIP2_RAT UniProtKB/TrEMBL
  A0A8I6GFL1_RAT UniProtKB/TrEMBL
  A6K1D8 ENTREZGENE
  CP3A1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q06884 ENTREZGENE, UniProtKB/TrEMBL
  Q6LEQ2 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q64580 UniProtKB/Swiss-Prot
1 to 39 of 39 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Cyp3a23-3a1  cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1  AABR07035343.1    Data merged from RGD:15014538 737654 PROVISIONAL
2021-03-09 Cyp3a23-3a1  cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1  LOC100910877  cytochrome P450 3A1-like  Data merged from RGD:6495986 737654 PROVISIONAL
2020-04-16 Cyp3a23-3a1  cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1  Cyp3a23-3a1  cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 1  Name changed 629549 APPROVED
2020-04-16 Cyp3a23-3a1  cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 1  Cyp3a23/3a1  cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 1  Symbol changed 629549 APPROVED
2019-11-08 AABR07035343.1        Symbol and Name status set to provisional 45752 PROVISIONAL
2012-07-05 LOC100910877  cytochrome P450 3A1-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-09-08 Cyp3a23/3a1  cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 1  Cyp3a23/3a1_retired  cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 1_retired  Data merged from RGD:2478 737654 APPROVED
2007-09-21 Cyp3a23/3a1  cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 1  Cyp3a1  cytochrome P450, family 3, subfamily a, polypeptide 1  Symbol and Name updated 1299863 APPROVED
2007-09-21 Cyp3a23/3a1_retired  cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 1_retired  Cyp3a23/3a1  cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 1  Symbol and Name updated 1299863 PROVISIONAL
2007-07-06 Cyp3a23/3a1  cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 1  Cyp3a3  cytochrome P450, subfamily 3A, polypeptide 3  Name updated 1299863 APPROVED
2005-09-08 Cyp3a1  cytochrome P450, family 3, subfamily a, polypeptide 1  Cyp3A1  cytochrome P-450PCN (PNCN inducible)  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2003-02-27 Cyp3A1  cytochrome P-450PCN (PNCN inducible)      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-11-06 Cyp3a3  cytochrome P450, subfamily 3A, polypeptide 3    Cytochrome P450, subfamily IIIA, polypeptide 3  Name updated 625702 APPROVED
2002-06-10 Cyp3a3  Cytochrome P450, subfamily IIIA, polypeptide 3      Symbol and Name status set to approved 70586 APPROVED

Note Type Note Reference
gene_drugs induced strongly by pregnenolone 16 alpha-carbonitrile and dexamethasone (DEX) and weakly by phenobarbital (PB) and triacetyloleandomycin 1298860
gene_expression expressed in liver 1298860