Nts (neurotensin) - Rat Genome Database

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Gene: Nts (neurotensin) Rattus norvegicus
Analyze
Symbol: Nts
Name: neurotensin
RGD ID: 621612
Description: Predicted to enable neuropeptide receptor binding activity and receptor ligand activity. Involved in several processes, including cellular response to lithium ion; response to antipsychotic drug; and response to glucocorticoid. Located in axon terminus and neuronal cell body. Used to study nicotine dependence. Biomarker of sciatic neuropathy. Human ortholog(s) of this gene implicated in depressive disorder. Orthologous to human NTS (neurotensin); INTERACTS WITH (S)-colchicine; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC299757; neuromedin N; neurotensin/neuromedin N; neurotensin/neuromedin N gene
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8739,451,484 - 39,460,888 (-)NCBIGRCr8
mRatBN7.2737,564,944 - 37,574,350 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl737,564,533 - 37,574,423 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx739,491,733 - 39,501,228 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0741,694,804 - 41,704,299 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0741,469,771 - 41,479,266 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0744,111,594 - 44,120,998 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl744,111,151 - 44,121,130 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0744,140,647 - 44,150,051 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4740,474,654 - 40,484,058 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1740,494,497 - 40,495,295 (-)NCBI
Celera734,527,468 - 34,536,872 (-)NCBICelera
Cytogenetic Map7q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
NtsRatdepressive disorder  ISONTS (Homo sapiens)401854249DNA:SNP:CDS:multiple (human)RGD 
NtsRatExperimental Arthritis  IEP 9743903 RGD 
NtsRatHypovolemia  IEP 9727453mRNA:increased expression:neuron:RGD 
NtsRatmetabolic dysfunction-associated steatotic liver disease  ISONTS (Homo sapiens)596992335protein:increased expression:serumRGD 
NtsRatnicotine dependence amelioratesIDA 597000688 RGD 
NtsRatPeripheral Nerve Injuries  IEP 9743915mRNA and protein:increased expression:neuron:RGD 
NtsRatsciatic neuropathy  IEP 9743903 RGD 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
NtsRatbreast ductal carcinoma  ISONTS (Homo sapiens)8554872ClinVar Annotator: match by term: Ductal breast carcinomaClinVar 
NtsRatinvasive ductal carcinoma  ISONTS (Homo sapiens)8554872ClinVar Annotator: match by term: Breast cancer and invasive ductalClinVar 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
NtsRatBradycardia  ISONTS (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:2326505
NtsRatCatalepsy  ISONTS (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:20882060
NtsRatHyperkinesis  ISONTS (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:3748325 and PMID:6682440
NtsRatMuscle Rigidity  ISONTS (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:8036282

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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
NtsRat(S)-amphetamine increases expressionISONts (Mus musculus)6480464Dextroamphetamine results in increased expression of NTS mRNACTDPMID:11120399
NtsRat(S)-colchicine increases expressionEXP 6480464Colchicine results in increased expression of NTS mRNACTDPMID:1850078
NtsRat1,2-dimethylhydrazine decreases expressionISONts (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of NTS mRNACTDPMID:22206623
NtsRat17beta-estradiol increases expressionEXP 6480464Estradiol results in increased expression of NTS mRNACTDPMID:20068009
NtsRat17beta-estradiol increases expressionISONTS (Homo sapiens)6480464Estradiol results in increased expression of NTS mRNACTDPMID:21795739
NtsRat17beta-estradiol multiple interactionsISONTS (Homo sapiens)6480464[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of NTS mRNA and Progesterone inhibits the reaction [Estradiol results in increased expression of NTS mRNA]CTDPMID:20823114 and PMID:21795739
NtsRat17beta-hydroxy-5alpha-androstan-3-one affects expressionISONTS (Homo sapiens)6480464Dihydrotestosterone affects the expression of NTS mRNACTDPMID:17094431
NtsRat2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of NTS mRNACTDPMID:15977195
NtsRat2,4,6-trinitrobenzenesulfonic acid multiple interactionsISONts (Mus musculus)6480464NTS protein promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of VWF protein]CTDPMID:25307345
NtsRat3,4-methylenedioxymethamphetamine increases expressionEXP 6480464N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of NTS mRNACTDPMID:15661373
NtsRat3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione multiple interactionsISONTS (Homo sapiens)6480464bisindolylmaleimide I affects the reaction [NTS protein results in increased chemical synthesis of Inositol Phosphates] more ...CTDPMID:18313772
NtsRat3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione increases activityISONTS (Homo sapiens)6480464bisindolylmaleimide I results in increased activity of NTS proteinCTDPMID:18313772
NtsRat3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione increases activityEXP 6480464bisindolylmaleimide I results in increased activity of NTS proteinCTDPMID:18313772
NtsRat5-azacytidine decreases expressionISONTS (Homo sapiens)6480464Azacitidine results in decreased expression of NTS mRNACTDPMID:20823114
NtsRat5-fluorouracil affects response to substanceISONTS (Homo sapiens)6480464NTS protein affects the susceptibility to FluorouracilCTDPMID:16217747
NtsRat6-propyl-2-thiouracil increases expressionEXP 6480464Propylthiouracil results in increased expression of NTS mRNACTDPMID:24780913 and PMID:25825206
NtsRat8-(3-chlorostyryl)caffeine multiple interactionsEXP 64804648-(3-chlorostyryl)caffeine inhibits the reaction [Haloperidol results in increased expression of NTS mRNA]CTDPMID:10199625
NtsRatacrylamide decreases expressionISONTS (Homo sapiens)6480464Acrylamide results in decreased expression of NTS mRNACTDPMID:32763439
NtsRataflatoxin B1 increases expressionISONts (Mus musculus)6480464Aflatoxin B1 results in increased expression of NTS mRNACTDPMID:19770486
NtsRataflatoxin B1 increases expressionISONTS (Homo sapiens)6480464Aflatoxin B1 results in increased expression of NTS mRNACTDPMID:21641981

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Biological Process
1 to 20 of 24 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
NtsRatblood vessel diameter maintenance involved_inIEAUniProtKB-KW:KW-08381600115GO_REF:0000043UniProtGO_REF:0000043
NtsRatcellular response to dexamethasone stimulus  IEP 9727457 RGD 
NtsRatcellular response to lithium ion  IEP 9743905 RGD 
NtsRatcellular response to nerve growth factor stimulus  IEP 9743905 RGD 
NtsRatdigestive tract development  IEP 9743850 RGD 
NtsRathyperosmotic response  IEP 9698448 RGD 
NtsRatliver development  IEP 9743870 RGD 
NtsRatnegative regulation of gene expression acts_upstream_ofISONTS (Homo sapiens)1624291 PMID:21806946RGDPMID:21806946
NtsRatnegative regulation of gene expression acts_upstream_ofIEAUniProtKB:P30990 and ensembl:ENSP000002560101600115GO_REF:0000107EnsemblGO_REF:0000107
NtsRatneuropeptide signaling pathway involved_inIEAUniProtKB:P30990 and ensembl:ENSP000002560101600115GO_REF:0000107EnsemblGO_REF:0000107
NtsRatneuropeptide signaling pathway involved_inISONTS (Homo sapiens)1624291UniProtKB:P30989 more ...RGDPMID:11294867 and PMID:21806946
NtsRatpositive regulation of gene expression acts_upstream_ofISONTS (Homo sapiens)1624291 PMID:21806946RGDPMID:21806946
NtsRatpositive regulation of gene expression acts_upstream_ofIEAUniProtKB:P30990 and ensembl:ENSP000002560101600115GO_REF:0000107EnsemblGO_REF:0000107
NtsRatpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction acts_upstream_ofISONTS (Homo sapiens)1624291 PMID:21806946RGDPMID:21806946
NtsRatpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction acts_upstream_ofIEAUniProtKB:P30990 and ensembl:ENSP000002560101600115GO_REF:0000107EnsemblGO_REF:0000107
NtsRatregulation of locomotion involved in locomotory behavior  IMP 596948427 RGD 
NtsRatresponse to amphetamine  IEP 9698453 RGD 
NtsRatresponse to antipsychotic drug  IEP 9698450 RGD 
NtsRatresponse to axon injury  IEP 9743915 RGD 
NtsRatresponse to cocaine  IEP 9727458 RGD 
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Cellular Component
1 to 11 of 11 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
NtsRataxon terminus  IDA 9727452 RGD 
NtsRataxon terminus is_active_inIBAPANTHER:PTN000394547 and Nts (Rattus norvegicus)1600115GO_REF:0000033GO_CentralGO_REF:0000033
NtsRatcytoplasmic vesicle located_inIEAUniProtKB-KW:KW-09681600115GO_REF:0000043UniProtGO_REF:0000043
NtsRatextracellular region located_inIEAUniProtKB-SubCell:SL-02431600115GO_REF:0000044UniProtGO_REF:0000044
NtsRatextracellular region located_inIEAInterPro:IPR0080551600115GO_REF:0000002InterProGO_REF:0000002
NtsRatextracellular region located_inIEAUniProtKB-KW:KW-09641600115GO_REF:0000043UniProtGO_REF:0000043
NtsRatintracellular membrane-bounded organelle located_inISONTS (Homo sapiens)1624291 RGDGO_REF:0000052
NtsRatintracellular membrane-bounded organelle located_inIEAUniProtKB:Q6FH20 and ensembl:ENSP000002560101600115GO_REF:0000107EnsemblGO_REF:0000107
NtsRatintracellular membrane-bounded organelle located_inIEAUniProtKB:P30990 and ensembl:ENSP000002560101600115GO_REF:0000107EnsemblGO_REF:0000107
NtsRatneuronal cell body  IDA 9698452 RGD 
NtsRattransport vesicle located_inIEAUniProtKB-SubCell:SL-02441600115GO_REF:0000044UniProtGO_REF:0000044
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Molecular Function

  


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#
Reference Title
Reference Citation
1. Differential effects of cocaine and methamphetamine on neurotensin/neuromedin N and preprotachykinin messenger RNA expression in unique regions of the striatum. Adams DH, etal., Neuroscience. 2001;102(4):843-51.
2. Estrogen-inducible neurotensin immunoreactivity in the preoptic area of the female rat. Alexander MJ and Leeman SE, J Comp Neurol. 1994 Jul 22;345(4):496-509.
3. Cellular distribution of neurotensin receptors in rat brain: immunohistochemical study using an antipeptide antibody against the cloned high affinity receptor. Boudin H, etal., J Comp Neurol. 1996 Sep 9;373(1):76-89.
4. Synergistic induction of neurotensin gene transcription in PC12 cells parallels changes in AP-1 activity. Bullock BP, etal., Brain Res Mol Brain Res. 1994 Dec;27(2):232-42.
5. Biosynthesis and posttranslational processing of the neurotensin/neuromedin N precursor in the rat medullary thyroid carcinoma 6-23 cell line. Effect of dexamethasone. de Nadai F, etal., Endocrinology. 1993 Apr;132(4):1614-20.
6. Kinetics of neurotensin gene expression in the developing gut. Evers BM and Wang XF, Surgery. 1996 Feb;119(2):186-90.
7. Developmental expression of the neurotensin gene in the rat liver. Evers BM, etal., Ann Surg. 1993 Aug;218(2):183-8.
8. Distribution of the neurotensin receptor NTS1 in the rat CNS studied using an amino-terminal directed antibody. Fassio A, etal., Neuropharmacology. 2000 Jun 8;39(8):1430-42.
9. Neurotensin receptor antagonist administered during cocaine withdrawal decreases locomotor sensitization and conditioned place preference. Felszeghy K, etal., Neuropsychopharmacology. 2007 Dec;32(12):2601-10. doi: 10.1038/sj.npp.1301382. Epub 2007 Mar 14.
10. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. The rat gene encoding neurotensin and neuromedin N. Structure, tissue-specific expression, and evolution of exon sequences. Kislauskis E, etal., J Biol Chem 1988 Apr 5;263(10):4963-8.
12. Characterization of neurotensin receptors. Kitabgi P and Pelaprat D, Curr Protoc Pharmacol. 2004 May;Chapter 1:Unit 1.29. doi: 10.1002/0471141755.ph0129s24.
13. Effects of neurotensin in amygdaloid spatial learning mechanisms. Laszlo K, etal., Behav Brain Res. 2010 Jul 11;210(2):280-3. doi: 10.1016/j.bbr.2010.02.038. Epub 2010 Feb 26.
14. Effect of a novel neurotensin analog, NT69L, on nicotine-induced alterations in monoamine levels in rat brain. Liang Y, etal., Brain Res. 2008 Sep 22;1231:6-15. doi: 10.1016/j.brainres.2008.07.037. Epub 2008 Jul 19.
15. Mutation burden analysis of six common mental disorders in African Americans by whole genome sequencing. Liu Y, etal., Hum Mol Genet. 2022 Nov 10;31(22):3769-3776. doi: 10.1093/hmg/ddac129.
16. Coexpression of neurotensin and c-fos mRNAs in rat neostriatal neurons following acute haloperidol. Merchant KM and Miller MA, Brain Res Mol Brain Res. 1994 May;23(3):271-7.
17. Pro-Neurotensin as a Potential Novel Diagnostic Biomarker for Detection of Nonalcoholic Fatty Liver Disease. Mohamed AA, etal., Diabetes Metab Syndr Obes. 2022 Jun 22;15:1935-1943. doi: 10.2147/DMSO.S365147. eCollection 2022.
18. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
19. Acute, but not repeated, administration of the neurotensin NTS1 receptor agonist PD149163 decreases conditioned footshock-induced ultrasonic vocalizations in rats. Prus AJ, etal., Prog Neuropsychopharmacol Biol Psychiatry. 2014 Mar 3;49:78-84. doi: 10.1016/j.pnpbp.2013.11.011. Epub 2013 Nov 23.
20. Neurotensin antagonist acutely and robustly attenuates locomotion that accompanies stimulation of a neurotensin-containing pathway from rostrobasal forebrain to the ventral tegmental area. Reynolds SM, etal., Eur J Neurosci. 2006 Jul;24(1):188-96. doi: 10.1111/j.1460-9568.2006.04791.x.
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PMID:8471039   PMID:11294867   PMID:12074933   PMID:12080490   PMID:14552872   PMID:15193419   PMID:18155361   PMID:18182046   PMID:18252810   PMID:18456542   PMID:18556091   PMID:18607747  
PMID:18991855   PMID:18992283   PMID:19322170   PMID:19941912   PMID:20471454   PMID:20601081   PMID:21656844   PMID:21820035   PMID:22035146   PMID:24969625   PMID:27267684   PMID:27372546  
PMID:28522313   PMID:28877396   PMID:32327191   PMID:33682882  



Nts
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8739,451,484 - 39,460,888 (-)NCBIGRCr8
mRatBN7.2737,564,944 - 37,574,350 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl737,564,533 - 37,574,423 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx739,491,733 - 39,501,228 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0741,694,804 - 41,704,299 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0741,469,771 - 41,479,266 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0744,111,594 - 44,120,998 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl744,111,151 - 44,121,130 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0744,140,647 - 44,150,051 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4740,474,654 - 40,484,058 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1740,494,497 - 40,495,295 (-)NCBI
Celera734,527,468 - 34,536,872 (-)NCBICelera
Cytogenetic Map7q21NCBI
NTS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381285,874,295 - 85,882,992 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1285,874,295 - 85,882,992 (+)EnsemblGRCh38hg38GRCh38
GRCh371286,268,073 - 86,276,770 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361284,792,206 - 84,800,898 (+)NCBINCBI36Build 36hg18NCBI36
Build 341284,770,542 - 84,779,231NCBI
Celera1285,930,823 - 85,939,559 (+)NCBICelera
Cytogenetic Map12q21.31NCBI
HuRef1283,324,584 - 83,333,603 (+)NCBIHuRef
CHM1_11286,233,027 - 86,241,361 (+)NCBICHM1_1
T2T-CHM13v2.01285,854,932 - 85,863,806 (+)NCBIT2T-CHM13v2.0
Nts
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910102,317,617 - 102,326,294 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10102,317,617 - 102,326,347 (-)EnsemblGRCm39 Ensembl
GRCm3810102,481,756 - 102,490,418 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10102,481,756 - 102,490,486 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710101,944,390 - 101,953,052 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610101,911,444 - 101,920,106 (-)NCBIMGSCv36mm8
Celera10104,415,989 - 104,424,662 (-)NCBICelera
Cytogenetic Map10D1NCBI
cM Map1053.56NCBI
Nts
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540523,748,280 - 23,758,529 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540523,696,258 - 23,758,487 (+)NCBIChiLan1.0ChiLan1.0
NTS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21093,932,967 - 93,940,591 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11293,929,364 - 93,936,989 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01283,402,313 - 83,410,356 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11286,640,722 - 86,648,708 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1286,640,720 - 86,648,745 (+)Ensemblpanpan1.1panPan2
NTS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11527,361,002 - 27,372,232 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1527,361,002 - 27,372,232 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1527,806,896 - 27,818,114 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01527,977,054 - 27,988,287 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1527,977,054 - 27,988,287 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11527,329,416 - 27,340,646 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01527,370,112 - 27,381,344 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01527,659,448 - 27,670,671 (+)NCBIUU_Cfam_GSD_1.0
Nts
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494532,906,185 - 32,916,431 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365073,318,915 - 3,329,342 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365073,318,982 - 3,329,248 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NTS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl596,260,560 - 96,272,976 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1596,261,299 - 96,272,947 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.25101,076,752 - 101,088,628 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NTS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11181,270,147 - 81,278,327 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1181,270,593 - 81,277,713 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037164,046,316 - 164,054,238 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nts
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248375,035,159 - 5,045,651 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248375,035,237 - 5,045,560 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Nts
71 total Variants

Predicted Target Of
Summary Value
Count of predictions:82
Count of miRNA genes:66
Interacting mature miRNAs:78
Transcripts:ENSRNOT00000005706
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 30 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1354644Spl4Serum phospholipid level QTL 44.9blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)71965431749753746Rat
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72192119566921195Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)7986646760460686Rat
1641885Alcrsp9Alcohol response QTL 9alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)72409960669099606Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72475184169751841Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72940968384928080Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)7946224658265113Rat

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alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
7 1 23 101 65 71 46 9 46 2 118 39 92 25 41 25



Ensembl Acc Id: ENSRNOT00000005706   ⟹   ENSRNOP00000005706
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl737,564,533 - 37,574,423 (-)Ensembl
Rnor_6.0 Ensembl744,111,151 - 44,121,130 (-)Ensembl
RefSeq Acc Id: NM_001102381   ⟹   NP_001095851
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8739,451,484 - 39,460,888 (-)NCBI
mRatBN7.2737,564,944 - 37,574,350 (-)NCBI
Rnor_6.0744,111,594 - 44,120,998 (-)NCBI
Rnor_5.0744,140,647 - 44,150,051 (-)NCBI
RGSC_v3.4740,474,654 - 40,484,058 (-)RGD
Celera734,527,468 - 34,536,872 (-)RGD
Sequence:
Protein RefSeqs NP_001095851 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41712 (Get FASTA)   NCBI Sequence Viewer  
  EDM16790 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000005706
GenBank Protein P20068 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001095851   ⟸   NM_001102381
- Peptide Label: precursor
- UniProtKB: Q9QV80 (UniProtKB/Swiss-Prot),   P20068 (UniProtKB/Swiss-Prot),   A6IGA8 (UniProtKB/TrEMBL),   G3V6J4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000005706   ⟸   ENSRNOT00000005706

Name Modeler Protein Id AA Range Protein Structure
AF-P20068-F1-model_v2 AlphaFold P20068 1-169 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13695176
Promoter ID:EPDNEW_R5701
Type:single initiation site
Name:Nts_1
Description:neurotensin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0744,121,018 - 44,121,078EPDNEW


1 to 16 of 16 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-34223 BioCyc
Ensembl Genes ENSRNOG00000004179 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000005706 ENTREZGENE
InterPro NeurotensiN UniProtKB/Swiss-Prot
NCBI Gene Nts ENTREZGENE
PANTHER NEUROTENSIN/NEUROMEDIN N UniProtKB/Swiss-Prot
  PTHR15356 UniProtKB/Swiss-Prot
Pfam Pro-NT_NN UniProtKB/Swiss-Prot
PhenoGen Nts PhenoGen
PRINTS NEUROTENSIN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000004179 RatGTEx
UniProt A6IGA8 ENTREZGENE, UniProtKB/TrEMBL
  G3V6J4 ENTREZGENE, UniProtKB/TrEMBL
  NEUT_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q9QV80 ENTREZGENE
UniProt Secondary Q9QV80 UniProtKB/Swiss-Prot
1 to 16 of 16 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2007-10-18 Nts  neurotensin  Nts_predicted  neurotensin (predicted)  Data merged from RGD:1308997 737654 APPROVED
2005-01-20 Nts  neurotensin    neurotensin/neuromedin N gene  Name updated 1299863 APPROVED
2005-01-12 Nts_predicted  neurotensin (predicted)      Symbol and Name status set to approved 70820 APPROVED
2002-08-07 Nts  neurotensin/neuromedin N gene      Symbol and Name status set to provisional 70820 PROVISIONAL

Note Type Note Reference
gene_transcript neurotensin and neuromedin N coding domains are tandemly positioned on exon 4 728959