Srd5a2 (steroid 5 alpha-reductase 2) - Rat Genome Database

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Gene: Srd5a2 (steroid 5 alpha-reductase 2) Rattus norvegicus
Analyze
Symbol: Srd5a2
Name: steroid 5 alpha-reductase 2
RGD ID: 621480
Description: Enables 3-oxo-5-alpha-steroid 4-dehydrogenase activity and amide binding activity. Involved in several processes, including limbic system development; reproductive structure development; and steroid metabolic process. Located in cell body fiber and neuronal cell body. Biomarker of diabetes mellitus and hyperprolactinemia. Human ortholog(s) of this gene implicated in hypospadias and prostate cancer. Orthologous to human SRD5A2 (steroid 5 alpha-reductase 2); PARTICIPATES IN testosterone biosynthetic pathway; prostate cancer pathway; steroid hormone biosynthetic pathway; INTERACTS WITH 17beta-hydroxy-5alpha-androstan-3-one; 2,2',4,4',5,5'-hexachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 3-oxo-5-alpha-steroid 4-dehydrogenase 2; 5 alpha-SR2; S5AR 2; SR type 2; steroid 5-alpha-reductase 2; steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8627,178,089 - 27,217,588 (+)NCBIGRCr8
mRatBN7.2621,426,225 - 21,465,727 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl621,426,215 - 21,462,112 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx621,755,011 - 21,794,514 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0622,070,851 - 22,110,348 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0621,551,287 - 21,590,788 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0625,279,635 - 25,315,501 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl625,279,626 - 25,315,511 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0635,127,532 - 35,163,398 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4621,453,521 - 21,489,408 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1621,456,473 - 21,492,397 (+)NCBI
Celera620,976,906 - 21,012,848 (+)NCBICelera
Cytogenetic Map6q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
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Reference
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Original Reference(s)
Srd5a2Ratbreast carcinoma  ISOSRD5A2 (Homo sapiens)2302558mRNA:increased expression:breastRGD 
Srd5a2Ratdiabetes mellitus  IEP 1600067 RGD 
Srd5a2Rathyperprolactinemia  IEP 4891877mRNA:increased expression:prostate (rat)RGD 
Srd5a2Rathypospadias susceptibilityISOSRD5A2 (Homo sapiens)1600059protein:missense mutations:cds:p.R227Q and p.F186L (human)RGD 
Srd5a2Ratprostate cancer  ISOSRD5A2 (Homo sapiens)2302560mRNA:decreased expression:prostate glandRGD 
Srd5a2Ratprostate cancer susceptibilityISOSRD5A2 (Homo sapiens)4891929DNA:missense mutation:cds:p.A49T (human)RGD 
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Original Reference(s)
Srd5a2Ratautism spectrum disorder  ISOSRD5A2 (Homo sapiens)8554872ClinVar Annotator: match by term: Autism spectrum disordersClinVarPMID:10898110 more ...
Srd5a2RatAutoinflammation with Infantile Enterocolitis  ISOSRD5A2 (Homo sapiens)8554872ClinVar Annotator: match by term: Autoinflammation with infantile enterocolitisClinVarPMID:28492532
Srd5a2Ratfamilial cold autoinflammatory syndrome 4  ISOSRD5A2 (Homo sapiens)8554872ClinVar Annotator: match by term: Familial cold autoinflammatory syndrome 4ClinVarPMID:28492532
Srd5a2Ratgenetic disease  ISOSRD5A2 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVar 
Srd5a2Rathereditary spastic paraplegia 4  ISOSRD5A2 (Homo sapiens)8554872ClinVar Annotator: match by term: Hereditary spastic paraplegia 4ClinVarPMID:28492532
Srd5a2RatPenis Agenesis  ISOSRD5A2 (Homo sapiens)8554872ClinVar Annotator: match by term: MicropenisClinVarPMID:10898110 more ...
Srd5a2RatPseudovaginal Perineoscrotal Hypospadias  ISOSRD5A2 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10501358 more ...
Srd5a2Ratxanthinuria  ISOSRD5A2 (Homo sapiens)8554872ClinVar Annotator: match by term: XDH deficiencyClinVar 
Srd5a2Ratxanthinuria type II  ISOSRD5A2 (Homo sapiens)8554872ClinVar Annotator: match by term: Xanthinuria type IIClinVarPMID:18384427 and PMID:28492532
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Original Reference(s)
Srd5a2Ratalopecia  ISOSRD5A2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17136762
Srd5a2RatEndometrial Neoplasms  ISOSRD5A2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:23200943
Srd5a2Ratendometriosis  ISOSRD5A2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21232532
Srd5a2Ratprostatic hypertrophy  ISOSRD5A2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20823678
Srd5a2RatProstatic Neoplasms  ISOSRD5A2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16998812 more ...
Srd5a2RatPseudovaginal Perineoscrotal Hypospadias  ISOSRD5A2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:7554313
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Original Reference(s)
Srd5a2RatProstatic Neoplasms  ISOSRD5A2 (Homo sapiens)1331525 GAD 
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Original Reference(s)
Srd5a2RatPseudovaginal Perineoscrotal Hypospadias  ISOSRD5A2 (Homo sapiens)7240710 OMIM 

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Original Reference(s)
Srd5a2Rat(-)-epigallocatechin 3-gallate decreases expressionISOSRD5A2 (Homo sapiens)6480464epigallocatechin gallate results in decreased expression of SRD5A2 mRNACTDPMID:20706672
Srd5a2Rat1,2-dimethylhydrazine decreases expressionISOSrd5a2 (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of SRD5A2 mRNACTDPMID:22206623
Srd5a2Rat17beta-estradiol decreases expressionISOSRD5A2 (Homo sapiens)6480464Estradiol results in decreased expression of SRD5A2 mRNACTDPMID:20106945
Srd5a2Rat17beta-hydroxy-5alpha-androstan-3-one multiple interactionsISOSrd5a2 (Mus musculus)6480464hydroxyflutamide inhibits the reaction [Dihydrotestosterone results in increased expression of SRD5A2 mRNA]CTDPMID:15056816
Srd5a2Rat17beta-hydroxy-5alpha-androstan-3-one increases expressionEXP 6480464Dihydrotestosterone results in increased expression of SRD5A2 mRNACTDPMID:22131296
Srd5a2Rat17beta-hydroxy-5alpha-androstan-3-one increases expressionISOSrd5a2 (Mus musculus)6480464Dihydrotestosterone results in increased expression of SRD5A2 mRNACTDPMID:15056816
Srd5a2Rat2,2',4,4',5,5'-hexachlorobiphenyl multiple interactionsEXP 6480464[3 more ...CTDPMID:19464308
Srd5a2Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of SRD5A2 mRNACTDPMID:11222880
Srd5a2Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOSrd5a2 (Mus musculus)6480464Tetrachlorodibenzodioxin results in decreased expression of SRD5A2 mRNACTDPMID:28213091
Srd5a2Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOSrd5a2 (Mus musculus)6480464Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to SRD5A2 gene]CTDPMID:28213091
Srd5a2Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of SRD5A2 mRNACTDPMID:21724226
Srd5a2Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOSRD5A2 (Homo sapiens)6480464Tetrachlorodibenzodioxin affects the expression of SRD5A2 mRNACTDPMID:22298810
Srd5a2Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of SRD5A2 mRNACTDPMID:22298810
Srd5a2Rat2,3,7,8-Tetrachlorodibenzofuran decreases expressionEXP 64804642 more ...CTDPMID:21724226
Srd5a2Rat2,4-dibromophenyl 2,4,5-tribromophenyl ether affects expressionISOSrd5a2 (Mus musculus)64804642 more ...CTDPMID:38648751
Srd5a2Rat3,17-Androstanediol glucuronide decreases abundanceISOSRD5A2 (Homo sapiens)6480464SRD5A2 gene SNP results in decreased abundance of androstane-3 and 17-diol glucuronideCTDPMID:17136762
Srd5a2Rat3,3',4,4',5-pentachlorobiphenyl multiple interactionsEXP 6480464[3 more ...CTDPMID:19464308
Srd5a2Rat3H-1,2-dithiole-3-thione decreases expressionEXP 64804641 and 2-dithiol-3-thione results in decreased expression of SRD5A2 mRNACTDPMID:19162173
Srd5a2Rat4,4'-sulfonyldiphenol decreases expressionISOSrd5a2 (Mus musculus)6480464bisphenol S results in decreased expression of SRD5A2 mRNACTDPMID:39298647
Srd5a2Rat4,4'-sulfonyldiphenol decreases methylationISOSrd5a2 (Mus musculus)6480464bisphenol S results in decreased methylation of SRD5A2 exonCTDPMID:33297965

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Biological Process
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Original Reference(s)
Srd5a2Ratandrogen biosynthetic process acts_upstream_of_or_withinIEAUniProtKB:Q99N99 and ensembl:ENSMUSP000000488621600115GO_REF:0000107EnsemblGO_REF:0000107
Srd5a2Ratandrogen biosynthetic process  IDA 4891962dihydrotestosteroneRGD 
Srd5a2Ratandrogen biosynthetic process acts_upstream_of_or_withinISOSrd5a2 (Mus musculus)1624291 PMID:15249131RGDPMID:15249131
Srd5a2Ratandrogen biosynthetic process involved_inISOSrd5a2 (Mus musculus)1624291MGI:2178039 PMID:15249131 and PMID:35613877RGDPMID:15249131 and PMID:35613877
Srd5a2Ratandrogen biosynthetic process involved_inIEAARBA:ARBA000292221600115GO_REF:0000117UniProtGO_REF:0000117
Srd5a2Ratandrogen metabolic process involved_inISOSRD5A2 (Homo sapiens)1624291 PMID:1944596RGDPMID:1944596
Srd5a2Ratandrogen metabolic process  IDA 4891498 RGD 
Srd5a2Ratandrogen metabolic process involved_inIEAUniProtKB:P31213 and ensembl:ENSP000004775871600115GO_REF:0000107EnsemblGO_REF:0000107
Srd5a2Ratbiphenyl metabolic process  IEP 4891899Aroclor 1254RGD 
Srd5a2Ratbone development  IEP 4891061 RGD 
Srd5a2Ratcell differentiation involved_inIEAUniProtKB-KW:KW-02211600115GO_REF:0000043UniProtGO_REF:0000043
Srd5a2Ratdibenzo-p-dioxin metabolic process  IEP 4892000 RGD 
Srd5a2Ratfemale genitalia development  IEP 4892034 RGD 
Srd5a2Rathippocampus development  IEP 4145527 RGD 
Srd5a2Rathypothalamus development  IEP 4891928 RGD 
Srd5a2Ratlipid metabolic process involved_inIEAUniProtKB-KW:KW-04431600115GO_REF:0000043UniProtGO_REF:0000043
Srd5a2Ratlipid metabolic process involved_inIEAInterPro:IPR0011041600115GO_REF:0000002InterProGO_REF:0000002
Srd5a2Ratmale genitalia development  TAS 729939 RGD 
Srd5a2Ratmale genitalia development acts_upstream_of_or_withinIEAUniProtKB:Q99N99 and ensembl:ENSMUSP000000488621600115GO_REF:0000107EnsemblGO_REF:0000107
Srd5a2Ratmale genitalia development acts_upstream_of_or_withinISOSrd5a2 (Mus musculus)1624291MGI:2178039 PMID:11606430RGDPMID:11606430
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Cellular Component

  
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Original Reference(s)
Srd5a2Ratcell body fiber  IDA 4891939 RGD 
Srd5a2Ratendoplasmic reticulum located_inIEAUniProtKB-KW:KW-02561600115GO_REF:0000043UniProtGO_REF:0000043
Srd5a2Ratendoplasmic reticulum membrane located_inIEAUniProtKB-SubCell:SL-00971600115GO_REF:0000044UniProtGO_REF:0000044
Srd5a2Ratmembrane located_inIEAInterPro:IPR0166361600115GO_REF:0000002InterProGO_REF:0000002
Srd5a2Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Srd5a2Ratneuronal cell body  IDA 4891939 RGD 

Molecular Function
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Original Reference(s)
Srd5a2Rat3-oxo-5-alpha-steroid 4-dehydrogenase (NADP+) activity enablesISOSRD5A2 (Homo sapiens)1624291 PMID:1944596RGDPMID:1944596
Srd5a2Rat3-oxo-5-alpha-steroid 4-dehydrogenase (NADP+) activity enablesIEARHEA:543841600115GO_REF:0000116RHEAGO_REF:0000116
Srd5a2Rat3-oxo-5-alpha-steroid 4-dehydrogenase (NADP+) activity enablesIEAEC:1.3.1.221600115GO_REF:0000003UniProtGO_REF:0000003
Srd5a2Rat3-oxo-5-alpha-steroid 4-dehydrogenase (NADP+) activity enablesIEAUniProtKB:P31213 and ensembl:ENSP000004775871600115GO_REF:0000107EnsemblGO_REF:0000107
Srd5a2Rat3-oxo-5-alpha-steroid 4-dehydrogenase activity  IDA 729939 RGD 
Srd5a2Rat3-oxo-5-alpha-steroid 4-dehydrogenase activity enablesIEAInterPro:IPR0166361600115GO_REF:0000002InterProGO_REF:0000002
Srd5a2Rat3-oxo-5-alpha-steroid 4-dehydrogenase activity enablesIEAARBA:ARBA000448401600115GO_REF:0000117UniProtGO_REF:0000117
Srd5a2Rat3-oxo-5-alpha-steroid 4-dehydrogenase activity enablesIEAUniProtKB:Q99N99 and ensembl:ENSMUSP000000488621600115GO_REF:0000107EnsemblGO_REF:0000107
Srd5a2Rat3-oxo-5-alpha-steroid 4-dehydrogenase activity enablesISOSrd5a2 (Mus musculus)1624291MGI:2178039 PMID:11606430 more ...RGDPMID:11606430 more ...
Srd5a2Rat3-oxo-5-alpha-steroid 4-dehydrogenase activity enablesIBAMGI:2150380 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Srd5a2Rat3-oxo-5-alpha-steroid 4-dehydrogenase activity  IDA 2326072 RGD 
Srd5a2Ratamide binding  IPIPubChem_Compound:573634892035 RGD 
Srd5a2Ratoxidoreductase activity enablesIEAUniProtKB-KW:KW-05601600115GO_REF:0000043UniProtGO_REF:0000043
Srd5a2Ratoxidoreductase activity, acting on the CH-CH group of donors enablesIEAInterPro:IPR0011041600115GO_REF:0000002InterProGO_REF:0000002
Srd5a2Ratprotein binding enablesISOSRD5A2 (Homo sapiens)1624291UniProtKB:A8MQ03 more ...RGDPMID:32296183 and PMID:33961781
Srd5a2Rattestosterone dehydrogenase [NAD(P)+] activity enablesISOSRD5A2 (Homo sapiens)1624291 PMID:10898110RGDPMID:10898110
Srd5a2Rattestosterone dehydrogenase [NAD(P)+] activity enablesIEAUniProtKB:P31213 and ensembl:ENSP000004775871600115GO_REF:0000107EnsemblGO_REF:0000107
Srd5a2Rattestosterone dehydrogenase [NAD(P)+] activity enablesISSUniProtKB:P312131600115GO_REF:0000024UniProtGO_REF:0000024
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RGD Manual Annotations


  
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Original Reference(s)
Srd5a2Rattestosterone biosynthetic pathway   ISOSRD5A2 (Homo sapiens)2325883 RGD 

Imported Annotations - KEGG (archival)

Object Symbol
Species
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Reference
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Original Reference(s)
Srd5a2Ratprostate cancer pathway   IEA 6907045 KEGGrno:05215
Srd5a2Ratsteroid hormone biosynthetic pathway   IEArno:001506907045 KEGGrno:00140

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#
Reference Title
Reference Citation
1. Inhibition of rat alpha-reductases by finasteride: evidence for isozyme differences in the mechanism of inhibition. Azzolina B, etal., J Steroid Biochem Mol Biol. 1997 Apr;61(1-2):55-64.
2. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
3. Regulation of prostate 5alpha-reductase-2 gene expression and prostate weight by dietary fat and caloric intake in the rat. Cai LQ, etal., Prostate. 2006 May 15;66(7):738-48.
4. Dimorphic expression of testosterone metabolizing enzymes in the hypothalamic area of developing rats. Colciago A, etal., Brain Res Dev Brain Res. 2005 Mar 31;155(2):107-16.
5. Prenatal Aroclor 1254 exposure and brain sexual differentiation: effect on the expression of testosterone metabolizing enzymes and androgen receptors in the hypothalamus of male and female rats. Colciago A, etal., Reprod Toxicol. 2006 Nov;22(4):738-45. Epub 2006 Jul 14.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
9. 5alpha-reductase isoenzymes 1 and 2 in the rat testis during postnatal development. Killian J, etal., Biol Reprod. 2003 May;68(5):1711-8. Epub 2002 Dec 11.
10. Effects of in utero exposure to DI(n-Butyl) phthalate on development of male reproductive tracts in Sprague-Dawley rats. Kim TS, etal., J Toxicol Environ Health A. 2010 Jan;73(21-22):1544-59.
11. Semicomprehensive Analysis of the Postnatal Age-Related Changes in the mRNA Expression of Sex Steroidogenic Enzymes and Sex Steroid Receptors in the Male Rat Hippocampus. Kimoto T, etal., Endocrinology. 2010 Nov 3.
12. Expression of progesterone metabolizing enzyme genes (AKR1C1, AKR1C2, AKR1C3, SRD5A1, SRD5A2) is altered in human breast carcinoma. Lewis MJ, etal., BMC Cancer. 2004 Jun 22;4:27.
13. Decreased gene expression of steroid 5 alpha-reductase 2 in human prostate cancer: implications for finasteride therapy of prostate carcinoma. Luo J, etal., Prostate. 2003 Oct 1;57(2):134-9.
14. Association of mis-sense substitution in SRD5A2 gene with prostate cancer in African-American and Hispanic men in Los Angeles, USA. Makridakis NM, etal., Lancet. 1999 Sep 18;354(9183):975-8.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. Androgen synthesis in adrenarche. Miller WL Rev Endocr Metab Disord. 2009 Mar;10(1):3-17.
17. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. Tissue distribution and kinetic characteristics of rat steroid 5 alpha-reductase isozymes. Evidence for distinct physiological functions. Normington K and Russell DW, J Biol Chem 1992 Sep 25;267(27):19548-54.
19. Maternal exposure to a low dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) suppressed the development of reproductive organs of male rats: dose-dependent increase of mRNA levels of 5alpha-reductase type 2 in contrast to decrease of androgen receptor in the pubertal ventral prostate. Ohsako S, etal., Toxicol Sci. 2001 Mar;60(1):132-43.
20. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
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PMID:1944596   PMID:10898110   PMID:11606430   PMID:12899683   PMID:14592534   PMID:15249131   PMID:15576829   PMID:16818707   PMID:22131296   PMID:22776423   PMID:23122426   PMID:23405234  
PMID:27150077   PMID:27155079  



Srd5a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8627,178,089 - 27,217,588 (+)NCBIGRCr8
mRatBN7.2621,426,225 - 21,465,727 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl621,426,215 - 21,462,112 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx621,755,011 - 21,794,514 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0622,070,851 - 22,110,348 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0621,551,287 - 21,590,788 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0625,279,635 - 25,315,501 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl625,279,626 - 25,315,511 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0635,127,532 - 35,163,398 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4621,453,521 - 21,489,408 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1621,456,473 - 21,492,397 (+)NCBI
Celera620,976,906 - 21,012,848 (+)NCBICelera
Cytogenetic Map6q13NCBI
SRD5A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38231,522,480 - 31,663,009 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl231,522,480 - 31,580,938 (-)EnsemblGRCh38hg38GRCh38
GRCh37231,747,550 - 31,806,007 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36231,603,160 - 31,659,544 (-)NCBINCBI36Build 36hg18NCBI36
Build 34231,661,306 - 31,717,691NCBI
Celera231,590,884 - 31,647,296 (-)NCBICelera
Cytogenetic Map2p23.1NCBI
HuRef231,485,637 - 31,542,001 (-)NCBIHuRef
CHM1_1231,678,089 - 31,734,473 (-)NCBICHM1_1
T2T-CHM13v2.0231,567,195 - 31,707,768 (-)NCBIT2T-CHM13v2.0
Srd5a2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391774,321,886 - 74,354,855 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1774,323,950 - 74,354,911 (-)EnsemblGRCm39 Ensembl
GRCm381774,014,891 - 74,047,860 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1774,016,955 - 74,047,916 (-)EnsemblGRCm38mm10GRCm38
MGSCv371774,367,046 - 74,397,256 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361773,922,606 - 73,952,814 (-)NCBIMGSCv36mm8
Celera1778,309,438 - 78,339,442 (-)NCBICelera
Cytogenetic Map17E2NCBI
cM Map1745.39NCBI
Srd5a2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544110,443 - 95,743 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544112,149 - 95,733 (-)NCBIChiLan1.0ChiLan1.0
SRD5A2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21294,913,580 - 94,967,170 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A94,917,555 - 94,971,145 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A31,542,646 - 31,597,394 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A31,610,487 - 31,665,718 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A31,610,487 - 31,665,718 (-)Ensemblpanpan1.1panPan2
SRD5A2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11725,017,113 - 25,056,156 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1725,017,113 - 25,056,544 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1724,811,155 - 24,850,233 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01725,580,015 - 25,620,097 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1725,580,843 - 25,620,171 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11724,887,475 - 24,926,628 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01724,946,476 - 24,985,654 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01725,049,043 - 25,087,911 (-)NCBIUU_Cfam_GSD_1.0
Srd5a2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629269,130,023 - 69,175,570 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364931,663,911 - 1,708,502 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364931,663,999 - 1,708,530 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SRD5A2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3107,840,200 - 107,918,350 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13107,840,200 - 107,918,351 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23114,644,279 - 114,657,350 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SRD5A2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11475,915,495 - 75,971,280 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1475,917,260 - 75,970,365 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604536,088,943 - 36,288,753 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Srd5a2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473813,253,729 - 13,321,448 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473813,254,998 - 13,321,360 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Srd5a2
171 total Variants

Predicted Target Of
Summary Value
Count of predictions:82
Count of miRNA genes:70
Interacting mature miRNAs:72
Transcripts:ENSRNOT00000008983
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 34 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6141223769Rat
1549905Stresp10Stress response QTL 106.830.0066stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)6127574569Rat
8693645Alc31Alcohol consumption QTL 313.70.038drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)61753252124011952Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
1331743Uae28Urinary albumin excretion QTL 284.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)6134235784Rat
2292589Emca10Estrogen-induced mammary cancer QTL 100.048mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)61653614061536140Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449754641141Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6141223769Rat
1578758Tcas9Tongue tumor susceptibility QTL 93.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)6137618905Rat

1 to 10 of 34 rows
BE120616  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2621,456,451 - 21,456,635 (-)MAPPERmRatBN7.2
Rnor_6.0625,285,094 - 25,285,277NCBIRnor6.0
Rnor_5.0635,132,991 - 35,133,174UniSTSRnor5.0
RGSC_v3.4621,483,767 - 21,483,950UniSTSRGSC3.4
Celera621,007,206 - 21,007,389UniSTS
Cytogenetic Map6q13UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 2 13 104 32 27 8 15 8 6 107 44 84 44 52 19



Ensembl Acc Id: ENSRNOT00000008983   ⟹   ENSRNOP00000009254
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl621,426,215 - 21,462,112 (+)Ensembl
Rnor_6.0 Ensembl625,279,626 - 25,315,511 (-)Ensembl
RefSeq Acc Id: NM_022711   ⟹   NP_073202
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8627,178,089 - 27,217,588 (+)NCBI
mRatBN7.2621,426,225 - 21,465,727 (+)NCBI
Rnor_6.0625,279,635 - 25,315,501 (-)NCBI
Rnor_5.0635,127,532 - 35,163,398 (-)NCBI
RGSC_v3.4621,453,521 - 21,489,408 (+)RGD
Celera620,976,906 - 21,012,848 (+)NCBI
Sequence:
Protein RefSeqs NP_073202 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA42182 (Get FASTA)   NCBI Sequence Viewer  
  AAT67595 (Get FASTA)   NCBI Sequence Viewer  
  EDM02850 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000009254.4
  ENSRNOP00000108368
GenBank Protein P31214 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_073202   ⟸   NM_022711
- UniProtKB: P31214 (UniProtKB/Swiss-Prot),   A6H9Z5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000009254   ⟸   ENSRNOT00000008983
3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal

Name Modeler Protein Id AA Range Protein Structure
AF-P31214-F1-model_v2 AlphaFold P31214 1-254 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13694426
Promoter ID:EPDNEW_R4951
Type:single initiation site
Name:Srd5a2_1
Description:steroid 5 alpha-reductase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0625,315,501 - 25,315,561EPDNEW


1 to 27 of 27 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-38432 BioCyc
BioCyc Pathway PWY-7455 [allopregnanolone biosynthesis] BioCyc
  PWY-8200 [backdoor pathway of androgen biosynthesis] BioCyc
  PWY-8202 [11-oxyandrogens biosynthesis] BioCyc
  PWY66-378 [androgen biosynthesis] BioCyc
BioCyc Pathway Image PWY-7455 BioCyc
  PWY-8200 BioCyc
  PWY-8202 BioCyc
  PWY66-378 BioCyc
Ensembl Genes ENSRNOG00000027042 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000008983.8 UniProtKB/Swiss-Prot
  ENSRNOT00000170207 ENTREZGENE
Gene3D-CATH 1.20.120.1630 UniProtKB/Swiss-Prot
InterPro 3-oxo-5-alpha-steroid_4-DH UniProtKB/Swiss-Prot
  3-oxo-5_a-steroid_4-DH_C UniProtKB/Swiss-Prot
  SRD5A/TECR UniProtKB/Swiss-Prot
KEGG Report rno:64677 UniProtKB/Swiss-Prot
NCBI Gene 64677 ENTREZGENE
PANTHER 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE 2 UniProtKB/Swiss-Prot
  PTHR10556 UniProtKB/Swiss-Prot
Pfam Steroid_dh UniProtKB/Swiss-Prot
PhenoGen Srd5a2 PhenoGen
PIRSF 5_alpha-SR2 UniProtKB/Swiss-Prot
PROSITE S5A_REDUCTASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000027042 RatGTEx
UniProt A6H9Z5 ENTREZGENE, UniProtKB/TrEMBL
  P31214 ENTREZGENE, UniProtKB/Swiss-Prot
1 to 27 of 27 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-03 Srd5a2  steroid 5 alpha-reductase 2  Srd5a2  steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-18 Srd5a2  steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)  Srd5a2  steroid 5-alpha-reductase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-14 Srd5a2  steroid 5-alpha-reductase 2      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Srd5a2  steroid 5-alpha-reductase 2      Symbol and Name status set to provisional 70820 PROVISIONAL

Note Type Note Reference
gene_expression mRNA abundant in male reproductive tissues 729939
gene_regulation mRNA can be induced by dihydrotestosterone 729939