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Gene: SRD5A2 (steroid 5 alpha-reductase 2) Homo sapiens
Symbol: SRD5A2
Name: steroid 5 alpha-reductase 2
Description: Exhibits sterol 5-alpha reductase activity and testosterone dehydrogenase [NAD(P)] activity. Involved in androgen metabolic process; male gonad development; and testosterone biosynthetic process. Predicted to localize to the endoplasmic reticulum membrane. Implicated in hypospadias and prostate cancer. Biomarker of breast carcinoma and prostate cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 3-oxo-5 alpha-steroid 4-dehydrogenase 2; 3-oxo-5-alpha-steroid 4-dehydrogenase 2; 5 alpha-SR2; MGC138457; S5AR 2; SR type 2; steroid 5-alpha-reductase 2; steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2); type II 5-alpha reductase
Mus musculus (house mouse) : Srd5a2 (steroid 5 alpha-reductase 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Srd5a2 (steroid 5 alpha-reductase 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Srd5a2 (steroid 5 alpha-reductase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : SRD5A2 (steroid 5 alpha-reductase 2)
Canis lupus familiaris (dog) : SRD5A2 (steroid 5 alpha-reductase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Srd5a2 (steroid 5 alpha-reductase 2)
Sus scrofa (pig) : SRD5A2 (steroid 5 alpha-reductase 2)
Chlorocebus sabaeus (green monkey) : SRD5A2 (steroid 5 alpha-reductase 2)
Heterocephalus glaber (naked mole-rat) : Srd5a2 (steroid 5 alpha-reductase 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl231,522,480 - 31,580,938 (-)Ensembl
GRCh38231,522,480 - 31,665,651 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37231,749,656 - 31,806,040 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36231,603,160 - 31,659,544 (-)NCBINCBI36hg18NCBI36
Build 34231,661,306 - 31,717,691NCBI
Celera231,590,884 - 31,647,296 (-)NCBI
Cytogenetic Map2p23.1NCBI
HuRef231,485,637 - 31,542,001 (-)NCBIHuRef
CHM1_1231,678,089 - 31,734,473 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on SRD5A2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 737503
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.