Wnt2 (Wnt family member 2) - Rat Genome Database

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Gene: Wnt2 (Wnt family member 2) Rattus norvegicus
Analyze
Symbol: Wnt2
Name: Wnt family member 2
RGD ID: 621346
Description: Predicted to enable cytokine activity and frizzled binding activity. Involved in lung development and positive regulation of endothelial cell proliferation. Predicted to be located in collagen-containing extracellular matrix; cytoplasm; and extracellular region. Human ortholog(s) of this gene implicated in breast carcinoma; hepatocellular carcinoma; and urinary system cancer. Orthologous to human WNT2 (Wnt family member 2); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; basal cell carcinoma pathway; INTERACTS WITH 1,3-dinitrobenzene; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: protein Wnt-2; wingless-related MMTV integration site 2; wingless-type MMTV integration site 2; wingless-type MMTV integration site family member 2; Wnt
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8447,294,300 - 47,340,284 (-)NCBIGRCr8
mRatBN7.2446,328,408 - 46,374,673 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl446,333,998 - 46,374,402 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0445,286,845 - 45,332,899 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl445,292,437 - 45,332,420 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0445,892,395 - 45,936,605 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4443,649,783 - 43,689,596 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1443,857,074 - 43,859,488 (-)NCBI
Celera441,596,263 - 41,642,309 (-)NCBICelera
Cytogenetic Map4q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Wnt2Ratbreast cancer  ISOWNT2 (Homo sapiens)2291874mRNA:increased expression:breastRGD 
Wnt2Ratbreast carcinoma disease_progressionISOWNT2 (Homo sapiens)2291879DNA:amplification:breastRGD 
Wnt2Ratendometrial carcinoma  ISOWNT2 (Homo sapiens)2291875mRNA:decreased expression:endometriumRGD 
Wnt2RatExperimental Mammary Neoplasms  ISOWNT2 (Homo sapiens)2298863in vitro transformation of transfected C57MG mammary epithelial cell lineRGD 
Wnt2RatExperimental Mammary Neoplasms  ISOWNT2 (Homo sapiens)2298848in vitro transformation of transfected C57MG mammary epithelial cell lineRGD 
Wnt2RatExperimental Seizures  IEP 2326231mRNA:increased expression:hippocampusRGD 
Wnt2RatFibroadenoma  ISOWNT2 (Homo sapiens)2291878mRNA:increased expression:breastRGD 
Wnt2Rathepatocellular carcinoma susceptibilityISOWNT2 (Homo sapiens)14402040associated with hepatitis B and DNA:SNP: :rs4730775(human)RGD 
Wnt2Ratprostate cancer  ISOWNT2 (Homo sapiens)727214mRNA:decreased expression:prostate glandRGD 
Wnt2Raturinary system cancer  ISOWNT2 (Homo sapiens)2291877DNA:amplificationRGD 
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Object Symbol
Species
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Evidence
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Reference
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Source
Original Reference(s)
Wnt2Ratcystic fibrosis  ISOWNT2 (Homo sapiens)8554872ClinVar Annotator: match by term: Cystic fibrosisClinVarPMID:11781704 more ...
Wnt2Ratpleomorphic xanthoastrocytoma  ISOWNT2 (Homo sapiens)8554872ClinVar Annotator: match by term: Pleomorphic xanthoastrocytomaClinVarPMID:28299358
Wnt2Ratrenal cell carcinoma  ISOWNT2 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:28492532
Wnt2RatRenal Cell Carcinoma 1  ISOWNT2 (Homo sapiens)8554872ClinVar Annotator: match by term: Renal cell carcinoma 1ClinVarPMID:28492532
Object Symbol
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Qualifier
Evidence
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Reference
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Original Reference(s)
Wnt2Ratautistic disorder  ISOWNT2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:11449391 and PMID:19895723
Wnt2RatUterine Cervical Neoplasms  ISOWNT2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25061499

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Object Symbol
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Original Reference(s)
Wnt2Rat(1->4)-beta-D-glucan multiple interactionsISOWnt2 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of WNT2 mRNACTDPMID:36331819
Wnt2Rat1,3-dinitrobenzene increases expressionEXP 64804643-dinitrobenzene results in increased expression of WNT2 mRNACTDPMID:21983209
Wnt2Rat1-nitropyrene increases expressionISOWNT2 (Homo sapiens)64804641-nitropyrene results in increased expression of WNT2 mRNACTDPMID:21540303
Wnt2Rat17beta-estradiol increases expressionISOWNT2 (Homo sapiens)6480464Estradiol results in increased expression of WNT2 mRNACTDPMID:15072547
Wnt2Rat17beta-estradiol increases expressionEXP 6480464Estradiol results in increased expression of WNT2 mRNACTDPMID:32145629
Wnt2Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOWnt2 (Mus musculus)6480464[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of WNT2 mRNA and Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to WNT2 promoter]CTDPMID:16214954 and PMID:19654925
Wnt2Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOWNT2 (Homo sapiens)6480464Tetrachlorodibenzodioxin results in decreased expression of WNT2 mRNACTDPMID:36370075
Wnt2Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOWnt2 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of WNT2 mRNACTDPMID:26377647 and PMID:36222588
Wnt2Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOWnt2 (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of WNT2 mRNACTDPMID:18172886 and PMID:25975270
Wnt2Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of WNT2 mRNACTDPMID:23238561
Wnt2Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOWnt2 (Mus musculus)6480464Tetrachlorodibenzodioxin results in decreased expression of WNT2 mRNACTDPMID:23238561
Wnt2Rat2,4-dibromophenyl 2,4,5-tribromophenyl ether affects expressionISOWnt2 (Mus musculus)64804642 more ...CTDPMID:38648751
Wnt2Rat4,4'-diaminodiphenylmethane decreases expressionISOWnt2 (Mus musculus)64804644 and 4'-diaminodiphenylmethane results in decreased expression of WNT2 mRNACTDPMID:18648102
Wnt2Rat4,4'-sulfonyldiphenol increases expressionISOWnt2 (Mus musculus)6480464bisphenol S results in increased expression of WNT2 mRNACTDPMID:30951980
Wnt2Rat4,4'-sulfonyldiphenol decreases methylationISOWnt2 (Mus musculus)6480464bisphenol S results in decreased methylation of WNT2 exonCTDPMID:33297965
Wnt2Rat4-amino-2,6-dinitrotoluene affects expressionEXP 64804644-amino-2 and 6-dinitrotoluene affects the expression of WNT2 mRNACTDPMID:21346803
Wnt2Rat5-aza-2'-deoxycytidine multiple interactionsISOWNT2 (Homo sapiens)6480464Decitabine inhibits the reaction [bisphenol A results in increased methylation of WNT2 promoter]CTDPMID:30303745
Wnt2Rat6-propyl-2-thiouracil decreases expressionEXP 6480464Propylthiouracil results in decreased expression of WNT2 mRNACTDPMID:24780913 and PMID:30047161
Wnt2Ratafimoxifene increases expressionISOWNT2 (Homo sapiens)6480464afimoxifene results in increased expression of WNT2 mRNACTDPMID:15072547
Wnt2Ratall-trans-retinoic acid decreases expressionISOWNT2 (Homo sapiens)6480464Tretinoin results in decreased expression of WNT2 mRNACTDPMID:17045167

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Biological Process
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Object Symbol
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Original Reference(s)
Wnt2Ratanimal organ development involved_inIEAARBA:ARBA000292471600115GO_REF:0000117UniProtGO_REF:0000117
Wnt2Ratatrial cardiac muscle tissue morphogenesis acts_upstream_of_or_withinISOWnt2 (Mus musculus)1624291MGI:4361155 PMID:20159597RGDPMID:20159597
Wnt2Ratcanonical Wnt signaling pathway involved_inISOWNT2 (Homo sapiens)1624291 PMID:10347172 more ...RGDPMID:10347172 more ...
Wnt2Ratcanonical Wnt signaling pathway acts_upstream_of_or_withinISOWnt2 (Mus musculus)1624291MGI:1261834 more ...RGDPMID:19686689 more ...
Wnt2Ratcardiac epithelial to mesenchymal transition acts_upstream_of_or_withinISOWnt2 (Mus musculus)1624291MGI:4361155 PMID:20159597RGDPMID:20159597
Wnt2Ratcardiac muscle cell proliferation acts_upstream_ofISOWnt2 (Mus musculus)1624291MGI:4361155 PMID:20159597RGDPMID:20159597
Wnt2Ratcell proliferation in midbrain involved_inISOWNT2 (Homo sapiens)1624291 PMID:20018874RGDPMID:20018874
Wnt2Ratcell proliferation in midbrain involved_inISOWnt2 (Mus musculus)1624291 PMID:20018874RGDPMID:20018874
Wnt2Ratcell-cell signaling involved_inISOWNT2 (Homo sapiens)1624291 PMID:10557084RGDPMID:10557084
Wnt2Ratcellular response to transforming growth factor beta stimulus involved_inISOWNT2 (Homo sapiens)1624291 PMID:15040835RGDPMID:15040835
Wnt2Ratepithelial cell proliferation acts_upstream_ofISOWnt2 (Mus musculus)1624291MGI:4361155 PMID:19686689RGDPMID:19686689
Wnt2Ratepithelial cell proliferation involved in lung morphogenesis acts_upstream_ofISOWnt2 (Mus musculus)1624291MGI:4361155 PMID:19686689RGDPMID:19686689
Wnt2Ratlabyrinthine layer blood vessel development acts_upstream_of_or_withinISOWnt2 (Mus musculus)1624291MGI:2177935 PMID:8951051RGDPMID:8951051
Wnt2Ratlung development  IEP 2314905 RGD 
Wnt2Ratlung induction acts_upstream_of_or_withinISOWnt2 (Mus musculus)1624291MGI:1261834 PMID:19686689RGDPMID:19686689
Wnt2Ratmammary gland epithelium development involved_inISOWNT2 (Homo sapiens)1624291 PMID:8168088RGDPMID:8168088
Wnt2Ratmesenchymal cell proliferation acts_upstream_ofISOWnt2 (Mus musculus)1624291MGI:4361155 PMID:19686689RGDPMID:19686689
Wnt2Ratmidbrain dopaminergic neuron differentiation involved_inISOWNT2 (Homo sapiens)1624291 PMID:20018874RGDPMID:20018874
Wnt2Ratpositive regulation of cardiac muscle cell proliferation acts_upstream_of_or_withinISOWnt2 (Mus musculus)1624291MGI:4361155 PMID:20159597RGDPMID:20159597
Wnt2Ratpositive regulation of cell population proliferation involved_inISOWNT2 (Homo sapiens)1624291 PMID:10347172RGDPMID:10347172
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Cellular Component

  

Molecular Function

  

RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Wnt2RatWnt signaling pathway  ISOWnt2 (Mus musculus)2301993 RGD 
Wnt2RatWnt signaling, canonical pathway   ISOWNT2 (Homo sapiens)2313743 RGD 

Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Wnt2Ratbasal cell carcinoma pathway  IEA 6907045 KEGGrno:05217
Wnt2RatHedgehog signaling pathway   IEA 6907045 KEGGrno:04340
Wnt2RatWnt signaling pathway  IEA 6907045 KEGGrno:04310

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#
Reference Title
Reference Citation
1. Expression and hormone regulation of Wnt2, 3, 4, 5a, 7a, 7b and 10b in normal human endometrium and endometrial carcinoma. Bui TD, etal., Br J Cancer. 1997;75(8):1131-6.
2. Differential expression of Wnt genes in normal and flat variants of PC12 cells, a cell line responsive to ectopic Wnt1 expression. Erdreich-Epstein A and Shackleford GM, Growth Factors 1998;15(2):149-58.
3. Long-term feeding of various fat diets modulates azoxymethane-induced colon carcinogenesis through Wnt/beta-catenin signaling in rats. Fujise T, etal., Am J Physiol Gastrointest Liver Physiol. 2007 Apr;292(4):G1150-6. Epub 2006 Dec 28.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Oncogene amplification in urothelial cancers with p53 gene mutation or MDM2 amplification. Habuchi T, etal., J Natl Cancer Inst. 1994 Sep 7;86(17):1331-5.
7. Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue. Huguet EL, etal., Cancer Res. 1994 May 15;54(10):2615-21.
8. Frizzled-9 is activated by Wnt-2 and functions in Wnt/beta -catenin signaling. Karasawa T, etal., J Biol Chem 2002 Oct 4;277(40):37479-86.
9. Wnt2 acts as a cell type-specific, autocrine growth factor in rat hepatic sinusoidal endothelial cells cross-stimulating the VEGF pathway. Klein D, etal., Hepatology. 2008 Mar;47(3):1018-31.
10. Growth and developmental regulation of wnt-2 (irp) gene in mesenchymal cells of fetal lung. Levay-Young BK and Navre M, Am J Physiol. 1992 Jun;262(6 Pt 1):L672-83.
11. Influence of polymorphisms in the Wnt/β-catenin pathway genes on hepatocellular carcinoma risk in a Chinese Han population. Li QM, etal., Medicine (Baltimore). 2017 Mar;96(12):e6127. doi: 10.1097/MD.0000000000006127.
12. Chronic electroconvulsive seizure up-regulates beta-catenin expression in rat hippocampus: role in adult neurogenesis. Madsen TM, etal., Biol Psychiatry. 2003 Nov 15;54(10):1006-14.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Analysis of genetic alterations related to the development and progression of breast carcinoma. Nagayama K and Watatani M, Jpn J Cancer Res. 1993 Nov;84(11):1159-64.
15. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
17. GOA pipeline RGD automated data pipeline
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Comprehensive gene review and curation RGD comprehensive gene curation
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PMID:8951051   PMID:9652750   PMID:10347172   PMID:10557084   PMID:11092808   PMID:15040835   PMID:15474371   PMID:15507471   PMID:16772171   PMID:16806007   PMID:16949068   PMID:17948129  
PMID:19038973   PMID:19239325   PMID:19686689   PMID:19734317   PMID:20018874   PMID:20159597   PMID:22517624   PMID:23124852   PMID:23271279   PMID:23610556   PMID:26541456   PMID:28887537  
PMID:33927285   PMID:35177206  



Wnt2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8447,294,300 - 47,340,284 (-)NCBIGRCr8
mRatBN7.2446,328,408 - 46,374,673 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl446,333,998 - 46,374,402 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0445,286,845 - 45,332,899 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl445,292,437 - 45,332,420 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0445,892,395 - 45,936,605 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4443,649,783 - 43,689,596 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1443,857,074 - 43,859,488 (-)NCBI
Celera441,596,263 - 41,642,309 (-)NCBICelera
Cytogenetic Map4q22NCBI
WNT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387117,275,451 - 117,323,058 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7117,275,451 - 117,323,152 (-)EnsemblGRCh38hg38GRCh38
GRCh377116,915,505 - 116,963,112 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367116,704,518 - 116,750,579 (-)NCBINCBI36Build 36hg18NCBI36
Build 347116,511,232 - 116,557,294NCBI
Celera7111,724,862 - 111,771,525 (-)NCBICelera
Cytogenetic Map7q31.2NCBI
HuRef7111,282,485 - 111,328,966 (-)NCBIHuRef
CHM1_17116,850,055 - 116,896,705 (-)NCBICHM1_1
T2T-CHM13v2.07118,590,786 - 118,638,396 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27116,312,120 - 116,358,781 (-)NCBI
Wnt2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39617,988,939 - 18,032,771 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl617,988,939 - 18,030,584 (-)EnsemblGRCm39 Ensembl
GRCm38617,985,474 - 18,032,772 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl617,988,940 - 18,030,585 (-)EnsemblGRCm38mm10GRCm38
MGSCv37617,938,940 - 17,980,445 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36617,938,940 - 17,980,356 (-)NCBIMGSCv36mm8
Celera618,070,129 - 18,111,436 (-)NCBICelera
Cytogenetic Map6A2NCBI
cM Map68.08NCBI
Wnt2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543222,984,170 - 23,027,705 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543222,988,208 - 23,024,530 (-)NCBIChiLan1.0ChiLan1.0
WNT2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26154,101,025 - 154,151,405 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan176,111,284 - 6,161,665 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07109,244,772 - 109,291,472 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17121,939,254 - 121,985,862 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7121,936,031 - 121,985,862 (-)Ensemblpanpan1.1panPan2
WNT2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11456,123,735 - 56,172,113 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1456,129,248 - 56,172,069 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1455,519,061 - 55,567,484 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01456,163,101 - 56,211,441 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1456,166,256 - 56,213,190 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11456,195,055 - 56,243,473 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01455,884,128 - 55,931,047 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01456,253,933 - 56,302,214 (-)NCBIUU_Cfam_GSD_1.0
Wnt2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511844,819,573 - 44,865,128 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365891,825,209 - 1,866,889 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365891,825,209 - 1,866,898 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WNT2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1828,946,326 - 28,993,961 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11828,945,825 - 28,993,969 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21830,790,071 - 30,838,269 (-)NCBISscrofa10.2Sscrofa10.2susScr3
WNT2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12185,955,517 - 86,005,664 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2185,955,145 - 86,001,730 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604217,730,443 - 17,777,632 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Wnt2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248272,045,595 - 2,089,442 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248272,045,733 - 2,088,284 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Wnt2
190 total Variants

Predicted Target Of
Summary Value
Count of predictions:111
Count of miRNA genes:92
Interacting mature miRNAs:99
Transcripts:ENSRNOT00000010427
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


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The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829457114705Rat
2303585Bw86Body weight QTL 864body mass (VT:0001259)body weight (CMO:0000012)41467806559678065Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)44043338885433388Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44345797688457976Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)41008408955084089Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)426775591168368347Rat
1331807Rf31Renal function QTL 312.988urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)43952426474726312Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)41008408955084089Rat
8552782Vie1Viral induced encephalitis QTL 126.4brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat

1 to 10 of 38 rows
RH141342  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2446,365,759 - 46,365,947 (+)MAPPERmRatBN7.2
Rnor_6.0445,323,804 - 45,323,991NCBIRnor6.0
Rnor_5.0445,927,743 - 45,927,930UniSTSRnor5.0
RGSC_v3.4443,680,955 - 43,681,142UniSTSRGSC3.4
Celera441,633,214 - 41,633,401UniSTS
RH 3.4 Map4281.51UniSTS
Cytogenetic Map4q21-q22UniSTS
RH130031  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2446,334,021 - 46,334,214 (+)MAPPERmRatBN7.2
Rnor_6.0445,292,068 - 45,292,260NCBIRnor6.0
Rnor_5.0445,896,007 - 45,896,199UniSTSRnor5.0
RGSC_v3.4443,649,219 - 43,649,411UniSTSRGSC3.4
Celera441,601,486 - 41,601,678UniSTS
RH 3.4 Map4284.1UniSTS
Cytogenetic Map4q21-q22UniSTS
REN63976  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2446,368,043 - 46,368,267 (+)MAPPERmRatBN7.2
Rnor_6.0445,326,088 - 45,326,311NCBIRnor6.0
Rnor_5.0445,930,027 - 45,930,250UniSTSRnor5.0
RGSC_v3.4443,683,239 - 43,683,462UniSTSRGSC3.4
Celera441,635,498 - 41,635,721UniSTS
Cytogenetic Map4q21-q22UniSTS
Wnt2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2446,366,948 - 46,367,198 (+)MAPPERmRatBN7.2
Rnor_6.0445,324,993 - 45,325,242NCBIRnor6.0
Rnor_5.0445,928,932 - 45,929,181UniSTSRnor5.0
RGSC_v3.4443,682,144 - 43,682,393UniSTSRGSC3.4
Celera441,634,403 - 41,634,652UniSTS
Cytogenetic Map4q21-q22UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
8 11 48 113 91 90 59 25 59 6 216 96 93 45 60 31



Ensembl Acc Id: ENSRNOT00000083039   ⟹   ENSRNOP00000071025
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl446,333,998 - 46,374,402 (-)Ensembl
Rnor_6.0 Ensembl445,292,437 - 45,332,420 (-)Ensembl
RefSeq Acc Id: NM_053695   ⟹   NP_446147
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8447,294,300 - 47,340,284 (-)NCBI
Protein RefSeqs NP_446147 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAK32712 (Get FASTA)   NCBI Sequence Viewer  
  AAK32713 (Get FASTA)   NCBI Sequence Viewer  
  AAR16313 (Get FASTA)   NCBI Sequence Viewer  
  EDM15125 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000071025.1
  ENSRNOP00000104014
Ensembl Acc Id: ENSRNOP00000071025   ⟸   ENSRNOT00000083039
RefSeq Acc Id: NP_446147   ⟸   NM_053695
- Peptide Label: precursor
- UniProtKB: A0A0G2JZF4 (UniProtKB/TrEMBL),   A6IE38 (UniProtKB/TrEMBL),   Q2IBD1 (UniProtKB/TrEMBL)

Name Modeler Protein Id AA Range Protein Structure
AF-Q2IBD1-F1-model_v2 AlphaFold Q2IBD1 1-360 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 27 of 27 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-45543 BioCyc
Ensembl Genes ENSRNOG00000051905 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000089988 ENTREZGENE
Ensembl Transcript ENSRNOT00000083039.2 UniProtKB/TrEMBL
  ENSRNOT00000169749 ENTREZGENE
Gene3D-CATH 3.30.2460.20 UniProtKB/TrEMBL
InterPro Wnt2 UniProtKB/TrEMBL
  Wnt_C UniProtKB/TrEMBL
  Wnt_CS UniProtKB/TrEMBL
  Wnt_SF UniProtKB/TrEMBL
NCBI Gene 114487 ENTREZGENE
PANTHER PROTEIN WNT-2 UniProtKB/TrEMBL
  Wnt UniProtKB/TrEMBL
Pfam wnt UniProtKB/TrEMBL
PhenoGen Wnt2 PhenoGen
PRINTS WNT2PROTEIN UniProtKB/TrEMBL
  WNTPROTEIN UniProtKB/TrEMBL
PROSITE WNT1 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000051905 RatGTEx
  ENSRNOG00000089988 RatGTEx
SMART WNT1 UniProtKB/TrEMBL
UniProt A0A0G2JZF4 ENTREZGENE, UniProtKB/TrEMBL
  A6IE38 ENTREZGENE, UniProtKB/TrEMBL
  Q2IBD1 ENTREZGENE
  Q99MC1_RAT UniProtKB/TrEMBL
  Q99MC2_RAT UniProtKB/TrEMBL
UniProt Secondary Q2IBD1 UniProtKB/TrEMBL
1 to 27 of 27 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-03-29 Wnt2  Wnt family member 2  Wnt2  wingless-type MMTV integration site family member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-14 Wnt2  wingless-type MMTV integration site family member 2  Wnt2  wingless-related MMTV integration site 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Wnt2  wingless-related MMTV integration site 2      Symbol and Name updated 629477 APPROVED
2003-03-12 Wnt2  wingless-related MMTV integration site 2  Wnt    Data merged from RGD:619763 628472 PROVISIONAL
2002-08-07 Wnt2        Symbol and Name status set to provisional 70820 PROVISIONAL
2002-08-07 Wnt        Symbol and Name status set to provisional 70820 PROVISIONAL

Note Type Note Reference
gene_expression expressed in uterus 70557
gene_process upregulated in uterine tumors 70557