Mitf (melanocyte inducing transcription factor) - Rat Genome Database

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Gene: Mitf (melanocyte inducing transcription factor) Rattus norvegicus
Analyze
Symbol: Mitf
Name: melanocyte inducing transcription factor
RGD ID: 3092
Description: Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; E-box binding activity; and protein dimerization activity. Involved in several processes, including cellular response to zinc ion starvation; osteoclast differentiation; and response to ethanol. Predicted to be located in lysosomal membrane. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Tietz syndrome; Tietze's syndrome; Waardenburg syndrome; Waardenburg syndrome type 2A; and familial melanoma. Orthologous to human MITF (melanocyte inducing transcription factor); PARTICIPATES IN interleukin-6 signaling pathway; melanoma pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: melanogenesis associated transcription factor; microphthalmia-associated transcription factor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84131,965,676 - 132,177,790 (+)NCBIGRCr8
mRatBN7.24130,409,020 - 130,621,145 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4130,409,217 - 130,621,145 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4135,833,861 - 136,047,084 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04131,614,906 - 131,828,127 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04130,232,868 - 130,446,103 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04130,172,484 - 130,425,496 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4130,172,727 - 130,425,532 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04194,667,943 - 194,921,498 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44132,534,187 - 132,745,669 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14132,971,000 - 132,989,691 (+)NCBI
Celera4119,282,401 - 119,497,938 (+)NCBICelera
Cytogenetic Map4q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-artemisinic acid  (ISO)
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
9-cis-retinal  (ISO)
9-cis-retinoic acid  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
afzelin  (ISO)
Alisol B  (ISO)
all-trans-retinoic acid  (ISO)
alpha-melanocyte stimulating hormone  (ISO)
alpha-pinene  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbaryl  (ISO)
carbon nanotube  (ISO)
celecoxib  (ISO)
CGP 52608  (ISO)
chaetocin  (ISO)
chlorpromazine  (ISO)
ciguatoxin CTX1B  (ISO)
ciprofloxacin  (ISO)
cisplatin  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cordycepin  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
cyanamide  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
DDT  (EXP)
disodium selenite  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
emodin  (ISO)
entinostat  (ISO)
fenofibrate  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
ivermectin  (ISO)
lawsone  (ISO)
lead diacetate  (ISO)
lithium chloride  (ISO)
loliolide  (ISO)
LY294002  (ISO)
melphalan  (ISO)
mercury dibromide  (ISO)
methapyrilene  (ISO)
methoxychlor  (EXP)
methylseleninic acid  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-phenylthiourea  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nonanedioic acid  (ISO)
oxidopamine  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
permethrin  (EXP)
phenylmercury acetate  (ISO)
phytol  (ISO)
pifithrin-?  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
Ptaquiloside  (ISO)
quercetin  (ISO)
resorcinol  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
stilbenoid  (ISO)
Sweroside  (ISO)
tamoxifen  (ISO)
taurine  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP)
theophylline  (ISO)
thioacetamide  (EXP)
thymol  (ISO)
thymol sulfate(1-)  (ISO)
torcetrapib  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vemurafenib  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (ISO,ISS)
lysosomal membrane  (IEA,ISO)
nucleus  (IBA,IEA,ISO,ISS)
protein-containing complex  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Zinc deficiency decreases osteoblasts and osteoclasts associated with the reduced expression of Runx2 and RANK. Hie M, etal., Bone. 2011 Dec;49(6):1152-9. doi: 10.1016/j.bone.2011.08.019. Epub 2011 Aug 26.
4. Ethanol increases osteoclastogenesis associated with the increased expression of RANK, PU.1 and MITF in vitro and in vivo. Iitsuka N, etal., Int J Mol Med. 2012 Jul;30(1):165-72. doi: 10.3892/ijmm.2012.974. Epub 2012 Apr 20.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Comprehensive gene review and curation RGD comprehensive gene curation
14. Microphthalmia-associated transcription factor and tyrosinase as markers of melanoma cells in blood of patients with melanoma. Samija I, etal., Croat Med J. 2004 Apr;45(2):142-8.
15. Tietz syndrome (hypopigmentation/deafness) caused by mutation of MITF. Smith SD, etal., J Med Genet. 2000 Jun;37(6):446-8.
16. The mutational spectrum in Waardenburg syndrome. Tassabehji M, etal., Hum Mol Genet. 1995 Nov;4(11):2131-7.
17. Age-resolving osteopetrosis: a rat model implicating microphthalmia and the related transcription factor TFE3. Weilbaecher KN, etal., J Exp Med 1998 Mar 2;187(5):775-85.
18. LysRS serves as a key signaling molecule in the immune response by regulating gene expression. Yannay-Cohen N, etal., Mol Cell. 2009 Jun 12;34(5):603-11. doi: 10.1016/j.molcel.2009.05.019.
Additional References at PubMed
PMID:2379821   PMID:8995290   PMID:9199364   PMID:9647758   PMID:11930005   PMID:12086670   PMID:12204775   PMID:12235125   PMID:14575687   PMID:14737107   PMID:15304486   PMID:15576400  
PMID:15716956   PMID:15729346   PMID:16411896   PMID:17442941   PMID:19188590   PMID:19201870   PMID:20530484   PMID:21209915   PMID:22234890   PMID:22523078   PMID:23207919   PMID:23980096  
PMID:24769727   PMID:26388265   PMID:27889061  


Genomics

Comparative Map Data
Mitf
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84131,965,676 - 132,177,790 (+)NCBIGRCr8
mRatBN7.24130,409,020 - 130,621,145 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4130,409,217 - 130,621,145 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4135,833,861 - 136,047,084 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04131,614,906 - 131,828,127 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04130,232,868 - 130,446,103 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04130,172,484 - 130,425,496 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4130,172,727 - 130,425,532 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04194,667,943 - 194,921,498 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44132,534,187 - 132,745,669 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14132,971,000 - 132,989,691 (+)NCBI
Celera4119,282,401 - 119,497,938 (+)NCBICelera
Cytogenetic Map4q34NCBI
MITF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38369,739,464 - 69,968,332 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl369,739,456 - 69,968,336 (+)EnsemblGRCh38hg38GRCh38
GRCh37369,788,615 - 70,017,483 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36369,871,323 - 70,100,177 (+)NCBINCBI36Build 36hg18NCBI36
Build 34370,010,945 - 70,100,176NCBI
Celera369,715,972 - 69,944,858 (+)NCBICelera
Cytogenetic Map3p13NCBI
HuRef369,788,411 - 70,016,737 (+)NCBIHuRef
CHM1_1369,739,823 - 69,968,702 (+)NCBICHM1_1
T2T-CHM13v2.0369,776,362 - 70,005,284 (+)NCBIT2T-CHM13v2.0
Mitf
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39697,783,966 - 97,998,321 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl697,784,013 - 97,998,310 (+)EnsemblGRCm39 Ensembl
GRCm38697,807,002 - 98,021,360 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl697,807,052 - 98,021,349 (+)EnsemblGRCm38mm10GRCm38
MGSCv37697,757,052 - 97,971,352 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36697,957,255 - 97,984,170 (+)NCBIMGSCv36mm8
Celera699,672,554 - 99,880,690 (+)NCBICelera
Cytogenetic Map6D3NCBI
cM Map645.05NCBI
Mitf
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542117,947,277 - 18,154,090 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542117,948,117 - 18,157,379 (-)NCBIChiLan1.0ChiLan1.0
MITF
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2269,693,359 - 69,921,387 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1369,698,199 - 69,926,175 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0369,674,064 - 69,902,078 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1371,037,671 - 71,265,445 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl371,037,665 - 71,265,445 (+)Ensemblpanpan1.1panPan2
MITF
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12021,772,147 - 21,873,545 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2021,612,927 - 21,870,578 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2021,826,585 - 21,857,697 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02021,883,312 - 22,101,930 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2021,886,050 - 22,101,945 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12021,572,611 - 21,603,715 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02021,921,161 - 21,952,266 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02021,991,588 - 22,022,704 (-)NCBIUU_Cfam_GSD_1.0
Mitf
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049421,682,409 - 1,858,295 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366031,682,513 - 1,858,173 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366031,682,411 - 1,858,295 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MITF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1351,178,203 - 51,422,093 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11351,177,356 - 51,422,096 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21356,593,519 - 56,594,255 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MITF
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12230,747,747 - 30,971,951 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2230,748,440 - 30,972,168 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041135,815,967 - 136,039,769 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mitf
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247734,346,007 - 4,562,969 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247734,346,072 - 4,561,218 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mitf
801 total Variants
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir182rno-miR-182Mirtarbaseexternal_infoWestern blotFunctional MTI19167416
Mir96rno-miR-96-5pMirtarbaseexternal_infoWestern blotFunctional MTI19167416

Predicted Target Of
Summary Value
Count of predictions:204
Count of miRNA genes:140
Interacting mature miRNAs:164
Transcripts:ENSRNOT00000051121
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)445456990146803430Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)450119848146803430Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)456647873149491524Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)459948935154902892Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)470362013132642728Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)473169846132642728Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482798864152731274Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)485253748148090731Rat
12798523Anxrr56Anxiety related response QTL 562.830.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)485253748150276390Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
61476Aia3Adjuvant induced arthritis QTL 33.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)486730991131730991Rat
1578662Bss15Bone structure and strength QTL 1519.6femur width (VT:1000666)femoral neck width (CMO:0001695)487327165132327165Rat
1578670Bss14Bone structure and strength QTL 1416.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)487327165132327165Rat
1578655Bmd11Bone mineral density QTL 1111femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)490850165135850165Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
631689Scl4Serum cholesterol level QTL 41.90.008blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)495174120140174120Rat
61434Cia3Collagen induced arthritis QTL 34.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4103194656148194656Rat
2302049Pia32Pristane induced arthritis QTL 325.10.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)4105789505150789505Rat
731165Uae21Urinary albumin excretion QTL 212.40.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)4106649412151649412Rat
61406Scwia1Streptococcal cell wall induced arthritis QTL 12.3joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)4106805662151805662Rat
7207480Bss105Bone structure and strength QTL 1058.1femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)4109827074154827074Rat
1549832Bss3Bone structure and strength QTL 311femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)4109827074154827074Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4114627026159627026Rat
1300116Hrtrt5Heart rate QTL 53.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)4116179486151161268Rat
724535Cm18Cardiac mass QTL 182.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)4118856416163856416Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4119428175157578333Rat
12798527Anxrr58Anxiety related response QTL 584.110.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4119463257147278687Rat
70201Gcr1Gastric cancer resistance QTL 12.7stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)4120260281147278687Rat
2293840Kiddil9Kidney dilation QTL 92.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)4120926564148090731Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4123143783168143783Rat
631683Bp116Blood pressure QTL 1160.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4124303370169303370Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4124778595169778595Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4125590636170590636Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4126395976167139601Rat

Markers in Region
D4Rat116  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24130,492,986 - 130,493,224 (+)MAPPERmRatBN7.2
Rnor_6.04130,297,677 - 130,297,914NCBIRnor6.0
Rnor_5.04194,793,679 - 194,793,916UniSTSRnor5.0
RGSC_v3.44132,619,103 - 132,619,340UniSTSRGSC3.4
RGSC_v3.44132,619,018 - 132,619,344RGDRGSC3.4
RGSC_v3.14132,863,944 - 132,864,181RGD
Celera4119,365,717 - 119,365,954UniSTS
RH 3.4 Map4805.7RGD
RH 3.4 Map4805.7UniSTS
RH 2.0 Map4867.2RGD
SHRSP x BN Map456.66RGD
FHH x ACI Map477.9799RGD
Cytogenetic Map4q34-q41UniSTS
D4Got97  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.04194,882,127 - 194,882,230NCBIRnor5.0
Rnor_5.04194,882,126 - 194,882,230NCBIRnor5.0
Rnor_5.04194,882,087 - 194,882,230NCBIRnor5.0
Rnor_5.04194,882,086 - 194,882,230NCBIRnor5.0
RGSC_v3.44132,709,022 - 132,709,164UniSTSRGSC3.4
RGSC_v3.44132,709,061 - 132,709,164RGDRGSC3.4
RGSC_v3.44132,709,021 - 132,709,164RGDRGSC3.4
RGSC_v3.44132,709,062 - 132,709,164UniSTSRGSC3.4
RGSC_v3.14132,953,863 - 132,954,005RGD
Celera4119,458,562 - 119,458,656UniSTS
RH 3.4 Map4795.01RGD
RH 3.4 Map4795.01UniSTS
Cytogenetic Map4q34-q41UniSTS
Mitf  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24130,538,293 - 130,538,433 (+)MAPPERmRatBN7.2
Rnor_6.04130,342,654 - 130,342,793NCBIRnor6.0
Rnor_5.04194,838,656 - 194,838,795UniSTSRnor5.0
RGSC_v3.44132,665,646 - 132,665,785UniSTSRGSC3.4
Celera4119,410,997 - 119,411,136UniSTS
Cytogenetic Map4q34-q41UniSTS
BE097660  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24130,453,838 - 130,453,996 (+)MAPPERmRatBN7.2
Rnor_6.04130,217,446 - 130,217,603NCBIRnor6.0
Rnor_5.04194,712,765 - 194,712,922UniSTSRnor5.0
RGSC_v3.44132,579,691 - 132,579,848UniSTSRGSC3.4
Celera4119,326,747 - 119,326,904UniSTS
RH 3.4 Map4805.3UniSTS
Cytogenetic Map4q34-q41UniSTS
AU048069  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24130,561,057 - 130,561,191 (+)MAPPERmRatBN7.2
Rnor_6.04130,365,409 - 130,365,542NCBIRnor6.0
Rnor_5.04194,861,411 - 194,861,544UniSTSRnor5.0
RGSC_v3.44132,688,401 - 132,688,534UniSTSRGSC3.4
Celera4119,433,721 - 119,433,854UniSTS
Cytogenetic Map4q34-q41UniSTS
RH139322  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24130,489,447 - 130,489,587 (+)MAPPERmRatBN7.2
Rnor_6.04130,294,138 - 130,294,277NCBIRnor6.0
Rnor_5.04194,790,140 - 194,790,279UniSTSRnor5.0
RGSC_v3.44132,615,564 - 132,615,703UniSTSRGSC3.4
Celera4119,362,176 - 119,362,315UniSTS
RH 3.4 Map1850.2UniSTS
Cytogenetic Map4q34-q41UniSTS
UniSTS:496619  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24130,586,060 - 130,587,341 (+)MAPPERmRatBN7.2
Rnor_6.04130,390,412 - 130,391,692NCBIRnor6.0
Rnor_5.04194,886,414 - 194,887,694UniSTSRnor5.0
RGSC_v3.44132,713,348 - 132,714,628UniSTSRGSC3.4
Celera4119,462,844 - 119,464,124UniSTS
Cytogenetic Map4q34-q41UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 42 23 6 2
Low 3 1 57 41 19 41 8 11 74 12 32 9 8
Below cutoff 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000051121   ⟹   ENSRNOP00000044350
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4130,409,217 - 130,621,145 (+)Ensembl
Rnor_6.0 Ensembl4130,172,727 - 130,422,735 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000083127   ⟹   ENSRNOP00000073565
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4130,527,867 - 130,621,145 (+)Ensembl
Rnor_6.0 Ensembl4130,332,076 - 130,425,532 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000094478   ⟹   ENSRNOP00000084182
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4130,584,902 - 130,621,145 (+)Ensembl
RefSeq Acc Id: NM_001191089   ⟹   NP_001178018
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84131,965,740 - 132,177,790 (+)NCBI
mRatBN7.24130,409,085 - 130,621,145 (+)NCBI
Rnor_6.04130,172,856 - 130,425,496 (+)NCBI
Rnor_5.04194,667,943 - 194,921,498 (+)NCBI
Celera4119,282,401 - 119,497,938 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001398550   ⟹   NP_001385479
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84131,965,740 - 132,177,790 (+)NCBI
mRatBN7.24130,409,085 - 130,621,145 (+)NCBI
RefSeq Acc Id: XM_017592478   ⟹   XP_017447967
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84132,083,188 - 132,177,790 (+)NCBI
mRatBN7.24130,526,535 - 130,617,941 (+)NCBI
Rnor_6.04130,332,222 - 130,425,496 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039107083   ⟹   XP_038963011
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84131,965,677 - 132,177,790 (+)NCBI
mRatBN7.24130,409,020 - 130,617,941 (+)NCBI
RefSeq Acc Id: XM_039107085   ⟹   XP_038963013
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84131,965,676 - 132,177,790 (+)NCBI
mRatBN7.24130,409,217 - 130,617,941 (+)NCBI
RefSeq Acc Id: XM_039107087   ⟹   XP_038963015
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84131,984,382 - 132,177,790 (+)NCBI
mRatBN7.24130,427,689 - 130,617,941 (+)NCBI
RefSeq Acc Id: XM_039107089   ⟹   XP_038963017
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84131,965,678 - 132,177,790 (+)NCBI
mRatBN7.24130,409,024 - 130,621,145 (+)NCBI
RefSeq Acc Id: XM_063285573   ⟹   XP_063141643
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84132,083,187 - 132,177,790 (+)NCBI
RefSeq Acc Id: XM_063285574   ⟹   XP_063141644
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84131,984,326 - 132,177,790 (+)NCBI
RefSeq Acc Id: XM_063285575   ⟹   XP_063141645
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84131,965,678 - 132,177,790 (+)NCBI
RefSeq Acc Id: XM_063285576   ⟹   XP_063141646
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84132,142,851 - 132,177,790 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001178018   ⟸   NM_001191089
- Peptide Label: isoform 1
- UniProtKB: F1LQV3 (UniProtKB/Swiss-Prot),   O88368 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017447967   ⟸   XM_017592478
- Peptide Label: isoform X3
- UniProtKB: A0A0G2K5U8 (UniProtKB/TrEMBL),   A0A8I5ZYC4 (UniProtKB/TrEMBL),   A6IBG2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000044350   ⟸   ENSRNOT00000051121
RefSeq Acc Id: ENSRNOP00000073565   ⟸   ENSRNOT00000083127
RefSeq Acc Id: XP_038963011   ⟸   XM_039107083
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038963017   ⟸   XM_039107089
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038963013   ⟸   XM_039107085
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038963015   ⟸   XM_039107087
- Peptide Label: isoform X5
- UniProtKB: A0A8L2ULS4 (UniProtKB/TrEMBL),   A0A8I5ZYC4 (UniProtKB/TrEMBL),   A6IBG2 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000084182   ⟸   ENSRNOT00000094478
RefSeq Acc Id: NP_001385479   ⟸   NM_001398550
- Peptide Label: isoform 2
RefSeq Acc Id: XP_063141645   ⟸   XM_063285575
- Peptide Label: isoform X7
RefSeq Acc Id: XP_063141644   ⟸   XM_063285574
- Peptide Label: isoform X5
- UniProtKB: A0A8L2ULS4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063141643   ⟸   XM_063285573
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063141646   ⟸   XM_063285576
- Peptide Label: isoform X8
Protein Domains
bHLH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88368-F1-model_v2 AlphaFold O88368 1-526 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693271
Promoter ID:EPDNEW_R3796
Type:single initiation site
Name:Mitf_1
Description:melanogenesis associated transcription factor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04130,172,727 - 130,172,787EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3092 AgrOrtholog
BioCyc Gene G2FUF-43595 BioCyc
Ensembl Genes ENSRNOG00000008658 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00055003910 UniProtKB/Swiss-Prot
  ENSRNOG00060004277 UniProtKB/Swiss-Prot
  ENSRNOG00065024159 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000051121.5 UniProtKB/TrEMBL
  ENSRNOT00000083127.2 UniProtKB/TrEMBL
  ENSRNOT00000094478.1 UniProtKB/TrEMBL
  ENSRNOT00055006260 UniProtKB/Swiss-Prot
  ENSRNOT00060007191 UniProtKB/Swiss-Prot
  ENSRNOT00065041614 UniProtKB/Swiss-Prot
Gene3D-CATH 4.10.280.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro bHLH_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HLH_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MiT/TFE_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MiT/TFE_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25094 UniProtKB/Swiss-Prot
NCBI Gene 25094 ENTREZGENE
PANTHER MIP04163P UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR45776:SF4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DUF3371 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MITF_TFEB_C_3_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mitf PhenoGen
PROSITE BHLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008658 RatGTEx
  ENSRNOG00055003910 RatGTEx
  ENSRNOG00060004277 RatGTEx
  ENSRNOG00065024159 RatGTEx
SMART HLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47459 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K5U8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZYC4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2ULS4 ENTREZGENE, UniProtKB/TrEMBL
  A6IBG2 ENTREZGENE, UniProtKB/TrEMBL
  F1LQV3 ENTREZGENE
  MITF_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary F1LQV3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-10-16 Mitf  melanocyte inducing transcription factor  Mitf  melanogenesis associated transcription factor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-06-02 Mitf  melanogenesis associated transcription factor  Mitf  microphthalmia-associated transcription factor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Mitf  Microphthalmia-associated transcription factor      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease deletion in gene may be associated with osteopetrosis 729082
gene_process may be involved in pigmentation, mast cells, and bone development 729082