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Gene: Mitf (melanogenesis associated transcription factor) Mus musculus
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Symbol: Mitf
Name: melanogenesis associated transcription factor
Description: Exhibits several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; E-box binding activity; and protein dimerization activity. Involved in several processes, including canonical Wnt signaling pathway involved in negative regulation of apoptotic process; osteoclast differentiation; and regulation of osteoclast differentiation. Localizes to the nucleus. Used to study Tietz syndrome; Waardenburg's syndrome (multiple); ocular albinism with sensorineural deafness; and osteosclerosis (multiple). Human ortholog(s) of this gene implicated in Tietz syndrome; Tietze's syndrome; Waardenburg's syndrome (multiple); familial melanoma; and ocular albinism with sensorineural deafness. Is expressed in several structures, including alimentary system; central nervous system; integumental system; mesenchyme derived from neural crest; and sensory organ. Orthologous to human MITF (melanocyte inducing transcription factor).
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: BCC2; bHLHe32; black eyed white; bw; Gsfbcc2; MGC124309; MGC124310; mi; microphtalmia-associated transcription factor; microphthalmia-associated transcription factor; vit; Vitiligo; Wh
Orthologs:
Homo sapiens (human) : MITF (melanocyte inducing transcription factor)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Mitf (melanocyte inducing transcription factor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mitf (melanocyte inducing transcription factor)
Pan paniscus (bonobo/pygmy chimpanzee) : MITF (melanocyte inducing transcription factor)
Canis lupus familiaris (dog) : MITF (melanocyte inducing transcription factor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mitf (melanocyte inducing transcription factor)
Sus scrofa (pig) : MITF (melanocyte inducing transcription factor)
Chlorocebus sabaeus (green monkey) : MITF (melanocyte inducing transcription factor)
Heterocephalus glaber (naked mole-rat) : Mitf (melanocyte inducing transcription factor)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl697,807,052 - 98,021,349 (+)Ensembl
GRCm38697,807,002 - 98,021,360 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37697,757,052 - 97,971,352 (+)NCBIGRCm37mm9NCBIm37
MGSCv36697,957,255 - 97,984,170 (+)NCBImm8
Celera699,672,554 - 99,880,690 (+)NCBICelera
Cytogenetic Map6D3NCBI
cM Map645.05NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
Nomenclature History
 
More on Mitf
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 735983
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2020-02-11
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.