Gene: Mitf (melanogenesis associated transcription factor) Mus musculus
Analyze
Symbol:
Mitf
Name:
melanogenesis associated transcription factor
Description:
Exhibits several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; E-box binding activity; and protein dimerization activity. Involved in several processes, including canonical Wnt signaling pathway involved in negative regulation of apoptotic process; osteoclast differentiation; and regulation of osteoclast differentiation. Localizes to the nucleus. Used to study Tietz syndrome; Waardenburg's syndrome (multiple); ocular albinism with sensorineural deafness; and osteosclerosis (multiple). Human ortholog(s) of this gene implicated in Tietz syndrome; Tietze's syndrome; Waardenburg's syndrome (multiple); familial melanoma; and ocular albinism with sensorineural deafness. Is expressed in several structures, including alimentary system; central nervous system; integumental system; mesenchyme derived from neural crest; and sensory organ. Orthologous to human MITF (melanocyte inducing transcription factor).
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
BCC2; bHLHe32; black eyed white; bw; Gsfbcc2; MGC124309; MGC124310; mi; microphtalmia-associated transcription factor; microphthalmia-associated transcription factor; vit; Vitiligo; Wh
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
MITF (melanocyte inducing transcription factor) HGNC
EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Rattus norvegicus (Norway rat):
Mitf (melanocyte inducing transcription factor) HGNC
Treefam, EggNOG, NCBI, OMA, HomoloGene, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Mitf (melanocyte inducing transcription factor) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
MITF (melanocyte inducing transcription factor) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
MITF (melanocyte inducing transcription factor) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Mitf (melanocyte inducing transcription factor) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
MITF (melanocyte inducing transcription factor) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):
MITF (melanocyte inducing transcription factor) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Mitf (melanocyte inducing transcription factor) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
TFE3 (transcription factor binding to IGHM enhancer 3) HGNC
OrthoDB
Alliance orthologs 3
Rattus norvegicus (Norway rat):
Mitf (melanocyte inducing transcription factor)
Alliance
DIOPT (Ensembl Compara, OMA, OrthoFinder, OrthoInspector, PANTHER, TreeFam)
Homo sapiens (human):
MITF (melanocyte inducing transcription factor)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Danio rerio (zebrafish):
mitfb (melanocyte inducing transcription factor b)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam, ZFIN)
Danio rerio (zebrafish):
mitfa (melanocyte inducing transcription factor a)
Alliance
DIOPT (Ensembl Compara, PANTHER, PhylomeDB, Roundup, TreeFam, ZFIN)
Saccharomyces cerevisiae (baker's yeast):
HMS1
Alliance
DIOPT (InParanoid, Roundup)
Caenorhabditis elegans (roundworm):
hlh-30
Alliance
DIOPT (Ensembl Compara, InParanoid, OrthoInspector, PANTHER, Roundup)
Drosophila melanogaster (fruit fly):
Mitf
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Latest Assembly:
GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm38 Ensembl 6 97,807,052 - 98,021,349 (+) Ensembl GRCm38 6 97,807,002 - 98,021,360 (+) NCBI GRCm38 GRCm38 mm10 GRCm38 MGSCv37 6 97,757,052 - 97,971,352 (+) NCBI GRCm37 mm9 NCBIm37 MGSCv36 6 97,957,255 - 97,984,170 (+) NCBI mm8 Celera 6 99,672,554 - 99,880,690 (+) NCBI Celera Cytogenetic Map 6 D3 NCBI cM Map 6 45.05 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Disease Annotations
Imported Annotations - ClinVar
COLOBOMA, OSTEOPETROSIS, MICROPHTHALMIA, MACROCEPHALY, ALBINISM, AND DEAFNESS ISO RGD:735982 8554872 ClinVar Annotator: match by term: Coloboma, osteopetrosis, microphthalmia, macrocephaly, albinism, and deafness ClinVar PMID:27889061 Deafness ISO RGD:735982 8554872 ClinVar Annotator: match by term: Deafness ClinVar PMID:25741868 more ... familial melanoma ISO RGD:735982 8554872 ClinVar Annotator: match by term: MELANOMA AND RENAL CELL CARCINOMA, SUSCEPTIBILITY TO ClinVar PMID:22012259 more ... Hearing Loss ISO RGD:735982 8554872 ClinVar Annotator: match by term: Hypoacusis ClinVar PMID:25741868 more ... Hereditary Neoplastic Syndromes ISO RGD:735982 8554872 ClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary ClinVar PMID:22012259 more ... Heterochromia Iridis ISO RGD:735982 8554872 ClinVar Annotator: match by term: Heterochromia iridis ClinVar PMID:25741868 more ... microphthalmia ISO RGD:735982 8554872 ClinVar Annotator: match by term: Anophthalmia - microphthalmia ClinVar PMID:26893459 Microphthalmia, Syndromic 1 ISO RGD:735982 8554872 ClinVar Annotator: match by term: Anophthalmia - microphthalmia ClinVar PMID:26893459 nonsyndromic deafness ISO RGD:735982 8554872 ClinVar Annotator: match by term: Nonsyndromic Deafness ClinVar PMID:25741868 sensorineural hearing loss ISO RGD:735982 8554872 ClinVar Annotator: match by term: Congenital sensorineural hearing impairment ClinVar PMID:25741868 , PMID:29407415 Tietz syndrome ISO RGD:735982 8554872 ClinVar Annotator: match by term: Tietz syndrome ClinVar PMID:24033266 more ... Tietz syndrome ISO RGD:735982 8554872 ClinVar Annotator: match by term: Tietz syndrome ClinVar PMID:22012259 more ... Tietz syndrome ISO RGD:735982 8554872 ClinVar Annotator: match by term: Tietz syndrome ClinVar PMID:28492532 Tietz syndrome ISO RGD:735982 8554872 ClinVar Annotator: match by term: Tietz syndrome ClinVar PMID:24033266 more ... Tietz syndrome ISO RGD:735982 8554872 ClinVar Annotator: match by term: Tietz syndrome ClinVar PMID:24033266 more ... Tietz syndrome ISO RGD:735982 8554872 ClinVar Annotator: match by term: Tietz syndrome ClinVar PMID:24033266 , PMID:28492532 Tietz syndrome ISO RGD:735982 8554872 ClinVar Annotator: match by term: Tietz syndrome ClinVar PMID:25741868 Tietz syndrome ISO RGD:735982 8554872 ClinVar Annotator: match by term: Tietz syndrome ClinVar Tietz syndrome ISO RGD:735982 8554872 ClinVar Annotator: match by term: Tietz syndrome ClinVar PMID:10851256 , PMID:13985019 Waardenburg syndrome type 1 ISO RGD:735982 8554872 ClinVar Annotator: match by term: Waardenburg syndrome type 1 ClinVar Waardenburg syndrome type 2A ISO RGD:735982 8554872 ClinVar Annotator: match by OMIM:193510 ClinVar Waardenburg syndrome type 2A ISO RGD:735982 8554872 ClinVar Annotator: match by term: WAARDENBURG SYNDROME WITHOUT DYSTOPIA CANTHORUM ClinVar PMID:22012259 more ... Waardenburg syndrome type 2A ISO RGD:735982 8554872 ClinVar Annotator: match by term: Waardenburg syndrome type 2A ClinVar PMID:25741868 Waardenburg syndrome type 2A ISO RGD:735982 8554872 ClinVar Annotator: match by term: Waardenburg syndrome type 2A ClinVar PMID:25741868 more ... Waardenburg syndrome type 2A ISO RGD:735982 8554872 ClinVar Annotator: match by term: Waardenburg syndrome type 2A ClinVar PMID:7874167 Waardenburg syndrome type 2A ISO RGD:735982 8554872 ClinVar Annotator: match by term: Waardenburg syndrome type 2A ClinVar PMID:10587587 , PMID:8589691 Waardenburg syndrome type 2A ISO RGD:735982 8554872 ClinVar Annotator: match by term: Waardenburg syndrome type 2A ClinVar PMID:25741868 , PMID:29407415 Waardenburg syndrome type 2A ISO RGD:735982 8554872 ClinVar Annotator: match by term: Waardenburg syndrome type 2A ClinVar PMID:27889061 Waardenburg syndrome type 2A ISO RGD:735982 8554872 ClinVar Annotator: match by term: Waardenburg syndrome type 2A ClinVar PMID:666627 , PMID:9158138 Waardenburg syndrome type 2A ISO RGD:735982 8554872 ClinVar Annotator: match by term: Waardenburg syndrome type 2A ClinVar PMID:8589691 Waardenburg syndrome type 2E ISO RGD:735982 8554872 ClinVar Annotator: match by term: Waardenburg syndrome type 2 ClinVar Waardenburg's syndrome ISO RGD:735982 8554872 ClinVar Annotator: match by term: Waardenburg syndrome ClinVar PMID:24033266 more ... Waardenburg's syndrome ISO RGD:735982 8554872 ClinVar Annotator: match by term: Waardenburg syndrome ClinVar PMID:24033266 more ... Waardenburg's syndrome ISO RGD:735982 8554872 ClinVar Annotator: match by term: Waardenburg syndrome ClinVar PMID:28492532 Waardenburg's syndrome ISO RGD:735982 8554872 ClinVar Annotator: match by term: Waardenburg syndrome ClinVar PMID:24033266 , PMID:28492532 Waardenburg's syndrome ISO RGD:735982 8554872 ClinVar Annotator: match by term: Waardenburg syndrome ClinVar PMID:24033266 more ... Waardenburg's syndrome ISO RGD:735982 8554872 ClinVar Annotator: match by term: Waardenburg syndrome ClinVar Waardenburg's syndrome ISO RGD:735982 8554872 ClinVar Annotator: match by term: Waardenburg syndrome ClinVar PMID:17318840 more ... Waardenburg's syndrome ISO RGD:735982 8554872 ClinVar Annotator: match by term: Waardenburg syndrome ClinVar PMID:15284851 , PMID:24033266 Waardenburg's syndrome ISO RGD:735982 8554872 ClinVar Annotator: match by term: Waardenburg syndrome ClinVar PMID:24033266 Waardenburg's syndrome ISO RGD:735982 8554872 ClinVar Annotator: match by term: Waardenburg syndrome ClinVar PMID:17627390 , PMID:24033266
Imported Annotations - CTD
Deafness ISO RGD:735982 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:9158138 familial melanoma ISO RGD:735982 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:22012259 melanoma ISO RGD:735982 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:25043973 Neoplastic Cell Transformation ISO RGD:735982 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:25401301 ocular albinism with sensorineural deafness ISO RGD:735982 11554173 CTD Direct Evidence: marker/mechanism CTD oculocutaneous albinism ISO RGD:735982 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:9158138 pigmentation disease ISO RGD:735982 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:9158138 renal cell carcinoma ISO RGD:735982 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:22012259 skin melanoma ISO RGD:735982 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:22080950 Waardenburg syndrome type 2E ISO RGD:735982 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:9158138 Imported Annotations - MGI
Camurati-Engelmann disease IEA 13592920 OMIM:131300 , OMIM:606631MouseDO ocular albinism with sensorineural deafness IEA 13592920 OMIM:103470 MouseDO osteopetrosis IEA 13592920 MouseDO Tietz syndrome IEA 13592920 OMIM:103500 MouseDO Waardenburg syndrome type 1 IEA 13592920 OMIM:193500 MouseDO Waardenburg syndrome type 2A IEA 13592920 OMIM:193510 MouseDO Imported Annotations - OMIM
COLOBOMA, OSTEOPETROSIS, MICROPHTHALMIA, MACROCEPHALY, ALBINISM, AND DEAFNESS ISO RGD:735982 7240710 OMIM familial melanoma susceptibility ISO RGD:735982 7240710 OMIM Tietz syndrome ISO RGD:735982 7240710 OMIM Waardenburg syndrome type 2A ISO RGD:735982 7240710 OMIM
(+)-artemisinic acid decreases expression ISO RGD:735982 6480464 artemisic acid results in decreased expression of MITF mRNA CTD PMID:23063590 (+)-schisandrin B multiple interactions ISO RGD:3092 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of MITF mRNA] CTD PMID:31150632 (-)-epigallocatechin 3-gallate multiple interactions ISO RGD:735982 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of MITF mRNA CTD PMID:22079256 17beta-estradiol multiple interactions ISO RGD:735982 6480464 [Estradiol co-treated with EGF protein] results in increased expression of MITF mRNA, [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of MITF mRNA CTD PMID:19619570 , PMID:24758408 17beta-estradiol increases expression EXP 6480464 Estradiol results in increased expression of MITF mRNA CTD PMID:19484750 17beta-estradiol increases expression ISO RGD:735982 6480464 Estradiol results in increased expression of MITF mRNA CTD PMID:19619570 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of MITF mRNA, Tetrachlorodibenzodioxin results in increased expression of MITF protein CTD PMID:24058054 , PMID:28029781 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:735982 6480464 [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of MITF mRNA CTD PMID:19619570 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:735982 6480464 Tetrachlorodibenzodioxin results in decreased expression of MITF mRNA CTD PMID:19619570 3,4-methylenedioxymethamphetamine decreases expression EXP 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in decreased expression of MITF mRNA CTD PMID:26251327 3-isobutyl-1-methyl-7H-xanthine increases expression EXP 6480464 1-Methyl-3-isobutylxanthine results in increased expression of MITF protein CTD PMID:26748310 3-isobutyl-1-methyl-7H-xanthine multiple interactions EXP 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [chaetocin inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased expression of MITF protein]], chaetocin inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased expression of MITF protein] CTD PMID:26748310 4,4'-sulfonyldiphenol increases expression EXP 6480464 bis(4-hydroxyphenyl)sulfone results in increased expression of MITF mRNA CTD PMID:30951980 4-hydroxynon-2-enal decreases expression ISO RGD:735982 6480464 4-hydroxy-2-nonenal results in decreased expression of MITF mRNA CTD PMID:23489423 4-hydroxyphenyl retinamide decreases expression EXP 6480464 Fenretinide results in decreased expression of MITF mRNA CTD PMID:28973697 5-aza-2'-deoxycytidine decreases expression ISO RGD:735982 6480464 Decitabine results in decreased expression of MITF mRNA CTD PMID:17785578 6-propyl-2-thiouracil decreases expression ISO RGD:3092 6480464 Propylthiouracil results in decreased expression of MITF mRNA CTD PMID:24780913 , PMID:25825206 9-cis-retinal multiple interactions ISO RGD:735982 6480464 ALDH1A1 mutant form inhibits the reaction [9-cis-retinal results in increased expression of MITF mRNA] CTD PMID:23489423 9-cis-retinal increases expression ISO RGD:735982 6480464 9-cis-retinal results in increased expression of MITF mRNA CTD PMID:23489423 9-cis-retinoic acid increases expression ISO RGD:735982 6480464 Alitretinoin results in increased expression of MITF mRNA CTD PMID:23489423 aflatoxin B1 increases expression ISO RGD:735982 6480464 Aflatoxin B1 results in increased expression of MITF mRNA CTD PMID:27153756 aflatoxin B1 increases methylation ISO RGD:735982 6480464 Aflatoxin B1 results in increased methylation of MITF gene CTD PMID:27153756 afzelin increases expression ISO RGD:735982 6480464 afzelin results in increased expression of MITF mRNA, afzelin results in increased expression of MITF protein CTD PMID:27287415 all-trans-retinoic acid increases expression ISO RGD:735982 6480464 Tretinoin results in increased expression of MITF mRNA CTD PMID:21934132 all-trans-retinoic acid increases expression EXP 6480464 Tretinoin results in increased expression of MITF mRNA CTD PMID:11851873 , PMID:17038669 amiodarone increases expression ISO RGD:735982 6480464 Amiodarone results in increased expression of MITF mRNA CTD PMID:19774075 ammonium chloride affects expression ISO RGD:3092 6480464 Ammonium Chloride affects the expression of MITF mRNA CTD PMID:16483693 benzene increases expression ISO RGD:735982 6480464 Benzene results in increased expression of MITF mRNA CTD PMID:19162166 benzo[a]pyrene decreases expression ISO RGD:735982 6480464 Benzo(a)pyrene results in decreased expression of MITF mRNA CTD PMID:20064835 benzo[a]pyrene diol epoxide I decreases expression ISO RGD:735982 6480464 7 more ... CTD PMID:19150397 benzo[e]pyrene increases methylation ISO RGD:735982 6480464 benzo(e)pyrene results in increased methylation of MITF intron CTD PMID:30157460 bis(2-ethylhexyl) phthalate decreases expression ISO RGD:735982 6480464 Diethylhexyl Phthalate results in decreased expression of MITF mRNA CTD PMID:31163220 bisphenol A affects expression ISO RGD:3092 6480464 bisphenol A affects the expression of MITF mRNA CTD PMID:25181051 bisphenol A affects methylation EXP 6480464 bisphenol A affects the methylation of MITF promoter CTD PMID:27334623 cadmium dichloride decreases expression ISO RGD:735982 6480464 Cadmium Chloride results in decreased expression of MITF mRNA CTD PMID:12160620 calcitriol decreases expression ISO RGD:735982 6480464 Calcitriol results in decreased expression of MITF mRNA CTD PMID:16002434 cannabidiol increases expression ISO RGD:735982 6480464 Cannabidiol results in increased expression of MITF mRNA, Cannabidiol results in increased expression of MITF protein CTD PMID:28601556 cannabidiol multiple interactions ISO RGD:735982 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Cannabidiol results in increased expression of MITF mRNA], SB 203580 inhibits the reaction [Cannabidiol results in increased expression of MITF mRNA] CTD PMID:28601556 carbamazepine affects expression ISO RGD:735982 6480464 Carbamazepine affects the expression of MITF mRNA CTD PMID:25979313 carbaryl decreases expression ISO RGD:735982 6480464 Carbaryl results in decreased expression of MITF mRNA CTD PMID:27829164 carbon nanotube increases expression EXP 6480464 Nanotubes, Carbon analog results in increased expression of MITF mRNA, Nanotubes, Carbon results in increased expression of MITF mRNA CTD PMID:25554681 , PMID:25620056 chaetocin multiple interactions EXP 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [chaetocin inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased expression of MITF protein]], chaetocin inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased expression of MITF protein] CTD PMID:26748310 chlorpromazine increases expression ISO RGD:735982 6480464 Chlorpromazine results in increased expression of MITF protein CTD PMID:25449126 ciguatoxin CTX1B affects expression EXP 6480464 Ciguatoxins affects the expression of MITF mRNA CTD PMID:18353800 cisplatin multiple interactions ISO RGD:735982 6480464 [Cisplatin co-treated with jinfukang] results in decreased expression of MITF mRNA CTD PMID:27392435 Colforsin dapropate hydrochloride increases expression ISO RGD:735982 6480464 Colforsin results in increased expression of MITF mRNA, Colforsin results in increased expression of MITF protein CTD PMID:17460731 , PMID:28601556 crocidolite asbestos increases expression ISO RGD:735982 6480464 Asbestos, Crocidolite results in increased expression of MITF mRNA CTD PMID:18687144 cyanamide decreases expression ISO RGD:735982 6480464 Cyanamide results in decreased expression of MITF mRNA CTD PMID:23489423 cyclosporin A decreases expression ISO RGD:735982 6480464 Cyclosporine results in decreased expression of MITF mRNA CTD PMID:20106945 , PMID:27989131 cyclosporin A increases methylation ISO RGD:735982 6480464 Cyclosporine results in increased methylation of MITF promoter CTD PMID:27989131 cylindrospermopsin increases expression ISO RGD:735982 6480464 cylindrospermopsin results in increased expression of MITF mRNA CTD PMID:24921660 DDT increases methylation ISO RGD:3092 6480464 DDT results in increased methylation of MITF gene CTD PMID:30207508 disodium selenite multiple interactions EXP 6480464 [ptaquiloside co-treated with Sodium Selenite] results in decreased expression of MITF mRNA CTD PMID:23274088 diuron decreases expression ISO RGD:3092 6480464 Diuron results in decreased expression of MITF mRNA CTD PMID:25152437 dorsomorphin multiple interactions ISO RGD:735982 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 emodin decreases expression ISO RGD:735982 6480464 Emodin results in decreased expression of MITF protein CTD PMID:26972667 entinostat increases expression ISO RGD:735982 6480464 entinostat results in increased expression of MITF mRNA CTD PMID:26272509 fenofibrate decreases expression EXP 6480464 Fenofibrate results in decreased expression of MITF mRNA, Fenofibrate results in decreased expression of MITF protein CTD PMID:23872139 formaldehyde decreases expression ISO RGD:735982 6480464 Formaldehyde results in decreased expression of MITF mRNA CTD PMID:27664576 lead diacetate increases expression EXP 6480464 lead acetate results in increased expression of MITF mRNA CTD PMID:20542052 lithium chloride increases expression ISO RGD:735982 6480464 Lithium Chloride results in increased expression of MITF mRNA CTD PMID:23527032 LY294002 multiple interactions EXP 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Drugs, Chinese Herbal results in decreased expression of MITF protein], 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sweroside results in increased expression of MITF protein] CTD PMID:21816215 , PMID:26051519 LY294002 increases expression EXP 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of MITF protein CTD PMID:26051519 melphalan decreases expression ISO RGD:735982 6480464 Melphalan results in decreased expression of MITF mRNA CTD PMID:22363485 mercury dibromide increases expression ISO RGD:735982 6480464 mercuric bromide results in increased expression of MITF mRNA CTD PMID:26272509 mercury dibromide multiple interactions ISO RGD:735982 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MITF mRNA CTD PMID:27188386 methapyrilene increases methylation ISO RGD:735982 6480464 Methapyrilene results in increased methylation of MITF intron CTD PMID:30157460 methylseleninic acid increases expression ISO RGD:735982 6480464 methylselenic acid results in increased expression of MITF mRNA CTD PMID:18548127 N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide multiple interactions EXP 6480464 N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [isosakuranetin results in increased expression of MITF protein] CTD PMID:26524968 N-acetyl-L-cysteine multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [Phytol inhibits the reaction [alpha-MSH results in increased expression of MITF protein]] CTD PMID:29486182 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal multiple interactions EXP 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Phytol inhibits the reaction [alpha-MSH results in increased expression of MITF protein]] which results in decreased ubiquitination of MITF protein]] more ... CTD PMID:29486182 N-phenylthiourea increases expression EXP 6480464 Phenylthiourea results in increased expression of MITF protein CTD PMID:26051519 nickel atom decreases expression ISO RGD:735982 6480464 Nickel results in decreased expression of MITF mRNA CTD PMID:25583101 nickel sulfate increases expression ISO RGD:735982 6480464 nickel sulfate results in increased expression of MITF mRNA CTD PMID:16780908 nonanedioic acid decreases expression EXP 6480464 azelaic acid results in decreased expression of MITF protein CTD PMID:20804622 nonanedioic acid multiple interactions EXP 6480464 [Taurine co-treated with azelaic acid] results in decreased expression of MITF protein CTD PMID:20804622 paracetamol affects expression EXP 6480464 Acetaminophen affects the expression of MITF mRNA CTD PMID:17562736 paracetamol decreases expression ISO RGD:735982 6480464 Acetaminophen results in decreased expression of MITF mRNA CTD PMID:29067470 phenylmercury acetate increases expression ISO RGD:735982 6480464 Phenylmercuric Acetate results in increased expression of MITF mRNA CTD PMID:26272509 phenylmercury acetate multiple interactions ISO RGD:735982 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MITF mRNA CTD PMID:27188386 phytol multiple interactions EXP 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Phytol inhibits the reaction [alpha-MSH results in increased expression of MITF protein]] which results in decreased ubiquitination of MITF protein]] more ... CTD PMID:29486182 pirinixic acid multiple interactions ISO RGD:735982 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of MITF mRNA CTD PMID:19710929 pirinixic acid decreases expression EXP 6480464 pirinixic acid results in decreased expression of MITF mRNA CTD PMID:23811191 potassium chromate decreases expression ISO RGD:735982 6480464 potassium chromate(VI) results in decreased expression of MITF mRNA CTD PMID:22079256 potassium chromate multiple interactions ISO RGD:735982 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of MITF mRNA CTD PMID:22079256 progesterone increases expression ISO RGD:735982 6480464 Progesterone results in increased expression of MITF mRNA CTD PMID:20864642 Ptaquiloside multiple interactions EXP 6480464 [ptaquiloside co-treated with Sodium Selenite] results in decreased expression of MITF mRNA CTD PMID:23274088 quercetin increases expression ISO RGD:735982 6480464 Quercetin results in increased expression of MITF mRNA CTD PMID:15309432 quercetin multiple interactions EXP 6480464 Quercetin analog inhibits the reaction [POMC protein modified form results in increased expression of MITF protein] CTD PMID:26586997 resveratrol increases expression ISO RGD:735982 6480464 resveratrol results in increased expression of MITF mRNA CTD PMID:25888808 resveratrol multiple interactions EXP 6480464 resveratrol inhibits the reaction [alpha-MSH results in increased expression of MITF protein] CTD PMID:29486182 SB 203580 multiple interactions ISO RGD:735982 6480464 SB 203580 inhibits the reaction [Cannabidiol results in increased expression of MITF mRNA] CTD PMID:28601556 SB 431542 multiple interactions ISO RGD:735982 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 sodium arsenite multiple interactions ISO RGD:735982 6480464 sodium arsenite inhibits the reaction [EDN1 protein results in increased expression of MITF] CTD PMID:28470405 sodium arsenite affects methylation ISO RGD:735982 6480464 sodium arsenite affects the methylation of MITF gene CTD PMID:28589171 stilbenoid decreases expression EXP 6480464 Stilbenes analog results in decreased expression of MITF mRNA, Stilbenes analog results in decreased expression of MITF protein CTD PMID:29042215 Sweroside multiple interactions EXP 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sweroside results in increased expression of MITF protein], U 0126 inhibits the reaction [sweroside results in increased expression of MITF protein] CTD PMID:26051519 tamoxifen increases expression EXP 6480464 Tamoxifen results in increased expression of MITF mRNA CTD PMID:25123088 taurine multiple interactions EXP 6480464 [Taurine co-treated with azelaic acid] results in decreased expression of MITF protein CTD PMID:20804622 taurine decreases expression EXP 6480464 Taurine results in decreased expression of MITF protein CTD PMID:20804622 tert-butyl hydroperoxide decreases expression ISO RGD:735982 6480464 tert-Butylhydroperoxide results in decreased expression of MITF mRNA CTD PMID:15336504 tetrachloromethane increases expression ISO RGD:3092 6480464 Carbon Tetrachloride results in increased expression of MITF mRNA CTD PMID:31150632 tetrachloromethane multiple interactions ISO RGD:3092 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of MITF mRNA] CTD PMID:31150632 thymol multiple interactions EXP 6480464 Thymol inhibits the reaction [TNFSF11 protein results in increased expression of MITF mRNA] CTD PMID:30048646 thymol sulfate(1-) multiple interactions EXP 6480464 Thymol inhibits the reaction [TNFSF11 protein results in increased expression of MITF mRNA] CTD PMID:30048646 torcetrapib increases expression ISO RGD:735982 6480464 torcetrapib results in increased expression of MITF mRNA CTD PMID:23228038 trichostatin A increases expression ISO RGD:735982 6480464 trichostatin A results in increased expression of MITF mRNA CTD PMID:24935251 , PMID:26272509 trichostatin A affects expression ISO RGD:735982 6480464 trichostatin A affects the expression of MITF mRNA CTD PMID:28542535 trichostatin A multiple interactions ISO RGD:735982 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MITF mRNA CTD PMID:27188386 triclosan decreases expression ISO RGD:735982 6480464 Triclosan results in decreased expression of MITF mRNA CTD PMID:30510588 urethane increases expression ISO RGD:735982 6480464 Urethane results in increased expression of MITF mRNA CTD PMID:28818685 valproic acid affects expression EXP 6480464 Valproic Acid affects the expression of MITF mRNA CTD PMID:17963808 valproic acid decreases expression ISO RGD:735982 6480464 Valproic Acid results in decreased expression of MITF mRNA CTD PMID:23179753 , PMID:27188386 valproic acid multiple interactions ISO RGD:735982 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MITF mRNA CTD PMID:27188386 valproic acid increases expression ISO RGD:735982 6480464 Valproic Acid results in increased expression of MITF mRNA CTD PMID:19101580 more ... vemurafenib affects expression ISO RGD:735982 6480464 vemurafenib affects the expression of MITF protein CTD PMID:26640592 vinclozolin decreases expression ISO RGD:3092 6480464 vinclozolin results in decreased expression of MITF mRNA CTD PMID:22615374 vorinostat multiple interactions ISO RGD:735982 6480464 [NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MITF mRNA CTD PMID:27188386 zinc atom decreases expression ISO RGD:3092 6480464 Zinc deficiency results in decreased expression of MITF protein CTD PMID:21893222 zinc(0) decreases expression ISO RGD:3092 6480464 Zinc deficiency results in decreased expression of MITF protein CTD PMID:21893222
Biological Process bone remodeling IMP MGI:MGI:1856095 2290270 (MGI:MGI:2180980, PMID:12086670) MGI MGI:MGI:2180980 , PMID:12086670 camera-type eye development IGI MGI:MGI:88401 2290270 (MGI:MGI:3512656, PMID:15576400) MGI MGI:MGI:3512656 , PMID:15576400 canonical Wnt signaling pathway involved in negative regulation of apoptotic process IDA 2290270 (MGI:MGI:2386811, PMID:12235125) MGI MGI:MGI:2386811 , PMID:12235125 cell differentiation IMP MGI:MGI:1856094 2290270 (MGI:MGI:893238, PMID:9199364) MGI MGI:MGI:893238 , PMID:9199364 cell fate commitment IMP MGI:MGI:1856085 2290270 (MGI:MGI:3512656, PMID:15576400) MGI MGI:MGI:3512656 , PMID:15576400 melanocyte differentiation IGI MGI:MGI:88138 2290270 (MGI:MGI:2180980, PMID:12086670) MGI MGI:MGI:2180980 , PMID:12086670 melanocyte differentiation IBA MGI:MGI:104554 , PANTHER:PTN000000820 2290270 (PMID:21873635) GO_Central PMID:21873635 melanocyte differentiation IMP MGI:MGI:1856095 2290270 (MGI:MGI:2180980, PMID:12086670) MGI MGI:MGI:2180980 , PMID:12086670 melanocyte differentiation IMP MGI:MGI:1856088 2290270 (MGI:MGI:77000, PMID:2379821) MGI MGI:MGI:77000 , PMID:2379821 multicellular organism development IEA UniProtKB-KW:KW-0217 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 negative regulation of apoptotic process IMP MGI:MGI:1856095 2290270 (MGI:MGI:2180980, PMID:12086670) MGI MGI:MGI:2180980 , PMID:12086670 negative regulation of cell migration ISO UniProtKB:O75030 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 negative regulation of transcription by RNA polymerase II ISO UniProtKB:O75030 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 osteoclast differentiation IMP MGI:MGI:1856095 2290270 (MGI:MGI:2180980, PMID:12086670) MGI MGI:MGI:2180980 , PMID:12086670 pigmentation IGI MGI:MGI:88138 2290270 (MGI:MGI:2180980, PMID:12086670) MGI MGI:MGI:2180980 , PMID:12086670 pigmentation IMP MGI:MGI:1856088 2290270 (MGI:MGI:77000, PMID:2379821) MGI MGI:MGI:77000 , PMID:2379821 pigmentation IMP MGI:MGI:1856095 2290270 (MGI:MGI:2180980, PMID:12086670) MGI MGI:MGI:2180980 , PMID:12086670 positive regulation of DNA-templated transcription, initiation ISO UniProtKB:O75030 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 positive regulation of gene expression ISO UniProtKB:O75030 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 positive regulation of transcription by RNA polymerase II ISS 2290270 (MGI:MGI:2180980, PMID:12086670) MGI MGI:MGI:2180980 , PMID:12086670 positive regulation of transcription by RNA polymerase II IDA 2290270 (MGI:MGI:3529668 more ... NTNU_SB MGI:MGI:3529668 more ... positive regulation of transcription by RNA polymerase II ISO UniProtKB:O75030 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 positive regulation of transcription by RNA polymerase II IGI MGI:MGI:98358 2290270 (MGI:MGI:3530428, PMID:15729346) MGI MGI:MGI:3530428 , PMID:15729346 positive regulation of transcription by RNA polymerase II IGI UniProtKB:Q9R0G7 2290270 (MGI:MGI:5574413, PMID:24769727) BHF-UCL MGI:MGI:5574413 , PMID:24769727 positive regulation of transcription, DNA-templated IDA 2290270 (MGI:MGI:2679126, PMID:14575687) MGI MGI:MGI:2679126 , PMID:14575687 positive regulation of transcription, DNA-templated ISO UniProtKB:O75030 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 protein-containing complex assembly ISO UniProtKB:O75030 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 regulation of cell population proliferation IDA 2290270 (MGI:MGI:2386811, PMID:12235125) MGI MGI:MGI:2386811 , PMID:12235125 regulation of gene expression IMP MGI:MGI:1856095 2290270 (MGI:MGI:2180980, PMID:12086670) MGI MGI:MGI:2180980 , PMID:12086670 regulation of osteoclast differentiation IMP MGI:MGI:1856085 2290270 (MGI:MGI:3041714, PMID:11930005) MGI MGI:MGI:3041714 , PMID:11930005 regulation of osteoclast differentiation IGI MGI:MGI:98511 2290270 (MGI:MGI:3041714, PMID:11930005) MGI MGI:MGI:3041714 , PMID:11930005 regulation of RNA biosynthetic process ISO UniProtKB:O75030 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 regulation of transcription by RNA polymerase II IMP 2290270 (MGI:MGI:5461240, PMID:23207919) UniProtKB MGI:MGI:5461240 , PMID:23207919 regulation of transcription by RNA polymerase II IDA 2290270 (MGI:MGI:2386811, PMID:12235125) MGI MGI:MGI:2386811 , PMID:12235125 regulation of transcription, DNA-templated ISO UniProtKB:O75030 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 transcription, DNA-templated ISO RGD:3092 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 Wnt signaling pathway IDA 2290270 (MGI:MGI:2386811, PMID:12235125) MGI MGI:MGI:2386811 , PMID:12235125 Cellular Component nucleus IC GO:0003700 2290270 (MGI:MGI:2679126, PMID:14575687) MGI MGI:MGI:2679126 , PMID:14575687 nucleus ISO UniProtKB:O75030 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 nucleus IDA 2290270 (MGI:MGI:2386811, PMID:12235125) MGI MGI:MGI:2386811 , PMID:12235125 protein-containing complex ISO UniProtKB:O75030 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 Molecular Function chromatin binding IDA 2290270 (MGI:MGI:3530428, PMID:15729346) MGI MGI:MGI:3530428 , PMID:15729346 DNA binding IDA 2290270 (MGI:MGI:2679126, PMID:14575687) MGI MGI:MGI:2679126 , PMID:14575687 DNA-binding transcription activator activity, RNA polymerase II-specific ISO UniProtKB:O75030 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 DNA-binding transcription activator activity, RNA polymerase II-specific IDA 2290270 (MGI:MGI:3529668, PMID:15716956) NTNU_SB MGI:MGI:3529668 , PMID:15716956 DNA-binding transcription factor activity IDA 2290270 (MGI:MGI:2386811 more ... MGI MGI:MGI:2386811 more ... DNA-binding transcription factor activity, RNA polymerase II-specific IDA 2290270 (MGI:MGI:3530428, PMID:15729346) MGI MGI:MGI:3530428 , PMID:15729346 DNA-binding transcription factor activity, RNA polymerase II-specific IMP 2290270 (MGI:MGI:5461240, PMID:23207919) UniProtKB MGI:MGI:5461240 , PMID:23207919 E-box binding ISO UniProtKB:O75030 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 E-box binding IDA 2290270 (MGI:MGI:5461240, PMID:23207919) UniProtKB MGI:MGI:5461240 , PMID:23207919 protein binding IPI UniProtKB:O54714 2290270 (MGI:MGI:3836131, PMID:17442941) MGI MGI:MGI:3836131 , PMID:17442941 protein dimerization activity IPI UniProtKB:Q08874 2290270 (MGI:MGI:5461240, PMID:23207919) UniProtKB MGI:MGI:5461240 , PMID:23207919 RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO UniProtKB:O75030 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA 2290270 (MGI:MGI:3529668 more ... NTNU_SB MGI:MGI:3529668 more ... sequence-specific DNA binding ISA UniProtKB:P10415 2290270 (MGI:MGI:2180980, PMID:12086670) MGI MGI:MGI:2180980 , PMID:12086670
Gene-Chemical Interaction Annotations
