Tnfrsf22 (tumor necrosis factor receptor superfamily, member 22) - Rat Genome Database

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Gene: Tnfrsf22 (tumor necrosis factor receptor superfamily, member 22) Rattus norvegicus
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Symbol: Tnfrsf22
Name: tumor necrosis factor receptor superfamily, member 22
RGD ID: 1586688
Description: Predicted to enable TRAIL binding activity. Predicted to act upstream of or within negative regulation of extrinsic apoptotic signaling pathway via death domain receptors. Predicted to be located in external side of plasma membrane. Orthologous to human TNFRSF10C (TNF receptor superfamily member 10c); PARTICIPATES IN Trail mediated signaling pathway; INTERACTS WITH 6-propyl-2-thiouracil; amitrole; methimazole.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC686008; similar to Tumor necrosis factor receptor superfamily member 22 (Tumor necrosis factor receptor p60 homolog 2) (TNF receptor family member SOBa) (Decoy TRAIL receptor 2) (TNF receptor homolog 2); tumor necrosis factor receptor superfamily member 22-like; tumor necrosis factor receptor superfamily member 23-like
RGD Orthologs
Human
Mouse
Bonobo
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81208,269,844 - 208,285,823 (-)NCBIGRCr8
mRatBN7.21198,840,452 - 198,860,713 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1198,840,453 - 198,856,309 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01216,845,789 - 216,859,606 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01223,705,592 - 223,719,409 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41204,033,555 - 204,035,482 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1196,407,550 - 196,419,882 (-)NCBICelera
Cytogenetic Map1q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
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Term
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Reference
Notes
Source
Original Reference(s)
Tnfrsf22RatCOVID-19  ISORGD:13502849068941mRNA:decreased expression:peripheral blood mononuclear cell (human)RGDPMID:32228226|REF_RGD_ID:28912744
Object Symbol
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Term
Qualifier
Evidence
With
Reference
Notes
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Original Reference(s)
Tnfrsf22RatConotruncal Cardiac Defects  ISORGD:13502848554872ClinVar Annotator: match by term: Conotruncal heart malformationsClinVarPMID:28492532
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tnfrsf22Ratjuvenile rheumatoid arthritis  ISORGD:135028411554173CTD Direct Evidence: marker/mechanismCTDPMID:19565504

1 to 20 of 87 rows

  
Object Symbol
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Term
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Evidence
With
Reference
Notes
Source
Original Reference(s)
Tnfrsf22Rat(1->4)-beta-D-glucan multiple interactionsISORGD:16142556480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of TNFRSF22 mRNACTDPMID:36331819
Tnfrsf22Rat17beta-estradiol multiple interactionsISORGD:13502846480464[Estradiol co-treated with TGFB1 protein] results in decreased expression of TNFRSF10C mRNACTDPMID:30165855
Tnfrsf22Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISORGD:16142556480464Tetrachlorodibenzodioxin affects the expression of TNFRSF22 mRNACTDPMID:21570461|PMID:26377647
Tnfrsf22Rat3-methylcholanthrene increases expressionISORGD:16142556480464Methylcholanthrene results in increased expression of TNFRSF22 mRNACTDPMID:20713471
Tnfrsf22Rat4,4'-sulfonyldiphenol increases methylationISORGD:13502846480464bisphenol S results in increased methylation of TNFRSF10C promoterCTDPMID:30616060
Tnfrsf22Rat5-fluorouracil increases expressionISORGD:13502846480464Fluorouracil results in increased expression of TNFRSF10C proteinCTDPMID:15585621
Tnfrsf22Rat6-propyl-2-thiouracil increases expressionEXP 6480464Propylthiouracil results in increased expression of TNFRSF22 mRNACTDPMID:30047161
Tnfrsf22Ratactinomycin D multiple interactionsISORGD:13502846480464[Dactinomycin co-treated with nutlin 3] results in increased expression of TNFRSF10C mRNACTDPMID:38460933
Tnfrsf22Rataflatoxin B1 increases expressionISORGD:13502846480464Aflatoxin B1 results in increased expression of TNFRSF10C mRNACTDPMID:22100608|PMID:27153756
Tnfrsf22Rataflatoxin B1 decreases expressionISORGD:13502846480464Aflatoxin B1 results in decreased expression of TNFRSF10C mRNACTDPMID:22100608
Tnfrsf22Ratall-trans-retinoic acid increases expressionISORGD:13502846480464Tretinoin results in increased expression of TNFRSF10C mRNA; Tretinoin results in increased expression of TNFRSF10C more ...CTDPMID:16242776|PMID:33167477
Tnfrsf22Ratamitrole increases expressionEXP 6480464Amitrole results in increased expression of TNFRSF22 mRNACTDPMID:30047161
Tnfrsf22Ratantirheumatic drug decreases expressionISORGD:13502846480464Antirheumatic Agents results in decreased expression of TNFRSF10C mRNACTDPMID:17696278|PMID:24449571
Tnfrsf22Rataripiprazole multiple interactionsISORGD:13502846480464Aripiprazole inhibits the reaction [Ozone results in decreased expression of TNFRSF10C mRNA]CTDPMID:31476115
Tnfrsf22Ratarsane multiple interactionsISORGD:13502846480464[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of TNFRSF10C more ...CTDPMID:39836092
Tnfrsf22Ratarsenic atom multiple interactionsISORGD:13502846480464[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of TNFRSF10C more ...CTDPMID:39836092
Tnfrsf22Ratarsenite(3-) increases methylationISORGD:13502846480464arsenite results in increased methylation of TNFRSF10C promoterCTDPMID:23974009
Tnfrsf22Ratarsenous acid multiple interactionsISORGD:13502846480464[Arsenic Trioxide co-treated with Curcumin] results in increased expression of TNFRSF10C proteinCTDPMID:27430728
Tnfrsf22Ratbenzo[a]pyrene increases expressionISORGD:16142556480464Benzo(a)pyrene results in increased expression of TNFRSF22 mRNACTDPMID:15034205
Tnfrsf22Ratbenzo[a]pyrene affects methylationISORGD:13502846480464Benzo(a)pyrene affects the methylation of TNFRSF10C promoterCTDPMID:27901495

1 to 20 of 87 rows

Biological Process

  
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Original Reference(s)
Tnfrsf22Ratnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors acts_upstream_of_or_withinISORGD:16142551624291 PMID:12466268RGDPMID:12466268

Cellular Component

  
Object Symbol
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Notes
Source
Original Reference(s)
Tnfrsf22Ratexternal side of plasma membrane located_inISORGD:16142551624291 PMID:12466268RGDPMID:12466268
Tnfrsf22Ratmembrane located_inIEAUniProtKB-SubCell:SL-01621600115GO_REF:0000044UniProtGO_REF:0000044
Tnfrsf22Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tnfrsf22Ratprotein binding enablesISORGD:16142551624291PR:P50592 PMID:12466268RGDPMID:12466268
Tnfrsf22Ratprotein binding enablesISORGD:13502841624291UniProtKB:O14863|UniProtKB:O43765|UniProtKB:O60883|UniProtKB:O75208|UniProtKB:O95279|UniProtKB:P00387|UniProtKB:P10620|UniProtKB:P11912|UniProtKB:P27105|UniProtKB:P48051|UniProtKB:Q13113|UniProtKB:Q13520|UniProtKB:Q3SXY8|UniProtKB:Q5JX71|UniProtKB:Q8TDT2|UniProtKB:Q8WWH4|UniProtKB:Q96A49|UniProtKB:Q96B21|UniProtKB:Q96BA8|UniProtKB:Q96HE8|UniProtKB:Q96KC8|UniProtKB:Q9Y282|UniProtKB:Q9Y676 PMID:32296183RGDPMID:32296183
Tnfrsf22RatTRAIL binding enablesISORGD:16142551624291 PMID:12466268RGDPMID:12466268

Imported Annotations - PID (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tnfrsf22RatTrail mediated signaling pathway   ISORGD:13502849068941 PIDPID:200068

#
Reference Title
Reference Citation
1. GOA pipeline RGD automated data pipeline
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:12466268  



Tnfrsf22
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81208,269,844 - 208,285,823 (-)NCBIGRCr8
mRatBN7.21198,840,452 - 198,860,713 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1198,840,453 - 198,856,309 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01216,845,789 - 216,859,606 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01223,705,592 - 223,719,409 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41204,033,555 - 204,035,482 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1196,407,550 - 196,419,882 (-)NCBICelera
Cytogenetic Map1q42NCBI
TNFRSF10C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38823,102,921 - 23,117,445 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl823,102,921 - 23,117,445 (+)EnsemblGRCh38hg38GRCh38
GRCh37822,960,434 - 22,974,958 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36823,016,379 - 23,030,895 (+)NCBINCBI36Build 36hg18NCBI36
Build 34823,016,378 - 23,030,893NCBI
Celera821,922,846 - 21,937,471 (+)NCBICelera
Cytogenetic Map8p21.3NCBI
HuRef821,504,474 - 21,519,103 (+)NCBIHuRef
CHM1_1823,162,395 - 23,177,021 (+)NCBICHM1_1
T2T-CHM13v2.0823,377,859 - 23,392,387 (+)NCBIT2T-CHM13v2.0
Tnfrsf22
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397143,188,540 - 143,203,412 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7143,188,543 - 143,203,398 (-)EnsemblGRCm39 Ensembl
GRCm387143,634,808 - 143,649,675 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7143,634,806 - 143,649,661 (-)EnsemblGRCm38mm10GRCm38
MGSCv377150,822,630 - 150,835,543 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367143,446,115 - 143,459,028 (-)NCBIMGSCv36mm8
Celera7143,392,418 - 143,405,331 (-)NCBICelera
Cytogenetic Map7F5NCBI
cM Map788.27NCBI
TNFRSF10C
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2741,589,266 - 41,627,205 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1817,334,063 - 17,349,852 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0822,352,777 - 22,368,737 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1819,292,020 - 19,307,726 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl819,292,020 - 19,307,719 (+)Ensemblpanpan1.1panPan2

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Variants in Tnfrsf22
114 total Variants

Predicted Target Of
Summary Value
Count of predictions:85
Count of miRNA genes:66
Interacting mature miRNAs:75
Transcripts:ENSRNOT00000054861, ENSRNOT00000058309, ENSRNOT00000072999
Prediction methods:Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 93 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1197814409242814409Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2302375Bw83Body weight QTL 834.870.0002body mass (VT:0001259)body weight (CMO:0000012)1197697768242697768Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1171629477216629477Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1171629477216629477Rat

1 to 10 of 93 rows






Ensembl Acc Id: ENSRNOT00000096469   ⟹   ENSRNOP00000096781
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1198,841,443 - 198,856,309 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000109409   ⟹   ENSRNOP00000082183
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1198,840,453 - 198,856,309 (-)Ensembl
RefSeq Acc Id: XM_006230917   ⟹   XP_006230979
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81208,269,844 - 208,285,704 (-)NCBI
mRatBN7.21198,840,452 - 198,860,710 (-)NCBI
Rnor_6.01216,845,789 - 216,859,606 (-)NCBI
Rnor_5.01223,705,592 - 223,719,409 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039101294   ⟹   XP_038957222
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81208,269,844 - 208,285,823 (-)NCBI
mRatBN7.21198,840,452 - 198,860,710 (-)NCBI
RefSeq Acc Id: XM_039101295   ⟹   XP_038957223
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81208,269,844 - 208,285,704 (-)NCBI
mRatBN7.21198,840,452 - 198,860,713 (-)NCBI
Protein RefSeqs XP_006230979 (Get FASTA)   NCBI Sequence Viewer  
  XP_038957222 (Get FASTA)   NCBI Sequence Viewer  
  XP_038957223 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000082183
  ENSRNOP00000082183.1
  ENSRNOP00000096781.1
RefSeq Acc Id: XP_006230979   ⟸   XM_006230917
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZU03 (UniProtKB/TrEMBL),   A0A8I6GM86 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038957223   ⟸   XM_039101295
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038957222   ⟸   XM_039101294
- Peptide Label: isoform X2
- UniProtKB: A0A8I6GM86 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000082183   ⟸   ENSRNOT00000109409
Ensembl Acc Id: ENSRNOP00000096781   ⟸   ENSRNOT00000096469
TNFR-Cys


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 20 of 20 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-56861 BioCyc
Ensembl Genes ENSRNOG00000070689 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000096469.1 UniProtKB/TrEMBL
  ENSRNOT00000109409 ENTREZGENE
  ENSRNOT00000109409.1 UniProtKB/TrEMBL
Gene3D-CATH Tumor Necrosis Factor Receptor, subunit A, domain 2 UniProtKB/TrEMBL
InterPro TNFR/NGFR_Cys_rich_reg UniProtKB/TrEMBL
  TNFRSF10 UniProtKB/TrEMBL
NCBI Gene 686008 ENTREZGENE
PANTHER TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 10B UniProtKB/TrEMBL
  TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 22 UniProtKB/TrEMBL
Pfam TNFR_c6 UniProtKB/TrEMBL
PhenoGen Tnfrsf22 PhenoGen
PROSITE TNFR_NGFR_1 UniProtKB/TrEMBL
  TNFR_NGFR_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000070689 RatGTEx
SMART TNFR UniProtKB/TrEMBL
Superfamily-SCOP TNF receptor-like UniProtKB/TrEMBL
UniProt A0A8I5ZU03 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GM86 ENTREZGENE, UniProtKB/TrEMBL
1 to 20 of 20 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-02-10 Tnfrsf22  tumor necrosis factor receptor superfamily, member 22  Tnfrsf22  tumor necrosis factor receptor superfamily, member 22  Data merged from RGD:149736337 737654 PROVISIONAL
2021-08-09 Tnfrsf22  tumor necrosis factor receptor superfamily, member 22      Symbol and Name status set to provisional 45752 PROVISIONAL
2008-03-05 Tnfrsf22  tumor necrosis factor receptor superfamily, member 22  LOC686008  similar to Tumor necrosis factor receptor superfamily member 22 (Tumor necrosis factor receptor p60 homolog 2) (TNF receptor family member SOBa) (Decoy TRAIL receptor 2) (TNF receptor homolog 2)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC686008  similar to Tumor necrosis factor receptor superfamily member 22 (Tumor necrosis factor receptor p60 homolog 2) (TNF receptor family member SOBa) (Decoy TRAIL receptor 2) (TNF receptor homolog 2)      Symbol and Name status set to provisional 70820 PROVISIONAL