Akr1c2 (aldo-keto reductase family 1, member C2) - Rat Genome Database

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Gene: Akr1c2 (aldo-keto reductase family 1, member C2) Rattus norvegicus
Analyze
Symbol: Akr1c2
Name: aldo-keto reductase family 1, member C2
RGD ID: 1311841
Description: Predicted to enable several functions, including NADP binding activity; ketosteroid monooxygenase activity; and steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Predicted to be involved in several processes, including cellular response to prostaglandin D stimulus; glycoside metabolic process; and positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in 46,XY sex reversal 8. Orthologous to human AKR1C2 (aldo-keto reductase family 1 member C2); INTERACTS WITH (+)-schisandrin B; 3,3',4,4',5-pentachlorobiphenyl; 3,4,5,3',4',5'-Hexachlorobiphenyl.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 17-alpha-HSD; 17-alpha-hydroxysteroid dehydrogenase; 3(17)alpha-hydroxysteroid dehydrogenase; 3(or 17)-alpha-hydroxysteroid dehydrogenase; 3-alpha-hydroxysteroid dehydrogenase; Akr1c21; aldo-keto reductase family 1 member C21; aldo-keto reductase family 1, member C21; LOC291283; RAKg
RGD Orthologs
Human
Mouse
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81770,669,684 - 70,717,935 (-)NCBIGRCr8
mRatBN7.21765,759,778 - 65,808,013 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1765,759,788 - 65,775,764 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1769,255,523 - 69,303,728 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01773,084,375 - 73,132,581 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01767,127,357 - 67,175,563 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01769,388,337 - 69,435,160 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1769,388,335 - 69,404,341 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01771,102,094 - 71,148,911 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41777,034,737 - 77,081,406 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11777,045,579 - 77,092,239 (-)NCBI
Celera1765,292,033 - 65,339,839 (-)NCBICelera
Cytogenetic Map17q12.2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
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Original Reference(s)
Akr1c2Ratobesity  ISORGD:13539019068941mRNA, protein:increased expression:adipose tissueRGDPMID:15494612|REF_RGD_ID:1626148
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Original Reference(s)
Akr1c2Rat46,XY sex reversal 8  ISORGD:13539018554872ClinVar Annotator: match by term: 46,XY sex reversal 8 | ClinVar Annotator: match by term: more ...ClinVarPMID:21802064|PMID:25741868|PMID:28106320|PMID:4352099
Akr1c2RatCIC-rearranged sarcoma  ISORGD:13539018554872ClinVar Annotator: match by term: CIC-rearranged sarcomaClinVarPMID:21802064
Akr1c2Rathypoparathyroidism-deafness-renal disease syndrome  ISORGD:13539018554872ClinVar Annotator: match by term: Hypoparathyroidism, deafness, renal disease syndromeClinVarPMID:25741868
Akr1c2Ratschizophrenia  ISORGD:13539018554872ClinVar Annotator: match by term: SchizophreniaClinVarPMID:21681106|PMID:30208311
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Original Reference(s)
Akr1c2Rat46,XY sex reversal 8  ISORGD:135390111554173CTD Direct Evidence: marker/mechanismCTD 
Akr1c2Ratautism spectrum disorder  ISORGD:135390111554173CTD Direct Evidence: marker/mechanismCTDPMID:35663546
Akr1c2Ratcontact dermatitis  ISORGD:135390111554173CTD Direct Evidence: marker/mechanismCTDPMID:25724174
Akr1c2Ratdisorder of sexual development  ISORGD:135390111554173CTD Direct Evidence: marker/mechanismCTDPMID:25304492
Akr1c2Ratendometriosis  ISORGD:135390111554173CTD Direct Evidence: marker/mechanismCTDPMID:21232532
Akr1c2Rathepatocellular carcinoma  ISORGD:135390111554173CTD Direct Evidence: marker/mechanismCTDPMID:21472284
Akr1c2RatNeoplasms, Hormone-Dependent  ISORGD:135390111554173CTD Direct Evidence: marker/mechanismCTDPMID:25304492
Akr1c2RatNeoplastic Cell Transformation  ISORGD:135390111554173CTD Direct Evidence: marker/mechanismCTDPMID:19696165
Akr1c2Ratosteoarthritis  ISORGD:135390111554173CTD Direct Evidence: marker/mechanismCTDPMID:18784066
Akr1c2Ratpolycystic ovary syndrome  ISORGD:135390111554173CTD Direct Evidence: marker/mechanismCTDPMID:22381227
Akr1c2RatWeight Gain  ISORGD:135390111554173CTD Direct Evidence: marker/mechanismCTDPMID:25322899
1 to 11 of 11 rows
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Original Reference(s)
Akr1c2Rat46,XY sex reversal 8  ISORGD:13539017240710 OMIM 

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Original Reference(s)
Akr1c2Rat(+)-schisandrin B multiple interactionsEXP 6480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of AKR1C2 mRNA]CTDPMID:31150632
Akr1c2Rat(-)-epigallocatechin 3-gallate increases expressionISORGD:13539016480464epigallocatechin gallate results in increased expression of AKR1C2 mRNACTDPMID:32512070
Akr1c2Rat(20S)-20-hydroxypregn-4-en-3-one increases chemical synthesisISORGD:13539016480464AKR1C2 protein results in increased chemical synthesis of 20-alpha-DihydroprogesteroneCTDPMID:11158055
Akr1c2Rat(E)-cinnamyl alcohol increases activityISORGD:13539016480464cinnamyl alcohol results in increased activity of AKR1C2 promoterCTDPMID:21195160
Akr1c2Rat1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane increases expressionISORGD:13539016480464o,p'-DDT results in increased expression of AKR1C2 mRNACTDPMID:18204070
Akr1c2Rat1,10-phenanthroline decreases activityISORGD:135390164804641,10-phenanthroline results in decreased activity of AKR1C2 proteinCTDPMID:12604236
Akr1c2Rat1,2-dimethylhydrazine increases expressionISORGD:132351064804641,2-Dimethylhydrazine results in increased expression of AKR1C21 mRNACTDPMID:22206623
Akr1c2Rat1,3-benzothiazole-2-thiol increases activityISORGD:13539016480464captax results in increased activity of AKR1C2 promoterCTDPMID:21195160
Akr1c2Rat1,3-benzothiazole-2-thiol increases expressionISORGD:13539016480464captax results in increased expression of AKR1C2 mRNACTDPMID:20491607|PMID:20713136
Akr1c2Rat1,4-benzoquinone increases expressionISORGD:13539016480464quinone results in increased expression of AKR1C2 mRNACTDPMID:20491607
Akr1c2Rat1,4-phenylenediamine increases activityISORGD:135390164804644-phenylenediamine results in increased activity of AKR1C2 promoterCTDPMID:21195160
Akr1c2Rat1,4-phenylenediamine increases expressionISORGD:135390164804644-phenylenediamine results in increased expression of AKR1C2 mRNACTDPMID:20491607|PMID:25724174
Akr1c2Rat1-chloro-2,4-dinitrobenzene increases activityISORGD:13539016480464Dinitrochlorobenzene results in increased activity of AKR1C2 promoterCTDPMID:21195160
Akr1c2Rat1-chloro-2,4-dinitrobenzene increases expressionISORGD:13539016480464Dinitrochlorobenzene results in increased expression of AKR1C2 mRNACTDPMID:20491607|PMID:20713136
Akr1c2Rat1-phenyl-1,2-propanedione increases expressionISORGD:135390164804641-phenyl-1,2-propanedione results in increased expression of AKR1C2 mRNACTDPMID:20491607
Akr1c2Rat17alpha-ethynylestradiol affects expressionISORGD:13235106480464Ethinyl Estradiol affects the expression of AKR1C21 mRNACTDPMID:17555576
Akr1c2Rat17beta-estradiol increases expressionISORGD:13539016480464Estradiol results in increased expression of AKR1C2 mRNACTDPMID:19619570
Akr1c2Rat17beta-estradiol multiple interactionsISORGD:13539016480464[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of AKR1C2 mRNACTDPMID:19619570
Akr1c2Rat17beta-hydroxy-5alpha-androstan-3-one multiple interactionsISORGD:13539016480464AKR1C2 protein results in increased metabolism of and results in decreased activity of Dihydrotestosterone; Flufenamic more ...CTDPMID:14672942|PMID:17170221
Akr1c2Rat17beta-hydroxy-5alpha-androstan-3-one increases metabolic processingISORGD:13539016480464AKR1C2 protein results in increased metabolism of DihydrotestosteroneCTDPMID:14672942|PMID:22245609

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Biological Process
1 to 20 of 20 rows

  
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Original Reference(s)
Akr1c2Ratcellular response to jasmonic acid stimulus involved_inISORGD:13539011624291 PMID:19487289RGDPMID:19487289
Akr1c2Ratcellular response to prostaglandin D stimulus involved_inISORGD:13539011624291 PMID:18508192RGDPMID:18508192
Akr1c2Ratdaunorubicin metabolic process involved_inISORGD:13539011624291 PMID:20837989RGDPMID:20837989
Akr1c2Ratdaunorubicin metabolic process involved_inIBAPANTHER:PTN000199031|UniProtKB:P17516|UniProtKB:P42330|UniProtKB:P52895|UniProtKB:Q048281600115GO_REF:0000033GO_CentralGO_REF:0000033
Akr1c2Ratdigestion involved_inISORGD:13539011624291 PMID:8573067RGDPMID:8573067
Akr1c2Ratdoxorubicin metabolic process involved_inISORGD:13539011624291 PMID:20837989RGDPMID:20837989
Akr1c2Ratdoxorubicin metabolic process involved_inIBAPANTHER:PTN000199031|UniProtKB:P17516|UniProtKB:P42330|UniProtKB:P52895|UniProtKB:Q048281600115GO_REF:0000033GO_CentralGO_REF:0000033
Akr1c2Ratepithelial cell differentiation involved_inISORGD:13539011624291 PMID:21492153RGDPMID:21492153
Akr1c2RatG protein-coupled receptor signaling pathway involved_inISORGD:13539011624291 PMID:18508192RGDPMID:18508192
Akr1c2Ratlipid metabolic process involved_inIEAUniProtKB-KW:KW-04431600115GO_REF:0000043UniProtGO_REF:0000043
Akr1c2Ratpositive regulation of cell population proliferation involved_inISORGD:13539011624291 PMID:18508192RGDPMID:18508192
Akr1c2Ratpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction involved_inISORGD:13539011624291 PMID:18508192RGDPMID:18508192
Akr1c2Ratprogesterone metabolic process involved_inISORGD:13539011624291 PMID:21232532RGDPMID:21232532
Akr1c2Ratprogesterone metabolic process involved_inIBAMGI:2145420|PANTHER:PTN000199031|RGD:708428|UniProtKB:P42330|UniProtKB:P52895|UniProtKB:Q048281600115GO_REF:0000033GO_CentralGO_REF:0000033
Akr1c2Ratprostaglandin metabolic process involved_inISORGD:13539011624291 PMID:8573067RGDPMID:8573067
Akr1c2Ratprostaglandin metabolic process involved_inIBAPANTHER:PTN000199031|UniProtKB:P42330|UniProtKB:P528951600115GO_REF:0000033GO_CentralGO_REF:0000033
Akr1c2Ratsteroid metabolic process involved_inIEAUniProtKB:Q91WR5|ensembl:ENSMUSP000000216281600115GO_REF:0000107EnsemblGO_REF:0000107
Akr1c2Ratsteroid metabolic process involved_inISORGD:13235101624291 PMID:20124700RGDPMID:20124700
Akr1c2Ratsteroid metabolic process involved_inIEAUniProtKB-KW:KW-07531600115GO_REF:0000043UniProtGO_REF:0000043
Akr1c2Ratsteroid metabolic process involved_inISORGD:13539011624291 PMID:8573067RGDPMID:8573067
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Cellular Component

  
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Original Reference(s)
Akr1c2Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Akr1c2Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Akr1c2Ratcytosol is_active_inIBAMGI:1353494|MGI:1929955|PANTHER:PTN000198921|RGD:708428|SGD:S000000353|UniProtKB:C9JRZ8|UniProtKB:P15121|UniProtKB:P51857|UniProtKB:Q04828|UniProtKB:Q46857|dictyBase:DDB_G02938501600115GO_REF:0000033GO_CentralGO_REF:0000033

Molecular Function
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Original Reference(s)
Akr1c2Rat17-beta-hydroxysteroid dehydrogenase (NADP+) activity enablesIEAUniProtKB:Q91WR5|ensembl:ENSMUSP000000216281600115GO_REF:0000107EnsemblGO_REF:0000107
Akr1c2Rat17-beta-hydroxysteroid dehydrogenase (NADP+) activity enablesISORGD:13235101624291 PMID:20124700RGDPMID:20124700
Akr1c2Rat5-alpha-androstane-3-beta,17-beta-diol dehydrogenase (NADP+) activity enablesIEAUniProtKB:Q91WR5|ensembl:ENSMUSP000000216281600115GO_REF:0000107EnsemblGO_REF:0000107
Akr1c2Rat5-alpha-androstane-3-beta,17-beta-diol dehydrogenase (NADP+) activity enablesISORGD:13235101624291 PMID:20124700RGDPMID:20124700
Akr1c2Rataldose reductase (NADPH) activity enablesISORGD:13539011624291 PMID:21232532RGDPMID:21232532
Akr1c2Rataldose reductase (NADPH) activity enablesIBAFB:FBgn0086254|MGI:1353494|MGI:1929955|PANTHER:PTN000198921|RGD:1308277|RGD:2092|RGD:708428|SGD:S000001146|SGD:S000002282|SGD:S000002776|SGD:S000003857|SGD:S000005646|UniProtKB:P15121|UniProtKB:P42330|UniProtKB:P52895|UniProtKB:Q04828|dictyBase:DDB_G02938501600115GO_REF:0000033GO_CentralGO_REF:0000033
Akr1c2Ratandrosterone dehydrogenase [NAD(P)+] activity enablesIEAUniProtKB:Q91WR5|ensembl:ENSMUSP000000216281600115GO_REF:0000107EnsemblGO_REF:0000107
Akr1c2Ratandrosterone dehydrogenase [NAD(P)+] activity enablesIEAEC:1.1.1.2091600115GO_REF:0000003UniProtGO_REF:0000003
Akr1c2Ratandrosterone dehydrogenase [NAD(P)+] activity enablesISORGD:13235101624291 PMID:15577209, PMID:20124700RGDPMID:15577209|PMID:20124700
Akr1c2Ratandrosterone dehydrogenase [NAD(P)+] activity enablesIBAMGI:1924587|MGI:2145458|PANTHER:PTN000199031|UniProtKB:P17516|UniProtKB:P42330|UniProtKB:Q048281600115GO_REF:0000033GO_CentralGO_REF:0000033
Akr1c2Ratandrosterone dehydrogenase [NAD(P)+] activity enablesIEARHEA:20377|RHEA:203811600115GO_REF:0000116RHEAGO_REF:0000116
Akr1c2Ratbile acid binding enablesISORGD:13539011624291 PMID:8573067RGDPMID:8573067
Akr1c2Ratbile acid binding enablesIBAMGI:1924587|PANTHER:PTN000199031|UniProtKB:P52895|UniProtKB:Q048281600115GO_REF:0000033GO_CentralGO_REF:0000033
Akr1c2Ratcarboxylic acid binding enablesISORGD:13539011624291 PMID:8573067RGDPMID:8573067
Akr1c2Ratketosteroid monooxygenase activity enablesISORGD:13539011624291 PMID:21232532RGDPMID:21232532
Akr1c2Ratketosteroid monooxygenase activity enablesIBAPANTHER:PTN000199026|UniProtKB:P42330|UniProtKB:P52895|UniProtKB:Q048281600115GO_REF:0000033GO_CentralGO_REF:0000033
Akr1c2Ratlithocholic acid binding enablesIEAUniProtKB:Q91WR5|ensembl:ENSMUSP000000216281600115GO_REF:0000107EnsemblGO_REF:0000107
Akr1c2Ratlithocholic acid binding enablesISORGD:13235101624291 PMID:20124700RGDPMID:20124700
Akr1c2RatNADP+ binding enablesISORGD:13235101624291 PMID:20124700RGDPMID:20124700
Akr1c2RatNADP+ binding enablesIEAUniProtKB:Q91WR5|ensembl:ENSMUSP000000216281600115GO_REF:0000107EnsemblGO_REF:0000107
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#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
PMID:8573067   PMID:15577209   PMID:17034817   PMID:17442338   PMID:18508192   PMID:19487289   PMID:20124700   PMID:20837989   PMID:21232532   PMID:21492153   PMID:21851338  



Akr1c2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81770,669,684 - 70,717,935 (-)NCBIGRCr8
mRatBN7.21765,759,778 - 65,808,013 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1765,759,788 - 65,775,764 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1769,255,523 - 69,303,728 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01773,084,375 - 73,132,581 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01767,127,357 - 67,175,563 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01769,388,337 - 69,435,160 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1769,388,335 - 69,404,341 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01771,102,094 - 71,148,911 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41777,034,737 - 77,081,406 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11777,045,579 - 77,092,239 (-)NCBI
Celera1765,292,033 - 65,339,839 (-)NCBICelera
Cytogenetic Map17q12.2NCBI
AKR1C2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38104,987,775 - 5,018,000 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl104,987,775 - 5,018,031 (-)EnsemblGRCh38hg38GRCh38
GRCh37105,029,967 - 5,060,192 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36105,021,965 - 5,050,207 (-)NCBINCBI36Build 36hg18NCBI36
Build 34105,021,965 - 5,050,207NCBI
Celera104,972,245 - 5,000,184 (-)NCBICelera
Cytogenetic Map10p15.1NCBI
HuRef104,920,321 - 4,955,422 (+)NCBIHuRef
CHM1_1105,030,308 - 5,060,576 (-)NCBICHM1_1
T2T-CHM13v2.0104,988,109 - 5,018,344 (-)NCBIT2T-CHM13v2.0
Akr1c21
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39134,624,074 - 4,636,542 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl134,624,074 - 4,636,540 (+)EnsemblGRCm39 Ensembl
GRCm38134,574,075 - 4,586,543 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl134,574,075 - 4,586,541 (+)EnsemblGRCm38mm10GRCm38
MGSCv37134,573,321 - 4,585,789 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36134,573,321 - 4,585,787 (+)NCBIMGSCv36mm8
Celera134,543,969 - 4,562,535 (+)NCBICelera
Cytogenetic Map13A1NCBI
cM Map132.56NCBI

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Variants in Akr1c2
110 total Variants

Predicted Target Of
Summary Value
Count of predictions:179
Count of miRNA genes:140
Interacting mature miRNAs:150
Transcripts:ENSRNOT00000051342, ENSRNOT00000066282
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


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The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
1358295Aocep1Aortic cell protein QTL 16.17e-07thoracic aorta cellular protein amount (VT:0010598)aortic cell percentage174099000585990005Rat
70210Cm15Cardiac mass QTL 156.5heart right ventricle mass (VT:0007033)heart right ventricle wet weight (CMO:0000072)175724672370156904Rat
152023626Bp403Blood pressure QTL 4033.86arterial blood pressure trait (VT:2000000)172393042179524188Rat
7411575Bw140Body weight QTL 14030.20.001body mass (VT:0001259)body weight gain (CMO:0000420)174856093586533673Rat
2301412Kidm40Kidney mass QTL 400.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)173747984782479847Rat
631502Cm26Cardiac mass QTL 263.71heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)176570358081153923Rat
1354588Bvd4Brain ventricular dilatation QTL 45.310.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)175349882882479847Rat
7411577Bw141Body weight QTL 1410.001body mass (VT:0001259)body weight gain (CMO:0000420)176261951686533673Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)172840914773409147Rat

1 to 10 of 44 rows



alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
5 10 12 41 56 55 31 20 31 6 113 49 24 20 33 24



Ensembl Acc Id: ENSRNOT00000051342   ⟹   ENSRNOP00000045355
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1765,759,788 - 65,775,764 (-)Ensembl
Rnor_6.0 Ensembl1769,388,347 - 69,404,323 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000066282   ⟹   ENSRNOP00000063166
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1765,759,788 - 65,775,764 (-)Ensembl
Rnor_6.0 Ensembl1769,388,335 - 69,404,341 (-)Ensembl
RefSeq Acc Id: NM_001013057   ⟹   NP_001013075
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81770,669,700 - 70,717,880 (-)NCBI
mRatBN7.21765,759,778 - 65,807,957 (-)NCBI
Rnor_6.01769,388,337 - 69,435,148 (-)NCBI
Rnor_5.01771,102,094 - 71,148,911 (-)NCBI
RGSC_v3.41777,034,737 - 77,081,406 (-)RGD
Celera1765,292,033 - 65,339,839 (-)RGD
Sequence:
RefSeq Acc Id: XM_006254183   ⟹   XP_006254245
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81770,669,684 - 70,717,935 (-)NCBI
mRatBN7.21765,759,895 - 65,808,013 (-)NCBI
Rnor_6.01769,388,374 - 69,435,160 (-)NCBI
Rnor_5.01771,102,094 - 71,148,911 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006254185   ⟹   XP_006254247
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81770,669,684 - 70,717,935 (-)NCBI
mRatBN7.21765,759,895 - 65,808,013 (-)NCBI
Rnor_6.01769,388,375 - 69,435,160 (-)NCBI
Rnor_5.01771,102,094 - 71,148,911 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039095531   ⟹   XP_038951459
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81770,669,684 - 70,717,897 (-)NCBI
mRatBN7.21765,759,895 - 65,807,943 (-)NCBI
RefSeq Acc Id: XM_063276235   ⟹   XP_063132305
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81770,669,684 - 70,717,897 (-)NCBI
1 to 10 of 10 rows
Protein RefSeqs NP_001013075 (Get FASTA)   NCBI Sequence Viewer  
  XP_006254245 (Get FASTA)   NCBI Sequence Viewer  
  XP_006254247 (Get FASTA)   NCBI Sequence Viewer  
  XP_038951459 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132305 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH78957 (Get FASTA)   NCBI Sequence Viewer  
  BBG31757 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000045355
  ENSRNOP00000107623
GenBank Protein Q6AYQ2 (Get FASTA)   NCBI Sequence Viewer  
1 to 10 of 10 rows
RefSeq Acc Id: NP_001013075   ⟸   NM_001013057
- UniProtKB: Q6AYQ2 (UniProtKB/Swiss-Prot),   F1LQ80 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006254247   ⟸   XM_006254185
- Peptide Label: isoform X2
- UniProtKB: F1LQ80 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006254245   ⟸   XM_006254183
- Peptide Label: isoform X1
- UniProtKB: A0A387KBL1 (UniProtKB/TrEMBL),   F1LQ80 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000045355   ⟸   ENSRNOT00000051342
Ensembl Acc Id: ENSRNOP00000063166   ⟸   ENSRNOT00000066282
NADP-dependent oxidoreductase

Name Modeler Protein Id AA Range Protein Structure
AF-Q6AYQ2-F1-model_v2 AlphaFold Q6AYQ2 1-318 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 26 of 26 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-8841 BioCyc
Ensembl Genes ENSRNOG00000029844 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000051342 ENTREZGENE
  ENSRNOT00000160073 ENTREZGENE
Gene3D-CATH 3.20.20.100 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7110806 IMAGE-MGC_LOAD
InterPro AKR1C UniProtKB/Swiss-Prot
  Aldo/ket_reductase_CS UniProtKB/Swiss-Prot
  Aldo/keto_reductase UniProtKB/Swiss-Prot
  NADP_OxRdtase_dom UniProtKB/Swiss-Prot
  NADP_OxRdtase_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:291283 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93821 IMAGE-MGC_LOAD
NCBI Gene 291283 ENTREZGENE
PANTHER ALDO/KETO REDUCTASE UniProtKB/Swiss-Prot
Pfam Aldo_ket_red UniProtKB/Swiss-Prot
PhenoGen Akr1c2 PhenoGen
PIRSF AKR UniProtKB/Swiss-Prot
PRINTS ALDKETRDTASE UniProtKB/Swiss-Prot
PROSITE ALDOKETO_REDUCTASE_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000029844 RatGTEx
Superfamily-SCOP SSF51430 UniProtKB/Swiss-Prot
UniProt A0A387KBL1 ENTREZGENE, UniProtKB/TrEMBL
  AK1CL_RAT UniProtKB/Swiss-Prot
  F1LQ80 ENTREZGENE, UniProtKB/TrEMBL
  Q6AYQ2 ENTREZGENE
1 to 26 of 26 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-04-15 Akr1c2  aldo-keto reductase family 1, member C2  Akr1c21  aldo-keto reductase family 1, member C21  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Akr1c21  aldo-keto reductase family 1, member C21  Akr1c21_predicted  aldo-keto reductase family 1, member C21 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Akr1c21_predicted  aldo-keto reductase family 1, member C21 (predicted)      Symbol and Name status set to approved 70820 APPROVED