Ppox (protoporphyrinogen oxidase) - Rat Genome Database

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Gene: Ppox (protoporphyrinogen oxidase) Rattus norvegicus
Analyze
Symbol: Ppox
Name: protoporphyrinogen oxidase
RGD ID: 1310543
Description: Enables oxygen-dependent protoporphyrinogen oxidase activity. Involved in heme biosynthetic process; protoporphyrinogen IX metabolic process; and response to xenobiotic stimulus. Located in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in variegate porphyria. Orthologous to human PPOX (protoporphyrinogen oxidase); PARTICIPATES IN heme biosynthetic pathway; acute intermittent porphyria pathway; erythropoietic porphyria pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC289219
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81386,230,111 - 86,235,028 (-)NCBIGRCr8
mRatBN7.21383,697,661 - 83,701,998 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1383,664,891 - 83,701,805 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1386,203,532 - 86,207,667 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01387,601,739 - 87,605,874 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01384,833,201 - 84,837,337 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01389,650,094 - 89,654,998 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1389,650,094 - 89,654,244 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01394,276,960 - 94,281,296 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41387,170,602 - 87,174,740 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11387,359,527 - 87,363,605 (-)NCBI
Celera1383,328,348 - 83,332,483 (-)NCBICelera
Cytogenetic Map13q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PpoxRatacute intermittent porphyria  ISOPpox (Mus musculus)4145363DNA:missense mutation:exon:p.R59W (mouse)RGD 
PpoxRatHepatic Porphyrias  ISOPPOX (Homo sapiens)1599174DNA:transition:cds:p.R59W (human)RGD 
PpoxRatHepatic Porphyrias  ISOPPOX (Homo sapiens)1599172DNA:missense mutation:cds:p.G232R (human)RGD 
PpoxRatHepatic Porphyrias  ISOPpox (Mus musculus)4145281protein:decreased activity:liver and kidney (mouse)RGD 
PpoxRatHepatic Porphyrias  ISOPPOX (Homo sapiens)1599176DNA:mutations:cds:multiple (human)RGD 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PpoxRatautoimmune interstitial lung, joint, and kidney disease  ISOPPOX (Homo sapiens)8554872ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndromeClinVarPMID:28492532
PpoxRatgastrointestinal stromal tumor  ISOPPOX (Homo sapiens)8554872ClinVar Annotator: match by term: Gastrointestinal stromal tumorClinVarPMID:28492532
PpoxRatgenetic disease  ISOPPOX (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:10486317 more ...
PpoxRatmigraine  ISOPPOX (Homo sapiens)8554872ClinVar Annotator: match by term: MigraineClinVarPMID:25741868
PpoxRatparathyroid carcinoma  ISOPPOX (Homo sapiens)8554872ClinVar Annotator: match by term: Parathyroid carcinomaClinVarPMID:28492532
PpoxRatvariegate porphyria  ISOPPOX (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10401000 more ...
PpoxRatVariegate Porphyria, Childhood-Onset  ISOPPOX (Homo sapiens)8554872ClinVar Annotator: match by term: Variegate porphyria and childhood-onsetClinVarPMID:10401000 more ...
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PpoxRatColorectal Neoplasms  ISOPPOX (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25944804
PpoxRatvariegate porphyria  ISOPPOX (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PpoxRatvariegate porphyria  ISSPpox (Mus musculus)13592920OMIM:176200MouseDO 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PpoxRatvariegate porphyria  ISOPPOX (Homo sapiens)7240710 OMIM 
PpoxRatVariegate Porphyria, Childhood-Onset  ISOPPOX (Homo sapiens)7240710 OMIM 

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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PpoxRat1,2-dichloroethane decreases expressionISOPpox (Mus musculus)6480464ethylene dichloride results in decreased expression of PPOX mRNACTDPMID:28960355
PpoxRat1,2-dimethylhydrazine increases expressionISOPpox (Mus musculus)64804641 and 2-Dimethylhydrazine results in increased expression of PPOX mRNACTDPMID:22206623
PpoxRat1,2-dimethylhydrazine multiple interactionsISOPpox (Mus musculus)6480464Folic Acid inhibits the reaction [1 and 2-Dimethylhydrazine results in increased expression of PPOX mRNA]CTDPMID:22206623
PpoxRat17alpha-ethynylestradiol increases expressionISOPpox (Mus musculus)6480464Ethinyl Estradiol results in increased expression of PPOX mRNACTDPMID:17942748
PpoxRat17alpha-ethynylestradiol multiple interactionsISOPpox (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PPOX mRNACTDPMID:17942748
PpoxRat17beta-estradiol increases expressionEXP 6480464Estradiol results in increased expression of PPOX mRNACTDPMID:32145629
PpoxRat17beta-estradiol decreases expressionISOPPOX (Homo sapiens)6480464Estradiol results in decreased expression of PPOX mRNACTDPMID:31614463
PpoxRat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOPpox (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PPOX mRNA and Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to PPOX gene]CTDPMID:17942748 and PMID:28213091
PpoxRat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of PPOX mRNACTDPMID:33387578
PpoxRat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of PPOX mRNACTDPMID:32109520
PpoxRat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOPpox (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of PPOX mRNACTDPMID:21570461 and PMID:24680724
PpoxRat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOPpox (Mus musculus)6480464Tetrachlorodibenzodioxin results in decreased expression of PPOX mRNACTDPMID:18163543 and PMID:28213091
PpoxRat2-butoxyethanol increases expressionISOPpox (Mus musculus)6480464n-butoxyethanol results in increased expression of PPOX mRNACTDPMID:19812364
PpoxRat3,3',4,4',5-pentachlorobiphenyl decreases expressionEXP 64804643 more ...CTDPMID:20959002
PpoxRatacetamide decreases expressionEXP 6480464acetamide results in decreased expression of PPOX mRNACTDPMID:31881176
PpoxRatacifluorfen decreases activityISOPPOX (Homo sapiens)6480464acifluorfen results in decreased activity of PPOX proteinCTDPMID:7697001
PpoxRatacifluorfen decreases activityISOPpox (Mus musculus)6480464acifluorfen results in decreased activity of PPOX proteinCTDPMID:7697001
PpoxRatacrylamide decreases expressionISOPPOX (Homo sapiens)6480464Acrylamide results in decreased expression of PPOX mRNACTDPMID:32763439
PpoxRatantirheumatic drug increases expressionISOPPOX (Homo sapiens)6480464Antirheumatic Agents results in increased expression of PPOX mRNACTDPMID:24449571
PpoxRataristolochic acid A decreases expressionISOPPOX (Homo sapiens)6480464aristolochic acid I results in decreased expression of PPOX mRNACTDPMID:33212167

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Biological Process
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Cellular Component

  

Molecular Function

  

RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PpoxRatheme biosynthetic pathway   ISOPPOX (Homo sapiens)4144542 RGD 
PpoxRatheme biosynthetic pathway   ISOPPOX (Homo sapiens)11554188 RGD 
PpoxRatheme biosynthetic pathway   IDA 1599180 RGD 
PpoxRatheme biosynthetic pathway   IEA 1578396 RGD 

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PpoxRatporphyrin and chlorophyll metabolic pathway  IEA 6907045 KEGGrno:00860

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#
Reference Title
Reference Citation
1. Effects of iron deficiency and chronic iron overloading on mitochondrial heme biosynthetic enzymes in rat liver. Abraham NG, etal., Biochim Biophys Acta. 1986 Mar 28;870(2):339-49.
2. Biosynthesis of heme in mammals. Ajioka RS, etal., Biochim Biophys Acta. 2006 Jul;1763(7):723-36. Epub 2006 Jun 3.
3. Synthesis, delivery and regulation of eukaryotic heme and Fe-S cluster cofactors. Barupala DP, etal., Arch Biochem Biophys. 2016 Feb 15;592:60-75. doi: 10.1016/j.abb.2016.01.010. Epub 2016 Jan 16.
4. The mitochondrial location of protoporphyrinogen oxidase. Deybach JC, etal., Eur J Biochem. 1985 Jun 3;149(2):431-5.
5. Mutations in the protoporphyrinogen oxidase gene in patients with variegate porphyria. Deybach JC, etal., Hum Mol Genet. 1996 Mar;5(3):407-10.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. GenMAPP: Gene Map Annotator and Pathway Profiler GenMAPP
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Variegate porphyria in South Africa, 1688-1996--new developments in an old disease. Hift RJ, etal., S Afr Med J. 1997 Jun;87(6):722-31.
10. Rat liver protoporphyrinogen IX oxidase: site of synthesis and factor influencing its activity. Kolarov J, etal., Biochem Biophys Res Commun. 1983 Oct 31;116(2):383-7.
11. Herbicide-induced experimental variegate porphyria in mice: tissue porphyrinogen accumulation and response to porphyrogenic drugs. Krijt J, etal., Can J Physiol Pharmacol. 1997 Oct-Nov;75(10-11):1181-7.
12. An h.p.l.c. assay for protoporphyrinogen oxidase activity in rat liver. Li F, etal., Biochem J. 1987 May 1;243(3):863-6.
13. Porphobilinogen deaminase deficiency in mice causes a neuropathy resembling that of human hepatic porphyria. Lindberg RL, etal., Nat Genet. 1996 Feb;12(2):195-9.
14. A mouse model for South African (R59W) variegate porphyria: construction and initial characterization. Medlock AE, etal., Cell Mol Biol (Noisy-le-grand). 2002 Feb;48(1):71-8.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
17. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
18. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
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PMID:3346226   PMID:7713909   PMID:14651853   PMID:18614015   PMID:30361391   PMID:34800366  



Ppox
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81386,230,111 - 86,235,028 (-)NCBIGRCr8
mRatBN7.21383,697,661 - 83,701,998 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1383,664,891 - 83,701,805 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1386,203,532 - 86,207,667 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01387,601,739 - 87,605,874 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01384,833,201 - 84,837,337 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01389,650,094 - 89,654,998 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1389,650,094 - 89,654,244 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01394,276,960 - 94,281,296 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41387,170,602 - 87,174,740 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11387,359,527 - 87,363,605 (-)NCBI
Celera1383,328,348 - 83,332,483 (-)NCBICelera
Cytogenetic Map13q24NCBI
PPOX
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381161,165,728 - 161,178,013 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1161,166,056 - 161,178,013 (+)EnsemblGRCh38hg38GRCh38
GRCh371161,136,216 - 161,141,010 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361159,402,818 - 159,407,634 (+)NCBINCBI36Build 36hg18NCBI36
Build 341157,949,266 - 157,954,085NCBI
Celera1134,203,334 - 134,208,163 (+)NCBICelera
Cytogenetic Map1q23.3NCBI
HuRef1132,493,123 - 132,497,952 (+)NCBIHuRef
CHM1_11162,532,431 - 162,537,260 (+)NCBICHM1_1
T2T-CHM13v2.01160,303,185 - 160,315,736 (+)NCBIT2T-CHM13v2.0
Ppox
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391171,104,564 - 171,108,955 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1171,103,563 - 171,108,760 (-)EnsemblGRCm39 Ensembl
GRCm381171,276,991 - 171,281,193 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1171,275,990 - 171,281,186 (-)EnsemblGRCm38mm10GRCm38
MGSCv371173,207,123 - 173,211,317 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361173,113,667 - 173,117,835 (-)NCBIMGSCv36mm8
Celera1173,733,013 - 173,737,208 (-)NCBICelera
Cytogenetic Map1H3NCBI
cM Map179.3NCBI
Ppox
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546812,930,495 - 12,934,437 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495546812,930,387 - 12,934,437 (+)NCBIChiLan1.0ChiLan1.0
PPOX
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2188,673,982 - 88,685,936 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1188,351,824 - 88,376,257 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01136,578,846 - 136,590,466 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11140,491,667 - 140,496,506 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1140,491,667 - 140,502,328 (+)Ensemblpanpan1.1panPan2
PPOX
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13821,306,973 - 21,310,892 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3821,306,974 - 21,311,012 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3821,381,833 - 21,385,563 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03821,424,824 - 21,428,556 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3821,424,825 - 21,428,486 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13821,312,659 - 21,316,388 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03821,727,092 - 21,730,828 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03822,136,240 - 22,139,973 (-)NCBIUU_Cfam_GSD_1.0
Ppox
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244050587,261,120 - 7,266,047 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936903470,344 - 478,025 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936903470,317 - 474,705 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPOX
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl489,284,500 - 89,288,902 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1489,277,984 - 89,288,946 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2497,134,711 - 97,145,648 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PPOX
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1202,814,571 - 2,819,384 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl202,814,571 - 2,818,936 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660381,861,663 - 1,867,108 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppox
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624794212,226 - 215,931 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624794212,220 - 215,891 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Ppox
19 total Variants

Predicted Target Of
Summary Value
Count of predictions:72
Count of miRNA genes:68
Interacting mature miRNAs:70
Transcripts:ENSRNOT00000004896
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


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The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1366451204106807694Rat
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)137486211785581182Rat
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134608804691088046Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)135987440885581182Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133466346187525369Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat

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W53272  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21383,703,257 - 83,703,366 (+)MAPPERmRatBN7.2
Rnor_6.01389,655,691 - 89,655,799NCBIRnor6.0
Rnor_5.01394,282,557 - 94,282,665UniSTSRnor5.0
RGSC_v3.41387,176,203 - 87,176,311UniSTSRGSC3.4
Celera1383,333,945 - 83,334,053UniSTS
Cytogenetic Map13q24UniSTS
RH129176  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21383,701,048 - 83,701,242 (+)MAPPERmRatBN7.2
Rnor_6.01389,653,481 - 89,653,674NCBIRnor6.0
Rnor_5.01394,280,347 - 94,280,540UniSTSRnor5.0
RGSC_v3.41387,173,992 - 87,174,185UniSTSRGSC3.4
Celera1383,331,735 - 83,331,928UniSTS
RH 3.4 Map13561.3UniSTS
Cytogenetic Map13q24UniSTS
AA859700  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81386,230,195 - 86,230,585 (+)Marker Load Pipeline
mRatBN7.21383,697,746 - 83,698,136 (+)MAPPERmRatBN7.2
Rnor_6.01389,650,179 - 89,650,568NCBIRnor6.0
Rnor_5.01394,277,045 - 94,277,434UniSTSRnor5.0
RGSC_v3.41387,170,687 - 87,171,076UniSTSRGSC3.4
Celera1383,328,433 - 83,328,822UniSTS
RH 3.4 Map13552.3UniSTS
Cytogenetic Map13q24UniSTS
BF405831  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21383,702,405 - 83,702,559 (+)MAPPERmRatBN7.2
Rnor_6.01389,654,838 - 89,654,991NCBIRnor6.0
Rnor_5.01394,281,704 - 94,281,857UniSTSRnor5.0
RGSC_v3.41387,175,349 - 87,175,502UniSTSRGSC3.4
Celera1383,333,092 - 83,333,245UniSTS
RH 3.4 Map13568.4UniSTS
Cytogenetic Map13q24UniSTS
Ppox  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21383,697,781 - 83,698,111 (+)MAPPERmRatBN7.2
Rnor_6.01389,650,214 - 89,650,543NCBIRnor6.0
Rnor_5.01394,277,080 - 94,277,409UniSTSRnor5.0
RGSC_v3.41387,170,722 - 87,171,051UniSTSRGSC3.4
Celera1383,328,468 - 83,328,797UniSTS
Cytogenetic Map13q24UniSTS
G43283  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21383,702,692 - 83,702,832 (+)MAPPERmRatBN7.2
Rnor_6.01389,655,126 - 89,655,265NCBIRnor6.0
Rnor_5.01394,281,992 - 94,282,131UniSTSRnor5.0
RGSC_v3.41387,175,637 - 87,175,776UniSTSRGSC3.4
Celera1383,333,380 - 83,333,519UniSTS
Cytogenetic Map13q24UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000004896   ⟹   ENSRNOP00000004896
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1383,664,891 - 83,701,805 (-)Ensembl
Rnor_6.0 Ensembl1389,650,094 - 89,654,244 (-)Ensembl
RefSeq Acc Id: NM_001105968   ⟹   NP_001099438
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81386,230,111 - 86,234,246 (-)NCBI
mRatBN7.21383,697,662 - 83,701,797 (-)NCBI
Rnor_6.01389,650,094 - 89,654,229 (-)NCBI
Rnor_5.01394,276,960 - 94,281,296 (-)NCBI
RGSC_v3.41387,170,602 - 87,174,740 (-)RGD
Celera1383,328,348 - 83,332,483 (-)RGD
Sequence:
RefSeq Acc Id: XM_006250240   ⟹   XP_006250302
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81386,230,111 - 86,235,028 (-)NCBI
mRatBN7.21383,697,661 - 83,701,998 (-)NCBI
Rnor_6.01389,650,094 - 89,654,998 (-)NCBI
Rnor_5.01394,276,960 - 94,281,296 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006250241   ⟹   XP_006250303
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81386,230,111 - 86,234,271 (-)NCBI
mRatBN7.21383,697,661 - 83,701,822 (-)NCBI
Rnor_6.01389,650,094 - 89,654,262 (-)NCBI
Rnor_5.01394,276,960 - 94,281,296 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006250243   ⟹   XP_006250305
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81386,230,111 - 86,233,841 (-)NCBI
mRatBN7.21383,697,661 - 83,701,392 (-)NCBI
Rnor_6.01389,650,094 - 89,653,824 (-)NCBI
Rnor_5.01394,276,960 - 94,281,296 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039090506   ⟹   XP_038946434
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81386,230,111 - 86,235,028 (-)NCBI
mRatBN7.21383,697,661 - 83,701,998 (-)NCBI
RefSeq Acc Id: XM_039090508   ⟹   XP_038946436
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81386,230,111 - 86,233,597 (-)NCBI
mRatBN7.21383,697,661 - 83,701,148 (-)NCBI
RefSeq Acc Id: XM_039090509   ⟹   XP_038946437
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81386,230,863 - 86,235,028 (-)NCBI
mRatBN7.21383,698,407 - 83,701,998 (-)NCBI
RefSeq Acc Id: XM_063272128   ⟹   XP_063128198
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81386,230,111 - 86,233,454 (-)NCBI
RefSeq Acc Id: NP_001099438   ⟸   NM_001105968
- UniProtKB: A6JFW5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006250302   ⟸   XM_006250240
- Peptide Label: isoform X1
- UniProtKB: D3ZVN7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006250303   ⟸   XM_006250241
- Peptide Label: isoform X1
- UniProtKB: D3ZVN7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006250305   ⟸   XM_006250243
- Peptide Label: isoform X3
- Sequence:
Ensembl Acc Id: ENSRNOP00000004896   ⟸   ENSRNOT00000004896
Amine oxidase

Name Modeler Protein Id AA Range Protein Structure
AF-D3ZVN7-F1-model_v2 AlphaFold D3ZVN7 1-477 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13699000
Promoter ID:EPDNEW_R9525
Type:initiation region
Name:Ppox_1
Description:protoporphyrinogen oxidase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01389,654,237 - 89,654,297EPDNEW


1 to 21 of 21 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-17378 BioCyc
Ensembl Genes ENSRNOG00000003567 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000004896.7 UniProtKB/TrEMBL
Gene3D-CATH 3.50.50.60 UniProtKB/TrEMBL
InterPro Amino_oxidase UniProtKB/TrEMBL
  FAD/NAD-bd_sf UniProtKB/TrEMBL
  Flavin_amine_oxidase UniProtKB/TrEMBL
  Protoporphyrinogen_oxidase UniProtKB/TrEMBL
  Zeta_carotene_desat/Oxidored UniProtKB/TrEMBL
KEGG Report rno:289219 UniProtKB/TrEMBL
NCBI Gene 289219 ENTREZGENE
PANTHER PROTOPORPHYRINOGEN OXIDASE UniProtKB/TrEMBL
  PROTOPORPHYRINOGEN OXIDASE UniProtKB/TrEMBL
Pfam Amino_oxidase UniProtKB/TrEMBL
PhenoGen Ppox PhenoGen
PRINTS AMINEOXDASEF UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003567 RatGTEx
Superfamily-SCOP FAD-linked reductases, C-terminal domain UniProtKB/TrEMBL
  SSF51905 UniProtKB/TrEMBL
UniProt A6JFW5 ENTREZGENE, UniProtKB/TrEMBL
  D3ZVN7 ENTREZGENE, UniProtKB/TrEMBL
1 to 21 of 21 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Ppox  protoporphyrinogen oxidase   Ppox_predicted  protoporphyrinogen oxidase (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Ppox_predicted  protoporphyrinogen oxidase (predicted)      Symbol and Name status set to approved 70820 APPROVED