Bcl6 (BCL6, transcription repressor) - Rat Genome Database

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Gene: Bcl6 (BCL6, transcription repressor) Rattus norvegicus
Analyze
Symbol: Bcl6
Name: BCL6, transcription repressor
RGD ID: 1309345
Description: Predicted to enable several functions, including DNA binding activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; and transcription corepressor binding activity. Predicted to be involved in several processes, including positive regulation of regulatory T cell differentiation; regulation of gene expression; and type 2 immune response. Predicted to act upstream of or within several processes, including hemopoiesis; regulation of gene expression; and regulation of lymphocyte activation. Predicted to be located in Golgi apparatus; nuclear lumen; and replication fork. Predicted to be active in nucleoplasm. Human ortholog(s) of this gene implicated in B-cell lymphoma and diffuse large B-cell lymphoma. Orthologous to human BCL6 (BCL6 transcription repressor); PARTICIPATES IN interleukin-4 signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: B-cell CLL/lymphoma 6; B-cell leukemia/lymphoma 6; LOC303836
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81190,358,753 - 90,382,049 (+)NCBIGRCr8
mRatBN7.21176,854,090 - 76,877,389 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1176,854,090 - 76,877,389 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1185,634,592 - 85,657,897 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01178,269,810 - 78,293,116 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01177,348,906 - 77,372,205 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01180,255,790 - 80,279,075 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1180,255,790 - 80,279,075 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01180,454,014 - 80,477,192 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41179,006,123 - 79,030,555 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11179,063,711 - 79,088,148 (+)NCBI
Celera1175,736,211 - 75,759,558 (+)NCBICelera
Cytogenetic Map11q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(E)-thiamethoxam  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-phenylbutyric acid  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-formyltetrahydrofolic acid  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amphetamine  (EXP)
amphotericin B  (ISO)
antirheumatic drug  (ISO)
aripiprazole  (ISO)
aristolochic acid A  (EXP,ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
boron nitride  (ISO)
bortezomib  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
ciglitazone  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cypermethrin  (ISO)
DDT  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibenz[a,h]anthracene  (ISO)
dichloromethane  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
dieldrin  (EXP)
diethylstilbestrol  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
ethylbenzene  (ISO)
fluoranthene  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
furan  (EXP)
gamma-hexachlorocyclohexane  (ISO)
gemcitabine  (ISO)
genistein  (ISO)
gentamycin  (EXP)
geraniol  (ISO)
GW 501516  (ISO)
hydrazine  (ISO)
hydrogen peroxide  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indole-3-methanol  (EXP)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
menadione  (ISO)
metformin  (EXP)
methamphetamine  (EXP)
methapyrilene  (EXP)
methotrexate  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
N,N-diethyl-m-toluamide  (EXP)
N-acetyl-L-cysteine  (EXP)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
nickel dichloride  (EXP)
niclosamide  (ISO)
nitrofen  (EXP)
o-xylene  (ISO)
ochratoxin A  (EXP)
orphenadrine  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
permethrin  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
Pyridostigmine bromide  (EXP)
pyrimethamine  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
SCH 23390  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP,ISO)
sodium stibogluconate  (ISO)
styrene  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (ISO)
thiamethoxam  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
TMC-120A  (ISO)
toluene  (ISO)
topotecan  (EXP)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vanadyl sulfate  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (ISO)
B cell differentiation  (ISO)
B cell proliferation  (ISO)
biological_process  (ND)
cell morphogenesis  (ISO)
cell motility  (ISO)
cell population proliferation  (ISO)
cell-matrix adhesion  (ISO)
DNA damage response  (ISO)
erythrocyte development  (ISO)
germinal center formation  (ISO)
heterochromatin formation  (ISO)
isotype switching to IgE isotypes  (ISO)
mononuclear cell proliferation  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cell growth  (ISO)
negative regulation of cell-matrix adhesion  (ISO)
negative regulation of cellular senescence  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of isotype switching to IgE isotypes  (ISO)
negative regulation of mast cell cytokine production  (ISO)
negative regulation of mononuclear cell proliferation  (ISO)
negative regulation of Notch signaling pathway  (ISO)
negative regulation of plasma cell differentiation  (ISO)
negative regulation of Rho protein signal transduction  (ISO)
negative regulation of T-helper 2 cell differentiation  (ISO)
negative regulation of transcription by RNA polymerase II  (IBA,ISO)
negative regulation of type 2 immune response  (ISO)
plasma cell differentiation  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of B cell proliferation  (ISO)
positive regulation of cell motility  (ISO)
positive regulation of neuron differentiation  (ISO)
positive regulation of regulatory T cell differentiation  (ISO)
protein localization  (ISO)
pyramidal neuron differentiation  (ISO)
regulation of cell differentiation  (IBA)
regulation of cell population proliferation  (IBA)
regulation of cytokine production  (IBA)
regulation of immune system process  (IBA)
regulation of inflammatory response  (IBA,ISO)
regulation of memory T cell differentiation  (ISO)
regulation of T cell proliferation  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
Rho protein signal transduction  (ISO)
spermatogenesis  (ISO)
T-helper 2 cell differentiation  (ISO)
transcription by RNA polymerase II  (ISO)
type 2 immune response  (IBA,ISO)

Cellular Component
Golgi apparatus  (IEA,ISO)
nucleolus  (IEA,ISO)
nucleoplasm  (IBA,ISO)
nucleus  (ISO)
paraspeckles  (ISO)
replication fork  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Comprehensive gene review and curation RGD comprehensive gene curation
7. Expression of the bcl-6 and MUM1/IRF4 proteins correlate with overall and disease-specific survival in patients with primary cutaneous large B-cell lymphoma: a tissue microarray study. Sundram U, etal., J Cutan Pathol. 2005 Mar;32(3):227-34.
8. The gene for interleukin-21 receptor is the partner of BCL6 in t(3;16)(q27;p11), which is recurrently observed in diffuse large B-cell lymphoma. Ueda C, etal., Oncogene. 2002 Jan 17;21(3):368-76.
Additional References at PubMed
PMID:7795255   PMID:9110977   PMID:9171827   PMID:9236196   PMID:9632807   PMID:9927203   PMID:10438949   PMID:10490661   PMID:10490843   PMID:10898795   PMID:11092811   PMID:11929873  
PMID:12097386   PMID:12354385   PMID:12477932   PMID:12594267   PMID:12817026   PMID:14647274   PMID:15240675   PMID:15240705   PMID:15507530   PMID:15577913   PMID:15611242   PMID:15659391  
PMID:15661395   PMID:15860730   PMID:15950739   PMID:17125145   PMID:17908795   PMID:19797429   PMID:20630860   PMID:21190961   PMID:22387553   PMID:23160044   PMID:23209284   PMID:24863065  
PMID:25416956   PMID:29972264   PMID:30805081   PMID:31346987  


Genomics

Comparative Map Data
Bcl6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81190,358,753 - 90,382,049 (+)NCBIGRCr8
mRatBN7.21176,854,090 - 76,877,389 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1176,854,090 - 76,877,389 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1185,634,592 - 85,657,897 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01178,269,810 - 78,293,116 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01177,348,906 - 77,372,205 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01180,255,790 - 80,279,075 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1180,255,790 - 80,279,075 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01180,454,014 - 80,477,192 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41179,006,123 - 79,030,555 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11179,063,711 - 79,088,148 (+)NCBI
Celera1175,736,211 - 75,759,558 (+)NCBICelera
Cytogenetic Map11q23NCBI
BCL6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383187,721,377 - 187,745,468 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3187,721,377 - 187,745,725 (-)EnsemblGRCh38hg38GRCh38
GRCh373187,439,165 - 187,463,256 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363188,921,859 - 188,946,169 (-)NCBINCBI36Build 36hg18NCBI36
Build 343188,921,866 - 188,936,950NCBI
Celera3185,870,167 - 185,894,514 (-)NCBICelera
Cytogenetic Map3q27.3NCBI
HuRef3184,843,368 - 184,867,718 (-)NCBIHuRef
CHM1_13187,402,407 - 187,426,738 (-)NCBICHM1_1
T2T-CHM13v2.03190,538,887 - 190,562,977 (-)NCBIT2T-CHM13v2.0
Bcl6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391623,780,058 - 23,807,602 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1623,783,802 - 23,807,602 (-)EnsemblGRCm39 Ensembl
GRCm381623,965,050 - 23,988,866 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1623,965,052 - 23,988,852 (-)EnsemblGRCm38mm10GRCm38
MGSCv371623,965,138 - 23,988,698 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361623,880,401 - 23,903,961 (-)NCBIMGSCv36mm8
Celera1624,514,447 - 24,538,188 (-)NCBICelera
Cytogenetic Map16B1NCBI
cM Map1615.26NCBI
Bcl6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542019,998,742 - 20,022,259 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542019,998,960 - 20,021,200 (+)NCBIChiLan1.0ChiLan1.0
BCL6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22185,592,401 - 185,616,789 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13185,596,633 - 185,622,262 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03184,748,135 - 184,772,375 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13193,308,296 - 193,332,452 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3193,308,296 - 193,332,124 (-)Ensemblpanpan1.1panPan2
BCL6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13420,112,302 - 20,135,705 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3420,113,322 - 20,124,704 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3424,206,192 - 24,217,557 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03420,032,420 - 20,123,667 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3420,007,243 - 20,047,268 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13420,061,949 - 20,073,314 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03420,055,728 - 20,067,098 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03420,295,606 - 20,306,970 (-)NCBIUU_Cfam_GSD_1.0
Bcl6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602116,280,077 - 116,303,180 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365782,371,945 - 2,395,071 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365782,371,976 - 2,395,034 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BCL6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13125,377,250 - 125,393,330 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113125,377,247 - 125,401,328 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213134,660,904 - 134,685,055 (-)NCBISscrofa10.2Sscrofa10.2susScr3
BCL6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11581,997,659 - 82,022,059 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1581,998,545 - 82,009,946 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604155,495,443 - 55,520,875 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bcl6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473069,154,080 - 69,167,689 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473069,145,035 - 69,167,583 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Bcl6
76 total Variants
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir127rno-miR-127-3pMirtarbaseexternal_infoWestern blotFunctional MTI18942116

Predicted Target Of
Summary Value
Count of predictions:616
Count of miRNA genes:268
Interacting mature miRNAs:342
Transcripts:ENSRNOT00000002522
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)115513672982993457Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)115980279482566545Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)116642214886241447Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115635142486241447Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116034659086241447Rat
1354593Stl12Serum triglyceride level QTL 123.36blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)116642214886241447Rat
1354656Bvd3Brain ventricular dilatation QTL 33.640.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116944607082846715Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116611332182169223Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113491804179918041Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)115980279482566553Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115445753486241447Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114428575982566702Rat

Markers in Region
U41465  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21176,876,363 - 76,876,449 (+)MAPPERmRatBN7.2
Rnor_6.01180,278,050 - 80,278,135NCBIRnor6.0
Rnor_5.01180,454,954 - 80,455,039UniSTSRnor5.0
RGSC_v3.41179,029,530 - 79,029,615UniSTSRGSC3.4
Celera1175,758,533 - 75,758,618UniSTS
Cytogenetic Map11q23UniSTS
AU047979  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21176,856,078 - 76,856,356 (+)MAPPERmRatBN7.2
Rnor_6.01180,257,779 - 80,258,056NCBIRnor6.0
Rnor_5.01180,474,926 - 80,475,203UniSTSRnor5.0
RGSC_v3.41179,008,112 - 79,008,389UniSTSRGSC3.4
Celera1175,738,201 - 75,738,478UniSTS
Cytogenetic Map11q23UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 13 3 13 3 4 7 29 11 4 10 4
Low 1 43 44 38 6 38 4 4 45 24 37 1 4
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000002522   ⟹   ENSRNOP00000002522
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1176,854,090 - 76,877,389 (+)Ensembl
Rnor_6.0 Ensembl1180,255,790 - 80,279,075 (+)Ensembl
RefSeq Acc Id: NM_001107084   ⟹   NP_001100554
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81190,358,753 - 90,382,047 (+)NCBI
mRatBN7.21176,854,090 - 76,877,389 (+)NCBI
Rnor_6.01180,255,790 - 80,279,075 (+)NCBI
Rnor_5.01180,454,014 - 80,477,192 (-)NCBI
RGSC_v3.41179,006,123 - 79,030,555 (+)RGD
Celera1175,736,211 - 75,759,558 (+)RGD
Sequence:
RefSeq Acc Id: XM_039088297   ⟹   XP_038944225
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81190,366,208 - 90,382,049 (+)NCBI
mRatBN7.21176,861,543 - 76,876,315 (+)NCBI
RefSeq Acc Id: XM_039088298   ⟹   XP_038944226
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81190,365,223 - 90,382,049 (+)NCBI
mRatBN7.21176,858,631 - 76,876,315 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001100554 (Get FASTA)   NCBI Sequence Viewer  
  XP_038944225 (Get FASTA)   NCBI Sequence Viewer  
  XP_038944226 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI66425 (Get FASTA)   NCBI Sequence Viewer  
  EDL78099 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000002522
  ENSRNOP00000002522.4
Reference Protein Sequences
RefSeq Acc Id: NP_001100554   ⟸   NM_001107084
- UniProtKB: B2GUV8 (UniProtKB/TrEMBL),   F7FPB9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000002522   ⟸   ENSRNOT00000002522
RefSeq Acc Id: XP_038944226   ⟸   XM_039088298
- Peptide Label: isoform X1
- UniProtKB: B2GUV8 (UniProtKB/TrEMBL),   F7FPB9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038944225   ⟸   XM_039088297
- Peptide Label: isoform X1
- UniProtKB: B2GUV8 (UniProtKB/TrEMBL),   F7FPB9 (UniProtKB/TrEMBL)
Protein Domains
BTB   C2H2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B2GUV8-F1-model_v2 AlphaFold B2GUV8 1-707 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698240
Promoter ID:EPDNEW_R8765
Type:initiation region
Name:Bcl6_1
Description:B-cell CLL/lymphoma 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01180,255,872 - 80,255,932EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309345 AgrOrtholog
BioCyc Gene G2FUF-20886 BioCyc
Ensembl Genes ENSRNOG00000001843 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000002522 ENTREZGENE
  ENSRNOT00000002522.5 UniProtKB/TrEMBL
Gene3D-CATH Classic Zinc Finger UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7097735 IMAGE-MGC_LOAD
InterPro BTB/POZ-like UniProtKB/TrEMBL
  BTB/POZ_fold UniProtKB/TrEMBL
  Znf_C2H2/integrase_DNA-bd UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
KEGG Report rno:303836 UniProtKB/TrEMBL
MGC_CLONE MGC:187400 IMAGE-MGC_LOAD
NCBI Gene 303836 ENTREZGENE
PANTHER B-CELL CLL_LYMPHOMA 6 (ZINC FINGER PROTEIN 51)-RELATED UniProtKB/TrEMBL
  ZINC FINGER PROTEIN UniProtKB/TrEMBL
Pfam BTB UniProtKB/TrEMBL
  zf-C2H2 UniProtKB/TrEMBL
PhenoGen Bcl6 PhenoGen
PROSITE BTB UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001843 RatGTEx
SMART BTB UniProtKB/TrEMBL
  ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP BTB/POZ_fold UniProtKB/TrEMBL
  SSF57667 UniProtKB/TrEMBL
UniProt B2GUV8 ENTREZGENE, UniProtKB/TrEMBL
  F7FPB9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-11-09 Bcl6  BCL6, transcription repressor  Bcl6  B-cell CLL/lymphoma 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Bcl6  B-cell CLL/lymphoma 6  Bcl6  B-cell leukemia/lymphoma 6   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Bcl6  B-cell leukemia/lymphoma 6   Bcl6_predicted  B-cell leukemia/lymphoma 6 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Bcl6_predicted  B-cell leukemia/lymphoma 6 (predicted)      Symbol and Name status set to approved 70820 APPROVED