Symbol:
Tnip2
Name:
TNFAIP3 interacting protein 2
RGD ID:
1307717
Description:
Predicted to enable polyubiquitin modification-dependent protein binding activity and protein kinase binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; pattern recognition receptor signaling pathway; and positive regulation of leukocyte activation. Predicted to act upstream of or within negative regulation of canonical NF-kappaB signal transduction. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm. Orthologous to human TNIP2 (TNFAIP3 interacting protein 2); INTERACTS WITH 17beta-estradiol; 2,4-dinitrotoluene; amphetamine.
Type:
protein-coding
RefSeq Status:
VALIDATED
Previously known as:
LOC305451; TNFAIP3-interacting protein 2
RGD Orthologs
Alliance Orthologs
More Info
more info ...
More Info
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
TNIP2 (TNFAIP3 interacting protein 2)
HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):
Tnip2 (TNFAIP3 interacting protein 2)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):
Tnip2 (TNFAIP3 interacting protein 2)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
TNIP2 (TNFAIP3 interacting protein 2)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
TNIP2 (TNFAIP3 interacting protein 2)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Tnip2 (TNFAIP3 interacting protein 2)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
TNIP2 (TNFAIP3 interacting protein 2)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):
TNIP2 (TNFAIP3 interacting protein 2)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Tnip2 (TNFAIP3 interacting protein 2)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
RELCH (RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing)
HGNC
OMA
Alliance orthologs 3
Homo sapiens (human):
TNIP2 (TNFAIP3 interacting protein 2)
Alliance
DIOPT (HGNC|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Mus musculus (house mouse):
Tnip2 (TNFAIP3 interacting protein 2)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Danio rerio (zebrafish):
tnip2 (TNFAIP3 interacting protein 2)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):
tnip2
Alliance
DIOPT (Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PhylomeDB)
Latest Assembly:
GRCr8 - GRCr8 Assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 14 80,452,936 - 80,470,141 (+) NCBI GRCr8 mRatBN7.2 14 76,228,350 - 76,245,553 (+) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 14 76,228,371 - 76,275,265 (+) Ensembl mRatBN7.2 Ensembl UTH_Rnor_SHR_Utx 14 80,680,797 - 80,698,114 (+) NCBI Rnor_SHR UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 14 81,921,444 - 81,938,761 (+) NCBI Rnor_SHRSP UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 14 78,366,692 - 78,384,009 (+) NCBI Rnor_WKY UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 14 81,487,934 - 81,505,889 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 14 81,488,008 - 81,504,686 (+) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 14 82,175,144 - 82,192,502 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 14 81,870,935 - 81,888,169 (+) NCBI RGSC3.4 RGSC_v3.4 rn4 RGSC3.4 RGSC_v3.1 14 81,873,325 - 81,890,560 (+) NCBI Celera 14 75,152,826 - 75,170,060 (+) NCBI Celera Cytogenetic Map 14 q21 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Biological Process
CD40 signaling pathway (IEA,ISO) cellular response to lipopolysaccharide (IBA,IEA,ISO) interleukin-1-mediated signaling pathway (IEA,ISO) negative regulation of canonical NF-kappaB signal transduction (IEA,ISO) negative regulation of endothelial cell apoptotic process (IEA,ISO) positive regulation of B cell activation (IEA,ISO) positive regulation of canonical NF-kappaB signal transduction (IBA,IEA,ISO) positive regulation of macrophage activation (IEA,ISO) positive regulation of transcription by RNA polymerase II (IEA,ISO) protein stabilization (IEA,ISO) regulation of canonical NF-kappaB signal transduction (IEA) regulation of transcription by RNA polymerase II (IBA) toll-like receptor 2 signaling pathway (IBA,IEA,ISO) toll-like receptor 3 signaling pathway (IBA,IEA,ISO) toll-like receptor 9 signaling pathway (IEA,ISO)
Tnip2 (Rattus norvegicus - Norway rat)
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 14 80,452,936 - 80,470,141 (+) NCBI GRCr8 mRatBN7.2 14 76,228,350 - 76,245,553 (+) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 14 76,228,371 - 76,275,265 (+) Ensembl mRatBN7.2 Ensembl UTH_Rnor_SHR_Utx 14 80,680,797 - 80,698,114 (+) NCBI Rnor_SHR UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 14 81,921,444 - 81,938,761 (+) NCBI Rnor_SHRSP UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 14 78,366,692 - 78,384,009 (+) NCBI Rnor_WKY UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 14 81,487,934 - 81,505,889 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 14 81,488,008 - 81,504,686 (+) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 14 82,175,144 - 82,192,502 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 14 81,870,935 - 81,888,169 (+) NCBI RGSC3.4 RGSC_v3.4 rn4 RGSC3.4 RGSC_v3.1 14 81,873,325 - 81,890,560 (+) NCBI Celera 14 75,152,826 - 75,170,060 (+) NCBI Celera Cytogenetic Map 14 q21 NCBI
TNIP2 (Homo sapiens - human)
Human Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCh38 4 2,741,648 - 2,756,336 (-) NCBI GRCh38 GRCh38 hg38 GRCh38 GRCh38.p14 Ensembl 4 2,741,648 - 2,756,342 (-) Ensembl GRCh38 hg38 GRCh38 GRCh37 4 2,743,375 - 2,758,063 (-) NCBI GRCh37 GRCh37 hg19 GRCh37 Build 36 4 2,713,185 - 2,727,859 (-) NCBI NCBI36 Build 36 hg18 NCBI36 Build 34 4 2,780,592 - 2,795,267 NCBI Celera 4 2,654,688 - 2,669,415 (-) NCBI Celera Cytogenetic Map 4 p16.3 NCBI HuRef 4 2,682,483 - 2,696,862 (-) NCBI HuRef CHM1_1 4 2,741,351 - 2,756,073 (-) NCBI CHM1_1 T2T-CHM13v2.0 4 2,740,398 - 2,755,095 (-) NCBI T2T-CHM13v2.0
Tnip2 (Mus musculus - house mouse)
Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm39 5 34,653,440 - 34,671,323 (-) NCBI GRCm39 GRCm39 mm39 GRCm39 Ensembl 5 34,653,431 - 34,671,335 (-) Ensembl GRCm39 Ensembl GRCm38 5 34,496,096 - 34,513,979 (-) NCBI GRCm38 GRCm38 mm10 GRCm38 GRCm38.p6 Ensembl 5 34,496,087 - 34,513,991 (-) Ensembl GRCm38 mm10 GRCm38 MGSCv37 5 34,838,745 - 34,856,628 (-) NCBI GRCm37 MGSCv37 mm9 NCBIm37 MGSCv36 5 34,812,953 - 34,830,836 (-) NCBI MGSCv36 mm8 Celera 5 31,967,000 - 31,984,842 (-) NCBI Celera Cytogenetic Map 5 B2 NCBI cM Map 5 17.89 NCBI
Tnip2 (Chinchilla lanigera - long-tailed chinchilla)
Chinchilla Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl ChiLan1.0 NW_004955514 1,682,641 - 1,687,881 (-) NCBI ChiLan1.0 ChiLan1.0
TNIP2 (Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl NHGRI_mPanPan1-v2 3 3,077,308 - 3,092,199 (-) NCBI NHGRI_mPanPan1-v2 NHGRI_mPanPan1 4 3,013,213 - 3,028,094 (-) NCBI NHGRI_mPanPan1 Mhudiblu_PPA_v0 4 2,884,265 - 2,899,160 (-) NCBI Mhudiblu_PPA_v0 Mhudiblu_PPA_v0 panPan3 PanPan1.1 4 2,787,594 - 2,793,893 (-) NCBI panpan1.1 PanPan1.1 panPan2
TNIP2 (Canis lupus familiaris - dog)
Dog Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl CanFam3.1 3 61,511,676 - 61,535,480 (+) NCBI CanFam3.1 CanFam3.1 canFam3 CanFam3.1 Dog10K_Boxer_Tasha 3 64,094,717 - 64,118,689 (+) NCBI Dog10K_Boxer_Tasha ROS_Cfam_1.0 3 61,987,047 - 62,011,284 (+) NCBI ROS_Cfam_1.0 ROS_Cfam_1.0 Ensembl 3 61,987,047 - 62,012,472 (+) Ensembl ROS_Cfam_1.0 Ensembl UMICH_Zoey_3.1 3 61,478,352 - 61,502,338 (+) NCBI UMICH_Zoey_3.1 UNSW_CanFamBas_1.0 3 61,683,311 - 61,707,304 (+) NCBI UNSW_CanFamBas_1.0 UU_Cfam_GSD_1.0 3 62,042,935 - 62,067,151 (+) NCBI UU_Cfam_GSD_1.0
Tnip2 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl HiC_Itri_2 NW_024405285 67,105,267 - 67,139,845 (+) NCBI HiC_Itri_2 SpeTri2.0 Ensembl NW_004936477 20,834,849 - 20,841,535 (+) Ensembl SpeTri2.0 SpeTri2.0 Ensembl SpeTri2.0 NW_004936477 20,810,188 - 20,841,537 (+) NCBI SpeTri2.0 SpeTri2.0 SpeTri2.0
TNIP2 (Sus scrofa - pig)
Pig Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Sscrofa11.1 Ensembl 8 1,533,429 - 1,554,683 (-) Ensembl Sscrofa11.1 susScr11 Sscrofa11.1 Sscrofa11.1 8 1,530,534 - 1,554,677 (-) NCBI Sscrofa11.1 Sscrofa11.1 susScr11 Sscrofa11.1 Sscrofa10.2 8 1,115,215 - 1,136,000 (-) NCBI Sscrofa10.2 Sscrofa10.2 susScr3
TNIP2 (Chlorocebus sabaeus - green monkey)
Green Monkey Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl ChlSab1.1 27 46,001,814 - 46,017,676 (+) NCBI ChlSab1.1 ChlSab1.1 chlSab2 ChlSab1.1 Ensembl 27 46,001,872 - 46,018,494 (+) Ensembl ChlSab1.1 ChlSab1.1 Ensembl chlSab2 Vero_WHO_p1.0 NW_023666051 2,366,620 - 2,381,224 (+) NCBI Vero_WHO_p1.0 Vero_WHO_p1.0
Tnip2 (Heterocephalus glaber - naked mole-rat)
.
Predicted Target Of
Count of predictions: 180 Count of miRNA genes: 123 Interacting mature miRNAs: 154 Transcripts: ENSRNOT00000018477 Prediction methods: Miranda, Rnahybrid, Targetscan Result types: miRGate_prediction
2313089 Bss81 Bone structure and strength QTL 81 3.4 0.0001 body length (VT:0001256) body length, nose to rump (CMO:0000079) 14 37669719 82669719 Rat 9590294 Uminl4 Urine mineral level QTL 4 5.66 0.001 urine mineral amount (VT:0015086) urine electrolyte level (CMO:0000593) 14 55624247 100624247 Rat 1582236 Gluco22 Glucose level QTL 22 3.3 0.0164 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) 14 73415323 92554092 Rat 2300197 Scl59 Serum cholesterol level QTL 59 blood cholesterol amount (VT:0000180) serum total cholesterol level (CMO:0000363) 14 55147478 100147478 Rat 70153 Bp59 Blood pressure QTL 59 3.2 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 14 68757796 83368335 Rat 70187 Pancm5 Pancreatic morphology QTL 5 16.7 pancreas mass (VT:0010144) pancreas weight to body weight ratio (CMO:0000630) 14 30320092 80829842 Rat 631523 Pia13 Pristane induced arthritis QTL 13 3.3 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) 14 40793460 98037301 Rat 1582259 Gluco23 Glucose level QTL 23 3.1 0.0008 blood glucose amount (VT:0000188) blood glucose level area under curve (AUC) (CMO:0000350) 14 70053989 104886043 Rat 1582197 Gluco27 Glucose level QTL 27 3.4 0.0006 blood glucose amount (VT:0000188) blood glucose level area under curve (AUC) (CMO:0000350) 14 73415323 92554092 Rat 2313100 Bss82 Bone structure and strength QTL 82 3 0.0001 tibia size trait (VT:0100001) tibia midshaft cross-sectional area (CMO:0001717) 14 37669719 82669719 Rat 634328 Hc5 Hypercalciuria QTL 5 2.3 urine calcium amount (VT:0002985) urine calcium excretion rate (CMO:0000763) 14 58184885 103184885 Rat 1582250 Gluco26 Glucose level QTL 26 3.3 0.0009 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) 14 73415323 95876975 Rat 2317879 Alcrsp27 Alcohol response QTL 27 3.3 0.63 response to alcohol trait (VT:0010489) duration of loss of righting reflex (CMO:0002289) 14 56631369 101631369 Rat 1641900 Alcrsp11 Alcohol response QTL 11 alcohol metabolism trait (VT:0015089) blood ethanol level (CMO:0000535) 14 70053989 104886043 Rat 631839 Niddm37 Non-insulin dependent diabetes mellitus QTL 37 3.37 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) 14 11030622 95876975 Rat 1582255 Gluco29 Glucose level QTL 29 3.1 0.0025 blood glucose amount (VT:0000188) absolute change in blood glucose level area under curve (CMO:0002034) 14 73415323 92554092 Rat 9589034 Epfw11 Epididymal fat weight QTL 11 6 0.001 epididymal fat pad mass (VT:0010421) epididymal fat pad weight to body weight ratio (CMO:0000658) 14 55624247 100624247 Rat 1582209 Gluco20 Glucose level QTL 20 3.8 0.0005 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) 14 73415323 92554092 Rat 2313048 Bss84 Bone structure and strength QTL 84 3.1 0.0001 tibia strength trait (VT:1000284) tibia total energy absorbed before break (CMO:0001736) 14 37669719 82669719 Rat 1300136 Rf22 Renal function QTL 22 3.9 renal blood flow trait (VT:2000006) absolute change in renal vascular resistance (CMO:0001900) 14 42262529 95023211 Rat 1549834 Scl45 Serum cholesterol level QTL 45 5.8 blood cholesterol amount (VT:0000180) serum total cholesterol level (CMO:0000363) 14 50023211 95023211 Rat 738037 Hcas6 Hepatocarcinoma susceptibility QTL 6 2.93 liver integrity trait (VT:0010547) liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464) 14 39057237 83368335 Rat 2313084 Bss83 Bone structure and strength QTL 83 2.9 0.0001 tibia size trait (VT:0100001) tibia midshaft endosteal cross-sectional area (CMO:0001716) 14 37669719 82669719 Rat
RH134898
Rat Assembly Chr Position (strand) Source JBrowse mRatBN7.2 14 76,245,222 - 76,245,429 (+) MAPPER mRatBN7.2 Rnor_6.0 14 81,504,688 - 81,504,894 NCBI Rnor6.0 Rnor_5.0 14 82,192,172 - 82,192,378 UniSTS Rnor5.0 RGSC_v3.4 14 81,887,848 - 81,888,054 UniSTS RGSC3.4 Celera 14 75,169,739 - 75,169,945 UniSTS Cytogenetic Map 14 q21 UniSTS
Click on a value in the shaded box below the category label to view a detailed expression data table for that system.
alimentary part of gastrointestinal system
9
11
49
113
91
90
59
25
59
6
218
97
93
45
60
31
Too many to show, limit is 500. Download them if you would like to view them all.
Ensembl Acc Id:
ENSRNOT00000018477 ⟹ ENSRNOP00000018477
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source mRatBN7.2 Ensembl 14 76,228,371 - 76,275,265 (+) Ensembl Rnor_6.0 Ensembl 14 81,488,008 - 81,504,686 (+) Ensembl
Ensembl Acc Id:
ENSRNOT00000108907 ⟹ ENSRNOP00000084407
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source mRatBN7.2 Ensembl 14 76,228,371 - 76,275,265 (+) Ensembl
RefSeq Acc Id:
NM_001394684 ⟹ NP_001381613
RefSeq Status:
VALIDATED
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 14 80,452,936 - 80,470,141 (+) NCBI mRatBN7.2 14 76,228,350 - 76,245,553 (+) NCBI
RefSeq Acc Id:
NR_172145
RefSeq Status:
VALIDATED
Type:
NON-CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 14 80,452,936 - 80,470,141 (+) NCBI mRatBN7.2 14 76,228,350 - 76,245,553 (+) NCBI
Ensembl Acc Id:
ENSRNOP00000018477 ⟸ ENSRNOT00000018477
Ensembl Acc Id:
ENSRNOP00000084407 ⟸ ENSRNOT00000108907
RefSeq Acc Id:
NP_001381613 ⟸ NM_001394684
- UniProtKB:
Q4V7E7 (UniProtKB/TrEMBL), A6IK30 (UniProtKB/TrEMBL), G3V7R6 (UniProtKB/TrEMBL), A0A8I5ZX56 (UniProtKB/TrEMBL)
RGD ID: 13699401
Promoter ID: EPDNEW_R9925
Type: multiple initiation site
Name: Tnip2_1
Description: TNFAIP3 interacting protein 2
SO ACC ID: SO:0000170
Source: EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/ )
Experiment Methods: Single-end sequencing.
Position: Rat Assembly Chr Position (strand) Source Rnor_6.0 14 81,488,079 - 81,488,139 EPDNEW
Date
Current Symbol
Current Name
Previous Symbol
Previous Name
Description
Reference
Status
2005-12-06
Tnip2
TNFAIP3 interacting protein 2
Tnip2_predicted
TNFAIP3 interacting protein 2 (predicted)
Symbol and Name updated
1559027
APPROVED
2005-01-12
Tnip2_predicted
TNFAIP3 interacting protein 2 (predicted)
Symbol and Name status set to approved
70820
APPROVED