Asap1 (ArfGAP with SH3 domain, ankyrin repeat and PH domain 1) - Rat Genome Database

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Gene: Asap1 (ArfGAP with SH3 domain, ankyrin repeat and PH domain 1) Rattus norvegicus
Analyze
Symbol: Asap1
Name: ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
RGD ID: 1307379
Description: Predicted to enable GTPase activator activity and phospholipid binding activity. Predicted to be involved in several processes, including positive regulation of membrane tubulation; protein localization to cilium; and regulation of postsynapse organization. Predicted to act upstream of or within negative regulation of dendritic spine development. Predicted to be located in several cellular components, including Golgi apparatus; centriolar satellite; and dendritic spine. Predicted to be active in glutamatergic synapse and podosome. Orthologous to human ASAP1 (ArfGAP with SH3 domain, ankyrin repeat and PH domain 1); PARTICIPATES IN Arf family mediated signaling pathway; endocytosis pathway; Fc gamma receptor mediated signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; all-trans-retinoic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase-activating protein; 130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein; ADP-ribosylation factor-directed GTPase-activating protein 1; ARF GTPase-activating protein 1; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1; Ddef1; DEF-1; development and differentiation enhancing; development and differentiation enhancing factor 1; development and differentiation-enhancing factor 1; differentiation-enhancing factor 1; LOC314961; PIP2-dependent ARF1 GAP
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8797,675,354 - 97,982,523 (-)NCBIGRCr8
mRatBN7.2795,786,130 - 96,093,111 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl795,787,818 - 96,092,754 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx797,559,806 - 97,822,370 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0799,761,470 - 100,024,009 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0799,683,352 - 99,953,092 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07104,670,076 - 104,951,090 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7104,669,672 - 104,801,045 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0791,673,052 - 91,955,738 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47101,303,973 - 101,575,856 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17101,337,297 - 101,575,548 (-)NCBI
Celera792,385,527 - 92,648,016 (-)NCBICelera
Cytogenetic Map7q33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
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Source
Original Reference(s)
Asap1Ratjuvenile rheumatoid arthritis  ISOASAP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19565504
Asap1Ratpulmonary tuberculosis  ISOASAP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25774636
Asap1Raturinary bladder cancer  ISOASAP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:26039340

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Original Reference(s)
Asap1Rat(-)-epigallocatechin 3-gallate multiple interactionsISOASAP1 (Homo sapiens)6480464[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ASAP1 mRNACTDPMID:22079256
Asap1Rat1,2-dimethylhydrazine multiple interactionsISOAsap1 (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of ASAP1 mRNACTDPMID:22206623
Asap1Rat1,2-dimethylhydrazine decreases expressionISOAsap1 (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of ASAP1 mRNACTDPMID:22206623
Asap1Rat17beta-estradiol decreases expressionISOASAP1 (Homo sapiens)6480464Estradiol results in decreased expression of ASAP1 mRNACTDPMID:19167446
Asap1Rat17beta-estradiol multiple interactionsISOASAP1 (Homo sapiens)6480464[Estradiol co-treated with TGFB1 protein] results in increased expression of ASAP1 mRNACTDPMID:30165855
Asap1Rat17beta-estradiol increases expressionISOASAP1 (Homo sapiens)6480464Estradiol results in increased expression of ASAP1 mRNACTDPMID:20106945
Asap1Rat2,2',4,4'-Tetrabromodiphenyl ether decreases expressionISOASAP1 (Homo sapiens)64804642 more ...CTDPMID:31675489
Asap1Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOASAP1 (Homo sapiens)6480464Tetrachlorodibenzodioxin affects the expression of ASAP1 mRNACTDPMID:22298810
Asap1Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of ASAP1 mRNACTDPMID:32109520 and PMID:34747641
Asap1Rat2,4,6-tribromophenol decreases expressionISOASAP1 (Homo sapiens)64804642 more ...CTDPMID:31675489
Asap1Rat2,4-dinitrotoluene affects expressionEXP 64804642 and 4-dinitrotoluene affects the expression of ASAP1 mRNACTDPMID:21346803
Asap1Rat3,3',5,5'-tetrabromobisphenol A decreases expressionISOASAP1 (Homo sapiens)6480464tetrabromobisphenol A results in decreased expression of ASAP1 proteinCTDPMID:31675489
Asap1Rat4,4'-diaminodiphenylmethane decreases expressionISOAsap1 (Mus musculus)64804644 and 4'-diaminodiphenylmethane results in decreased expression of ASAP1 mRNACTDPMID:18648102
Asap1Rat4,4'-sulfonyldiphenol decreases expressionISOAsap1 (Mus musculus)6480464bisphenol S results in decreased expression of ASAP1 mRNACTDPMID:39298647
Asap1Ratacrolein multiple interactionsISOASAP1 (Homo sapiens)6480464[Acrolein co-treated with methacrylaldehyde co-treated with Ozone] results in decreased expression of ASAP1 mRNACTDPMID:32845096
Asap1Rataflatoxin B1 increases expressionISOASAP1 (Homo sapiens)6480464Aflatoxin B1 results in increased expression of ASAP1 mRNACTDPMID:27153756
Asap1Rataflatoxin B1 increases methylationISOASAP1 (Homo sapiens)6480464Aflatoxin B1 results in increased methylation of ASAP1 geneCTDPMID:27153756
Asap1RatAflatoxin B2 alpha decreases methylationISOASAP1 (Homo sapiens)6480464aflatoxin B2 results in decreased methylation of ASAP1 intronCTDPMID:30157460
Asap1Ratall-trans-retinoic acid increases expressionEXP 6480464Tretinoin results in increased expression of ASAP1 mRNACTDPMID:20488242
Asap1Ratall-trans-retinoic acid increases expressionISOASAP1 (Homo sapiens)6480464Tretinoin results in increased expression of ASAP1 mRNACTDPMID:33167477

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Biological Process
1 to 12 of 12 rows

  
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Original Reference(s)
Asap1Ratcell projection organization involved_inIEAUniProtKB-KW:KW-09701600115GO_REF:0000043UniProtGO_REF:0000043
Asap1Ratcilium assembly involved_inIEAUniProtKB:Q9ULH1 and ensembl:ENSP000004299001600115GO_REF:0000107EnsemblGO_REF:0000107
Asap1Ratcilium assembly involved_inIBAPANTHER:PTN008699531 and UniProtKB:Q9ULH11600115GO_REF:0000033GO_CentralGO_REF:0000033
Asap1Ratcilium assembly involved_inISOASAP1 (Homo sapiens)1624291 PMID:20393563RGDPMID:20393563
Asap1Ratcilium assembly involved_inISSUniProtKB:Q9ULH11600115GO_REF:0000024UniProtGO_REF:0000024
Asap1Ratnegative regulation of dendritic spine development acts_upstream_of_or_withinISOAsap1 (Mus musculus)1624291 PMID:23050017RGDPMID:23050017
Asap1Ratpositive regulation of membrane tubulation involved_inIBAMGI:1342335 and PANTHER:PTN0086995311600115GO_REF:0000033GO_CentralGO_REF:0000033
Asap1Ratpositive regulation of membrane tubulation acts_upstream_of_or_withinISOAsap1 (Mus musculus)1624291 PMID:16431365RGDPMID:16431365
Asap1Ratprotein localization to cilium involved_inIEAUniProtKB:Q9ULH1 and ensembl:ENSP000004299001600115GO_REF:0000107EnsemblGO_REF:0000107
Asap1Ratprotein localization to cilium involved_inISSUniProtKB:Q9ULH11600115GO_REF:0000024UniProtGO_REF:0000024
Asap1Ratprotein localization to cilium involved_inISOASAP1 (Homo sapiens)1624291 PMID:25673879RGDPMID:25673879
Asap1Ratregulation of postsynapse organization involved_inISOAsap1 (Mus musculus)1624291 PMID:23050017RGDPMID:23050017
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Cellular Component
1 to 20 of 23 rows

  
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Original Reference(s)
Asap1Ratcentriolar satellite located_inISOASAP1 (Homo sapiens) and UniProtKB:Q9ULH1-11624291 RGDGO_REF:0000052
Asap1Ratcentriolar satellite located_inIEAUniProtKB:Q9ULH1 and ensembl:ENSP000004299001600115GO_REF:0000107EnsemblGO_REF:0000107
Asap1Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Asap1Ratcytoplasm located_inIEAInterPro:IPR0041481600115GO_REF:0000002InterProGO_REF:0000002
Asap1Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Asap1Ratdendritic spine located_inISOAsap1 (Mus musculus)1624291 PMID:23050017RGDPMID:23050017
Asap1Ratglutamatergic synapse is_active_inISOAsap1 (Mus musculus)1624291 PMID:23050017RGDPMID:23050017
Asap1RatGolgi apparatus located_inISOASAP1 (Homo sapiens) and UniProtKB:Q9ULH1-11624291 RGDGO_REF:0000052
Asap1RatGolgi apparatus located_inIEAUniProtKB:Q9ULH1 and ensembl:ENSP000004299001600115GO_REF:0000107EnsemblGO_REF:0000107
Asap1RatGolgi apparatus located_inIEAUniProtKB-SubCell:SL-01321600115GO_REF:0000044UniProtGO_REF:0000044
Asap1RatGolgi apparatus located_inIEAUniProtKB-KW:KW-03331600115GO_REF:0000043UniProtGO_REF:0000043
Asap1RatGolgi membrane located_inIEAUniProtKB:Q9ULH1 and ensembl:ENSP000004299001600115GO_REF:0000107EnsemblGO_REF:0000107
Asap1RatGolgi membrane located_inISSUniProtKB:Q9ULH11600115GO_REF:0000024UniProtGO_REF:0000024
Asap1RatGolgi membrane located_inISOASAP1 (Homo sapiens)1624291 PMID:25673879RGDPMID:25673879
Asap1Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Asap1Ratmembrane located_inIEAUniProtKB-SubCell:SL-01621600115GO_REF:0000044UniProtGO_REF:0000044
Asap1Ratplasma membrane located_inIEAUniProtKB:Q9ULH1 and ensembl:ENSP000004299001600115GO_REF:0000107EnsemblGO_REF:0000107
Asap1Ratplasma membrane located_inISOASAP1 (Homo sapiens) and UniProtKB:Q9ULH1-11624291 RGDGO_REF:0000052
Asap1Ratpodosome is_active_inIBAMGI:1342335 and PANTHER:PTN0086995311600115GO_REF:0000033GO_CentralGO_REF:0000033
Asap1Ratpodosome located_inISOAsap1 (Mus musculus)1624291 PMID:21352810RGDPMID:21352810
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Molecular Function
1 to 15 of 15 rows

  
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Original Reference(s)
Asap1RatGTPase activator activity enablesISOAsap1 (Mus musculus)1624291 PMID:10734117 and PMID:16431365RGDPMID:10734117 and PMID:16431365
Asap1RatGTPase activator activity enablesIBAMGI:1342335 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Asap1RatGTPase activator activity enablesIEAUniProtKB-KW:KW-03431600115GO_REF:0000043UniProtGO_REF:0000043
Asap1RatGTPase activator activity enablesIEAInterPro:IPR001164 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Asap1RatGTPase activator activity enablesIEAInterPro:IPR001164 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Asap1RatGTPase activator activity enablesIEAInterPro:IPR037844 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Asap1RatGTPase activator activity enablesIEAInterPro:IPR001164 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Asap1Ratmetal ion binding enablesIEAUniProtKB-KW:KW-04791600115GO_REF:0000043UniProtGO_REF:0000043
Asap1Ratphosphatidylinositol-3,4,5-trisphosphate binding enablesISOAsap1 (Mus musculus)1624291 PMID:10734117RGDPMID:10734117
Asap1Ratphosphatidylinositol-4,5-bisphosphate binding enablesISOAsap1 (Mus musculus)1624291 PMID:10734117RGDPMID:10734117
Asap1Ratphosphatidylserine binding enablesISOAsap1 (Mus musculus)1624291 PMID:16431365RGDPMID:16431365
Asap1Ratprotein binding enablesISOASAP1 (Homo sapiens)1624291UniProtKB:O75154 more ...RGDPMID:12029088 more ...
Asap1Ratprotein binding enablesISOPR:Q9QWY8-1 more ...1624291UniProtKB:P00523 and PMID:9819391RGDPMID:9819391
Asap1Ratprotein binding enablesISOAsap1 (Mus musculus)1624291PR:Q60875 more ...RGDPMID:12771146 and PMID:21352810
Asap1Ratzinc ion binding enablesIEAUniProtKB-KW:KW-08631600115GO_REF:0000043UniProtGO_REF:0000043
1 to 15 of 15 rows

Imported Annotations - KEGG (archival)

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Original Reference(s)
Asap1Ratendocytosis pathway  IEA 6907045 KEGGrno:04144
Asap1RatFc gamma receptor mediated signaling pathway  IEA 6907045 KEGGrno:04666

Imported Annotations - PID (archival)

Object Symbol
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Original Reference(s)
Asap1RatArf family mediated signaling pathway  ISOASAP1 (Homo sapiens)6484113 PIDPID:200195

#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. The tyrosine kinase Pyk2 regulates Arf1 activity by phosphorylation and inhibition of the Arf-GTPase-activating protein ASAP1. Kruljac-Letunic A, etal., J Biol Chem. 2003 Aug 8;278(32):29560-70. Epub 2003 May 27.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:9819391   PMID:10734117   PMID:16431365   PMID:17893324   PMID:20154719   PMID:20393563   PMID:21352810   PMID:23050017   PMID:25468996  



Asap1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8797,675,354 - 97,982,523 (-)NCBIGRCr8
mRatBN7.2795,786,130 - 96,093,111 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl795,787,818 - 96,092,754 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx797,559,806 - 97,822,370 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0799,761,470 - 100,024,009 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0799,683,352 - 99,953,092 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07104,670,076 - 104,951,090 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7104,669,672 - 104,801,045 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0791,673,052 - 91,955,738 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47101,303,973 - 101,575,856 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17101,337,297 - 101,575,548 (-)NCBI
Celera792,385,527 - 92,648,016 (-)NCBICelera
Cytogenetic Map7q33NCBI
ASAP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388130,052,104 - 130,443,674 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8130,052,104 - 130,443,674 (-)EnsemblGRCh38hg38GRCh38
GRCh378131,064,350 - 131,455,920 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368131,133,535 - 131,483,399 (-)NCBINCBI36Build 36hg18NCBI36
Build 348131,133,534 - 131,483,399NCBI
Celera8127,244,326 - 127,594,327 (-)NCBICelera
Cytogenetic Map8q24.21-q24.22NCBI
HuRef8126,384,999 - 126,734,847 (-)NCBIHuRef
CHM1_18131,103,607 - 131,496,464 (-)NCBICHM1_1
T2T-CHM13v2.08131,178,779 - 131,571,038 (-)NCBIT2T-CHM13v2.0
Asap1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391563,958,704 - 64,254,922 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1563,958,706 - 64,254,768 (-)EnsemblGRCm39 Ensembl
GRCm381564,086,840 - 64,382,941 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1564,086,857 - 64,382,919 (-)EnsemblGRCm38mm10GRCm38
MGSCv371563,920,101 - 64,214,481 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361563,918,212 - 64,212,592 (-)NCBIMGSCv36mm8
Celera1565,591,405 - 65,885,771 (-)NCBICelera
Cytogenetic Map15D1NCBI
cM Map1528.55NCBI
Asap1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554614,811,069 - 5,133,257 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554614,813,228 - 5,083,548 (-)NCBIChiLan1.0ChiLan1.0
ASAP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27147,421,012 - 147,815,414 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan18122,937,455 - 123,329,737 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v08126,688,608 - 127,080,662 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.18129,420,586 - 130,028,270 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8129,418,796 - 130,021,261 (-)Ensemblpanpan1.1panPan2
ASAP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11327,111,785 - 27,468,476 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1327,113,994 - 27,430,758 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1327,078,250 - 27,434,794 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01327,456,229 - 27,813,403 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1327,456,243 - 27,813,396 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11327,172,486 - 27,529,425 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01327,291,577 - 27,648,950 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01327,593,113 - 27,950,475 (-)NCBIUU_Cfam_GSD_1.0
Asap1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530310,913,682 - 11,214,295 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647018,339,616 - 18,640,624 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647018,340,120 - 18,640,396 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ASAP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl410,179,758 - 10,451,929 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1410,103,860 - 10,451,928 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2410,385,433 - 10,423,543 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ASAP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18124,515,274 - 124,912,076 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl8124,514,210 - 124,869,668 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603915,203,778 - 15,599,896 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Asap1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473525,409,902 - 25,732,967 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473525,410,002 - 25,732,847 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Asap1
1623 total Variants

Predicted Target Of
Summary Value
Count of predictions:124
Count of miRNA genes:55
Interacting mature miRNAs:62
Transcripts:ENSRNOT00000031906, ENSRNOT00000068192
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 39 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)780221299124373579Rat
2317035Aia16Adjuvant induced arthritis QTL 162.71joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)759238038104238038Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)794811326116294265Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)743747012108555253Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)769736356112729554Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)791412594129807172Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat

1 to 10 of 39 rows
D7Rat14  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8797,979,284 - 97,979,453 (+)Marker Load Pipeline
mRatBN7.2796,090,077 - 96,090,246 (+)MAPPERmRatBN7.2
Rnor_6.07104,982,653 - 104,982,821NCBIRnor6.0
Rnor_5.0791,988,027 - 91,988,195UniSTSRnor5.0
RGSC_v3.47101,619,417 - 101,619,586RGDRGSC3.4
RGSC_v3.47101,619,418 - 101,619,586UniSTSRGSC3.4
RGSC_v3.17101,653,648 - 101,653,816RGD
Celera792,679,755 - 92,679,923UniSTS
RH 3.4 Map7663.3UniSTS
RH 3.4 Map7663.3RGD
RH 2.0 Map7525.0RGD
SHRSP x BN Map757.9199RGD
Cytogenetic Map7q33UniSTS
D7Rat218  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8797,774,973 - 97,775,221 (+)Marker Load Pipeline
mRatBN7.2795,885,756 - 95,886,004 (+)MAPPERmRatBN7.2
Rnor_6.07104,767,076 - 104,767,323NCBIRnor6.0
Rnor_5.0791,770,089 - 91,770,336UniSTSRnor5.0
RGSC_v3.47101,402,079 - 101,402,326UniSTSRGSC3.4
RGSC_v3.47101,402,078 - 101,402,326RGDRGSC3.4
RGSC_v3.17101,436,308 - 101,436,556RGD
Celera792,482,546 - 92,482,793UniSTS
FHH x ACI Map746.7UniSTS
FHH x ACI Map746.7RGD
Cytogenetic Map7q33UniSTS
RH131168  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2795,787,900 - 95,788,093 (+)MAPPERmRatBN7.2
Rnor_6.07104,669,256 - 104,669,448NCBIRnor6.0
Rnor_5.0791,672,232 - 91,672,424UniSTSRnor5.0
RGSC_v3.47101,303,153 - 101,303,345UniSTSRGSC3.4
Celera792,384,707 - 92,384,899UniSTS
RH 3.4 Map7658.2UniSTS
Cytogenetic Map7q33UniSTS
BF406006  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2795,879,516 - 95,879,721 (+)MAPPERmRatBN7.2
Rnor_6.07104,760,836 - 104,761,040NCBIRnor6.0
Rnor_5.0791,763,849 - 91,764,053UniSTSRnor5.0
RGSC_v3.47101,395,839 - 101,396,043UniSTSRGSC3.4
Celera792,476,306 - 92,476,510UniSTS
RH 3.4 Map7659.0UniSTS
Cytogenetic Map7q33UniSTS
AU047703  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2796,027,924 - 96,028,001 (+)MAPPERmRatBN7.2
Rnor_6.07104,920,167 - 104,920,244NCBIRnor6.0
Rnor_6.07104,920,081 - 104,920,244NCBIRnor6.0
Rnor_5.0791,924,037 - 91,924,200UniSTSRnor5.0
Rnor_5.0791,924,123 - 91,924,200UniSTSRnor5.0
RGSC_v3.47101,545,072 - 101,545,153UniSTSRGSC3.4
RGSC_v3.47101,544,986 - 101,545,153UniSTSRGSC3.4
Cytogenetic Map7q33UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31


1 to 18 of 18 rows
RefSeq Transcripts NM_001044245 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039079174 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039079177 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039079178 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039079180 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263530 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263533 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263534 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263535 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263536 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005486633 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH473950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ238622 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ238623 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ238624 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 18 of 18 rows

Ensembl Acc Id: ENSRNOT00000079524   ⟹   ENSRNOP00000070164
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl795,787,836 - 96,092,754 (-)Ensembl
Rnor_6.0 Ensembl7104,670,076 - 104,801,045 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000079981   ⟹   ENSRNOP00000072909
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl795,787,836 - 96,092,691 (-)Ensembl
Rnor_6.0 Ensembl7104,669,672 - 104,749,552 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000085650   ⟹   ENSRNOP00000071134
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl795,787,818 - 96,020,812 (-)Ensembl
Rnor_6.0 Ensembl7104,670,076 - 104,800,536 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000094033   ⟹   ENSRNOP00000077111
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl795,787,836 - 96,020,950 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000107914   ⟹   ENSRNOP00000084328
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl795,787,836 - 95,920,279 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000108328   ⟹   ENSRNOP00000087244
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl795,787,818 - 96,020,812 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000112210   ⟹   ENSRNOP00000080846
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl795,787,836 - 96,092,754 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000117838   ⟹   ENSRNOP00000096504
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl795,789,860 - 96,058,369 (-)Ensembl
RefSeq Acc Id: NM_001044245   ⟹   NP_001037710
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8797,675,354 - 97,981,950 (-)NCBI
mRatBN7.2795,786,130 - 96,092,743 (-)NCBI
Rnor_6.07104,670,076 - 104,951,090 (-)NCBI
Rnor_5.0791,673,052 - 91,955,738 (-)NCBI
RGSC_v3.47101,303,973 - 101,575,856 (-)RGD
Celera792,385,527 - 92,648,016 (-)RGD
Sequence:
RefSeq Acc Id: XM_039079174   ⟹   XP_038935102
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8797,675,354 - 97,982,523 (-)NCBI
mRatBN7.2795,786,130 - 96,092,935 (-)NCBI
RefSeq Acc Id: XM_039079177   ⟹   XP_038935105
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8797,675,354 - 97,982,523 (-)NCBI
mRatBN7.2795,786,130 - 96,092,939 (-)NCBI
RefSeq Acc Id: XM_039079178   ⟹   XP_038935106
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8797,675,354 - 97,910,381 (-)NCBI
mRatBN7.2795,786,130 - 96,021,050 (-)NCBI
RefSeq Acc Id: XM_039079180   ⟹   XP_038935108
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8797,675,354 - 97,982,523 (-)NCBI
mRatBN7.2795,786,130 - 96,092,937 (-)NCBI
RefSeq Acc Id: XM_063263529   ⟹   XP_063119599
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8797,675,354 - 97,981,632 (-)NCBI
RefSeq Acc Id: XM_063263530   ⟹   XP_063119600
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8797,675,354 - 97,910,381 (-)NCBI
RefSeq Acc Id: XM_063263531   ⟹   XP_063119601
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8797,675,354 - 97,947,569 (-)NCBI
RefSeq Acc Id: XM_063263533   ⟹   XP_063119603
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8797,675,354 - 97,910,380 (-)NCBI
RefSeq Acc Id: XM_063263534   ⟹   XP_063119604
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8797,675,354 - 97,771,189 (-)NCBI
RefSeq Acc Id: XM_063263535   ⟹   XP_063119605
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8797,675,354 - 97,883,200 (-)NCBI
RefSeq Acc Id: XM_063263536   ⟹   XP_063119606
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8797,757,201 - 97,982,523 (-)NCBI
RefSeq Acc Id: XR_005486633
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8797,762,161 - 97,982,523 (-)NCBI
mRatBN7.2795,872,940 - 96,093,079 (-)NCBI
1 to 5 of 20 rows
1 to 5 of 20 rows
RefSeq Acc Id: NP_001037710   ⟸   NM_001044245
- UniProtKB: Q1AAU6 (UniProtKB/Swiss-Prot),   Q1AAU5 (UniProtKB/Swiss-Prot),   Q1AAU4 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000070164   ⟸   ENSRNOT00000079524
Ensembl Acc Id: ENSRNOP00000071134   ⟸   ENSRNOT00000085650
Ensembl Acc Id: ENSRNOP00000072909   ⟸   ENSRNOT00000079981
RefSeq Acc Id: XP_038935105   ⟸   XM_039079177
- Peptide Label: isoform X4
- UniProtKB: Q1AAU6 (UniProtKB/Swiss-Prot),   Q1AAU5 (UniProtKB/Swiss-Prot),   Q1AAU4 (UniProtKB/Swiss-Prot)
Arf-GAP   PH   SH3

Name Modeler Protein Id AA Range Protein Structure
AF-Q1AAU6-F1-model_v2 AlphaFold Q1AAU6 1-1144 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 40 of 77 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-33141 BioCyc
Ensembl Genes ENSRNOG00000058733 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000079524 ENTREZGENE
  ENSRNOT00000079524.2 UniProtKB/TrEMBL
  ENSRNOT00000079981 ENTREZGENE
  ENSRNOT00000079981.2 UniProtKB/TrEMBL
  ENSRNOT00000085650 ENTREZGENE
  ENSRNOT00000085650.2 UniProtKB/TrEMBL
  ENSRNOT00000094033.1 UniProtKB/TrEMBL
  ENSRNOT00000107914 ENTREZGENE
  ENSRNOT00000107914.1 UniProtKB/TrEMBL
  ENSRNOT00000108328.1 UniProtKB/TrEMBL
  ENSRNOT00000112210.1 UniProtKB/TrEMBL
  ENSRNOT00000117838.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.220.150 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.1270.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.25.40.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.25.40.950 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 Domains UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AH/BAR_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ankyrin_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ARFGAP/RecO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ArfGAP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ArfGAP_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ASAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ASAP1_BAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ASAP1_SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BAR_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_ASAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:314961 UniProtKB/Swiss-Prot
NCBI Gene 314961 ENTREZGENE
PANTHER ARF-GAP WITH SH3 DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR45854 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ank_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
1 to 40 of 77 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-15 Asap1  ArfGAP with SH3 domain, ankyrin repeat and PH domain 1  Ddef1  development and differentiation enhancing factor 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Ddef1  development and differentiation enhancing factor 1  Ddef1  development and differentiation enhancing   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Ddef1  development and differentiation enhancing   Ddef1_predicted  development and differentiation enhancing (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Ddef1_predicted  development and differentiation enhancing (predicted)      Symbol and Name status set to approved 70820 APPROVED