Map3k5 (mitogen-activated protein kinase kinase kinase 5) - Rat Genome Database

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Gene: Map3k5 (mitogen-activated protein kinase kinase kinase 5) Rattus norvegicus
Analyze
Symbol: Map3k5
Name: mitogen-activated protein kinase kinase kinase 5
RGD ID: 1306565
Description: Enables MAP kinase kinase kinase activity. Involved in several processes, including endothelial cell apoptotic process; positive regulation of MAPK cascade; and positive regulation of cardiac muscle cell apoptotic process. Located in external side of plasma membrane. Used to study cerebral infarction and myocardial infarction. Biomarker of membranous glomerulonephritis; transient cerebral ischemia; and visual epilepsy. Human ortholog(s) of this gene implicated in Huntington's disease. Orthologous to human MAP3K5 (mitogen-activated protein kinase kinase kinase 5); PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway; p38 MAPK signaling pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-Tetrachlorodibenzofuran; 4-vinylcyclohexene dioxide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: apoptosis signal regulating kinase 1; Ask1; LOC365057; RGD1306565; similar to apoptosis signal-regulating kinase 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8116,505,387 - 16,723,899 (+)NCBIGRCr8
mRatBN7.2114,685,776 - 14,904,935 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl114,685,492 - 14,904,800 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx114,451,174 - 14,657,631 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0120,453,039 - 20,659,558 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0114,666,217 - 14,883,508 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0115,412,603 - 15,613,752 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl115,412,603 - 15,613,746 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0116,961,080 - 17,160,996 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4115,205,361 - 15,346,422 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1115,204,326 - 15,346,541 (+)NCBI
Celera113,127,308 - 13,336,631 (+)NCBICelera
Cytogenetic Map1p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(S)-naringenin  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-dithiothreitol  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-hydroxypropanoic acid  (ISO)
3-methyladenine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitrophenol  (ISO)
4-phenylbutyric acid  (ISO)
4-vinylcyclohexene dioxide  (EXP)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
andrographolide  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
belinostat  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
berberine  (ISO)
bicuculline  (ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (EXP)
cadmium dichloride  (EXP,ISO)
cadmium sulfide  (ISO)
calcitriol  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
cannabigerol  (ISO)
carbon nanotube  (ISO)
Carnosol  (ISO)
chenodeoxycholic acid  (ISO)
chloroethene  (ISO)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
D-glucose  (ISO)
daunorubicin  (ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
Dibutyl phosphate  (ISO)
dieldrin  (ISO)
dimethyl sulfoxide  (EXP)
dimethylarsinic acid  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
edaravone  (ISO)
efavirenz  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
fingolimod hydrochloride  (ISO)
flutamide  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP,ISO)
gamma-aminobutyric acid  (ISO)
geldanamycin  (ISO)
gentamycin  (EXP)
glucose  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
hexadecanoic acid  (ISO)
hydrogen peroxide  (EXP,ISO)
indole-3-methanol  (EXP,ISO)
inulin  (ISO)
irinotecan  (ISO)
isoprenaline  (ISO)
kainic acid  (ISO)
KN-93  (EXP)
L-1,4-dithiothreitol  (ISO)
L-ascorbic acid  (ISO)
lactulose  (EXP)
lead diacetate  (EXP)
lead(0)  (EXP)
lenvatinib  (EXP)
lipopolysaccharide  (ISO)
LY 379268  (EXP)
mancozeb  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
MK-2206  (ISO)
muscimol  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-acetylsphingosine  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
neoechinulin A  (ISO)
nickel subsulfide  (ISO)
nickel sulfate  (ISO)
Nor-9-carboxy-delta9-THC  (ISO)
obeticholic acid  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
platycodin D  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
procymidone  (ISO)
protein kinase inhibitor  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
Salidroside  (ISO)
salubrinal  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sevoflurane  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
streptozocin  (EXP,ISO)
succimer  (ISO)
surfactin  (ISO)
surfactin C  (ISO)
tamoxifen  (ISO)
tartrazine  (ISO)
temozolomide  (ISO)
teprenone  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
tributylstannane  (ISO)
trichostatin A  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Brain-targeting delivery for RNAi neuroprotection against cerebral ischemia reperfusion injury. An S, etal., Biomaterials. 2013 Nov;34(35):8949-59. doi: 10.1016/j.biomaterials.2013.07.060. Epub 2013 Aug 19.
2. ASK1 and MAP2K6 as modifiers of age at onset in Huntington's disease. Arning L, etal., J Mol Med (Berl). 2008 Apr;86(4):485-90. doi: 10.1007/s00109-007-0299-6. Epub 2008 Mar 8.
3. Tumor necrosis factor-alpha and apoptosis signal-regulating kinase 1 control reactive oxygen species release, mitochondrial autophagy, and c-Jun N-terminal kinase/p38 phosphorylation during necrotizing enterocolitis. Baregamian N, etal., Oxid Med Cell Longev. 2009 Nov-Dec;2(5):297-306. doi: 10.4161/oxim.2.5.9541.
4. Inhibition of apoptosis signal-regulating kinase 1 reduces endoplasmic reticulum stress and nuclear huntingtin fragments in a mouse model of Huntington disease. Cho KJ, etal., Neuroscience. 2009 Nov 10;163(4):1128-34. doi: 10.1016/j.neuroscience.2009.07.048. Epub 2009 Jul 28.
5. Mechanisms and functions of p38 MAPK signalling. Cuadrado A and Nebreda AR, Biochem J. 2010 Aug 1;429(3):403-17. doi: 10.1042/BJ20100323.
6. NQDI 1, an inhibitor of ASK1 attenuates acute ischemic renal injury by modulating oxidative stress and cell death. El Eter E Cardiovasc Hematol Agents Med Chem. 2013 Sep;11(3):179-86.
7. Evidence for apoptosis signal-regulating kinase 1 in the regenerating palatal epithelium upon acute injury. Funato N, etal., Lab Invest. 1998 Apr;78(4):477-83.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. An apoptosis signal-regulating kinase 1 inhibitor reduces cardiomyocyte apoptosis and infarct size in a rat ischemia-reperfusion model. Gerczuk PZ, etal., J Cardiovasc Pharmacol. 2012 Sep;60(3):276-82. doi: 10.1097/FJC.0b013e31825ea0fa.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. Activation of ASK1, downstream MAPKK and MAPK isoforms during cardiac ischaemia. Harding SJ, etal., Biochim Biophys Acta. 2010 Sep;1802(9):733-40. doi: 10.1016/j.bbadis.2010.06.005. Epub 2010 Jun 13.
12. Activation of the stress-activated MAP kinase, p38, but not JNK in cortical motor neurons during early presymptomatic stages of amyotrophic lateral sclerosis in transgenic mice. Holasek SS, etal., Brain Res. 2005 May 31;1045(1-2):185-98. Epub 2005 Apr 25.
13. Activation of apoptosis signal-regulating kinase 1 in injured artery and its critical role in neointimal hyperplasia. Izumi Y, etal., Circulation. 2003 Dec 2;108(22):2812-8. Epub 2003 Nov 24.
14. Curcumin induced human gastric cancer BGC-823 cells apoptosis by ROS-mediated ASK1-MKK4-JNK stress signaling pathway. Liang T, etal., Int J Mol Sci. 2014 Sep 5;15(9):15754-65. doi: 10.3390/ijms150915754.
15. Endogenous nitric oxide induces activation of apoptosis signal-regulating kinase 1 via S-nitrosylation in rat hippocampus during cerebral ischemia-reperfusion. Liu DH, etal., Neuroscience. 2013 Jan 15;229:36-48. doi: 10.1016/j.neuroscience.2012.10.055. Epub 2012 Nov 5.
16. Bax inhibitor-1 suppresses early brain injury following experimental subarachnoid hemorrhage in rats. Liu J, etal., Int J Mol Med. 2018 Nov;42(5):2891-2902. doi: 10.3892/ijmm.2018.3858. Epub 2018 Sep 5.
17. MicroRNA-145 Protects against Myocardial Ischemia Reperfusion Injury via CaMKII-Mediated Antiapoptotic and Anti-Inflammatory Pathways. Liu Z, etal., Oxid Med Cell Longev. 2019 Sep 10;2019:8948657. doi: 10.1155/2019/8948657. eCollection 2019.
18. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
19. Induction of apoptosis signal regulating kinase 1 (ASK1) after spinal cord injury in rats: possible involvement of ASK1-JNK and -p38 pathways in neuronal apoptosis. Nakahara S, etal., J Neuropathol Exp Neurol. 1999 May;58(5):442-50.
20. ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats. Nishitoh H, etal., Genes Dev. 2002 Jun 1;16(11):1345-55.
21. Blocking Daxx trafficking attenuates neuronal cell death following ischemia/reperfusion in rat hippocampus CA1 region. Niu YL, etal., Arch Biochem Biophys. 2011 Nov;515(1-2):89-98. doi: 10.1016/j.abb.2011.07.016. Epub 2011 Aug 6.
22. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
23. Role of apoptosis signal-regulating kinase 1 in complement-mediated glomerular epithelial cell injury. Ren G, etal., Mol Immunol. 2008 Apr;45(8):2236-46. doi: 10.1016/j.molimm.2007.11.013. Epub 2008 Feb 21.
24. GOA pipeline RGD automated data pipeline
25. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
26. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
27. Inhibition of apoptosis-regulated signaling kinase-1 and prevention of congestive heart failure by estrogen. Satoh M, etal., Circulation. 2007 Jun 26;115(25):3197-204. Epub 2007 Jun 11.
28. Formation of a tumour necrosis factor receptor 1 molecular scaffolding complex and activation of apoptosis signal-regulating kinase 1 during seizure-induced neuronal death. Shinoda S, etal., Eur J Neurosci. 2003 May;17(10):2065-76.
29. The effect of apoptosis signal-regulating kinase 1 gene transfer on rat collagen induced arthritis. Terauchi R, etal., J Rheumatol. 2005 Dec;32(12):2373-80.
30. Apoptosis signal-regulating kinase 1 is a novel target molecule for cognitive impairment induced by chronic cerebral hypoperfusion. Toyama K, etal., Arterioscler Thromb Vasc Biol. 2014 Mar;34(3):616-25. doi: 10.1161/ATVBAHA.113.302440. Epub 2013 Dec 26.
31. Targeted deletion of apoptosis signal-regulating kinase 1 attenuates left ventricular remodeling. Yamaguchi O, etal., Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15883-8. Epub 2003 Dec 9.
32. Novel mechanism and role of angiotensin II induced vascular endothelial injury in hypertensive diastolic heart failure. Yamamoto E, etal., Arterioscler Thromb Vasc Biol. 2007 Dec;27(12):2569-75. Epub 2007 Oct 11.
33. Hypercapnic acidosis confers antioxidant and anti-apoptosis effects against ventilator-induced lung injury. Yang WC, etal., Lab Invest. 2013 Dec;93(12):1339-49. doi: 10.1038/labinvest.2013.118. Epub 2013 Oct 14.
34. Hydrogen peroxide predisposes neonatal rat ventricular myocytes to Fas-mediated apoptosis. Yaniv G, etal., Biochem Biophys Res Commun. 2005 Oct 28;336(3):740-6. doi: 10.1016/j.bbrc.2005.08.167.
35. Biphasic activation of apoptosis signal-regulating kinase 1-stress-activated protein kinase 1-c-Jun N-terminal protein kinase pathway is selectively mediated by Ca2+-permeable alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors involving oxidative stress following brain ischemia in rat hippocampus. Zhang Q, etal., Neurosci Lett. 2003 Jan 30;337(1):51-5.
Additional References at PubMed
PMID:9743501   PMID:11096076   PMID:11920685   PMID:11959862   PMID:12165419   PMID:12215209   PMID:12869527   PMID:14575811   PMID:15629441   PMID:15767678   PMID:15983381   PMID:16006035  
PMID:16316999   PMID:16648474   PMID:16762504   PMID:16891268   PMID:17015265   PMID:17068291   PMID:17210579   PMID:17306896   PMID:17481747   PMID:17543279   PMID:17937911   PMID:18007661  
PMID:18948261   PMID:19451227   PMID:19805025   PMID:20518594   PMID:20674765   PMID:21076890   PMID:21530592   PMID:21771788   PMID:22070384   PMID:22110360   PMID:22337877   PMID:22997161  
PMID:23000344   PMID:23504235   PMID:23744074   PMID:24578161   PMID:25541364   PMID:25713304   PMID:25996168   PMID:29107962   PMID:29277546   PMID:29657313   PMID:30024858   PMID:31505169  
PMID:31547465   PMID:31830507   PMID:32567007   PMID:37306338   PMID:37735821   PMID:37786374   PMID:38879082  


Genomics

Comparative Map Data
Map3k5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8116,505,387 - 16,723,899 (+)NCBIGRCr8
mRatBN7.2114,685,776 - 14,904,935 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl114,685,492 - 14,904,800 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx114,451,174 - 14,657,631 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0120,453,039 - 20,659,558 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0114,666,217 - 14,883,508 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0115,412,603 - 15,613,752 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl115,412,603 - 15,613,746 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0116,961,080 - 17,160,996 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4115,205,361 - 15,346,422 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1115,204,326 - 15,346,541 (+)NCBI
Celera113,127,308 - 13,336,631 (+)NCBICelera
Cytogenetic Map1p12NCBI
MAP3K5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386136,557,046 - 136,793,091 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6136,557,046 - 136,793,097 (-)EnsemblGRCh38hg38GRCh38
GRCh376136,878,184 - 137,113,615 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366136,919,880 - 137,155,349 (-)NCBINCBI36Build 36hg18NCBI36
Build 346136,919,880 - 137,155,349NCBI
Celera6137,618,672 - 137,854,128 (-)NCBICelera
Cytogenetic Map6q23.3NCBI
HuRef6134,442,506 - 134,677,689 (-)NCBIHuRef
CHM1_16137,140,796 - 137,376,381 (-)NCBICHM1_1
T2T-CHM13v2.06137,745,240 - 137,981,287 (-)NCBIT2T-CHM13v2.0
Map3k5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391019,809,847 - 20,018,496 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1019,810,218 - 20,018,499 (+)EnsemblGRCm39 Ensembl
GRCm381019,934,101 - 20,142,750 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1019,934,472 - 20,142,753 (+)EnsemblGRCm38mm10GRCm38
MGSCv371019,654,332 - 19,862,556 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361019,623,888 - 19,831,139 (+)NCBIMGSCv36mm8
Celera1019,821,331 - 20,029,886 (+)NCBICelera
Cytogenetic Map10A3NCBI
cM Map109.35NCBI
Map3k5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955439163,103 - 377,808 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955439162,499 - 376,919 (+)NCBIChiLan1.0ChiLan1.0
MAP3K5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25156,523,085 - 156,789,428 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16154,421,795 - 154,688,128 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06134,316,841 - 134,582,843 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16138,406,398 - 138,641,720 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6138,406,398 - 138,641,727 (-)Ensemblpanpan1.1panPan2
MAP3K5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1129,107,813 - 29,306,437 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl129,108,591 - 29,306,503 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha129,990,542 - 30,188,619 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0129,268,427 - 29,467,057 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl129,268,507 - 29,467,038 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1129,153,995 - 29,352,081 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0129,038,857 - 29,237,270 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0129,337,976 - 29,536,372 (-)NCBIUU_Cfam_GSD_1.0
Map3k5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946124,209,480 - 124,418,731 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365603,989,420 - 4,197,501 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365603,988,696 - 4,197,953 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAP3K5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl127,380,142 - 27,600,493 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1127,380,143 - 27,600,500 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2130,747,576 - 30,980,371 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MAP3K5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11336,614,489 - 36,858,524 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1336,615,633 - 36,858,601 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660408,796,832 - 9,040,884 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Map3k5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624886969,623 - 1,190,709 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624886970,415 - 1,189,595 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Map3k5
1438 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:136
Count of miRNA genes:57
Interacting mature miRNAs:67
Transcripts:ENSRNOT00000051496, ENSRNOT00000067070
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1578650Bmd6Bone mineral density QTL 612.2femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)150910843284926Rat
1354647Despr8Despair related QTL 80.0000341locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1124744506Rat
1578651Bmd7Bone mineral density QTL 714.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)150910843284926Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1439328949393289Rat
2313070Bss52Bone structure and strength QTL 524.40.0001body length (VT:0001256)body length (CMO:0000013)1132356093Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
2298546Neuinf4Neuroinflammation QTL 45.1nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1128736750Rat
1300167Hrtrt2Heart rate QTL 24.35heart pumping trait (VT:2000009)heart rate (CMO:0000002)11148131275088344Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
2317755Glom22Glomerulus QTL 223.8urine protein amount (VT:0005160)urine protein level (CMO:0000591)11148148232355910Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)11183518156835181Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)1985600154856001Rat
2313090Bmd69Bone mineral density QTL 694.40.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)1132356093Rat
4889451Eae29Experimental allergic encephalomyelitis QTL 295.51nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1592587724697545Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
738020Pia8Pristane induced arthritis QTL 84.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1165833076Rat
1600360Mcs16Mammary carcinoma susceptibility QTL 162.4mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1224439043433040Rat
1578669Bss9Bone structure and strength QTL 96.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)150910843284926Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11099206555992065Rat
2313053Bss51Bone structure and strength QTL 513.80.0001tibia length (VT:0004357)tibia length (CMO:0000450)1132356093Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000051496   ⟹   ENSRNOP00000051338
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl114,685,492 - 14,904,800 (+)Ensembl
Rnor_6.0 Ensembl115,412,603 - 15,613,746 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000067070   ⟹   ENSRNOP00000063417
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl114,686,358 - 14,904,800 (+)Ensembl
Rnor_6.0 Ensembl115,412,603 - 15,613,746 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000096116   ⟹   ENSRNOP00000090845
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl114,685,492 - 14,904,800 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000104843   ⟹   ENSRNOP00000084904
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl114,685,492 - 14,904,800 (+)Ensembl
RefSeq Acc Id: NM_001277694   ⟹   NP_001264623
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8116,505,964 - 16,723,218 (+)NCBI
mRatBN7.2114,686,358 - 14,903,639 (+)NCBI
Rnor_6.0115,412,603 - 15,613,752 (+)NCBI
Rnor_5.0116,961,080 - 17,160,996 (+)NCBI
Celera113,127,308 - 13,336,631 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039084822   ⟹   XP_038940750
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8116,505,387 - 16,723,899 (+)NCBI
mRatBN7.2114,685,776 - 14,904,935 (+)NCBI
RefSeq Acc Id: XM_039084825   ⟹   XP_038940753
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8116,651,717 - 16,723,899 (+)NCBI
mRatBN7.2114,832,146 - 14,904,918 (+)NCBI
RefSeq Acc Id: NP_001264623   ⟸   NM_001277694
- UniProtKB: A0A8I6AEL0 (UniProtKB/TrEMBL),   A0A8I6A280 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000063417   ⟸   ENSRNOT00000067070
Ensembl Acc Id: ENSRNOP00000051338   ⟸   ENSRNOT00000051496
RefSeq Acc Id: XP_038940750   ⟸   XM_039084822
- Peptide Label: isoform X1
- UniProtKB: D3ZZH6 (UniProtKB/TrEMBL),   A0A8I6A280 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038940753   ⟸   XM_039084825
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000084904   ⟸   ENSRNOT00000104843
Ensembl Acc Id: ENSRNOP00000090845   ⟸   ENSRNOT00000096116
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZZH6-F1-model_v2 AlphaFold D3ZZH6 1-1379 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306565 AgrOrtholog
BioCyc Gene G2FUF-62211 BioCyc
Ensembl Genes ENSRNOG00000031700 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000051496.7 UniProtKB/TrEMBL
  ENSRNOT00000067070.4 UniProtKB/TrEMBL
  ENSRNOT00000096116.1 UniProtKB/TrEMBL
  ENSRNOT00000104843.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro DRHyd-ASK UniProtKB/TrEMBL
  DUF4071 UniProtKB/TrEMBL
  HisK-N-like UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  MAP3K_PH UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  SAM/pointed UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
KEGG Report rno:365057 UniProtKB/TrEMBL
NCBI Gene 365057 ENTREZGENE
PANTHER MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5 UniProtKB/TrEMBL
  SERINE/THREONINE PROTEIN KINASE UniProtKB/TrEMBL
Pfam ASK_PH UniProtKB/TrEMBL
  DRHyd-ASK UniProtKB/TrEMBL
  DUF4071 UniProtKB/TrEMBL
  HisK-N-like UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PhenoGen Map3k5 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
RatGTEx ENSRNOG00000031700 RatGTEx
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
  SAM_homology UniProtKB/TrEMBL
UniProt A0A8I6A280 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AEL0 ENTREZGENE, UniProtKB/TrEMBL
  D3ZW27_RAT UniProtKB/TrEMBL
  D3ZZH6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-10-10 RGD1306565  similar to apoptosis signal-regulating kinase 1  Map3k5  mitogen-activated protein kinase kinase kinase 5  Data merged from RGD:1306431 737654 APPROVED
2012-10-10 Map3k5  mitogen-activated protein kinase kinase kinase 5  RGD1306565  similar to apoptosis signal-regulating kinase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1306565  similar to apoptosis signal-regulating kinase 1   RGD1306565_predicted  similar to apoptosis signal-regulating kinase 1 (predicted)  'predicted' is removed 2292626 APPROVED
2008-04-30 Map3k5  mitogen-activated protein kinase kinase kinase 5   Map3k5_predicted  mitogen-activated protein kinase kinase kinase 5 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-20 RGD1306565_predicted  similar to apoptosis signal-regulating kinase 1 (predicted)  LOC365057_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC365057_predicted  similar to apoptosis signal-regulating kinase 1 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-12 Map3k5_predicted  mitogen-activated protein kinase kinase kinase 5 (predicted)      Symbol and Name status set to approved 70820 APPROVED