Gabra5 (gamma-aminobutyric acid type A receptor subunit alpha 5) - Rat Genome Database

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Gene: Gabra5 (gamma-aminobutyric acid type A receptor subunit alpha 5) Mus musculus
Analyze
Symbol: Gabra5
Name: gamma-aminobutyric acid type A receptor subunit alpha 5
RGD ID: 62151
MGI Page MGI
Description: Enables GABA-A receptor activity and GABA-gated chloride ion channel activity. Involved in cochlea development; inner ear receptor cell development; and innervation. Acts upstream of or within associative learning and behavioral fear response. Located in cell body and dendrite. Is expressed in several structures, including brain and palatal shelf. Human ortholog(s) of this gene implicated in bipolar disorder; depressive disorder; and developmental and epileptic encephalopathy 79. Orthologous to human GABRA5 (gamma-aminobutyric acid type A receptor subunit alpha5).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: A230018I05Rik; GABA(A) receptor subunit alpha-5; GABAA receptor alpha5 subunit; GABAAR subunit alpha-5; gamma-aminobutyric acid (GABA) A receptor, subunit alpha 5; gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 5; gamma-aminobutyric acid receptor subunit alpha-5; ligand-gated ion channel subunit
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39757,057,417 - 57,240,808 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl757,057,420 - 57,159,807 (-)EnsemblGRCm39 Ensembl
GRCm38757,407,669 - 57,591,016 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl757,407,672 - 57,510,059 (-)EnsemblGRCm38mm10GRCm38
MGSCv37764,663,039 - 64,765,379 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36757,275,688 - 57,377,873 (-)NCBIMGSCv36mm8
Celera754,720,522 - 54,830,242 (-)NCBICelera
Cytogenetic Map7B5NCBI
cM Map733.52NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
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Original Reference(s)
Gabra5Mouseautistic disorder  ISOGABRA5 (Homo sapiens)6480253 RGD 
Gabra5Mousebipolar disorder  ISOGABRA5 (Homo sapiens)1358630 RGD 
Gabra5Mousedepressive disorder  ISOGABRA5 (Homo sapiens)1358629DNA:repeat:: (human)RGD 
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Original Reference(s)
Gabra5MouseAngelman syndrome  ISOGABRA5 (Homo sapiens)8554872ClinVar Annotator: match by term: Angelman syndromeClinVarPMID:24088041 more ...
Gabra5Mouseautism spectrum disorder  ISOGABRA5 (Homo sapiens)8554872ClinVar Annotator: match by term: Autism spectrum disorderClinVarPMID:21844811 more ...
Gabra5Mouseautistic disorder  ISOGABRA5 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:21681106 more ...
Gabra5MouseChildhood Absence Epilepsy 1  ISOGABRA5 (Homo sapiens)8554872ClinVar Annotator: match by term: Epilepsy more ...ClinVarPMID:11198279 more ...
Gabra5Mousechromosome 15q11.2 deletion syndrome  ISOGABRA5 (Homo sapiens)8554872ClinVar Annotator: match by term: Chromosome 15q11-q13 duplication syndromeClinVarPMID:25741868 and PMID:31690835
Gabra5Mousedevelopmental and epileptic encephalopathy 79  ISOGABRA5 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:25741868 more ...
Gabra5Mouseepilepsy  ISOGABRA5 (Homo sapiens)8554872ClinVar Annotator: match by term: SeizureClinVarPMID:25741868
Gabra5Mousegenetic disease  ISOGABRA5 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:28518168 and PMID:32461654
Gabra5MouseNeurodevelopmental Disorders  ISOGABRA5 (Homo sapiens)8554872ClinVar Annotator: match by term: Neurodevelopmental disorderClinVarPMID:25741868
Gabra5MousePrader-Willi syndrome  ISOGABRA5 (Homo sapiens)8554872ClinVar Annotator: match by term: Prader-Willi syndromeClinVarPMID:28631899
Gabra5Mouseschizophrenia  ISOGABRA5 (Homo sapiens)8554872ClinVar Annotator: match by term: SchizophreniaClinVarPMID:21681106 and PMID:30208311
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Original Reference(s)
Gabra5Mouseautism spectrum disorder  ISOGABRA5 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:27231709
Gabra5Mouseautistic disorder  ISOGABRA5 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17353214
Gabra5MouseIsodicentric Chromosome 15 Syndrome  ISOGABRA5 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:23663378
Gabra5MouseMemory Disorders  ISOGABRA5 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20180861
Gabra5MouseSocial Communication Disorder  ISOGABRA5 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:27231709
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Original Reference(s)
Gabra5Mousedevelopmental and epileptic encephalopathy 79  ISOGABRA5 (Homo sapiens)7240710 OMIM 

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Gabra5Mouse(+)-pilocarpine multiple interactionsISOGabra5 (Rattus norvegicus)6480464bacoside A inhibits the reaction [Pilocarpine results in decreased expression of GABRA5 mRNA] and Carbamazepine inhibits the reaction [Pilocarpine results in decreased expression of GABRA5 mRNA]CTDPMID:20821261
Gabra5Mouse(+)-pilocarpine decreases expressionISOGabra5 (Rattus norvegicus)6480464Pilocarpine results in decreased expression of GABRA5 mRNACTDPMID:20821261
Gabra5Mouse(S)-nicotine increases expressionISOGabra5 (Rattus norvegicus)6480464Nicotine results in increased expression of GABRA5 mRNACTDPMID:28339662
Gabra5Mouse17beta-estradiol affects expressionISOGABRA5 (Homo sapiens)6480464Estradiol affects the expression of GABRA5 mRNACTDPMID:16000229
Gabra5Mouse2,3,7,8-tetrachlorodibenzodioxine increases expressionISOGABRA5 (Homo sapiens)6480464Tetrachlorodibenzodioxin results in increased expression of GABRA5 mRNACTDPMID:21296121
Gabra5Mouse2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOGabra5 (Rattus norvegicus)6480464Tetrachlorodibenzodioxin results in decreased expression of GABRA5 mRNACTDPMID:32109520
Gabra5Mouse2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of GABRA5 mRNACTDPMID:21570461
Gabra5Mouse2,3,7,8-Tetrachlorodibenzofuran decreases expressionISOGabra5 (Rattus norvegicus)64804642 more ...CTDPMID:32109520
Gabra5Mouse2-palmitoylglycerol increases expressionISOGABRA5 (Homo sapiens)64804642-palmitoylglycerol results in increased expression of GABRA5 mRNACTDPMID:37199045
Gabra5Mouse4,4'-sulfonyldiphenol increases methylationISOGABRA5 (Homo sapiens)6480464bisphenol S results in increased methylation of GABRA5 geneCTDPMID:31601247
Gabra5Mouse4,4'-sulfonyldiphenol affects methylationEXP 6480464bisphenol S affects the methylation of GABRA5 geneCTDPMID:31683443
Gabra5Mouse4,4'-sulfonyldiphenol multiple interactionsISOGABRA5 (Homo sapiens)6480464[bisphenol S co-treated with Fulvestrant] results in increased methylation of GABRA5 geneCTDPMID:31601247
Gabra5Mouse6-propyl-2-thiouracil increases expressionISOGabra5 (Rattus norvegicus)6480464Propylthiouracil results in increased expression of GABRA5 mRNACTDPMID:24780913
Gabra5Mouseacrylamide decreases expressionISOGABRA5 (Homo sapiens)6480464Acrylamide results in decreased expression of GABRA5 mRNACTDPMID:32763439
Gabra5Mouseantirheumatic drug increases expressionISOGABRA5 (Homo sapiens)6480464Antirheumatic Agents results in increased expression of GABRA5 mRNACTDPMID:24449571
Gabra5Mousearsane multiple interactionsISOGABRA5 (Homo sapiens)6480464[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased abundance of Manganese]] results in increased expression of GABRA5 mRNACTDPMID:39836092
Gabra5Mousearsenic atom multiple interactionsISOGABRA5 (Homo sapiens)6480464[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased abundance of Manganese]] results in increased expression of GABRA5 mRNACTDPMID:39836092
Gabra5MouseAzoxymethane multiple interactionsEXP 6480464[titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of GABRA5 mRNACTDPMID:29950665
Gabra5MouseBacoside a multiple interactionsISOGabra5 (Rattus norvegicus)6480464bacoside A inhibits the reaction [Pilocarpine results in decreased expression of GABRA5 mRNA]CTDPMID:20821261
Gabra5Mousebenzo[a]pyrene increases expressionISOGabra5 (Rattus norvegicus)6480464Benzo(a)pyrene results in increased expression of GABRA5 mRNACTDPMID:21839799

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Biological Process
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Original Reference(s)
Gabra5Mouseassociative learning acts_upstream_of_or_withinIMPMGI:21831702290270 PMID:12084936MGIPMID:12084936
Gabra5Mousebehavioral fear response acts_upstream_of_or_withinIMPMGI:21831702290270 PMID:12084936MGIPMID:12084936
Gabra5Mousechemical synaptic transmission  ISOGabra5 (Rattus norvegicus)9068941 RGDPMID:15246695 more ...
Gabra5Mousechemical synaptic transmission involved_inIEAUniProtKB:P19969 and ensembl:ENSRNOP000000723892290270 EnsemblGO_REF:0000107
Gabra5Mousechemical synaptic transmission involved_inISOGabra5 (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
Gabra5Mousechloride transmembrane transport involved_inIEAGO:0005254 and GO:00228512290270 GOCGO_REF:0000108
Gabra5Mousechloride transmembrane transport involved_inIBAPANTHER:PTN002316889 more ...2290270 GO_CentralGO_REF:0000033
Gabra5Mousecochlea development involved_inIMP 2290270 PMID:17021187DFLATPMID:17021187
Gabra5Mousegamma-aminobutyric acid signaling pathway involved_inIBAPANTHER:PTN001055383 more ...2290270 GO_CentralGO_REF:0000033
Gabra5Mousegamma-aminobutyric acid signaling pathway involved_inISOComplexPortal:CPX-21672290270 ComplexPortalGO_REF:0000114
Gabra5Mouseinhibitory synapse assembly involved_inIBAPANTHER:PTN001055383 more ...2290270 GO_CentralGO_REF:0000033
Gabra5Mouseinner ear receptor cell development involved_inIMP 2290270 PMID:17021187DFLATPMID:17021187
Gabra5Mouseinnervation involved_inIMP 2290270 PMID:17021187DFLATPMID:17021187
Gabra5Mouseneuron development involved_inIMP 2290270 PMID:17021187DFLATPMID:17021187
Gabra5Mouseregulation of postsynaptic membrane potential involved_inIEAGO:19043152290270 GOCGO_REF:0000108
Gabra5Mouseregulation of presynaptic membrane potential involved_inIEAGO:00995072290270 GOCGO_REF:0000108
Gabra5Mousesynaptic transmission, GABAergic involved_inIBAPANTHER:PTN000436343 more ...2290270 GO_CentralGO_REF:0000033
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Cellular Component
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Original Reference(s)
Gabra5Mousecell body located_inIDA 2290270 PMID:9682826MGIPMID:9682826
Gabra5Mousechloride channel complex part_ofIEAUniProtKB-KW:KW-08692290270 UniProtGO_REF:0000043
Gabra5Mousecytosol located_inISOUniProtKB:P316442290270 GO_CentralGO_REF:0000119
Gabra5Mousecytosol located_inIEAUniProtKB:P31644 and ensembl:ENSP000003355922290270 EnsemblGO_REF:0000107
Gabra5Mousedendrite  ISOGabra5 (Rattus norvegicus)9068941 RGDPMID:15246695 and REF_RGD_ID:1358392
Gabra5Mousedendrite located_inIDA 2290270 PMID:9682826MGIPMID:9682826
Gabra5Mousedendrite located_inISOGabra5 (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
Gabra5Mousedendrite membrane is_active_inIBAPANTHER:PTN000436343 more ...2290270 GO_CentralGO_REF:0000033
Gabra5MouseGABA-A receptor complex part_ofIBAPANTHER:PTN001055383 more ...2290270 GO_CentralGO_REF:0000033
Gabra5MouseGABA-A receptor complex part_ofISOComplexPortal:CPX-21672290270 ComplexPortalGO_REF:0000114
Gabra5MouseGABA-ergic synapse located_inIEAUniProtKB:P19969 and ensembl:ENSRNOP000000723892290270 EnsemblGO_REF:0000107
Gabra5MouseGABA-ergic synapse is_active_inISOGabra5 (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
Gabra5Mouseneuronal cell body membrane located_inISOGabra5 (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
Gabra5Mouseneuronal cell body membrane located_inIEAUniProtKB:P19969 and ensembl:ENSRNOP000000723892290270 EnsemblGO_REF:0000107
Gabra5Mouseneuronal cell body membrane  ISOGabra5 (Rattus norvegicus)9068941 RGDPMID:15246695 and REF_RGD_ID:1358392
Gabra5Mousenucleoplasm located_inISOUniProtKB:P316442290270 GO_CentralGO_REF:0000119
Gabra5Mousenucleoplasm located_inIEAUniProtKB:P31644 and ensembl:ENSP000003355922290270 EnsemblGO_REF:0000107
Gabra5Mouseplasma membrane located_inISOUniProtKB:P316442290270 GO_CentralGO_REF:0000119
Gabra5Mousepostsynapse is_active_inIBAPANTHER:PTN000436343 more ...2290270 GO_CentralGO_REF:0000033
Gabra5Mousepostsynaptic membrane is_active_inISOGabra5 (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
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Molecular Function
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Original Reference(s)
Gabra5Mousebenzodiazepine receptor activity contributes_toIBAPANTHER:PTN001055383 and Gabra6 (Rattus norvegicus)2290270 GO_CentralGO_REF:0000033
Gabra5Mousechloride channel activity contributes_toIBAPANTHER:PTN002316889 more ...2290270 GO_CentralGO_REF:0000033
Gabra5MouseGABA receptor binding enablesIEAUniProtKB:P19969 and ensembl:ENSRNOP000000723892290270 EnsemblGO_REF:0000107
Gabra5MouseGABA receptor binding enablesISOGabra5 (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
Gabra5MouseGABA receptor binding  ISOGabrg1 (Rattus norvegicus)9068941 RGDPMID:17959749 and REF_RGD_ID:6480233
Gabra5MouseGABA receptor binding  ISOGabrb1 (Rattus norvegicus)9068941 RGDPMID:17959749 and REF_RGD_ID:6480233
Gabra5MouseGABA-A receptor activity enablesISSUniProtKB:P199692290270 UniProtGO_REF:0000024
Gabra5MouseGABA-A receptor activity enablesISOGabra5 (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
Gabra5MouseGABA-A receptor activity enablesIMP 2290270 PMID:14993607UniProtPMID:14993607
Gabra5MouseGABA-A receptor activity  ISOGabra5 (Rattus norvegicus)9068941 RGDPMID:2153588 and REF_RGD_ID:61593
Gabra5MouseGABA-gated chloride ion channel activity enablesIBAPANTHER:PTN000436343 more ...2290270 GO_CentralGO_REF:0000033
Gabra5MouseGABA-gated chloride ion channel activity enablesIMP 2290270 PMID:14993607UniProtPMID:14993607
Gabra5MouseGABA-gated chloride ion channel activity enablesISSUniProtKB:P199692290270 UniProtGO_REF:0000024
Gabra5Mouseligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential enablesIEAUniProtKB:P31644 and ensembl:ENSP000003355922290270 EnsemblGO_REF:0000107
Gabra5Mouseligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential enablesISOUniProtKB:P316442290270 GO_CentralGO_REF:0000119
Gabra5Mouseprotein binding enablesIPIUniProtKB:Q5WQV52290270 PMID:16467845IntActPMID:16467845
Gabra5Mousetransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential enablesISOGabra5 (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
Gabra5Mousetransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential enablesIEAUniProtKB:P19969 and ensembl:ENSRNOP000000723892290270 EnsemblGO_REF:0000107
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Original Reference(s)
Gabra5Mouseabnormal auditory brainstem response waveform shape  IAGP 5509061 MGIPMID:17021187
Gabra5Mouseabnormal behavioral response to xenobiotic  IAGP 5509061 MGIPMID:12084936
Gabra5Mouseabnormal cochlea morphology  IAGP 5509061 MGIPMID:17021187
Gabra5Mouseabnormal cochlear OHC efferent innervation pattern  IAGP 5509061 MGIPMID:17021187
Gabra5Mouseabnormal contextual conditioning behavior  IAGP 5509061 MGIPMID:16597725
Gabra5Mouseabnormal distortion product otoacoustic emission  IAGP 5509061 MGIPMID:17021187
Gabra5Mouseabnormal GABA-mediated receptor currents  IAGP 5509061 MGIPMID:16597725
Gabra5Mouseabnormal heart morphology  IEA 5509061 MGI 
Gabra5Mouseabnormal hippocampus CA1 region morphology  IAGP 5509061 MGIPMID:12084936
Gabra5Mouseabnormal inhibitory postsynaptic currents  IAGP 5509061 MGIPMID:12097508
Gabra5Mouseabnormal long-term potentiation  IAGP 5509061 MGIPMID:16597725
Gabra5Mouseabnormal spatial learning  IAGP 5509061 MGIPMID:16597725
Gabra5Mouseabnormal spatial learning  IAGP 5509061 MGIPMID:12097508
Gabra5Mouseabnormal spleen morphology  IEA 5509061 MGI 
Gabra5Mouseabnormal testis morphology  IEA 5509061 MGI 
Gabra5Mouseabnormal thymus morphology  IEA 5509061 MGI 
Gabra5Mousecochlear ganglion degeneration  IAGP 5509061 MGIPMID:17021187
Gabra5Mousecochlear inner hair cell degeneration  IAGP 5509061 MGIPMID:17021187
Gabra5Mousecochlear outer hair cell degeneration  IAGP 5509061 MGIPMID:17021187
Gabra5Mousedecreased fluid intake  IAGP 5509061 MGIPMID:17638582
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Reference Title
Reference Citation
1. mRNA and protein levels for GABAAalpha4, alpha5, beta1 and GABABR1 receptors are altered in brains from subjects with autism. Fatemi SH, etal., J Autism Dev Disord. 2010 Jun;40(6):743-50.
2. Excess of allele1 for alpha3 subunit GABA receptor gene (GABRA3) in bipolar patients: a multicentric association study. Massat I, etal., Mol Psychiatry 2002;7(2):201-7.
3. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
4. MGDs mouse GO annotations MGD data from the GO Consortium
5. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
6. Positive association between the GABRA5 gene and unipolar recurrent major depression. Oruc L, etal., Neuropsychobiology 1997;36(2):62-4.
7. Association between the GABA(A) receptor alpha5 subunit gene locus (GABRA5) and bipolar affective disorder. Papadimitriou GN, etal., Am J Med Genet 1998 Feb 7;81(1):73-80.
8. Mouse MP Annotation Import Pipeline RGD automated import pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
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PMID:1338907   PMID:2561977   PMID:7560270   PMID:7601451   PMID:8001787   PMID:8146195   PMID:8388764   PMID:8389098   PMID:8389469   PMID:8392662   PMID:8601494   PMID:8889548  
PMID:9060416   PMID:9330366   PMID:9682826   PMID:9729294   PMID:9924185   PMID:10349636   PMID:10479684   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11745664   PMID:12084936  
PMID:12097508   PMID:12477932   PMID:14993607   PMID:15263904   PMID:15282283   PMID:15284346   PMID:15380015   PMID:15456818   PMID:15489334   PMID:15549469   PMID:15620220   PMID:16141072  
PMID:16141073   PMID:16253225   PMID:16452257   PMID:16467845   PMID:16597725   PMID:16870734   PMID:16987237   PMID:17021187   PMID:17525114   PMID:17638582   PMID:17715197   PMID:18077674  
PMID:18185516   PMID:18256262   PMID:18287559   PMID:19457072   PMID:19941877   PMID:20180861   PMID:20392949   PMID:20457185   PMID:21048709   PMID:21070817   PMID:21677750   PMID:21712993  
PMID:21825029   PMID:21862448   PMID:21873635   PMID:22514301   PMID:22569571   PMID:22640814   PMID:22677273   PMID:22723691   PMID:22768092   PMID:22999935   PMID:23516534   PMID:24952961  
PMID:25100596   PMID:25365226   PMID:25708312   PMID:25865415   PMID:25891999   PMID:26134653   PMID:26169564   PMID:26322928   PMID:26446222   PMID:27067130   PMID:27155990   PMID:27364953  
PMID:27779093   PMID:27792253   PMID:27793660   PMID:28717969   PMID:30104684   PMID:30121012   PMID:30177704   PMID:30282698   PMID:30523065   PMID:31665922   PMID:32750173   PMID:32877400  
PMID:33068001   PMID:33096025   PMID:34530841   PMID:35228700   PMID:36120438   PMID:36417873   PMID:36733270   PMID:36833213   PMID:38187761   PMID:38355793   PMID:38736483   PMID:38894703  
PMID:39738558  
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Gabra5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39757,057,417 - 57,240,808 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl757,057,420 - 57,159,807 (-)EnsemblGRCm39 Ensembl
GRCm38757,407,669 - 57,591,016 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl757,407,672 - 57,510,059 (-)EnsemblGRCm38mm10GRCm38
MGSCv37764,663,039 - 64,765,379 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36757,275,688 - 57,377,873 (-)NCBIMGSCv36mm8
Celera754,720,522 - 54,830,242 (-)NCBICelera
Cytogenetic Map7B5NCBI
cM Map733.52NCBI
GABRA5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381526,866,719 - 26,949,208 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1526,866,911 - 26,949,208 (+)EnsemblGRCh38hg38GRCh38
GRCh371527,111,866 - 27,194,355 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361524,663,151 - 24,679,797 (+)NCBINCBI36Build 36hg18NCBI36
Build 361524,742,696 - 24,776,749 (+)NCBINCBI36Build 36hg18NCBI36
Build 341524,742,694 - 24,776,749NCBI
Celera155,273,203 - 5,355,540 (+)NCBICelera
Cytogenetic Map15q12NCBI
HuRef155,288,011 - 5,322,374 (+)NCBIHuRef
HuRef155,241,009 - 5,262,207 (+)NCBIHuRef
CHM1_11527,061,401 - 27,143,890 (+)NCBICHM1_1
T2T-CHM13v2.01524,607,751 - 24,690,792 (+)NCBIT2T-CHM13v2.0
Gabra5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81117,404,446 - 117,517,424 (-)NCBIGRCr8
mRatBN7.21108,268,728 - 108,381,670 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1108,268,776 - 108,380,917 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1113,646,984 - 113,751,778 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01122,119,493 - 122,224,279 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01115,367,807 - 115,472,601 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01112,833,941 - 112,947,482 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1112,833,944 - 112,947,451 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01113,844,235 - 113,955,760 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41108,843,086 - 108,955,130 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11108,921,428 - 109,033,473 (-)NCBI
Celera1102,441,576 - 102,547,389 (-)NCBICelera
Cytogenetic Map1q22NCBI
Gabra5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555332,563,319 - 2,631,289 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555332,563,499 - 2,631,086 (-)NCBIChiLan1.0ChiLan1.0
GABRA5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2168,328,194 - 8,411,167 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11511,969,290 - 12,052,259 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0152,953,857 - 3,036,722 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11524,300,300 - 24,382,535 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1524,300,300 - 24,382,730 (+)Ensemblpanpan1.1panPan2
GABRA5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1333,663,414 - 33,746,120 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl333,664,169 - 33,744,328 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha336,353,800 - 36,436,241 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0333,999,325 - 34,081,790 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl333,999,318 - 34,081,948 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1333,539,876 - 33,622,259 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0333,802,491 - 33,884,937 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0333,949,742 - 34,032,243 (-)NCBIUU_Cfam_GSD_1.0
Gabra5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640121,933,396 - 122,009,905 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647139,781,451 - 39,975,518 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647139,781,451 - 39,856,766 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GABRA5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1140,486,104 - 140,567,894 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11140,486,107 - 140,568,204 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21156,791,330 - 156,874,272 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GABRA5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12655,147,512 - 55,227,801 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2655,147,511 - 55,227,297 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605437,978,006 - 38,060,544 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gabra5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248961,267,077 - 1,337,038 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Gabra5
10604 total Variants

Predicted Target Of
Summary Value
Count of predictions:250
Count of miRNA genes:202
Interacting mature miRNAs:221
Transcripts:ENSMUST00000068456
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 48 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
1301969Lbw5_mlupus NZB x NZW 5 (mouse)Not determined72684761560851775Mouse
27226778Femd11_mfemur midshaft diameter 11, 16 week (mouse)756949748134001729Mouse
1357586Mdmsc3_mmodifier of muscularity 3 (mouse)Not determined73444786968448018Mouse
38501068Tip1_mtuberculosis immunophenotype 1, spleen CFU (mouse)7360299972549748Mouse
39128210Lwq19_mliver weight QTL 19 (mouse)73349772758148965Mouse
11252140Fdr1_mfat response to dietary restriction 1 (mouse)74114882075148965Mouse
25823170Hrsq7_mhost response to SARS QTL 7, log titer (mouse)754819589116822815Mouse
1357469Kidq5_mkidney weight QTL 5 (mouse)Not determined73349772758148965Mouse
1301082Bbaa16_mB.burgdorferi-associated arthritis 16 (mouse)Not determined736280015116416877Mouse

1 to 10 of 48 rows
AW046005  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38757,407,922 - 57,408,009UniSTSGRCm38
MGSCv37764,663,292 - 64,663,379UniSTSGRCm37
Celera754,720,775 - 54,720,862UniSTS
Cytogenetic Map7CUniSTS
cM Map728.5UniSTS
Whitehead/MRC_RH7682.38UniSTS
14.MMHAP22FRE8.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38757,417,953 - 57,418,107UniSTSGRCm38
MGSCv37764,673,323 - 64,673,477UniSTSGRCm37
Cytogenetic Map7CUniSTS
cM Map728.5UniSTS
Whitehead_YAC7 UniSTS






1 to 16 of 16 rows
RefSeq Transcripts NM_001362161 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001362162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_176942 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006540556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006540557 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006540560 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030241988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC102129 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC109157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC160553 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF090374 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF540386 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK038476 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK083185 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC062112 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466599 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 16 of 16 rows

Ensembl Acc Id: ENSMUST00000068456   ⟹   ENSMUSP00000063276
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl757,057,420 - 57,159,757 (-)Ensembl
GRCm38.p6 Ensembl757,407,672 - 57,510,009 (-)Ensembl
Ensembl Acc Id: ENSMUST00000206382   ⟹   ENSMUSP00000146238
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl757,057,467 - 57,159,119 (-)Ensembl
GRCm38.p6 Ensembl757,407,719 - 57,509,371 (-)Ensembl
Ensembl Acc Id: ENSMUST00000206734   ⟹   ENSMUSP00000145685
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl757,057,653 - 57,159,807 (-)Ensembl
GRCm38.p6 Ensembl757,407,905 - 57,510,059 (-)Ensembl
RefSeq Acc Id: NM_001362161   ⟹   NP_001349090
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39757,057,417 - 57,159,807 (-)NCBI
GRCm38757,407,669 - 57,510,059 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001362162   ⟹   NP_001349091
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39757,057,417 - 57,159,757 (-)NCBI
GRCm38757,407,669 - 57,510,009 (-)NCBI
Sequence:
RefSeq Acc Id: NM_176942   ⟹   NP_795916
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39757,057,417 - 57,159,757 (-)NCBI
GRCm38757,407,669 - 57,510,009 (-)NCBI
MGSCv37764,663,039 - 64,765,379 (-)RGD
Celera754,720,522 - 54,830,242 (-)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006540556   ⟹   XP_006540619
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39757,057,420 - 57,159,381 (-)NCBI
GRCm38757,407,672 - 57,509,637 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006540557   ⟹   XP_006540620
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39757,057,420 - 57,159,382 (-)NCBI
GRCm38757,407,683 - 57,509,638 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006540560   ⟹   XP_006540623
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39757,057,420 - 57,159,856 (-)NCBI
GRCm38757,407,672 - 57,510,103 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030241988   ⟹   XP_030097848
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39757,057,420 - 57,240,808 (-)NCBI
GRCm38757,407,672 - 57,591,016 (-)NCBI
Sequence:
1 to 5 of 10 rows
1 to 5 of 10 rows
RefSeq Acc Id: NP_795916   ⟸   NM_176942
- Peptide Label: precursor
- UniProtKB: Q8BHJ7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006540623   ⟸   XM_006540560
- Peptide Label: isoform X1
- UniProtKB: Q8BHJ7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006540620   ⟸   XM_006540557
- Peptide Label: isoform X1
- UniProtKB: Q8BHJ7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006540619   ⟸   XM_006540556
- Peptide Label: isoform X1
- UniProtKB: Q8BHJ7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001349090   ⟸   NM_001362161
- Peptide Label: precursor
- UniProtKB: Q8BHJ7 (UniProtKB/Swiss-Prot)
Name Modeler Protein Id AA Range Protein Structure
AF-Q8BHJ7-F1-model_v2 AlphaFold Q8BHJ7 1-463 view protein structure

RGD ID:8664267
Promoter ID:EPDNEW_M10165
Type:initiation region
Name:Gabra5_1
Description:Mus musculus gamma-aminobutyric acid A receptor, subunit alpha5 , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38757,509,922 - 57,509,982EPDNEW


1 to 37 of 37 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSMUSG00000055078 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000068456 ENTREZGENE
  ENSMUST00000068456.8 UniProtKB/Swiss-Prot
  ENSMUST00000206382 ENTREZGENE
  ENSMUST00000206382.2 UniProtKB/Swiss-Prot
  ENSMUST00000206734 ENTREZGENE
  ENSMUST00000206734.2 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.58.390 UniProtKB/Swiss-Prot
  2.70.170.10 UniProtKB/Swiss-Prot
InterPro GABAA/Glycine_rcpt UniProtKB/Swiss-Prot
  GABAAa_rcpt UniProtKB/Swiss-Prot
  GABBAa5_rcpt UniProtKB/Swiss-Prot
  Gabra-1-6_TM UniProtKB/Swiss-Prot
  Neur_chan_lig-bd UniProtKB/Swiss-Prot
  Neur_chan_lig-bd_sf UniProtKB/Swiss-Prot
  Neur_channel UniProtKB/Swiss-Prot
  Neuro-gated_channel_TM_sf UniProtKB/Swiss-Prot
  Neuro_actylchol_rec UniProtKB/Swiss-Prot
  Neurotrans-gated_channel_TM UniProtKB/Swiss-Prot
  Neurotransmitter_ion_chnl_CS UniProtKB/Swiss-Prot
KEGG Report mmu:110886 UniProtKB/Swiss-Prot
MGD MGI:95617 ENTREZGENE
NCBI Gene Gabra5 ENTREZGENE
PANTHER PTHR18945 UniProtKB/Swiss-Prot
Pfam Neur_chan_LBD UniProtKB/Swiss-Prot
  Neur_chan_memb UniProtKB/Swiss-Prot
PhenoGen Gabra5 PhenoGen
PRINTS GABAARALPHA UniProtKB/Swiss-Prot
  GABAARALPHA5 UniProtKB/Swiss-Prot
  GABAARECEPTR UniProtKB/Swiss-Prot
  NRIONCHANNEL UniProtKB/Swiss-Prot
PROSITE NEUROTR_ION_CHANNEL UniProtKB/Swiss-Prot
Superfamily-SCOP SSF63712 UniProtKB/Swiss-Prot
  SSF90112 UniProtKB/Swiss-Prot
UniProt GBRA5_MOUSE UniProtKB/Swiss-Prot
  O88964_MOUSE UniProtKB/TrEMBL
  Q8BHJ7 ENTREZGENE
1 to 37 of 37 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-08-21 Gabra5  gamma-aminobutyric acid type A receptor subunit alpha 5  Gabra5  gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 5  Symbol and/or name change 5135510 APPROVED
2024-08-21 Gabra5  gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 5  Gabra5  gamma-aminobutyric acid type A receptor subunit alpha 5  Symbol and/or name change 5135510 APPROVED
2023-07-04 Gabra5  gamma-aminobutyric acid type A receptor subunit alpha 5  Gabra5  gamma-aminobutyric acid (GABA) A receptor, subunit alpha 5  Symbol and/or name change 5135510 APPROVED