RGD Reference Report - mRNA and protein levels for GABAAalpha4, alpha5, beta1 and GABABR1 receptors are altered in brains from subjects with autism. - Rat Genome Database

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mRNA and protein levels for GABAAalpha4, alpha5, beta1 and GABABR1 receptors are altered in brains from subjects with autism.

Authors: Fatemi, SH  Reutiman, TJ  Folsom, TD  Rooney, RJ  Patel, DH  Thuras, PD 
Citation: Fatemi SH, etal., J Autism Dev Disord. 2010 Jun;40(6):743-50.
RGD ID: 6480253
Pubmed: PMID:20066485   (View Abstract at PubMed)
PMCID: PMC2865581   (View Article at PubMed Central)
DOI: DOI:10.1007/s10803-009-0924-z   (Journal Full-text)

We have shown altered expression of gamma-aminobutyric acid A (GABA(A)) and gamma-aminobutyric acid B (GABA(B)) receptors in the brains of subjects with autism. In the current study, we sought to verify our western blotting data for GABBR1 via qRT-PCR and to expand our previous work to measure mRNA and protein levels of 3 GABA(A) subunits previously associated with autism (GABRalpha4; GABRalpha5; GABRbeta1). Three GABA receptor subunits demonstrated mRNA and protein level concordance in superior frontal cortex (GABRalpha4, GABRalpha5, GABRbeta1) and one demonstrated concordance in cerebellum (GABBetaR1). These results provide further evidence of impairment of GABAergic signaling in autism.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  

Objects Annotated

Genes (Rattus norvegicus)
Gabra4  (gamma-aminobutyric acid type A receptor subunit alpha 4)
Gabra5  (gamma-aminobutyric acid type A receptor subunit alpha 5)
Gabrb1  (gamma-aminobutyric acid type A receptor subunit beta1)

Genes (Mus musculus)
Gabra4  (gamma-aminobutyric acid type A receptor subunit alpha 4)
Gabra5  (gamma-aminobutyric acid type A receptor subunit alpha 5)
Gabrb1  (gamma-aminobutyric acid type A receptor subunit beta 1)

Genes (Homo sapiens)
GABRA4  (gamma-aminobutyric acid type A receptor subunit alpha4)
GABRA5  (gamma-aminobutyric acid type A receptor subunit alpha5)
GABRB1  (gamma-aminobutyric acid type A receptor subunit beta1)


Additional Information