RGD Reference Report - Positive association between the GABRA5 gene and unipolar recurrent major depression. - Rat Genome Database

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Positive association between the GABRA5 gene and unipolar recurrent major depression.

Authors: Oruc, L  Verheyen, GR  Furac, I  Ivezic, S  Jakovljevic, M  Raeymaekers, P  Van Broeckhoven, C 
Citation: Oruc L, etal., Neuropsychobiology 1997;36(2):62-4.
RGD ID: 1358629
Pubmed: PMID:9267853   (View Abstract at PubMed)

The gamma-aminobutyric acid (GABA) neurotransmitter system has been implicated in the pathogenesis of mood disorders. To test this hypothesis we carried out an association study between a dinucleotide repeat polymorphism in the GABAA receptor alpha 5 subunit gene and bipolar and unipolar mood disorders. Our results suggest a possible involvement of this gene in unipolar but not in bipolar disorder.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
GABRA5Humandepressive disorder  IAGP DNA:repeat:: (human)RGD 
Gabra5Ratdepressive disorder  ISOGABRA5 (Homo sapiens)DNA:repeat:: (human)RGD 
Gabra5Mousedepressive disorder  ISOGABRA5 (Homo sapiens)DNA:repeat:: (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Gabra5  (gamma-aminobutyric acid type A receptor subunit alpha 5)

Genes (Mus musculus)
Gabra5  (gamma-aminobutyric acid type A receptor subunit alpha 5)

Genes (Homo sapiens)
GABRA5  (gamma-aminobutyric acid type A receptor subunit alpha5)


Additional Information