Htr6 (5-hydroxytryptamine receptor 6) - Rat Genome Database

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Gene: Htr6 (5-hydroxytryptamine receptor 6) Rattus norvegicus
Analyze
Symbol: Htr6
Name: 5-hydroxytryptamine receptor 6
RGD ID: 62044
Description: Enables G protein-coupled serotonin receptor activity. Involved in several processes, including G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; long-term synaptic potentiation; and regulation of amine transport. Located in dendrite. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human HTR6 (5-hydroxytryptamine receptor 6); PARTICIPATES IN serotonin signaling pathway via receptors engaging G alphas protein family; calcium/calcium-mediated signaling pathway; INTERACTS WITH 6-propyl-2-thiouracil; acrylamide; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 5-HT-6; 5-HT6; 5-hydroxytryptamine (serotonin) receptor 6; 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled; serotonin receptor 6; ST-B17
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85156,579,901 - 156,595,147 (-)NCBIGRCr8
mRatBN7.25151,295,269 - 151,312,853 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5151,296,662 - 151,311,912 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5153,994,008 - 154,009,139 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05155,768,318 - 155,783,449 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05155,750,238 - 155,765,452 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05157,501,202 - 157,518,870 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5157,503,040 - 157,518,631 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05161,242,331 - 161,257,707 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera5149,681,578 - 149,696,742 (-)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
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Reference
Notes
Source
Original Reference(s)
Htr6RatAlzheimer's disease susceptibilityISOHTR6 (Homo sapiens)1358662DNA:silent mutation:cds: 267C>T (human)RGD 
Object Symbol
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Original Reference(s)
Htr6Rat3-hydroxy-3-methylglutaryl-CoA lyase deficiency  ISOHTR6 (Homo sapiens)8554872ClinVar Annotator: match by term: Deficiency of hydroxymethylglutaryl-CoA lyaseClinVarPMID:28492532
Htr6Ratchromosome 1p36 deletion syndrome  ISOHTR6 (Homo sapiens)8554872ClinVar Annotator: match by term: Chromosome 1p36 deletion syndromeClinVar 
Htr6Ratcongenital disorder of glycosylation Ir  ISOHTR6 (Homo sapiens)8554872ClinVar Annotator: match by term: Congenital disorder of glycosylation type IrClinVarPMID:28492532
Htr6Rathyperprolinemia type 2  ISOHTR6 (Homo sapiens)8554872ClinVar Annotator: match by term: Hyperprolinemia type 2ClinVarPMID:28492532
Htr6RatParkinson's disease 6  ISOHTR6 (Homo sapiens)8554872ClinVar Annotator: match by term: Autosomal recessive early-onset Parkinson disease 6ClinVarPMID:28492532
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Original Reference(s)
Htr6Ratamphetamine abuse  ISOHTR6 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20705401
Htr6RatMemory Disorders  ISOHTR6 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19733250
Htr6Ratschizophrenia  ISOHTR6 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12165372
Htr6Ratsubstance-induced psychosis  ISOHTR6 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20705401

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Original Reference(s)
Htr6Rat1,2-dichloroethane increases expressionISOHtr6 (Mus musculus)6480464ethylene dichloride results in increased expression of HTR6 mRNACTDPMID:28960355
Htr6Rat3',5'-cyclic AMP increases abundanceISOHtr6 (Mus musculus)6480464HTR6 protein results in increased abundance of Cyclic AMPCTDPMID:11406289
Htr6Rat3',5'-cyclic AMP multiple interactionsISOHtr6 (Mus musculus)6480464Serotonin promotes the reaction [HTR6 protein results in increased abundance of Cyclic AMP]CTDPMID:11406289
Htr6Rat4,4'-sulfonyldiphenol affects methylationISOHtr6 (Mus musculus)6480464bisphenol S affects the methylation of HTR6 geneCTDPMID:31683443
Htr6Rat6-propyl-2-thiouracil decreases expressionEXP 6480464Propylthiouracil results in decreased expression of HTR6 mRNACTDPMID:24780913
Htr6Ratacrylamide decreases expressionEXP 6480464Acrylamide results in decreased expression of HTR6 mRNACTDPMID:28959563
Htr6RatAflatoxin B2 alpha increases methylationISOHTR6 (Homo sapiens)6480464aflatoxin B2 results in increased methylation of HTR6 intronCTDPMID:30157460
Htr6Ratall-trans-retinoic acid multiple interactionsISOHtr6 (Mus musculus)6480464[mono-(2-ethylhexyl)phthalate co-treated with Tretinoin] results in increased expression of HTR6 mRNACTDPMID:36189433
Htr6Ratall-trans-retinoic acid increases expressionISOHtr6 (Mus musculus)6480464Tretinoin results in increased expression of HTR6 mRNACTDPMID:36189433
Htr6Ratammonium chloride affects expressionEXP 6480464Ammonium Chloride affects the expression of HTR6 mRNACTDPMID:16483693
Htr6Ratapomorphine increases response to substanceEXP 6480464HTR6 protein results in increased susceptibility to ApomorphineCTDPMID:17920665
Htr6Ratapomorphine multiple interactionsEXP 6480464Ro4368554 inhibits the reaction [HTR6 protein results in increased susceptibility to Apomorphine]CTDPMID:17920665
Htr6Ratbenzo[a]pyrene increases methylationISOHTR6 (Homo sapiens)6480464Benzo(a)pyrene results in increased methylation of HTR6 5' UTR more ...CTDPMID:27901495
Htr6Ratbisphenol A decreases expressionEXP 6480464bisphenol A results in decreased expression of HTR6 mRNACTDPMID:25181051 more ...
Htr6Ratbisphenol A decreases methylationISOHtr6 (Mus musculus)6480464bisphenol A results in decreased methylation of HTR6 promoterCTDPMID:27312807
Htr6Ratbisphenol F decreases expressionEXP 64804644 and 4'-bisphenol F results in decreased expression of HTR6 mRNACTDPMID:26186136
Htr6Ratcadmium atom multiple interactionsISOHtr6 (Mus musculus)6480464[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of HTR6 mRNACTDPMID:37325564
Htr6Ratcadmium dichloride multiple interactionsISOHtr6 (Mus musculus)6480464[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of HTR6 mRNACTDPMID:37325564
Htr6Ratchlorpyrifos affects expressionEXP 6480464Chlorpyrifos affects the expression of HTR6 mRNACTDPMID:17452286 and PMID:18835401
Htr6Ratclozapine multiple interactionsISOHtr6 (Mus musculus)6480464Clozapine binds to and results in decreased activity of HTR6 proteinCTDPMID:11406289

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Biological Process
1 to 20 of 24 rows

  
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Original Reference(s)
Htr6Ratadenylate cyclase-activating serotonin receptor signaling pathway involved_inISSUniProtKB:P504061600115GO_REF:0000024UniProtGO_REF:0000024
Htr6Ratadenylate cyclase-activating serotonin receptor signaling pathway involved_inISOHTR6 (Homo sapiens)1624291 PMID:35714614 more ...RGDPMID:35714614 more ...
Htr6Ratadenylate cyclase-modulating G protein-coupled receptor signaling pathway involved_inIBAFB:FBgn0011582 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Htr6Ratcerebral cortex cell migration involved_inISSUniProtKB:Q9R1C81600115GO_REF:0000024UniProtGO_REF:0000024
Htr6Ratcerebral cortex cell migration involved_inISOHtr6 (Mus musculus)1624291 PMID:25078650RGDPMID:25078650
Htr6Ratchemical synaptic transmission involved_inIBAMGI:88398 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Htr6RatG protein-coupled receptor signaling pathway involved_inIEAInterPro:IPR000276 and InterPro:IPR0022321600115GO_REF:0000002InterProGO_REF:0000002
Htr6RatG protein-coupled receptor signaling pathway involved_inIEAUniProtKB-KW:KW-02971600115GO_REF:0000043UniProtGO_REF:0000043
Htr6RatG protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger  IMP 729174 RGD 
Htr6RatG protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger involved_inIBAPANTHER:PTN000664111 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Htr6RatG protein-coupled serotonin receptor signaling pathway involved_inIEAGO:00049931600115GO_REF:0000108GOCGO_REF:0000108
Htr6Ratlearning  IDA 2316999instrumental learningRGD 
Htr6Ratlong-term synaptic potentiation  IMP 2316998 RGD 
Htr6Ratnegative regulation of acetylcholine secretion, neurotransmission  IMP 2317005 RGD 
Htr6Ratnegative regulation of gamma-aminobutyric acid secretion  IMP 2317005 RGD 
Htr6Ratnegative regulation of glutamate secretion  IMP 2317005 RGD 
Htr6Ratpositive regulation of dopamine secretion  IMP 2317005 RGD 
Htr6Ratpositive regulation of gamma-aminobutyric acid secretion  IMP 2316998 RGD 
Htr6Ratpositive regulation of TOR signaling involved_inISSUniProtKB:P504061600115GO_REF:0000024UniProtGO_REF:0000024
Htr6Ratpositive regulation of TOR signaling involved_inISOHtr6 (Mus musculus)1624291 PMID:23027611RGDPMID:23027611
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Cellular Component
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Object Symbol
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Original Reference(s)
Htr6Ratcilium located_inISOHtr6 (Mus musculus)1624291 PMID:22179047RGDPMID:22179047
Htr6Ratdendrite  IDA 2317011 RGD 
Htr6Ratdendrite is_active_inIBAPANTHER:PTN000664111 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Htr6Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Htr6Ratmembrane located_inIEAInterPro:IPR000276 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Htr6Ratplasma membrane located_inIEAUniProtKB-SubCell:SL-00391600115GO_REF:0000044UniProtGO_REF:0000044
Htr6Ratplasma membrane is_active_inIBAFB:FBgn0000037 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Htr6Ratplasma membrane is_active_inISOHTR6 (Homo sapiens)1624291 PMID:37327704RGDPMID:37327704
Htr6Ratplasma membrane located_inIEAUniProtKB-KW:KW-10031600115GO_REF:0000043UniProtGO_REF:0000043
Htr6Ratplasma membrane is_active_inISSUniProtKB:P504061600115GO_REF:0000024UniProtGO_REF:0000024
Htr6Ratsynapse located_inIEAGO:00072681600115GO_REF:0000108GOCGO_REF:0000108
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Molecular Function
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Imported Annotations - SMPDB

Object Symbol
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Original Reference(s)
Htr6Ratserotonin signaling pathway via receptors engaging G alphas protein family  ISOHTR6 (Homo sapiens)10402751 SMPDBSMP:00312

Imported Annotations - KEGG (archival)

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Original Reference(s)
Htr6Ratcalcium/calcium-mediated signaling pathway   IEA 6907045 KEGGrno:04020

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#
Reference Title
Reference Citation
1. Localization of 5-HT(6) receptors at the plasma membrane of neuronal cilia in the rat brain. Brailov I, etal., Brain Res. 2000 Jul 28;872(1-2):271-5.
2. Effects of clozapine and haloperidol on 5-HT6 receptor mRNA levels in rat brain. Frederick JA and Meador-Woodruff JH, Schizophr Res. 1999 Jul 27;38(1):7-12.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Characterization of 5-ht6 receptor and expression of 5-ht6 mRNA in the rat brain during ontogenetic development. Grimaldi B, etal., Naunyn Schmiedebergs Arch Pharmacol. 1998 Apr;357(4):393-400.
6. Antibodies and antisense oligonucleotide for probing the distribution and putative functions of central 5-HT6 receptors. Hamon M, etal., Neuropsychopharmacology. 1999 Aug;21(2 Suppl):68S-76S.
7. Direct interaction and functional coupling between human 5-HT6 receptor and the light chain 1 subunit of the microtubule-associated protein 1B (MAP1B-LC1). Kim SH, etal., PLoS One. 2014 Mar 10;9(3):e91402. doi: 10.1371/journal.pone.0091402. eCollection 2014.
8. Cloning, characterization, and chromosomal localization of a human 5-HT6 serotonin receptor. Kohen R, etal., J Neurochem 1996 Jan;66(1):47-56.
9. Lack of localization of 5-HT6 receptors on cholinergic neurons: implication of multiple neurotransmitter systems in 5-HT6 receptor-mediated acetylcholine release. Marcos B, etal., Eur J Neurosci. 2006 Sep;24(5):1299-306.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Increased expression of 5-HT6 receptors in the rat dorsomedial striatum impairs instrumental learning. Mitchell ES, etal., Neuropsychopharmacology. 2007 Jul;32(7):1520-30. Epub 2006 Dec 27.
12. Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs. Monsma FJ Jr, etal., Mol Pharmacol 1993 Mar;43(3):320-7.
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. Estradiol induces expression of 5-hydroxytryptamine (5-HT) 4, 5-HT5, and 5-HT6 receptor messenger ribonucleic acid in rat anterior pituitary cell aggregates and allows prolactin release via the 5-HT4 receptor. Papageorgiou A and Denef C, Endocrinology. 2007 Mar;148(3):1384-95. Epub 2006 Nov 22.
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
17. GOA pipeline RGD automated data pipeline
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. A novel rat serotonin (5-HT6) receptor: molecular cloning, localization and stimulation of cAMP accumulation. Ruat M, etal., Biochem Biophys Res Commun 1993 May 28;193(1):268-76.
20. Association analysis of the 5-HT6 receptor polymorphism C267T in Alzheimer's disease. Tsai SJ, etal., Neurosci Lett 1999 Dec 3;276(2):138-9.
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PMID:9225298   PMID:17543469   PMID:17998104   PMID:19549510   PMID:19902184   PMID:20093369   PMID:20514872   PMID:21619890   PMID:21714816   PMID:22179047   PMID:22982249   PMID:23027611  
PMID:24880860   PMID:25078650   PMID:25837696   PMID:25863121   PMID:25934037   PMID:26424380   PMID:26979176   PMID:27032690   PMID:27106213   PMID:28681593   PMID:31412259   PMID:38408524  



Htr6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85156,579,901 - 156,595,147 (-)NCBIGRCr8
mRatBN7.25151,295,269 - 151,312,853 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5151,296,662 - 151,311,912 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5153,994,008 - 154,009,139 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05155,768,318 - 155,783,449 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05155,750,238 - 155,765,452 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05157,501,202 - 157,518,870 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5157,503,040 - 157,518,631 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05161,242,331 - 161,257,707 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera5149,681,578 - 149,696,742 (-)NCBICelera
Cytogenetic Map5q36NCBI
HTR6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38119,664,875 - 19,680,966 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl119,664,875 - 19,680,966 (+)EnsemblGRCh38hg38GRCh38
GRCh37119,991,368 - 20,007,459 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36119,864,367 - 19,878,642 (+)NCBINCBI36Build 36hg18NCBI36
Build 34119,737,085 - 19,751,361NCBI
Celera118,318,551 - 18,332,825 (+)NCBICelera
Cytogenetic Map1p36.13NCBI
HuRef118,237,853 - 18,251,587 (+)NCBIHuRef
CHM1_1120,101,041 - 20,115,313 (+)NCBICHM1_1
T2T-CHM13v2.0119,488,252 - 19,504,342 (+)NCBIT2T-CHM13v2.0
Htr6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394138,787,017 - 138,802,881 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4138,788,419 - 138,802,881 (-)EnsemblGRCm39 Ensembl
GRCm384139,059,706 - 139,075,570 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4139,061,108 - 139,075,570 (-)EnsemblGRCm38mm10GRCm38
MGSCv374138,617,324 - 138,630,704 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364138,333,485 - 138,346,865 (-)NCBIMGSCv36mm8
Celera4140,846,418 - 140,859,919 (-)NCBICelera
Cytogenetic Map4D3NCBI
cM Map470.57NCBI
Htr6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955452323,641 - 338,312 (+)NCBIChiLan1.0ChiLan1.0
HTR6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21207,437,095 - 207,459,590 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11206,556,661 - 206,576,460 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0118,619,683 - 18,635,822 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1119,662,978 - 19,678,680 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl119,662,978 - 19,678,680 (+)Ensemblpanpan1.1panPan2
HTR6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1279,022,790 - 79,033,975 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl279,022,775 - 79,033,975 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha275,536,323 - 75,547,597 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0279,589,890 - 79,601,165 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl279,589,903 - 79,601,165 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1276,407,980 - 76,419,252 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0277,415,288 - 77,426,563 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0278,486,607 - 78,497,882 (-)NCBIUU_Cfam_GSD_1.0
Htr6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505840,023,901 - 40,033,703 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364745,848,707 - 5,859,749 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364745,848,719 - 5,858,520 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HTR6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1678,077,358 - 78,092,211 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2672,147,759 - 72,164,426 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HTR6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120112,873,132 - 112,887,533 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20112,874,734 - 112,887,066 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660333,273,572 - 3,288,466 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Htr6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247644,778,657 - 4,791,458 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247644,778,563 - 4,791,505 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Htr6
100 total Variants

Predicted Target Of
Summary Value
Count of predictions:51
Count of miRNA genes:47
Interacting mature miRNAs:51
Transcripts:ENSRNOT00000070865
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


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The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat
2302369Scl60Serum cholesterol level QTL 603.13blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)5143608201161165651Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
1300119Bp180Blood pressure QTL 1803.82arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5144358090157869054Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5106906205151906205Rat

1 to 10 of 37 rows
D5Got136  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25151,308,239 - 151,308,356 (+)MAPPERmRatBN7.2
Rnor_6.05157,514,839 - 157,514,955NCBIRnor6.0
Rnor_5.05161,254,035 - 161,254,151UniSTSRnor5.0
Celera5149,693,070 - 149,693,186UniSTS
RH 3.4 Map51033.01RGD
RH 3.4 Map51033.01UniSTS
RH 2.0 Map51005.8RGD
D5Got92  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25151,308,242 - 151,308,369 (+)MAPPERmRatBN7.2
Rnor_6.05157,514,842 - 157,514,968NCBIRnor6.0
Rnor_5.05161,254,038 - 161,254,164UniSTSRnor5.0
Celera5149,693,073 - 149,693,199UniSTS
RH 3.4 Map51033.4RGD
RH 3.4 Map51033.4UniSTS
RH 2.0 Map51021.2RGD




alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
3 1 92 18 7 13 3 33 25 78 5 26 7



Ensembl Acc Id: ENSRNOT00000070865   ⟹   ENSRNOP00000064366
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5151,296,662 - 151,311,912 (-)Ensembl
Rnor_6.0 Ensembl5157,503,040 - 157,518,511 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000078028   ⟹   ENSRNOP00000070830
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl5157,503,164 - 157,518,631 (-)Ensembl
RefSeq Acc Id: NM_024365   ⟹   NP_077341
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85156,579,901 - 156,595,147 (-)NCBI
mRatBN7.25151,296,662 - 151,311,912 (-)NCBI
Rnor_6.05157,503,040 - 157,518,511 (-)NCBI
Rnor_5.05161,242,331 - 161,257,707 (-)NCBI
Celera5149,681,578 - 149,696,742 (-)RGD
Sequence:
Protein RefSeqs NP_077341 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40611 (Get FASTA)   NCBI Sequence Viewer  
  AAA40618 (Get FASTA)   NCBI Sequence Viewer  
  AAA92633 (Get FASTA)   NCBI Sequence Viewer  
  AAB26908 (Get FASTA)   NCBI Sequence Viewer  
  EDL80902 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000064366
GenBank Protein P31388 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_077341   ⟸   NM_024365
- UniProtKB: A0A8L2QXZ5 (UniProtKB/TrEMBL),   A6ITK1 (UniProtKB/TrEMBL),   Q63004 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000064366   ⟸   ENSRNOT00000070865
Ensembl Acc Id: ENSRNOP00000070830   ⟸   ENSRNOT00000078028
G-protein coupled receptors family 1 profile

Name Modeler Protein Id AA Range Protein Structure
AF-P31388-F1-model_v2 AlphaFold P31388 1-436 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13694202
Promoter ID:EPDNEW_R4723
Type:single initiation site
Name:Htr6_1
Description:5-hydroxytryptamine receptor 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05157,518,678 - 157,518,738EPDNEW


1 to 25 of 25 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-39432 BioCyc
Ensembl Genes ENSRNOG00000049761 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000070865 ENTREZGENE
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro 5HT6_rcpt UniProtKB/Swiss-Prot
  GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
NCBI Gene 64354 ENTREZGENE
PANTHER 5-HYDROXYTRYPTAMINE RECEPTOR UniProtKB/Swiss-Prot
  5-HYDROXYTRYPTAMINE RECEPTOR 6 UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PharmGKB HTR6 RGD
PhenoGen Htr6 PhenoGen
PRINTS 5HT6RECEPTR UniProtKB/Swiss-Prot
  GPCRRHODOPSN UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000049761 RatGTEx
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
UniProt 5HT6R_RAT UniProtKB/Swiss-Prot
  A0A8L2QXZ5 ENTREZGENE, UniProtKB/TrEMBL
  A6ITK1 ENTREZGENE, UniProtKB/TrEMBL
  P31388 ENTREZGENE
  Q63004 ENTREZGENE, UniProtKB/TrEMBL
1 to 25 of 25 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Htr6  5-hydroxytryptamine receptor 6  Htr6  5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-17 Htr6  5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled  Htr6  5-hydroxytryptamine (serotonin) receptor 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Htr6  5-hydroxytryptamine (serotonin) receptor 6      Name updated 70584 APPROVED

Note Type Note Reference
gene_expression expressed in striatum, olfactory tubercle, nucleus accumbens and hippocampus 61636
gene_protein 436 amino acids 61636