RGD Reference Report - Localization of 5-HT(6) receptors at the plasma membrane of neuronal cilia in the rat brain. - Rat Genome Database

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Localization of 5-HT(6) receptors at the plasma membrane of neuronal cilia in the rat brain.

Authors: Brailov, I  Bancila, M  Brisorgueil, MJ  Miquel, MC  Hamon, M  Verge, D 
Citation: Brailov I, etal., Brain Res. 2000 Jul 28;872(1-2):271-5.
RGD ID: 2317009
Pubmed: PMID:10924708   (View Abstract at PubMed)

5-HT(6) receptor-like immunoreactivity has been previously found in association with both neuronal dendrites and cilia in the striatum, nucleus accumbens, olfactory tubercle and islands of Calleja of the rat brain. Using immunogold pre-embedding immunocytochemical techniques to investigate the subcellular localization of 5-HT(6) receptor-like immunoreactivity in cilia, we showed that immunogold particles were associated with their plasma membrane, and not with microtubules. This membrane localization is consistent with a possible physiological role, which is still unknown, of these receptors.

Objects referenced in this article
Gene Htr6 5-hydroxytryptamine receptor 6 Rattus norvegicus

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