Kcnk3 (potassium two pore domain channel subfamily K member 3) - Rat Genome Database

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Gene: Kcnk3 (potassium two pore domain channel subfamily K member 3) Rattus norvegicus
Analyze
Symbol: Kcnk3
Name: potassium two pore domain channel subfamily K member 3
RGD ID: 61997
Description: Enables open rectifier potassium channel activity. Involved in several processes, including cellular response to zinc ion; positive regulation of voltage-gated potassium channel activity; and regulation of resting membrane potential. Predicted to be located in plasma membrane. Used to study pulmonary hypertension and pulmonary venoocclusive disease. Biomarker of status epilepticus. Human ortholog(s) of this gene implicated in primary pulmonary hypertension. Orthologous to human KCNK3 (potassium two pore domain channel subfamily K member 3); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: acid-sensitive potassium channel protein TASK-1; potassium channel subfamily K member 3; potassium channel, subfamily K, member 3; potassium channel, two pore domain subfamily K, member 3; rTASK; Task-1; TWIK-related acid-sensitive K(+) channel 1; TWIK-related acid-sensitive K+ channel; two pore K(+) channel KT3.1; two pore potassium channel KT3.1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Kcnk3em1Ang  
Genetic Models: SD-Kcnk3em1Ang-/+ SD-Kcnk3em1Ang-/-
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2625,761,487 - 25,799,153 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl625,763,228 - 25,799,153 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx626,055,862 - 26,091,832 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0626,371,748 - 26,407,719 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0625,851,418 - 25,887,323 (-)NCBIRnor_WKY
Rnor_6.0627,154,274 - 27,190,209 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl627,151,612 - 27,190,132 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0636,969,843 - 37,005,778 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4625,745,923 - 25,782,144 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1625,748,881 - 25,785,097 (-)NCBI
Celera625,246,393 - 25,282,199 (-)NCBICelera
Cytogenetic Map6q14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Motoneurons express heteromeric TWIK-related acid-sensitive K+ (TASK) channels containing TASK-1 (KCNK3) and TASK-3 (KCNK9) subunits. Berg AP, etal., J Neurosci. 2004 Jul 28;24(30):6693-702.
2. Deafness associated changes in two-pore domain potassium channels in the rat inferior colliculus. Cui YL, etal., Neuroscience. 2007 Oct 26;149(2):421-33. Epub 2007 Jul 17.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Characterization of four types of background potassium channels in rat cerebellar granule neurons. Han J, etal., J Physiol 2002 Jul 15;542(Pt 2):431-44.
6. GABA(B) receptor activation augments TASK-1 in MAH cells and mediates autoreceptor feedback during hypoxia. Johnson RP and Fearon IM, Biochem Biophys Res Commun. 2003 Dec 12;312(2):421-5.
7. Postnatal changes in TASK-1 and TREK-1 expression in rat brain stem and cerebellum. Kanjhan R, etal., Neuroreport. 2004 Jun 7;15(8):1321-4.
8. Developmental expression of two-pore domain K+ channels, TASK-1 and TREK-1, in the rat cochlea. Kanjhan R, etal., Neuroreport. 2004 Mar 1;15(3):437-41.
9. Region-specific alterations in astroglial TWIK-related acid-sensitive K+-1 channel immunoreactivity in the rat hippocampal complex following pilocarpine-induced status epilepticus. Kim JE, etal., J Comp Neurol. 2008 Oct 10;510(5):463-74.
10. Characterization of Kcnk3-Mutated Rat, a Novel Model of Pulmonary Hypertension. Lambert M, etal., Circ Res. 2019 Sep 13;125(7):678-695. doi: 10.1161/CIRCRESAHA.119.314793. Epub 2019 Jul 26.
11. An open rectifier potassium channel with two pore domains in tandem cloned from rat cerebellum. Leonoudakis D, etal., J Neurosci 1998 Feb 1;18(3):868-77.
12. Comparison of Human and Experimental Pulmonary Veno-Occlusive Disease. Manaud G, etal., Am J Respir Cell Mol Biol. 2020 Jul;63(1):118-131. doi: 10.1165/rcmb.2019-0015OC.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. Forward transport. 14-3-3 binding overcomes retention in endoplasmic reticulum by dibasic signals. O'Kelly I, etal., Cell. 2002 Nov 15;111(4):577-88.
16. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
17. Hypoxic depolarization of cerebellar granule neurons by specific inhibition of TASK-1. Plant LD, etal., Stroke. 2002 Sep;33(9):2324-8.
18. The retention factor p11 confers an endoplasmic reticulum-localization signal to the potassium channel TASK-1. Renigunta V, etal., Traffic. 2006 Feb;7(2):168-81.
19. GOA pipeline RGD automated data pipeline
20. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. Structural and functional aspects of the multiplicity of Neu differentiation factors. Wen D, etal., Mol Cell Biol 1994 Mar;14(3):1909-19.
23. Adenosine stimulates depolarization and rise in cytoplasmic [Ca2+] in type I cells of rat carotid bodies. Xu F, etal., Am J Physiol Cell Physiol. 2006 Jun;290(6):C1592-8. Epub 2006 Jan 25.
Additional References at PubMed
PMID:9312005   PMID:12198146   PMID:12783883   PMID:14576090   PMID:14678492   PMID:15197476   PMID:16513667   PMID:16736155   PMID:18272437   PMID:18375952   PMID:18554317   PMID:18838117  
PMID:19363137   PMID:20019330   PMID:20835844   PMID:21357689   PMID:21710317   PMID:22017174   PMID:22419174   PMID:22846993   PMID:22977011   PMID:23219908   PMID:23620341   PMID:24989426  
PMID:26912814   PMID:29093631   PMID:29360952   PMID:30516300   PMID:30837397   PMID:30864194   PMID:31472119   PMID:31676368   PMID:32726132   PMID:32860629   PMID:32886017   PMID:33010302  
PMID:33483721   PMID:34073580   PMID:34571371  


Genomics

Comparative Map Data
Kcnk3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2625,761,487 - 25,799,153 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl625,763,228 - 25,799,153 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx626,055,862 - 26,091,832 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0626,371,748 - 26,407,719 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0625,851,418 - 25,887,323 (-)NCBIRnor_WKY
Rnor_6.0627,154,274 - 27,190,209 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl627,151,612 - 27,190,132 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0636,969,843 - 37,005,778 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4625,745,923 - 25,782,144 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1625,748,881 - 25,785,097 (-)NCBI
Celera625,246,393 - 25,282,199 (-)NCBICelera
Cytogenetic Map6q14NCBI
KCNK3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38226,692,722 - 26,733,420 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl226,692,722 - 26,733,420 (+)EnsemblGRCh38hg38GRCh38
GRCh37226,915,590 - 26,956,288 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36226,769,123 - 26,806,222 (+)NCBINCBI36Build 36hg18NCBI36
Build 34226,827,269 - 26,864,354NCBI
Celera226,759,188 - 26,800,097 (+)NCBICelera
Cytogenetic Map2p23.3NCBI
HuRef226,654,995 - 26,695,894 (+)NCBIHuRef
CHM1_1226,845,436 - 26,883,789 (+)NCBICHM1_1
T2T-CHM13v2.0226,731,837 - 26,774,979 (+)NCBIT2T-CHM13v2.0
Kcnk3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39530,745,514 - 30,782,614 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl530,745,514 - 30,782,615 (+)EnsemblGRCm39 Ensembl
GRCm38530,588,170 - 30,625,270 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl530,588,170 - 30,625,271 (+)EnsemblGRCm38mm10GRCm38
MGSCv37530,890,543 - 30,927,643 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36530,864,751 - 30,901,851 (+)NCBIMGSCv36mm8
Celera528,066,527 - 28,103,716 (+)NCBICelera
Cytogenetic Map5B1NCBI
cM Map516.68NCBI
Kcnk3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554698,709,999 - 8,747,467 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554698,710,749 - 8,744,423 (+)NCBIChiLan1.0ChiLan1.0
KCNK3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan12A99,788,296 - 99,829,151 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A26,688,938 - 26,729,860 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A26,780,475 - 26,819,123 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A26,780,475 - 26,819,123 (+)Ensemblpanpan1.1panPan2
KCNK3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11720,732,779 - 20,771,104 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1720,732,819 - 20,768,730 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1720,626,715 - 20,665,014 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01721,054,044 - 21,092,326 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1721,054,082 - 21,089,962 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11720,740,930 - 20,779,204 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01720,752,294 - 20,790,552 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01720,798,295 - 20,836,548 (+)NCBIUU_Cfam_GSD_1.0
Kcnk3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629265,067,699 - 65,071,786 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364935,770,103 - 5,772,326 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049364935,767,779 - 5,772,043 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNK3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3112,322,446 - 112,359,212 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13112,322,446 - 112,359,212 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23119,337,496 - 119,340,759 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KCNK3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11480,905,168 - 80,945,972 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1480,906,608 - 80,945,806 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604531,201,565 - 31,245,180 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnk3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247388,813,644 - 8,848,783 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247388,813,683 - 8,850,744 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kcnk3
90 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:174
Count of miRNA genes:91
Interacting mature miRNAs:117
Transcripts:ENSRNOT00000013107, ENSRNOT00000068412
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738023Alc17Alcohol consumption QTL 173.10.003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)6127574569Rat
1354616Despr12Despair related QTL 120.0012locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)6127574569Rat
1549905Stresp10Stress response QTL 106.830.0066stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)6127574569Rat
2300176Bmd51Bone mineral density QTL 5111.70.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)6127574569Rat
2300190Bmd52Bone mineral density QTL 5211.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)6127574569Rat
1331743Uae28Urinary albumin excretion QTL 284.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)6134235784Rat
1578758Tcas9Tongue tumor susceptibility QTL 93.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)6137618905Rat
1598843Cm63Cardiac mass QTL 632.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)6139036266Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6141223769Rat
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6141223769Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6141223769Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6141223769Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6141223769Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6142487980Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6142487980Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6142487980Rat
7411584Foco4Food consumption QTL 44.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6142838846Rat
738024Sach5Saccharine consumption QTL 53.90.00039consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)6143394190Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6172227641Rat
1300128Rf16Renal function QTL 163.89renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449734434305Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449754641141Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
1578665Bss16Bone structure and strength QTL 164.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)61173566972593685Rat
1578668Bmd14Bone mineral density QTL 143.8femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)61173566972593685Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
1359023Bp272Blood pressure QTL 2722.5arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)61653614027261739Rat
2292589Emca10Estrogen-induced mammary cancer QTL 100.048mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)61653614061536140Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)61653614071636405Rat
1641898Colcr4Colorectal carcinoma resistance QTL43.710.0007intestine integrity trait (VT:0010554)well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)62033877762613667Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat

Markers in Region
D6Wox33  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2625,763,424 - 25,763,544 (+)MAPPERmRatBN7.2
Rnor_6.0627,154,482 - 27,154,599NCBIRnor6.0
Rnor_5.0636,970,051 - 36,970,168UniSTSRnor5.0
RGSC_v3.4625,746,131 - 25,746,248UniSTSRGSC3.4
Celera625,246,601 - 25,246,718UniSTS
Cytogenetic Map6q14UniSTS
PMC16288P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2625,764,388 - 25,764,512 (+)MAPPERmRatBN7.2
Rnor_6.0627,155,444 - 27,155,567NCBIRnor6.0
Rnor_5.0636,971,013 - 36,971,136UniSTSRnor5.0
RGSC_v3.4625,747,093 - 25,747,216UniSTSRGSC3.4
Celera625,247,563 - 25,247,686UniSTS
Cytogenetic Map6q14UniSTS
PMC16288P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2625,764,143 - 25,764,512 (+)MAPPERmRatBN7.2
Rnor_6.0627,155,199 - 27,155,567NCBIRnor6.0
Rnor_5.0636,970,768 - 36,971,136UniSTSRnor5.0
RGSC_v3.4625,746,848 - 25,747,216UniSTSRGSC3.4
Celera625,247,318 - 25,247,686UniSTS
Cytogenetic Map6q14UniSTS


Genetic Models
This gene Kcnk3 is modified in the following models/strains

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 35 9 1 16 5
Low 3 8 35 28 9 28 2 2 50 32 36 11 2
Below cutoff 13 13 9 13 6 9 8 3 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000013107   ⟹   ENSRNOP00000013107
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl627,151,612 - 27,190,132 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000068412   ⟹   ENSRNOP00000063456
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl625,763,800 - 25,799,070 (-)Ensembl
Rnor_6.0 Ensembl627,154,855 - 27,190,126 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000108628   ⟹   ENSRNOP00000079208
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl625,763,228 - 25,799,153 (-)Ensembl
RefSeq Acc Id: NM_033376   ⟹   NP_203694
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2625,763,217 - 25,799,153 (-)NCBI
Rnor_6.0627,154,274 - 27,190,209 (-)NCBI
Rnor_5.0636,969,843 - 37,005,778 (-)NCBI
RGSC_v3.4625,745,923 - 25,782,144 (-)RGD
Celera625,246,393 - 25,282,199 (-)RGD
Sequence:
RefSeq Acc Id: XM_039111849   ⟹   XP_038967777
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2625,761,487 - 25,773,882 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_203694   ⟸   NM_033376
- UniProtKB: O54912 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000063456   ⟸   ENSRNOT00000068412
RefSeq Acc Id: ENSRNOP00000013107   ⟸   ENSRNOT00000013107
RefSeq Acc Id: XP_038967777   ⟸   XM_039111849
- Peptide Label: isoform X1
- UniProtKB: Q9ESM4 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000079208   ⟸   ENSRNOT00000108628
Protein Domains
Potassium channel

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O54912-F1-model_v2 AlphaFold O54912 1-411 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61997 AgrOrtholog
BioCyc Gene G2FUF-38312 BioCyc
Ensembl Genes ENSRNOG00000009790 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000063456.1 UniProtKB/TrEMBL
  ENSRNOP00000079208 ENTREZGENE
  ENSRNOP00000079208.1 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000068412.2 UniProtKB/TrEMBL
  ENSRNOT00000108628 ENTREZGENE
  ENSRNOT00000108628.1 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 2pore_dom_K_chnl UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2pore_dom_K_chnl_TASK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KCNK3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29553 UniProtKB/Swiss-Prot
NCBI Gene 29553 ENTREZGENE
PANTHER PTHR11003 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11003:SF138 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ion_trans_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB KCNK3 RGD
PhenoGen Kcnk3 PhenoGen
PIRSF K_channel_subfamily_K_type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS 2POREKCHANEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TASK1CHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TASKCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Voltage-gated potassium channels UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt G3V9Y8_RAT UniProtKB/TrEMBL
  KCNK3_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q9ESM4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Kcnk3  potassium two pore domain channel subfamily K member 3  Kcnk3  potassium channel, two pore domain subfamily K, member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-26 Kcnk3  potassium channel, two pore domain subfamily K, member 3  Kcnk3  potassium channel, subfamily K, member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Kcnk3  potassium channel, subfamily K, member 3      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains 4 putative transmembrane domains, a PDZ interaction domain, and potential phosphorylation sites for PKC, PKA, and tyrosine kinase 61647
gene_expression expressed most abundantly in heart, lung, brain 61647
gene_function tandem pore domain open rectifier potassium channel 61647
gene_protein 411 amino acid, 45.3 kDa protein 61647
gene_transcript 4 kb transcript 61647