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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61997
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Kcnk3
Name: potassium two pore domain channel subfamily K member 3
Acc ID: CHEBI:80920
Term: alpha-Sanshool
Definition: A fatty amide that has formula C16H25NO.
Chemical ID: MESH:C100574
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kcnk3affects response to substanceISOKCNK3 (Homo sapiens)6480464CTDKCNK3 protein affects the susceptibility to sanshoolPMID:18568022
Kcnk3decreases activityISOKCNK3 (Homo sapiens)6480464CTDsanshool results in decreased activity of KCNK3 proteinPMID:18568022
Kcnk3multiple interactionsISOKCNK3 (Homo sapiens)6480464CTDsanshool inhibits the reaction [[KCNK3 protein binds to KCNK9 protein] which results in increased transport of Potassium]; sanshool inhibits the reaction [KCNK3 protein results in increased transport of Potassium]; sanshool results in decreased activity of [KCNK3 protein binds to KCNK9 protein]PMID:18568022
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