Kcnk3<sup>em1Ang</sup> (potassium two pore domain channel subfamily K member 3; CRISPR/Cas9 induced mutant1, Ang) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Kcnk3em1Ang (potassium two pore domain channel subfamily K member 3; CRISPR/Cas9 induced mutant1, Ang) Rattus norvegicus
Analyze
Symbol: Kcnk3em1Ang
Name: potassium two pore domain channel subfamily K member 3; CRISPR/Cas9 induced mutant1, Ang
RGD ID: 126908015
Description: The mutation created by CRISPR/Cas9 in Crl:SD embryos contained a 94- bp deletion in exon1 of resulted a premature stop codon.
ASSOCIATED WITH abnormal pulmonary collagen fibril morphology; decreased vasodilation; increased heart rate; ASSOCIATED WITH pulmonary hypertension
Type: allele  of Kcnk3  
Previously known as: Kcnk3em1Ang-/-; Kcnk3^[em1Ang]
Is Marker For: Strains:   SD-Kcnk3em1Ang-/-   SD-Kcnk3em1Ang-/+  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Characterization of Kcnk3-Mutated Rat, a Novel Model of Pulmonary Hypertension. Lambert M, etal., Circ Res. 2019 Sep 13;125(7):678-695. doi: 10.1161/CIRCRESAHA.119.314793. Epub 2019 Jul 26.

Genomics


Related Rat Strains
The following Strains have been annotated to Kcnk3em1Ang
SD-Kcnk3em1Ang-/+     SD-Kcnk3em1Ang-/-    


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences


Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-05-10 Kcnk3em1Ang  potassium two pore domain channel subfamily K member 3; CRISPR/Cas9 induced mutant1, Ang  Kcnk3em1Ang-/-  potassium two pore domain channel subfamily K member 3; CRISPR/Cas9 induced mutant1, Ang  Symbol changed 629549 APPROVED