Kcnk3<sup>em1Ang</sup> (potassium two pore domain channel subfamily K member 3; CRISPR/Cas9 induced mutant1, Ang) - Rat Genome Database

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Gene: Kcnk3em1Ang (potassium two pore domain channel subfamily K member 3; CRISPR/Cas9 induced mutant1, Ang) Rattus norvegicus
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Symbol: Kcnk3em1Ang
Name: potassium two pore domain channel subfamily K member 3; CRISPR/Cas9 induced mutant1, Ang
RGD ID: 126908015
Description: The mutation created by CRISPR/Cas9 in Crl:SD embryos contained a 94- bp deletion in exon1 of resulted a premature stop codon.
ASSOCIATED WITH abnormal pulmonary collagen fibril morphology; decreased vasodilation; increased heart rate; ASSOCIATED WITH pulmonary hypertension
Type: allele  of Kcnk3  
Previously known as: Kcnk3em1Ang-/-; Kcnk3^[em1Ang]
Is Marker For: Strains:   SD-Kcnk3em1Ang-/-   SD-Kcnk3em1Ang-/+  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Characterization of Kcnk3-Mutated Rat, a Novel Model of Pulmonary Hypertension. Lambert M, etal., Circ Res. 2019 Sep 13;125(7):678-695. doi: 10.1161/CIRCRESAHA.119.314793. Epub 2019 Jul 26.

Genomics


Related Rat Strains
The following Strains have been annotated to Kcnk3em1Ang
SD-Kcnk3em1Ang-/+     SD-Kcnk3em1Ang-/-    


Expression


Sequence

Nucleotide Sequences


Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-05-10 Kcnk3em1Ang  potassium two pore domain channel subfamily K member 3; CRISPR/Cas9 induced mutant1, Ang  Kcnk3em1Ang-/-  potassium two pore domain channel subfamily K member 3; CRISPR/Cas9 induced mutant1, Ang  Symbol changed 629549 APPROVED