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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61997
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Kcnk3
Name: potassium two pore domain channel subfamily K member 3
Acc ID: CHEBI:76018
Term: riociguat
Definition: A carbamate ester that is the methyl ester of {4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}methylcarbamic acid. It is used for treatment of chronic thromboembolic pulmonary hypertension and pulmonary arterial hypertension
Chemical ID: MESH:C542595
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kcnk3decreases response to substanceISORGD:13454976480464CTDKCNK3 protein mutant form results in decreased susceptibility to riociguat

PMID:30365877
Kcnk3increases activityISORGD:13454976480464CTDriociguat results in increased activity of KCNK3 protein

PMID:30365877
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.